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Search Results: 1 - 10 of 1479 matches for " Simona Murgo "
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The tumor suppressor gene KCTD11REN is regulated by Sp1 and methylation and its expression is reduced in tumors
M Michela Mancarelli, Francesca Zazzeroni, Lucia Ciccocioppo, Daria Capece, Agnese Po, Simona Murgo, Raffaello Di Camillo, Christian Rinaldi, Elisabetta Ferretti, Alberto Gulino, Edoardo Alesse
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-172
Abstract: TSGs often locate at chromosomal regions, which are frequently deleted and/or methylated in tumors. High levels of 17p13 somatic alterations have been showed in several tumors, distal and independent of the p53 locus [1-4].Our group has identified KCTD11 as an immediate-early gene induced by neurogenic signals [5] and encoding a novel adaptor of Cullin3 ubiquitin E3 ligase complex targeting Histone Deacetylase 1 [6]. Importantly, KCTD11 is a novel TSG that inhibits cell growth and is mapping on human chromosome 17p13.2, whose expression is frequently lost in human MB [4].To analyze whether the down-regulation of KCTD11 represents a specific feature of MB, as well to other cancers, we performed a wide screening for KCTD11 expression, analyzing 177 human tumor samples and 177 normal matching samples, representing 18 different cancer types. Normal tissues, including larynx, esophagus, stomach, colon-rectum, urinary bladder, lung, breast, gallbladder and endometrium, exhibited a nuclear KCTD11 positive immunohistochemical staining between 40 to 78% (Fig. 1B), whereas the matching tumor samples showed a significant reduction of 0 to 18% of nuclear KCTD11 staining (Fig. 1A and 1B). Reduced KCTD11 expression was not observed in thyroid and kidney tumor tissues vs normal suggesting a tumorigenic specific role of KCTD11 for the above mentioned tissues (Fig. 1A and 1B and data not shown). Moreover KCTD11 was undetected both in normal and cancer tissues from liver, lymph-node and exocrine pancreas (data not shown). Together, these findings clearly indicated that selective tissues expressing KCTD11 have down-regulated this gene during tumorigenesis.To understand the transcriptional regulation of KCTD11, we identified and analyzed the promoter region. Human KCTD11 proximal promoter is a 623 bp region (Fig. 2A). It turned out to be a TATA- and CAAT-less promoter. The transcription start site (TSS) was previously identified [4] (Fig. 2A). Using the TRANSFACT software, we identifie
PRIMEROS POBLADORES ESPA OLES EN EL FUERTE-POBLADO DE EL CARMEN, PATAGONIA ARGENTINA (FINALES DEL SIGLO XVIII)
María Laura Casanueva,Andrea Murgo
Revista de Arqueología Histórica Argentina y Latinoamericana , 2009,
Abstract: In this work we present our current historic- anthropologic investigation aboutthe first Spanish settlers installed on the end of 18th century in Fuerte de El Carmen town (Buenos Aires province, Argentina). The objective to colonize this territory was toconsolidate Spanish possessions in the South Atlantic, threatened by constant foreigner presence. This is how Spanish people arrived from different regions, attracted by promises of lands, work and inhabitation. Nevertheless, once arrived, authorities did not complywith those promises and families had to build their houses digging caves in the Rio Negroscarps, known today as Maragatos caves.Nowdays, our work is focused on those first homes and face to the main objective of the project, which is to: access to the knowledge of the historic change processes,the restructuration and continuity of those populations of creole-european origin, and to study their link with aboriginal inhabitants during XVIIIth and XIXth centuries in thePampa-Patagonia region. Besides, our objective is to investigate the maragato’s popular origin myth of these home-caves dig in the north cliff of Rio Negro.
Arthroscopic synovectomy in chronic inflammatory rheumatism: clinical and functional aspects
A. Murgo,E. Paresce,F. Fantini
Reumatismo , 2011, DOI: 10.4081/reumatismo.2003.39
Abstract: By now many authors regard arthroscopic synovectomy an integral part of therapeutic treatment of many rheumatic diseases with favourable results on post operating course and clinical picture in the long term. The pathologic synovial tissue during articular inflammatory rheumatism is well known to have a damaging effect responsible of early cartilage injury, as well as symptomatic action (e.g. articular stiffness, effusion, pain, functional limitation). Therefore to value the removal of such a tissue you should think of the secondary prevention of cartilage injury, besides the symptomatic point of view. Since 1996 we performed 190 arthroscopic synovectomy, the adopted criteria of judgement were: pain (spontaneous, during active and passive movements), effusion or swelling presence, articular range and cartilage state (evaluated during arthroscopy according to Outerbridg’s classification). 70% of the cases showed good results and six years later the beginning of this activity we retain arthroscopic synovectomy as a valid help in articular inflammatory rheumatism treatment.
