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Search Results: 1 - 10 of 1925 matches for " Simona Rinaldi "
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Treatises and Ars construendi: Teaching’s Method Theory and Practice of Critical History’s Application Based on Teacher-Student Relationships  [PDF]
Carlos Alberto Cacciavillani, Simona Rinaldi
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.49016
Abstract: The topic of this lecture is the results’ description obtained during many years of teaching. We shall illustrate how students use the same analytical techniques to study two different aspects: 1) Architectural Treatises are first studied separately and then in a comparative way. The purpose of this graphic analysis is to reach a new interpretation of them through the realization of original graphics; 2) The Roman Ars construendi: architectural techniques and buildings’ typologies used by the Romans are investigated in the archaeological sites, where the reading of buildings’ stratification in different historical periods becomes an important teaching tool.
Limit cycles and Hopf bifurcations in a Kolmogorov type system
Simona Muratori,Sergio Rinaldi
Modeling, Identification and Control , 1989, DOI: 10.4173/mic.1989.2.3
Abstract: The paper is devoted to the study of a class of Kolmogorov type systems which can be used to represent the dynamic behaviour of prey and predators. The model is an extension of the classical prey-predator model since it allows intra-specific competition for the predator's species. The analysis shows that the system can only have Kolmogorov's two modes of behaviour: a globally stable equilibrium or a globally stable limit cycle. Moreover, the transition from one of these two modes to the other is a non-catastrophic Hopf bifurcation which can be specified analytically.
Performance evaluation of positive regulators for population control
Simona Muratori,Sergio Rinaldi,Bruno Trinchera
Modeling, Identification and Control , 1989, DOI: 10.4173/mic.1989.3.1
Abstract: This paper deals with real time control of age-structured populations described by Leslie models with positive inputs. The classical industrial and pole-assignment regulators are adapted to this class of positive systems and their performance is evaluated through simulation. The influence of noise on cost and robustness of the controlled system and the role of the information structure are discussed in some detail.
Effects of Sildenafil on the Gastrocnemius and Cardiac Muscles of Rats in a Model of Prolonged Moderate Exercise Training
Barbara Rinaldi, Maria Donniacuo, Loredana Sodano, Giulia Gritti, Simona Signoriello, Elisabetta Parretta, Liberato Berrino, Konrad Urbanek, Annalisa Capuano, Francesco Rossi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069954
Abstract: Moderate exercise training improves energetic metabolism, tissue perfusion and induces cardiac and skeletal muscle remodeling. Sildenafil, a potent phosphodiesterase-5 inhibitor used to treat erectile dysfunction, reduces infarct size and increases tissue oxygenation in experimental models of cardiovascular disease. We have evaluated the effects of prolonged moderate exercise training and a repeat administration of sildenafil on the rat gastrocnemius and cardiac muscles. Animals were divided into two groups: sedentary and trained. Each group was subdivided into animals treated with vehicle or with two doses of sildenafil (10 or 15 mg/kg/day) during the last week of training. Physical exercise did not induce cardiac hypertrophy, whereas it increased mRNA levels of the PGC-1α, HIF-1α and VEGF genes, which are involved in mitochondrial biogenesis and angiogenesis, and reduced mRNA levels of FoxO3a, MuRF-1 and Atrogin-1. Sildenafil dose-dependently promoted both angiogenesis, as shown by increased capillary density, and muscle atrophy, as shown by muscle fibre size. These effects were more pronounced in trained animals. Our data confirm the beneficial effects of a moderate and prolonged training on cardiovascular and skeletal systems and document the positive and negative effects of sildenafil on these tissues at doses higher than those used in clinical practice. This report may impact on the use of sildenafil as a substance able to influence sports performance.
