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Hvad skal vi bruge videov rkstederne til?
Tove Heidemann
MedieKultur : Journal of Media and Communication Research , 1989,
Abstract: Med udgangspunkt i erfaringerne fra "MEDIEBIXEN - det bne medie- v rksted for unge og indvandrere i Haderslev" understreger fors gs- projektets rapporter vigtigheden af, at initiativtagere til et mediev rk- sted p forh nd enes om, hvad form let med virksomheden er. Medieproduktion kan indg i p dagogisk, socialp dagogisk eller pro- duktionsorienteret sammenh ng, men den kan ogs "blot" v re en fritidsaktivitet.
Isolated trisomy 7q21.2-31.31 resulting from a complex familial rearrangement involving chromosomes 7, 9 and 10
J?rg Weimer, Simone Heidemann, Constantin S von Kaisenberg, Werner Grote, Norbert Arnold, Susanne Bens, Almuth Caliebe
Molecular Cytogenetics , 2011, DOI: 10.1186/1755-8166-4-28
Abstract: The proband's mother showed a complex balanced translocation t(9;10)(p13;q23) with insertion of 7q21.2-31.31 at the translocation breakpoint at 9p13. The daughter inherited the rearranged chromosomes 9 and 10 but the normal chromosome 7 from her mother, resulting in partial trisomy 7q21.2 to 7q31.31. The phenotype of the patient consisted of marked developmental retardation, facial dysmorphism, short stature, strabism, and hyperextensible metacarpophalangeal joints.For better understanding of genotype-phenotype correlation a new classification of 7q duplications which will be based on findings of molecular karyotyping is needed. Therefore, the description of well-defined patients is valuable. This case shows that FISH-microdissection is of great benefit for precise breakpoint designation in balanced rearrangements.Phenotypic reports of chromosomal imbalances are an important source for genetic counselling especially in prenatal diagnosis. Chromosomal imbalances arise de novo or as the result of a familial rearrangement. The most common familial rearrangements are translocations. In case of an unbalanced segregation in an offspring the resulting imbalances consist of a combination of partial trisomy and partial monosomy. In most of the cases it is impossible to exactly relate the phenotypic consequences of an unbalanced translocation to either the underlying partial trisomy or the partial monosomy. Therefore many case reports are of limited value for genetic counselling because the phenotypic effects of trisomy and monosomy overlap [1]. Another difficulty in the description of phenotypic consequences of a certain chromosomal imbalance is the breakpoint designation. The precise description of the breakpoint is important for the genotype-phenotype correlation. In solely cytogenetically investigated patients, breakpoint designation remains doubtful due to the limited resolution of chromosome banding techniques. In recent years comparative genomic hybridisation (CGH) suc
DNA-Methylation Profiling of Fetal Tissues Reveals Marked Epigenetic Differences between Chorionic and Amniotic Samples
Christel Eckmann-Scholz, Susanne Bens, Julia Kolarova, Sina Schneppenheim, Almuth Caliebe, Simone Heidemann, Constantin von Kaisenberg, Monika Kautza, Walter Jonat, Reiner Siebert, Ole Ammerpohl
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039014
Abstract: Epigenetic mechanisms including DNA methylation are supposed to play a key role in fetal development. Here we have investigated fetal DNA-methylation levels of 27,578 CpG loci in 47 chorionic villi (CVS) and 16 amniotic cell (AC) samples. Methylation levels differed significantly between karyotypically normal AC and CVS for 2,014 genes. AC showed more extreme DNA-methylation levels of these genes than CVS and the differentially methylated genes are significantly enriched for processes characteristic for the different cell types sampled. Furthermore, we identified 404 genes differentially methylated in CVS with trisomy 21. These genes were significantly enriched for high CG dinucleotid (CpG) content and developmental processes associated with Down syndrome. Our study points to major tissue-specific differences of fetal DNA-methylation and gives rise to the hypothesis that part of the Down syndrome phenotype is epigenetically programmed in the first trimester of pregnancy.