Interesses profissionais e afetos positivos e negativos: estudo exploratório com estudantes de ensino médio Intereses profesionales y afectos positivos y negativos: estudio exploratorio con estudiantes de Ense anza Secundaria Professional interests and affects positive and negative: exploratory study with youngers from high school
Ana Paula Porto Noronha,Camélia Santina Murgo Mans?o
Psico-USF , 2012, DOI: 10.1590/s1413-82712012000200016
Abstract: A Orienta o Profissional enquanto área de interven o e pesquisa tem buscado a compreens o de variáveis que interferem na tomada de decis o e no desenvolvimento de carreira. Trata-se de um estudo exploratório entre interesses profissionais e afetos positivos e negativos. Participaram 529 estudantes do ensino médio de escolas públicas e particulares com idades entre 14 a 27 anos (M=16; DP=1,48). No que se refere ao sexo, 223 (42,2%) eram homens e 306 (57,8%), mulheres. Os instrumentos aplicados foram a EAZ - Escala de Afetos de Zanon e a EAP - Escala de Aconselhamento Profissional. Os participantes apresentaram maiores médias para afetos positivos, o que indica julgamento mais positivo da vida, de modo geral. A compara o entre os instrumentos revelou alguns coeficientes positivos e significativos, mas de baixa magnitude. Sugere-se que novos estudos sejam realizados com os construtos da Psicologia Positiva na orienta o profissional e desenvolvimento de carreira. La Orientación Profesional como área de intervención e investigación ha buscado entender la comprensión de variables que interfieren en las decisiones y en el desarrollo de carrera. Se trata de un estudio exploratorio entre intereses profesionales y afectos positivos y negativos. Participaron 529 estudiantes de la Ense anza Secundaria de escuelas públicas y privadas con edades entre14 a 27 a os (M=16; DP= 1,48). En lo referente al sexo, 223 (42,2%) eran hombres y 306 (57,8%) mujeres. Los instrumentos aplicados fueron la Escala de Afetos de Zanon - EAZ y la Escala de Aconselhamento Profissional - EAP. Los participantes presentaron promedios mayores para los afectos positivos, lo que indica juicio más positivo de la vida, en general. La comparación entre los instrumentos mostró algunos coeficientes positivos y significativos, pero de magnitud baja. Se sugiere que nuevos estudios sean realizados con los constructos de la Psicología Positiva en la orientación profesional y desarrollo de carrera. Professional Orientation while field of research and intervention has sought to comprehend variables which interfere in decision making and career development. This study investigates the relationship between professional interests and positive and negative affects. A total of 529 public and private high school students, 223 men (42.2%) and 306 (57.8%) women, ages between 14 and 27 (M=16; DP=1.48) participated. Each volunteer was given the EAZ - Zanon Affect Scale and the EAP - Professional Counseling Scale. Participants presented higher averages in positive affects, which indicates a more positive outlook
Simultaneous ultrasonography and arthroscopy for the study of the joint environment: indications and limits
O. De Lucia,E. Paresce,A. Murgo,O. Epis
Reumatismo , 2011, DOI: 10.4081/reumatismo.2007.146
Abstract: Arthroscopy is a mini-invasive technique that allows the direct observation of the joint cavity and the execution of diagnostic and therapeutic procedures; arthroscopy needs a very long learning-time curve as well as dedicated spaces and instruments. Ultrasonography is an imaging technique that enables to perform an immediate extension of the standard physical examination. The opportunity to visualize soft tissues, to obtain multiplanar and dynamic images in real time makes this practice easy repeatable at low costs. Ultrasonography allows to detect a variety of changes during inflammatory processes. The wide experience in arthroscopy of rheumatic patients acquired through the years by our team at the G. Pini Institute led us to study in vivo, during arthroscopy, the correspondence between arthroscopic and ultrasonographic images. Up to now three knee arthroscopies have been conducted with the double equipment (ultrasonographic and arthroscopic devices) in operating room. In our experience, the combination of the two methods in operating room may improve the validation of ultrasonography with arthroscopy as gold standard, helps to train the ultrasonographer to give immediate answers in order to clear the doubts aroused by ultrasonographic images; it also allows the arthroscopist to visualize the deeper layers of the synovial membrane making double guided targeted biopsies possible. Limits are the complexity of the procedure (instruments, operators, spaces, training of the doctors), the loose of power-doppler signal with the blood tourniquet and the always difficult evaluation of cartilage.
Limited Bandwidths and Correlation Ambiguities: Do They Co-Exist in Galileo Receivers  [PDF]
Elena Simona Lohan
Positioning (POS) , 2011, DOI: 10.4236/pos.2011.21002
Abstract: Galileo is the Global Navigation Satellite System that Europe is building and it is planned to be operational in the next 3-5 years. Several Galileo signals use split-spectrum modulations, such as Composite Binary Offset Carrier (CBOC) modulation, which create correlation ambiguities when processed with large or infinite front-end bandwidths (i.e., in wideband receivers). The correlation ambiguities refer to the notches in the correlation shape (i.e., in the envelope of the correlation between incoming signal and reference modulated code) which happen within +/– 1 chip from the main peak. These correlation ambiguities affect adversely the detection probabilities in the code acquisition process and are usually dealt with by using some form of unambiguous processing (e.g., BPSK-like techniques, sideband processing, etc.). In some applications, such as mass-market applications, a narrowband Galileo receiver (i.e., with considerable front-end bandwidth limitation) is likely to be employed. The question addressed in this paper, which has not been answered before, is whether or not this bandwidth limitation can cope inherently with the ambiguities of the correlation function, to which extent, and which the best design options are in the acquisition process (e.g., in terms of time-bin step and ambiguity mitigation mechanisms).
Efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis: a randomized, double-blind three-arm dose finding study  [PDF]
Simona Holcová, Marie Hladiková
Health (Health) , 2011, DOI: 10.4236/health.2011.31010
Abstract: A dose-finding study was performed with respect to the clinical applicability and tolerability of three different concentrations of propolis special extract GH 2002 in a lip balm (0.1%, 0.5% and 1%). The trial was designed as a double-blind, randomized dermatological study in 150 outpatients with Herpes labialis. The primary parameter was the duration in days until painless incrustation in 50% or 90% of the patients (observable in 121 patients). Secondary parameters were local pain (assessed on a visual analogue scale), itching, burning and tension/ swelling on a verbal rating scale, and tolerability. Visits were performed on days 2/3, 5/6 and 8/9. Best efficacy results with shortest healing time (3.4 and 5.4 days in the 50th and 90th percentile, respectively; p = 0.008 vs. 1% and 0.09 vs. 0.1%) and good tolerability were observed with the 0.5% concentration. All three concentrations achieved highly significant therapeutic results in comparison with baseline values (p < 0.0005) for all secondary parameters as early as day 2/3. Analgesia was the most prominent effect for the patients. Conclusion: The 0.5 % concentration of propolis special extract GH 2002 in a lip balm was found to have the best risk-benefit ratio for the treatment of Herpes labialis.
Analysis on Long Precipitation Series in Piedmont (North-West Italy)  [PDF]
Fiorella Acquaotta, Simona Fratianni
American Journal of Climate Change (AJCC) , 2013, DOI: 10.4236/ajcc.2013.21002
Abstract:

This study analyses thirteen daily precipitation series of Piedmont, region of North-West Italy. The meteorological series have been chosen because they were meteorological observatories operating continuously from the beginning of 1900 until 2011. As the first step an historical research over each station has been carried out. In this way, the potential breaks, in the series, either due to changes of locations or instruments, have been determined and the missing values have been recovered. On the precipitation daily series a quality control have been effectuated and by metadata identification it was possible to assess the homogeneity of the meteorological series. In this way we have obtained the complete and correct series on which trends have been computed. In order to better understand the consequences of climate variations on our environment and society, we have calculated the climate indices proposed by “CCL/CLIVAR Working Group on Climate Change Detection” (dry and wet days, rainy days, intensity of precipitation…) over the time. The values of precipitation have also allowed beginning the climatic analysis with the aim at defining the principle local peculiarity in Piedmont.

Diagnosis and Treatment Options for Pulmonary Embolism (PE) in the Acute Care Setting  [PDF]
Simona Campa, Raymund Gantioque
World Journal of Cardiovascular Diseases (WJCD) , 2018, DOI: 10.4236/wjcd.2018.82015
Abstract: Thromboembolic diseases continue to be one of the most prevalent medical problems today and can lead to life-threatening conditions, such as pulmonary embolism (PE). Currently, PE diagnosis and treatment are a challenge because of acute onset right ventricular strain with right-sided heart failure, sudden death, pulmonary infarction, and cardiogenic shock, which limit the time for therapeutic success.The aim of this study was to evaluate our perception, knowledge, and concerns regarding PE, discuss the importance of promptly diagnosing PE to provide appropriate treatment options for this life-threatening condition, list the most common clinical manifestations present when PE is suspected, and review the clinical approach to patients with suspected PE in an inpatient setting.In addition, this study reviews the risk stratification of patients with PE and treatment options beyond anticoagulation, compares new treatment options for patients presenting with acute symptomatic PE, and compares aspiration catheters (10 F Pronto .035” and 14 F XL extraction catheter (Vascular Solutions, Minneapolis, MN)) and ultrasound-assisted catheter-directed thrombolysis (USAT) versus systemic thrombolysis.This literature review was limited by the quality and number of studies available regarding new treatment options for patients presenting with acute symptomatic PE. Thus, more studies are needed to prove the validity of newer treatment options being trialed, such as aspiration catheters (10 F Pronto .035” and 14 F XL extraction catheter) and USAT, with the hope that further studies will guide patient management and increase our understanding of next generation aspiration catheters, which may provide novel insights on treating acute symptomatic PE.
Treatises and Ars construendi: Teaching’s Method Theory and Practice of Critical History’s Application Based on Teacher-Student Relationships  [PDF]
Carlos Alberto Cacciavillani, Simona Rinaldi
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.49016
Abstract: The topic of this lecture is the results’ description obtained during many years of teaching. We shall illustrate how students use the same analytical techniques to study two different aspects: 1) Architectural Treatises are first studied separately and then in a comparative way. The purpose of this graphic analysis is to reach a new interpretation of them through the realization of original graphics; 2) The Roman Ars construendi: architectural techniques and buildings’ typologies used by the Romans are investigated in the archaeological sites, where the reading of buildings’ stratification in different historical periods becomes an important teaching tool.
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