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Search Results: 1 - 9 of 9 matches for " Simaan AbouRizk "
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Knowledge Discovery in Data: A Case Study  [PDF]
Ahmed Hammad, Simaan AbouRizk
Journal of Computer and Communications (JCC) , 2014, DOI: 10.4236/jcc.2014.25001

It is common in industrial construction projects for data to be collected and discarded without being analyzed to extract useful knowledge. A proposed integrated methodology based on a five-step Knowledge Discovery in Data (KDD) model was developed to address this issue. The framework transfers existing multidimensional historical data from completed projects into useful knowledge for future projects. The model starts by understanding the problem domain, industrial construction projects. The second step is analyzing the problem data and its multiple dimensions. The target dataset is the labour resources data generated while managing industrial construction projects. The next step is developing the data collection model and prototype data ware-house. The data warehouse stores collected data in a ready-for-mining format and produces dynamic On Line Analytical Processing (OLAP) reports and graphs. Data was collected from a large western-Canadian structural steel fabricator to prove the applicability of the developed methodology. The proposed framework was applied to three different case studies to validate the applicability of the developed framework to real projects data.

Toward Environmentally Sustainable Construction Processes: The U.S. and Canada’s Perspective on Energy Consumption and GHG/CAP Emissions
Changbum Ahn,SangHyun Lee,Feniosky Pe?a-Mora,Simaan Abourizk
Sustainability , 2010, DOI: 10.3390/su2010354
Abstract: In the building and construction sector, most efforts related to sustainable development have concentrated on the environmental performance of the operation of buildings and infrastructure. However, several studies have called for the need to mitigate the considerable environmental impacts, especially air pollutant emissions and energy consumption, generated by construction processes. To provide a point of reference for initiating the development of environmentally sustainable construction processes, this article identifies energy consumption and air emissions resulting from construction activities and examines previous approaches utilized to assess such environmental impact. This research also identifies the opportunities and challenges to mitigate such environmental impact from construction processes, based on the investigation of current technology policies, regulations, incentives, and guidelines.
The effect of nebivolol on the production of nitric oxide induced by bacterial lipopolysaccharide and peptidoglycan in mice  [PDF]
Fadi El-Rami, Hampartsoum Barsoumian, Joseph Simaan, Alexander M. Abdelnoor
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.212166
Abstract: Nitric oxide (NO) plays a pivotal role in main- taining balance of physiological events in many systems including the autonomic, cardiovas- cular, hematological, and pulmonary systems. Lipopolysaccharide (LPS) and peptidoglycan (PGN), components of the outer cell membranes of Gram-negative bacteria and cell walls of Gram-positive bacteria respectively, are in- criminated in NO-induced septic shock. Ne- bivolol is a third generation β1- adrenoceptor blocker with a vasodilatory property attributed to enhanced availability of nitric oxide and re- duction of cellular oxidative stress through an unknown mechanism. The current study ex- plored the hypothesis that if nebivolol enhances the availability of NO, pretreatment with ne- bivolol may enhance production of NO in re- sponse to subsequent treatment with LPS and PGN, an observation that may have relevance in clinical septic shock. Groups of female BALB/c mice each containing 12 mice (6-8 weeks old) were injected intraperitoneally with LPS (30 µg/mouse), PGN (100 µg/mouse), nebivolol (0.25 µg/g, 0.35 µg/g, 0.7 µg/g), LPS and nebivolol (0.25 µg/g), LPS and nebivolol (0.35 µg/g), LPS and nebivolol (0.7 µg/g), PGN and nebivolol (0.25 µg/g), PGN and nebivolol (0.35µg/g). One group of mice was injected with saline and an- other served as control. Three mice from each group were bled 1, 3, 6 and 9 hours post-injec- tion, the blood was pooled and the nitrite serum levels, reflecting NO concentration, were de- termined using Greiss reagent. The following results were obtained: 1) Treatment with saline did not induce NO production; 2) LPS induced NO production to a maximal limit of 545% at 9 hours as compared to treatment with saline; 3) PGN did not induce NO production; 4) nebivolol at most doses and periods (7 out of 10 deter- minations) increased NO production over a range of 18-110% as compared to treatment with saline; 5) Nebivolol enhanced LPS-induced production of NO by 58% at a dose of 0.7 µg/gm at 9 hours. It is concluded that nebivolol in- duces NO production. At low doses nebivolol initially appeared to have a suppressive or no effect on NO production induced by LPS. In- crease in the dose of nebivolol resulted in augmentation of LPS-induced production of NO. PGN, in the dose tested, did not have an effect on NO production.
