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Search Results: 1 - 10 of 236140 matches for " Simone C.;Castro "
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Sepsis in burned patients
Macedo, Jefferson Lessa S. de;Rosa, Simone C.;Castro, Cleudson;
Revista da Sociedade Brasileira de Medicina Tropical , 2003, DOI: 10.1590/S0037-86822003000600001
Abstract: a prospective study was conducted from june 2001 to may 2002 at the burns unit of hospital regional da asa norte, brasília, brazil. during the period of the study, 252 patients were treated at the burns unit, 49 (19.4%) developed clinically and microbiologically proven sepsis. twenty-six (53.1%) were males and 23 (46.9%) females with a mean age of 22 years (range one to 89 years) and mean burned body surface area of 37.7 ± 18.4% (range 7 to 84%). forty-three patients had flame burns, five a scald and one an electric burn. these 49 patients had a total of 62 septic episodes. forty (81.6%) patients had only one and nine (18.4%) had up to three episodes of sepsis. thirty (61.2%) patients had their first septicemic episode either earlier or by one week postburn. out of 62 septic episodes, 58 were due to bacteria and four due to candida sp. the most common bacteria isolated from blood culture were staphylococcus aureus, coagulase-negative staphylococcus, acinetobacter baumannii, enterobacter cloacae and klebsiella pneumoniae. eleven (18.9%) episodes were due to oxacillin resistant staphylococcus aureus. acinetobacter baumannii was sensitive to ampicillin/sulbactam in 71.4% and to imipenem in 85.7% of the cases. the primary foci of sepsis were the burn wound in 15 ( 24.2% ) episodes. the most common clinical findings of sepsis in these patients were fever, dyspnea, hypotension and oliguria. the most common laboratory findings of these patients were anemia, leukocytosis, hypoalbuminemia and thrombocytopenia. twelve (24.5%) patients died. the appropriate knowledge of clinical, epidemiological, laboratorial and microbiological aspects of sepsis in burned patients permits an adequate diagnosis and treatment of this complication.
Sepsis in burned patients
Macedo Jefferson Lessa S. de,Rosa Simone C.,Castro Cleudson
Revista da Sociedade Brasileira de Medicina Tropical , 2003,
Abstract: A prospective study was conducted from June 2001 to May 2002 at the Burns Unit of Hospital Regional da Asa Norte, Brasília, Brazil. During the period of the study, 252 patients were treated at the Burns Unit, 49 (19.4%) developed clinically and microbiologically proven sepsis. Twenty-six (53.1%) were males and 23 (46.9%) females with a mean age of 22 years (range one to 89 years) and mean burned body surface area of 37.7 ± 18.4% (range 7 to 84%). Forty-three patients had flame burns, five a scald and one an electric burn. These 49 patients had a total of 62 septic episodes. Forty (81.6%) patients had only one and nine (18.4%) had up to three episodes of sepsis. Thirty (61.2%) patients had their first septicemic episode either earlier or by one week postburn. Out of 62 septic episodes, 58 were due to bacteria and four due to Candida sp. The most common bacteria isolated from blood culture were Staphylococcus aureus, coagulase-negative Staphylococcus, Acinetobacter baumannii, Enterobacter cloacae and Klebsiella pneumoniae. Eleven (18.9%) episodes were due to oxacillin resistant Staphylococcus aureus. Acinetobacter baumannii was sensitive to ampicillin/sulbactam in 71.4% and to imipenem in 85.7% of the cases. The primary foci of sepsis were the burn wound in 15 ( 24.2% ) episodes. The most common clinical findings of sepsis in these patients were fever, dyspnea, hypotension and oliguria. The most common laboratory findings of these patients were anemia, leukocytosis, hypoalbuminemia and thrombocytopenia. Twelve (24.5%) patients died. The appropriate knowledge of clinical, epidemiological, laboratorial and microbiological aspects of sepsis in burned patients permits an adequate diagnosis and treatment of this complication.