Conflicting results of prenatal FISH with different probes for Down's Syndrome critical regions associated with mosaicism for a de novo del(21)(q22) characterised by molecular karyotyping: Case report
Christel Eckmann-Scholz, Stefan Gesk, Inga Nagel, Andrea Haake, Susanne Bens, Simone Heidemann, Monika Kautza, Christian Timke, Reiner Siebert, Almuth Caliebe
Molecular Cytogenetics , 2010, DOI: 10.1186/1755-8166-3-16
Abstract: Fluorescence in situ hybridisation (FISH) on uncultured amniotic fluid cells is a widely used means for the rapid prenatal diagnosis of common aneuploidies. Different commercial suppliers provide FISH assays for the detection of trisomies involving the Down syndrome critical regions (DSCR) in 21q22 which have been extensively validated in single institution series [1,2] and multicenter trials [3]. Interpretation of FISH results may be difficult if unexpected results are detected which for example can be caused by structural aberrations or mosaicism. Here we present a case in which rapid FISH screening with different commercial probes for the Down's syndrome critical regions yielded conflicting results with regard to a partial monosomy 21q. Moreover, by extensive conventional and molecular karyotyping we show this diagnostic problem to be caused by a de novo del(21)(q22) as part of a mosaic karyotype. Deletion of 21q is a rare chromosome disorder. In a recent review of 23 patients of whom reliable mapping data are available the variable phenotype depending on the deleted region became obvious [4]. Intrauterine growth retardation which was the initial presentation of the proband seems to be a constant finding.A 35-year-old woman presented at 24+0 weeks of gestation of her fourth pregnancy. She had suffered two early pregnancy losses. The third pregnancy ended in the delivery of a healthy boy. Medical and family history of the proposita and her partner were unremarkable. First trimester-screening including ultrasound and maternal serum biochemistry had been normal (adjusted risks +21 = 1:1839; +18 = 1:610; +13 = 1:3515). In the 25th week, ultrasound revealed symmetric foetal retardation with cerebral ventriculomegaly, partial agenesis of the corpus callosum, short nasal bone and hyperechogenic bowel. Therefore, amniocentesis was performed and foetal karyotyping initiated. For rapid screening for aneuploidies, FISH was performed according to standard methods on uncultur
Corporate Entrepreneurship: An Empirical Study of the Importance of Strategic Considerations in the Creation of Radical Innovation
Astrid Heidemann Lassen
Managing Global Transitions , 2007,
Abstract: The recognition of the importance of entrepreneurial dynamics in corporate context is increasingly acknowledged in both entrepreneurship and strategic management literature, as firms today face a reality in which frame-breaking innovation is an important element of survival. From this understanding, the concept of Strategic Entrepreneurship (SE) has arisen, arguing a logic of focusing on the intersections between the two fields. This paper sets out to explore the SE construct empirically. Through seven case studies evolving around radical technological innovations, evidence is found of the importance of incorporation of strategic considerations taking place at several different levels of the organization, in order to obtain a desirable balance between entrepreneurial and strategic forces. An Integrative Model of Strategic Entrepreneurship is suggested based on this evidence.
The Importance of Continuous Value Based Project Management in the Context of Requirements Engineering
Gilbert Fridgen,Julia Heidemann
Computer Science , 2013,
Abstract: Despite several scientific achievements in the last years, there are still a lot of IT projects that fail. Researchers found that one out of five IT-projects run out of time, budget or value. Major reasons for this failure are unexpected economic risk factors that emerge during the runtime of projects. In order to be able to identify emerging risks early and to counteract reasonably, financial methods for a continuous IT-project-steering are necessary, which as of today to the best of our knowledge are missing within scientific literature.
