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Search Results: 1 - 10 of 8990 matches for " Silvia Scurati "
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Specific immunotherapy by the sublingual route for respiratory allergy
Cristoforo Incorvaia, Simonetta Masieri, Patrizia Berto, Silvia Scurati, Franco Frati
Allergy, Asthma & Clinical Immunology , 2010, DOI: 10.1186/1710-1492-6-29
Abstract: Allergic diseases have high and increasing world prevalence [1,2]. In particular, respiratory allergy is caused by sensitization to environmental aeroallergens such as pollens, house dust mites, moulds, and animal epithelia and is clinically expressed as rhinitis and asthma.The management of respiratory allergy relies upon, when possible, allergen avoidance, drug treatment, and allergen-specific immunotherapy (SIT) [3]. SIT is the practice of administering gradually increasing doses of the specific causative allergen to reduce the clinical reactivity of allergic subjects. SIT has central importance because of its ability to modify the natural history of the disease and to extend its effectiveness also after treatment withdrawal, provided it is administered for an adequate duration [4]. The subcutaneous route has been for decades the traditional route of administration, but in recent years the sublingual route emerged as an actual treatment option [5]. The main reason to introduce sublingual immunotherapy (SLIT) was the safety problems with subcutaneous immunotherapy (SCIT), which may include systemic reactions, sometimes severe and, though very rarely, even fatal [6].The first studies on SLIT used low allergen dosages [7,8] but it was soon apparent that doses much higher than those administered by SCIT were needed to ensure clinical efficacy. In consensus documents, an optimal dosage as high as at least 50 times the dose administered by injection was suggested [3], though this ratio may be not pertinent for all products.The high number of trials on SLIT conducted in recent years allowed an accurate evidence-based assessment of its effectiveness by several meta-analyses on the whole patient population as well as on subgroups defined by clinical expression (rhinitis and asthma) or age (adults and children) parameters [9-16]. At the same time, other studies evaluated important aspects defining the suitability of SLIT, such as the compliance and the cost-effectiveness.T
Idiopathic eosinophilic parotitis in an eight-year-old boy: a case report
Franco Frati, Rachele Boccardo, Silvia Scurati, Matteo Gelardi, Cristoforo Incorvaia
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-385
Abstract: The patient was an eight-year-old Caucasian boy who presented with a two-year history of recurring acute parotitis with no fever. He had had a total of five episodes with no response to antibiotics, but remission had been achieved with oral corticosteroid therapy. We performed allergy tests for inhalant and food allergens and for haptens, but the results were all negative. The results of echography ruled out sialodochitis. Instead, a swab from the parotid duct led to the detection of a high number of eosinophils.This report is first in the literature to describe a case of eosinophilic parotitis, and we suggest that a cytological assessment, which is quite simple yet rarely used by physicians, be performed when patients with parotitis of uncertain origin are under evaluation.A number of medical conditions are associated with increased production of eosinophils. A few of the most well known are eosinophilic pneumonia [1], eosinophilic bronchitis [2], and non-allergic rhinitis with eosinophilia syndrome nares and related disorders [3], but new entities such as eosinophilic esophagitis [4] and others are being added to this list. Very recently, a case of eosinophilic sialodochitis, that is, an inflammation of the parotid salivary duct was reported [5]. In this report, we describe the first case of eosinophilic parotitis in the literature. Parotitis is an inflammation of the parotid salivary gland that can be acute or chronic with acute exacerbations. Concerning the etiology, viral parotitis is more common than bacterial parotitis, and mumps is the most common viral cause of parotitis [6]. The diagnosis is made on the basis of the presence of firm, erythematous swelling in the pre- and post-auricular areas, intense local pain and tenderness, and high fever and chills. Later, massive swelling of the neck and respiratory obstruction may occur. Microbiological data may be obtained by collecting specimens by aspiration from the parotid duct orifice or, when this is not feasi