Intervalo QT corrigido e fatores de risco tradicionais para doen?a aterosclerótica em pacientes com diabetes tipo 1
Castro, Simone Henriques de;Faria-Neto, Hugo C. Castro;Gomes, Marilia de Brito;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2007, DOI: 10.1590/S0004-27302007000700019
Abstract: to evaluate the qtc interval and its relation with clinical, laboratorial variables and ldl susceptibility to in vitro oxidation in patients with type 1 dm, we studied 40 diabetics and 33 non diabetics with 24.83 ± 10.21 and 23.51 ± 7.28 years old, respectively matched by sex, age and body mass index (bmi). we evaluated metabolic control, a and b apolipoproteins, ldl oxidation coefficient for spectrophotometry and electrocardiogram (ecg). interval qtc was calculated by the bazett?s formula. there was no difference in qtc between diabetic and non diabetic groups (394.43 ± 19.98 ms versus 401.31 ± 17.83 ms; p = 0.2065). five diabetics showed increased qtc (396.76 ± 14.63 ms versus 429.75 ± 1.89 ms; p < 0.001) and lesser a apolipoprotein levels than rest of diabetic group (74.60 ± 25.42 mg/dl versus 113.64 ± 29.79 mg/dl; p = 0,011). in pooled sample, there was correlation between qtc and bmi (rho = -0.288; p = 0.045), pot-prandial glycemia (rho = 0.357; p = 0.016) and 3 h oxidation coefficient (oxc3h) (r = -0.293; p = 0.039). in diabetics, there was correlation between qtc and triglycerides (rho = -0.420; p = 0.023) and oxc3h (r = -0.427; p = 0.021). although there was no difference between qtc of diabetics and the non diabetics subjects studied, there was correlation with risk factors for the atherosclerotic disease. further studies are necessary to establish the real predictive value of qtc for this type of disease in the patients with type 1 dm.
Diagnóstico laboratorial das leucemias mielóides agudas
Silva, Graziele C. da;Pilger, Diogo A.;Castro, Simone M. de;Wagner, Sandrine C.;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2006, DOI: 10.1590/S1676-24442006000200004
Abstract: the acute leukemias are characterized by the clonal proliferation and maturative blockage of hematopoietic cells, with diffuse substitution of the bone marrow by neoplasic cells. the acute myeloid leukemia (aml) is a heterogeneous group of clonal disease in the hematopoietic tissue and predominantly affects people older than 60. the aml has eight morphologically different subtypes: aml m0 to m7. the diagnostic methods for identification of aml and subtypes classification are based on morphological, cytochemical and immunophenotyping patterns, besides genetic and molecular analyses. the diagnosis of leukemia is important to the lineage differentiation in aml or all and also for the identification of biphenotypic acute leukemia (bal). the aim of this study was to perform a bibliographic review of aml, giving emphasis on laboratory methods useful for its identification and differentiation.
Avalia??o da suscetibilidade do LDL de pacientes com diabetes mellitus tipo 1 à oxida??o in vitro e sua rela??o com o controle glicêmico
Castro, Simone H. de;Castro-Faria-Neto, Hugo C.;Clemente, Eliete L.S.;Gomes, Marília B.;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2004, DOI: 10.1590/S0004-27302004000400012
Abstract: in 38 patients with type 1 diabetes (dm 1) and 24 non-diabetics we investigated ldl susceptibility to in vitro oxidation. fast and post-prandial glycaemia (ppg), glycated hemoglobin (hba1c) and lipid profile were determined, together with an spectrophotometric analysis of ldl oxidation before and 1, 3, 6 and 24 hours after addition of the oxidant substance - copper sulphate (cuso4). the ldl oxidation coefficient in the two groups presented similar basal values; however 3 hours after cuso4, ldl was more oxidized in patients with dm1. there was a negative correlation with ppg (r= -0.2511; p<0.05) and hba1c (r= -0.2541; p<0.05). we conclude that in our sample of dm patients ldl was oxidized earlier than in the non-diabetics and that the glycemic control is important in this event.
Triagem neonatal para hemoglobinopatias: experiência de um ano na rede de saúde pública do Rio Grande do Sul, Brasil
Sommer, Camila K.;Goldbeck, Ana Stela;Wagner, Sandrine C.;Castro, Simone M.;
Cadernos de Saúde Pública , 2006, DOI: 10.1590/S0102-311X2006000800019
Abstract: hemoglobinopathies are the most common inherited disorders in humans; the most frequent are hemoglobins s and c (hb s and hb c). studies in brazil show the high prevalence of hb s and hb c heterozygotes, indicating the need for diagnosis to allow medical care and suitable genetic counseling. this study evaluates the prevalence of hemoglobin patterns in different areas of rio grande do sul state, brazil, using neonatal data from the public health system. blood samples from 117,320 newborns, obtained by heel stick, and 2,389 blood samples from parents of newborns, obtained by venopuncture, were submitted to ief and hplc. among the newborns, 1,629 (1.4%) showed abnormal hemoglobin patterns: 1,342 fas; 225 fac; 45 fad; 2 fsc; 1 fs and 26 variant hemoglobin heterozygotes. we conclude that the methods used are able to identify a broad variety of hemoglobin patterns with high specificity and sensitivity. the information is of paramount importance for transmitting knowledge in the public health field, besides facilitating planning and resource allocation.
Triagem neonatal para hemoglobinopatias: experiência de um ano na rede de saúde pública do Rio Grande do Sul, Brasil
Sommer Camila K.,Goldbeck Ana Stela,Wagner Sandrine C.,Castro Simone M.