Comparison of the systemic and pulmonary inflammatory response to endotoxin of neutropenic and non-neutropenic rats
Sabrina M Heidemann, Maria Glibetic
Journal of Inflammation , 2007, DOI: 10.1186/1476-9255-4-7
Abstract: Rats were divided into four groups: 1) control, 2) neutropenic, 3) endotoxemic and 4) endotoxemic and neutropenic. Tumor necrosis factor (TNF)-α and macrophage inflammatory protein (MIP-2) were measured in the blood, lung lavage and for mRNA in the lung. Arterial blood gases were measured to determine the alveolar-arterial oxygen gradient which reflects on lung injury.In endotoxemia, the neutropenic rats had lower plasma TNF-α (116 ± 73 vs. 202 ± 31 pg/ml) and higher plasma MIP-2 (26.8 + 11.9 vs. 15.6 + 6.9 ng/ml) when compared to non-neutropenic rats. The endotoxemic, neutropenic rats had worse lung injury than the endotoxemic, non-neutropenic rats as shown by increase in the alveolar-arterial oxygen gradient (24 ± 5 vs. 12 ± 9 torr). However, lavage concentrations of TNF-α and MIP-2 were similar in both groups.Neutrophils may regulate TNF-α and MIP-2 production in endotoxemia. The elevation in plasma MIP-2 in the endotoxemic, neutropenic rat may be secondary to the lack of a neutrophil response to inhibit production or release of MIP-2. In endotoxemia, the severe lung injury observed in neutropenic rats does not depend on TNF-α or MIP-2 produced in the lung.Sepsis is a leading cause of morbidity and mortality in the intensive care unit. Improvements in the treatment of cancer have led to a growing population of immunocompromised patients with longer survival times and a propensity to develop sepsis and acute respiratory distress syndrome (ARDS) [1,2]. It is important to study the role of neutrophils in sepsis in order to better understand the effect of neutropenia on the inflammatory response in sepsis. Different treatment modalities may be necessary in the neutropenic versus the non-neutropenic host.Neutropenia is commonly induced by cyclophosphamide in cancer-stricken patients. In these patients, white cells are markedly diminished in number but not absent. It is known that cyclophosphamide has effects on other cells in the body [3-5]. This drug may decrease the
Governan a pública: novo modelo regulatório para as rela es entre Estado, mercado e sociedade?
Leo Kissler,Francisco G. Heidemann
Revista de Administra??o Pública , 2006, DOI: 10.1590/s0034-76122006000300008
Fallbericht: Das andere Karpaltunnelsyndrom
Heidemann M,Krüger T,Banyai M
Zeitschrift für Gef??medizin , 2013,
Abstract: Wir berichten zum ersten Mal von einer thrombosierten A. mediana als Ursache eines Karpaltunnelsyndroms bei einem m nnlichen Patienten. Die A. mediana ist eine anatomische Variation der arteriellen Versorgung der Hand, die in unterschiedlicher H ufigkeit je nach Land und Kontinent in bis zu 30 % einer Population vorkommen kann. Ein Karpaltunnelsyndrom aufgrund einer thrombosierten A. mediana verursacht typischerweise einen lokalen akuten Schmerz im Handgelenk volar. Bis dato existieren Fallberichte ausschlie lich von Frauen, deren Arbeit überwiegend aus manuellen T tigkeiten besteht. Als lokale Ausl ser finden sich h ufig lokale mechanische Traumata, zus tzlich spielen m glicherweise hormonelle Kontrazeption wie auch Nikotinabusus eine Rolle. Therapie der Wahl ist in den meisten F llen die Resektion der thrombosierten Anteile der A. mediana.
On Line Media Market and New Advertising Agencies: Analysis of an Italian Case  [PDF]
Simone Guercini
Journal of Service Science and Management (JSSM) , 2009, DOI: 10.4236/jssm.2009.22015
Abstract: This article focuses on the profile of agencies which offer communication services through new media related to the information role of the major search engines systems (like Google, Yahoo and others). In particular, attention is paid to firms operating in that context which are taking an innovative profile when compared to communication agencies linked to traditional media. The article develops the following steps: in a first part the characteristics are taken into consideration through inno-vative communication systems search engines in relation to market trends and the latest configuration of actors linked to them; a second step considers the case of an Italian company acting as an agency in the so-called "online media market", highlighting the type of skills and relationships developed through this; finally in a third part some thoughts on the characteristics of the new communication agencies are proposed in comparison with those of the traditional ad-vertising agencies operating with the help of the more traditional mass media. At the conclusion of the article some implications of the analysis are developed and evaluations are made about the development of new business communication services object of our analysis.
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