Development of a sublingual allergy vaccine for grass pollinosis
Franco Frati, Silvia Scurati, Paola Puccinelli, et al
Drug Design, Development and Therapy , 2010, DOI: http://dx.doi.org/10.2147/DDDT.S10044
Abstract: pment of a sublingual allergy vaccine for grass pollinosis Review (5608) Total Article Views Authors: Franco Frati, Silvia Scurati, Paola Puccinelli, et al Published Date June 2010 Volume 2010:4 Pages 99 - 105 DOI: http://dx.doi.org/10.2147/DDDT.S10044 Franco Frati1,2, Silvia Scurati1, Paola Puccinelli1, Marie David3, Cecile Hilaire4, Maurizio Capecce4, Francesco Marcucci2, Cristoforo Incorvaia5 1Medical and Scientific Department, Stallergenes, Milan, Italy; 2University Department of Medical and Surgical Specialties and Public Health, Perugia, Italy; 3Laboratoire Stallergenes, Antony, France; 4Marketing Department, Stallergenes, Milan, Italy; 5Allergy/Pulmonary Rehabilitation Unit, ICP Hospital, Milan, Italy Abstract: Grass pollen is a very common cause of allergic rhinitis and asthma. The only treatment targeting the underlying causes of allergy is immunotherapy (IT). Sublingual immunotherapy (SLIT) has been introduced to solve the problem of systemic reactions to subcutaneous IT (SCIT). This article evaluates the characteristics of the allergen extract, Staloral, in terms of practical administration, effectiveness, safety, and mechanism of action. Efficacy data were obtained from double-blind, placebo-controlled studies using Staloral in patients sensitized to grass pollen, while practical administration, cost-effectiveness, and mechanism of action data were provided by well designed studies. The efficacy and safety of Staloral, as demonstrated by review of published studies which used doses up to 1125 times those administered with SCIT, shows that this allergen extract has optimal characteristics for treating patients with seasonal allergies due to grass pollens. The main mechanism of action is the interaction between dendritic cells of the oral mucosa and the subsequent tolerance induced in T-cells.
The current role of sublingual immunotherapy in the treatment of allergic rhinitis in adults and children
Cristoforo Incorvaia, Simonetta Masieri, Silvia Scurati, et al
Journal of Asthma and Allergy , 2011, DOI: http://dx.doi.org/10.2147/JAA.S16632
Abstract: urrent role of sublingual immunotherapy in the treatment of allergic rhinitis in adults and children Review (6402) Total Article Views Authors: Cristoforo Incorvaia, Simonetta Masieri, Silvia Scurati, et al Published Date February 2011 Volume 2011:4 Pages 13 - 17 DOI: http://dx.doi.org/10.2147/JAA.S16632 Cristoforo Incorvaia1, Simonetta Masieri2, Silvia Scurati3, Silvia Soffia3, Paola Puccinelli3, Franco Frati3 1Allergy/Pulmonary rehabilitation, Istituti Clinici di Perfezionamento, Milan, Italy; 2ENT Clinic, University La Sapienza, Rome, Italy; 3Medical and Scientific Department, Stallergenes, Milan, Italy Abstract: Allergic rhinitis is a very common disease affecting about 20% of people. It may be treated by allergen avoidance when possible, by antiallergic drugs such as antihistamines and topical corticosteroids, and by allergen-specific immunotherapy. The latter is the only treatment able to act on the causes and not only on the symptoms of respiratory allergy and is able to maintain its efficacy even after stopping, provided an adequate duration of treatment of 3–5 years is ensured. Sublingual immunotherapy (SLIT) was introduced in the 1990s as a possible solution to the problem of adverse systemic reactions to subcutaneous immunotherapy and has been demonstrated by more than 50 trials and globally evaluated thus far by five meta-analyses as an effective and safe treatment for allergic rhinitis. Life-threatening reactions are extremely rare. However, it is important to note that clinical efficacy occurs only if SLIT meets its needs, ie, sufficiently high doses are regularly administered for at least 3 consecutive years. This is often overlooked in the current practice and may prevent the same success reported by trials from being achieved.