The tumor suppressor gene KCTD11REN is regulated by Sp1 and methylation and its expression is reduced in tumors
M Michela Mancarelli, Francesca Zazzeroni, Lucia Ciccocioppo, Daria Capece, Agnese Po, Simona Murgo, Raffaello Di Camillo, Christian Rinaldi, Elisabetta Ferretti, Alberto Gulino, Edoardo Alesse
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-172
Abstract: TSGs often locate at chromosomal regions, which are frequently deleted and/or methylated in tumors. High levels of 17p13 somatic alterations have been showed in several tumors, distal and independent of the p53 locus [1-4].Our group has identified KCTD11 as an immediate-early gene induced by neurogenic signals [5] and encoding a novel adaptor of Cullin3 ubiquitin E3 ligase complex targeting Histone Deacetylase 1 [6]. Importantly, KCTD11 is a novel TSG that inhibits cell growth and is mapping on human chromosome 17p13.2, whose expression is frequently lost in human MB [4].To analyze whether the down-regulation of KCTD11 represents a specific feature of MB, as well to other cancers, we performed a wide screening for KCTD11 expression, analyzing 177 human tumor samples and 177 normal matching samples, representing 18 different cancer types. Normal tissues, including larynx, esophagus, stomach, colon-rectum, urinary bladder, lung, breast, gallbladder and endometrium, exhibited a nuclear KCTD11 positive immunohistochemical staining between 40 to 78% (Fig. 1B), whereas the matching tumor samples showed a significant reduction of 0 to 18% of nuclear KCTD11 staining (Fig. 1A and 1B). Reduced KCTD11 expression was not observed in thyroid and kidney tumor tissues vs normal suggesting a tumorigenic specific role of KCTD11 for the above mentioned tissues (Fig. 1A and 1B and data not shown). Moreover KCTD11 was undetected both in normal and cancer tissues from liver, lymph-node and exocrine pancreas (data not shown). Together, these findings clearly indicated that selective tissues expressing KCTD11 have down-regulated this gene during tumorigenesis.To understand the transcriptional regulation of KCTD11, we identified and analyzed the promoter region. Human KCTD11 proximal promoter is a 623 bp region (Fig. 2A). It turned out to be a TATA- and CAAT-less promoter. The transcription start site (TSS) was previously identified [4] (Fig. 2A). Using the TRANSFACT software, we identifie
Yaws: A Second (and Maybe Last?) Chance for Eradication
Andrea Rinaldi
PLOS Neglected Tropical Diseases , 2008, DOI: 10.1371/journal.pntd.0000275
The Global Campaign to Eliminate Leprosy
Andrea Rinaldi
PLOS Medicine , 2005, DOI: 10.1371/journal.pmed.0020341
Counting tillers
Andrea Rinaldi
Genome Biology , 2003, DOI: 10.1186/gb-spotlight-20030410-02
Abstract: Li et al. screened rice plant collections for mutants with altered tiller numbers. Genetic analysis with reciprocal crosses between tiller mutants and wild-type plants revealed that mutants possess a recessive mutation in a single locus, termed Monoculm 1 (MOC1). The MOC1 gene was then mapped to the long arm of chromosome 6, and encoded a nuclear-localized protein of 441 amino-acid residues. Tiller mutants transformed with up to three copies of the MOC1 gene produced 2-3 fold more tillers than wild-type plants, confirming the role of the gene in branching control. High-tillering transformed plants were also observed to be shorter than wild-type plants, indicating that MOC1 affects both rice tillering and plant height - another economically important trait.Although MOC1 seems to be a key regulator of rice tillering, this is expected to be a complex process which involves the finely-tuned expression of many genes. The identification of the other parties is likely to benefit from the recent completion of several drafts of the rice genome, produced by the International Rice Genome Sequencing Project and other sequencing programs.
tmRNA to the rescue
Andrea Rinaldi
Genome Biology , 2003, DOI: 10.1186/gb-spotlight-20030404-01
Abstract: Valle et al. used purified Thermus thermophilus extracts and prepared a stalled ribosome with a docked tmRNA. They added the protein synthesis elongation factor Tu (EF-Tu), SmpB, a small protein required for tmRNA-mediated peptide tagging activity, and kirromycin, an antibiotic that traps ribosome rescue at an early stage. The cryo-EM image of the complex yielded novel details of tmRNA entry into the ribosome, revealing that tmRNA initially binds the ribosome and EF-Tu in a manner similar to canonical tRNAs. SmpB acted by facilitating the contacts between tmRNA and the stalled ribosome, and tmRNA pseudoknots played a role in the presentation of the molecule to the ribosome, helping to orient the alanyl-tRNA like domain and the open reading frame."Predictably, the cryo-EM images presented by Valle et al. only whet our appetite for higher-resolution structural information about each stage of ribosome rescue", note Sean Moore and colleagues from the Massachusetts Institute of Technology, Cambridge, MA, USA, in an accompanying Perspectives article.
Maternal impact of chromatin reorganization
Andrea Rinaldi
Genome Biology , 2003, DOI: 10.1186/gb-spotlight-20030425-01
Abstract: Using Xenopus NPM2 as a template, Burns et al. isolated the murine NPM2 ortholog. In situ hybridization showed that expression of the NPM2 protein was limited to growing oocytes. To study the NPM2 activity, they used embryonic stem cell technology to generate homozygous NPM2-null mice. Although Xenopus NPM2 decondenses sperm DNA, the same process seems to proceed without NPM2 in mice, as NPM2-null males were fertile and normal. In contrast, NPM2 knockout females were found to be subfertile or infertile. Analysis of fertilization and post-fertilization events in vitro and in vivo revealed impaired early embryo development, mostly due to failure of the one-cell to two-cell transition. Examining oocytes and eggs from NPM2-null females, they detected gross defects, including an absence of coalesced nucleolar structures and loss of heterochromatin and deacetylated histone H3 that normally circumscribe nucleoli in oocytes and early zygotes, respectively.NPM2 is one of a family of oocyte-derived proteins for which a role in zygote development has been demonstrated. "In the future it will be important to define the functional domains of NPM2… and to assess whether NPM2-gene mutations may cause infertility in women," conclude the authors.
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