Cadernos de Saúde Pública , 2006,
Abstract: As hemoglobinopatias s o as desordens hereditárias mais comuns nos seres humanos, sendo que as mais freqüentes s o as hemoglobinas S e C (Hb S e Hb C). Estudos realizados no Brasil mostram a alta prevalência de heterozigotos para Hb S e Hb C, indicando a necessidade de seu diagnóstico, permitindo o atendimento médico e o aconselhamento genético adequados. O presente estudo avaliou a prevalência dos padr es hemoglobínicos em diferentes regi es do Estado do Rio Grande do Sul, Brasil, obtidos de recém-nascidos atendidos pela rede de saúde pública. Amostras de sangue coletadas sob papel filtro de 117.320 recém-nascidos e de 2.389 pais de recém-nascidos foram avaliadas por FIE e HPLC. Dentre os recém-nascidos, 1.629 (1,4%) apresentaram padr o hemoglobínico alterado: 1.342 FAS, 225 FAC, 45 FAD, 2 FSC, 1 FS e 26 heterozigotos para variantes raras. Concluiu-se que os métodos utilizados s o capazes de identificar com alta especificidade e sensibilidade uma grande variedade de padr es hemoglobínicos. As informa es s o importantes para tornar possível o planejamento e aloca o de recursos, além de ser um mecanismo de transmiss o de conhecimentos para profissionais de saúde.
Increase in mitotic recombination in diploid cells of Aspergillus nidulans in response to ethidium bromide
Becker, Tania C.A.;Chiuchetta, Simone J.R.;Baptista, Francielle;Castro-Prado, Marialba A.A. de;
Genetics and Molecular Biology , 2003, DOI: 10.1590/S1415-47572003000300026
Abstract: ethidium bromide (eb) is an intercalating inhibitor of topoisomerase ii and its activities are related to chemotherapeutic drugs used in anti-cancer treatments. eb promotes several genotoxic effects in exposed cells by stabilising the dna-enzyme complex. the recombinagenic potential of eb was evaluated in our in vivo study by the loss of heterozygosity of nutritional markers in diploid aspergillus nidulans cells through homozygotization index (hi). a dna repair mutation, uvsz and a chromosome duplication dp (ii-i) were introduced in the genome of tested cells to obtain a sensitive system for the recombinagenesis detection. eb-treated diploid cells had hi values significantly greater than the control at both concentrations (4.0 x 10-3 and 5.0 x 10-3 mm). results indicate that the intercalating agent is potentially capable of inducing mitotic crossing-over in diploid a. nidulans cells.
Increase in mitotic recombination in diploid cells of Aspergillus nidulans in response to ethidium bromide
Becker Tania C.A.,Chiuchetta Simone J.R.,Baptista Francielle,Castro-Prado Marialba A.A. de
Genetics and Molecular Biology , 2003,
Abstract: Ethidium bromide (EB) is an intercalating inhibitor of topoisomerase II and its activities are related to chemotherapeutic drugs used in anti-cancer treatments. EB promotes several genotoxic effects in exposed cells by stabilising the DNA-enzyme complex. The recombinagenic potential of EB was evaluated in our in vivo study by the loss of heterozygosity of nutritional markers in diploid Aspergillus nidulans cells through Homozygotization Index (HI). A DNA repair mutation, uvsZ and a chromosome duplication DP (II-I) were introduced in the genome of tested cells to obtain a sensitive system for the recombinagenesis detection. EB-treated diploid cells had HI values significantly greater than the control at both concentrations (4.0 x 10-3 and 5.0 x 10-3 mM). Results indicate that the intercalating agent is potentially capable of inducing mitotic crossing-over in diploid A. nidulans cells.
Diagnóstico laboratorial das leucemias linfóides agudas
Farias, Mariela Granero;Castro, Simone Martins de;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2004, DOI: 10.1590/S1676-24442004000200008
Abstract: acute lymphoid leukemia (all) is the commonest type of cancer in childhood, representing 70% of cases. in adults its incidence is 20% only. the initial diagnosis approach consists of a peripheral blood and bone marrow cytomorphological examination. the rate of correctly classified cases is increased up to 99% through immunophenotypic study, which allows to identify the cell line (t or b) and the different stages of cell maturation. nearly 20% derive from t cells, 75% from b-cell precursors and 5% from mature b-cells. the cytogenetic techniques have markedly contributed to the better understanding of molecular biology and all treatment. chromosomal abnormalities, associated with the immunophenotyping panel, are the most important parameter for leukemia classification. together with clinical and in vitro factors, this parameter allows the patients stratification in different risk groups, which is of great importance for establishing a prognosis and a suitable treatment. the aim of this study was to perform a bibliographic review of the laboratory methods by morphological, cytochemical, immune, cytogenetic and molecular genetic patterns, which are useful tools for acute lymphoid leukemia classification and diagnosis.
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