Adherence issues related to sublingual immunotherapy as perceived by allergists
Silvia Scurati, Franco Frati, Gianni Passalacqua, et al
Patient Preference and Adherence , 2010, DOI: http://dx.doi.org/10.2147/PPA.S10217
Abstract: dherence issues related to sublingual immunotherapy as perceived by allergists Original Research (3692) Total Article Views Authors: Silvia Scurati, Franco Frati, Gianni Passalacqua, et al Published Date June 2010 Volume 2010:4 Pages 141 - 145 DOI: http://dx.doi.org/10.2147/PPA.S10217 Silvia Scurati1, Franco Frati1, Gianni Passalacqua2, Paola Puccinelli1, Cecile Hilaire1, Cristoforo Incorvaia3, Italian Study Group on SLIT Compliance 1Scientific and Medical Department, Stallergenes, Milan, Italy; 2Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy Objectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence. Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10. Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists. Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers.
Adherence issues related to sublingual immunotherapy as perceived by allergists
Silvia Scurati,Franco Frati,Gianni Passalacqua,et al
Patient Preference and Adherence , 2010,
Abstract: Silvia Scurati1, Franco Frati1, Gianni Passalacqua2, Paola Puccinelli1, Cecile Hilaire1, Cristoforo Incorvaia3, Italian Study Group on SLIT Compliance 1Scientific and Medical Department, Stallergenes, Milan, Italy; 2Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, ItalyObjectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence.Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10.Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists.Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers.Keywords: adherence, sublingual immunotherapy, efficacy, cost, side effects
Development of a sublingual allergy vaccine for grass pollinosis
Franco Frati,Silvia Scurati,Paola Puccinelli,et al
Drug Design, Development and Therapy , 2010,
Abstract: Franco Frati1,2, Silvia Scurati1, Paola Puccinelli1, Marie David3, Cecile Hilaire4, Maurizio Capecce4, Francesco Marcucci2, Cristoforo Incorvaia51Medical and Scientific Department, Stallergenes, Milan, Italy; 2University Department of Medical and Surgical Specialties and Public Health, Perugia, Italy; 3Laboratoire Stallergenes, Antony, France; 4Marketing Department, Stallergenes, Milan, Italy; 5Allergy/Pulmonary Rehabilitation Unit, ICP Hospital, Milan, ItalyAbstract: Grass pollen is a very common cause of allergic rhinitis and asthma. The only treatment targeting the underlying causes of allergy is immunotherapy (IT). Sublingual immunotherapy (SLIT) has been introduced to solve the problem of systemic reactions to subcutaneous IT (SCIT). This article evaluates the characteristics of the allergen extract, Staloral, in terms of practical administration, effectiveness, safety, and mechanism of action. Efficacy data were obtained from double-blind, placebo-controlled studies using Staloral in patients sensitized to grass pollen, while practical administration, cost-effectiveness, and mechanism of action data were provided by well designed studies. The efficacy and safety of Staloral, as demonstrated by review of published studies which used doses up to 1125 times those administered with SCIT, shows that this allergen extract has optimal characteristics for treating patients with seasonal allergies due to grass pollens. The main mechanism of action is the interaction between dendritic cells of the oral mucosa and the subsequent tolerance induced in T-cells.Keywords: allergen extracts, high-dose, efficacy, safety, sublingual immunotherapy
The current role of sublingual immunotherapy in the treatment of allergic rhinitis in adults and children
Cristoforo Incorvaia,Simonetta Masieri,Silvia Scurati,et al
Journal of Asthma and Allergy , 2011,