Is There a Relation between Adenosine and Caffeines’ Mechanisms of Action and Toll-Like Receptor-4 (TLR-4)?  [PDF]
Sarah Moodad, Nayla Al-Akl, Joseph Simaan, Alexander M. Abdelnoor
Open Journal of Immunology (OJI) , 2015, DOI: 10.4236/oji.2015.54017
Abstract: Previous studies showed that endogenous adenosine, an anti-inflammatory agent, was released at sites of injury and inflammation thereby decreasing the excessive production of pro-inflammatory cytokines. Caffeine, a non-specific adenosine blocker, has been reported in several studies to have opposing immune-modulatory effects. In this study, the effects of caffeine and adenosine on TLR-4 in promoting or decreasing the production of TNF-α and IL-12 by LPS-stimulated monocytes were investigated. Monocytes were isolated using Pluribead® kit from pooled blood obtained from ten volunteers. The monocytes were then incubated for 24 hours with Lipopolysaccharide (pLPS) extracted from Escherichia coli (aTLR-4 ligand activator), adenosine, caffeine and LPS extracted from Rhodobacter sphaeroides (LPS-RS, a TLR-4 ligand blocker), each alone or in different combinations. Later, the levels of pro-inflammatory cytokines TNFα and IL-12 were assessed in supernatants using an Enzyme Linked Immuno Assay (ELISA). Caffeine and adenosine significantly reduced the amount of TNFα and IL-12 produced by LPS-stimulated monocytes. Regarding non-stimulated and LPS-RS blocked monocytes, the presence of adenosine and caffeine significantly decreased TNFα levels produced by these cells but had little or non-significant effect on the levels of IL-12. In conclusion, both caffeine and adenosine blocked the production of the pro-inflammatory cytokines by pLPS-stimulated-monocytes. TLR-4 did not appear to be involved in the signaling pathway of caffeine and adenosine since blocking of TLR-4 did not abolish the effects of adenosine and caffeine on production of cytokines, in particular TNF-α.
Characterization of Cu(II)-ACC Complexes and Conversion of the Bound ACC into Ethylene in the Presence of Hydrogen Peroxide. Detection of a Brown Intermediate at Low Temperature
Wadih Ghattas,Michel Giorgi,Christian Gaudin,Antal Rockenbauer,Marius Réglier,A. Jalila Simaan
Bioinorganic Chemistry and Applications , 2007, DOI: 10.1155/2007/43424
Abstract: Two copper(II)-ACC complexes were prepared and characterized: [Cu(bpy)(ACC)(H2O)]⋅CO4 (1) and [Cu(ACC)2]3⋅4H2O (2). Their crystallographic structures are described and analyzed. Spectroscopic characterizations (UV-visible and EPR) confirm that the structure is maintained in solution. These complexes are able to produce ethylene in the presence of hydrogen peroxide in an “ACC Oxidase-like” reaction in water and in methanol. The conversion of ACC into ethylene depends on the amount of base, and, in methanol, 3 equivalents of NaOH are needed for optimum activity. The base is proposed to play a role in H2O2 deprotonation. The presence of an exogenic ligand (bpy) is important for the reactivity and may stabilize a reaction intermediate. Indeed, a brown intermediate with an absorption band centered at 433 nm can be detected at low temperature when 1 is treated with 10 equivalents of H2O2.
Using Bayesian Optimization to Guide Probing of a Flexible Environment for Simultaneous Registration and Stiffness Mapping
Elif Ayvali,Rangaprasad Arun Srivatsan,Long Wang,Rajarshi Roy,Nabil Simaan,Howie Choset
Computer Science , 2015,
Abstract: One of the goals of computer-aided surgery is to match intraoperative data to preoperative images of the anatomy and add complementary information that can facilitate the task of surgical navigation. In this context, mechanical palpation can reveal critical anatomical features such as arteries and cancerous lumps which are stiffer that the surrounding tissue. This work uses position and force measurements obtained during mechanical palpation for registration and stiffness mapping. Prior approaches, including our own, exhaustively palpated the entire organ to achieve this goal. To overcome the costly palpation of the entire organ, a Bayesian optimization framework is introduced to guide the end effector to palpate stiff regions while simultaneously updating the registration of the end effector to an a priori geometric model of the organ, hence enabling the fusion of ntraoperative data into the a priori model obtained through imaging. This new framework uses Gaussian processes to model the stiffness distribution and Bayesian optimization to direct where to sample next for maximum information gain. The proposed method was evaluated with experimental data obtained using a Cartesian robot interacting with a silicone organ model and an ex vivo porcine liver.
Abscesso esplênico por Brucella abortus
Santos-Neto, Leopoldo Luiz dos;Costa, Gustavo Paiva;Simaan, Cézar Kozak;Correia-Lima, Francisco Aires;
Revista da Sociedade Brasileira de Medicina Tropical , 1999, DOI: 10.1590/S0037-86821999000100010
Abstract: a 23 year-old man with prolonged fever caused by brucella abortus is reported. the uncommon feature of this case was the presence of a spleen abscess identified by computer tomography of the abdomen. patient evolution was favorable after treatment with antibiotics, with complete regression of the lesions.
Abscesso esplênico por Brucella abortus
Santos-Neto Leopoldo Luiz dos,Costa Gustavo Paiva,Simaan Cézar Kozak,Correia-Lima Francisco Aires
Revista da Sociedade Brasileira de Medicina Tropical , 1999,
Abstract: é relatado caso de um homem de 23 anos de idade com febre prolongada por Brucella abortus. O incomum neste caso foi a presen a de abscesso esplênico, identificado através de tomografia computadorizada de abd men. A evolu o foi favorável com a introdu o apenas de antibióticos, havendo regress o completa das les es.
Alta parasitemia pelo Trypanosoma cruzi em paciente com lupus eritematoso sistêmico
Santos-Neto, Leopoldo Luiz dos;Polcheira, Máira F.;Castro, Cleudson;Lima, Rodrigo Aires Corrêa;Simaan, César Kozak;Corrêa-Lima, Francisco Aires;
Revista da Sociedade Brasileira de Medicina Tropical , 2003, DOI: 10.1590/S0037-86822003000500012
Abstract: a case of trypanosoma cruzi high parasitemia in patient with systemic lupus erythematosus is reported. a xenodiagnostic test was useful in the identification of high and uncommon parasitemia, and benznidazole was able to reduce the parasitemia. benznidazole can be an alternative to control the trypanosoma cruzi high parasitemia in people with autoimmune disease and immunosuppression.
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