Abstract: Cristoforo Incorvaia1, Simonetta Masieri2, Silvia Scurati3, Silvia Soffia3, Paola Puccinelli3, Franco Frati31Allergy/Pulmonary rehabilitation, Istituti Clinici di Perfezionamento, Milan, Italy; 2ENT Clinic, University La Sapienza, Rome, Italy; 3Medical and Scientific Department, Stallergenes, Milan, ItalyAbstract: Allergic rhinitis is a very common disease affecting about 20% of people. It may be treated by allergen avoidance when possible, by antiallergic drugs such as antihistamines and topical corticosteroids, and by allergen-specific immunotherapy. The latter is the only treatment able to act on the causes and not only on the symptoms of respiratory allergy and is able to maintain its efficacy even after stopping, provided an adequate duration of treatment of 3–5 years is ensured. Sublingual immunotherapy (SLIT) was introduced in the 1990s as a possible solution to the problem of adverse systemic reactions to subcutaneous immunotherapy and has been demonstrated by more than 50 trials and globally evaluated thus far by five meta-analyses as an effective and safe treatment for allergic rhinitis. Life-threatening reactions are extremely rare. However, it is important to note that clinical efficacy occurs only if SLIT meets its needs, ie, sufficiently high doses are regularly administered for at least 3 consecutive years. This is often overlooked in the current practice and may prevent the same success reported by trials from being achieved.Keywords: allergic rhinitis, sublingual immunotherapy, efficacy, safety, compliance, meta-analysis
+874(T→A) single nucleotide gene polymorphism does not represent a risk factor for Alzheimer's disease
Lorenza Galimberti, Beatrice Arosio, Carmen Calabresi, Silvia Scurati, Susanna Hamilton, Simona Carpini, Carlo Vergani, Giorgio Annoni
Immunity & Ageing , 2004, DOI: 10.1186/1742-4933-1-6
Abstract: In the human brain several cell types are responsible for initiating and amplifying a specific inflammatory response. In Alzheimer disease (AD) signs of an inflammatory activation of microglia and astroglia are present both inside and outside amyloid deposits. Cell cultures and animal models suggest an interactive relationship between inflammatory response activation, reduced neuronal functioning and amyloid deposition. Furthermore cells associated with extracellular plaques within AD brains can produce a variety of cytokines, chemokines and other related proteins that influence plaque and tangle formation [1]. For these reasons cytokines could play a critical role in the pathogenesis of AD. In the recent years, several cytokines have been associated with AD development and progression and many studies have correlated this risk with polymorphisms in the genes encoding these molecules [2-4]. Inside this research area we described that single nucleotide polymorphisms (SNP)s of the intereleukin(IL)-10 and IL-6 genes were associated with highest risk of AD with apparent interaction between these two genes [5]; these results supported the theory that the overall risk of developing AD may be governed by a 'susceptibility profile' and reflected the combined influence of inheriting multiple high-risk alleles. Also the type 1 cytokine interferon (IFN)-γ belongs to a cytokine class that affects the immune function; in fact it plays a major role in defence against viruses and intracellular pathogens but also in the induction of the immune-mediated inflammatory response [6]. It has been reported that the polymorphism +874(T→A) of the gene encoding IFN-γ is associated with a different production of this molecule, in particular the T allele correlates with increased levels of the cytokine [7]. In regards to the hypothesis that IFN-γ SNP may represent a genetic risk factor for AD, a recent study did not support this possibility [8]. Therefore with reference to this paper we try to
Per una pedagogia dello sport: riflessioni dall'Italia
Scurati,Cesare;
Educación y Educadores , 2009,
Abstract: the current image of sports is fundamentally negative. however, the connection between education and sports should be reinforced, while recognizing it as being hypothetic rather than automatic, and subject to the necessary educational controls. each sport has its own perfection and can contribute to the moral, social, intellectual and ethical development of human beings. the analysis considers some of the areas where that development occurs and underscores a few of the more relevant problems (early competition, education for life, impact of the mass media, etc.) to be addressed for the sake of establishing progress later on.
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