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Search Results: 1 - 10 of 133777 matches for " Silvia Le?o;Dorlhiac-Llacer "
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Hemolytic disease of the newborn due to anti-U
Novaretti, Marcia Cristina Zago;Jens, Eduardo;Pagliarini, Thiago;Bonifácio, Silvia Leo;Dorlhiac-Llacer, Pedro Enrique;Chamone, Dalton de Alencar Fischer;
Revista do Hospital das Clínicas , 2003, DOI: 10.1590/S0041-87812003000600006
Abstract: anti-u is a rare red blood cell alloantibody that has been found exclusively in blacks. it can cause hemolytic disease of the newborn and hemolytic transfusion reactions. we describe the case of a female newborn presenting a strongly positive direct antiglobulin test due to an igg antibody in cord blood. anti-u was recovered from cord blood using acid eluate technique. her mother presented positive screening of antibodies with anti-u identified at delivery. it was of igg1 and igg3 subclasses and showed a titer of 32. monocyte monolayer assay showed moderate interaction of fc receptors with maternal serum with a positive result (3.1%). the newborn was treated only with 48 hours of phototherapy for mild hemolytic disease. she recovered well and was discharged on the 4th day of life. we conclude that whenever an antibody against a high frequency erythrocyte antigen is identified in brown and black pregnant women, anti-u must be investigated.
Aplica??o do índice prognóstico internacional em pacientes com linfoma difuso de grandes células B em uma institui??o brasileira
Hallack Neto, Abrah?o E.;Pereira, Juliana;Dorlhiac-Llacer, Pedro;Beitler, Beatriz;Chamone, Dalton A. F.;
Revista Brasileira de Hematologia e Hemoterapia , 2005, DOI: 10.1590/S1516-84842005000100008
Abstract: diffuse large b-cell lymphomas (dlbcl) correspond to 50% of non-hodgkin's lymphomas. since 1993 the treatment of these patients has been directed by the international prognostic index (ipi), validated in several studies. however, the use of the ipi has not been evaluated in our population and social-economical conditions. in this study, we evaluate the impact of the age-adapted ipi (aipi) in the complete response, overall survival and disease-free survival in under 60-year-old dlbcl sufferers treated in the hematology service of hcfmusp. of the 111 evaluated patients, 60 were classified as aipi low and intermediate risk and 51 as aipi intermediate-high and high risk. the patients with low and intermediate risk were analyzed as a whole with adapted low risk and patients with intermediate-high and high risk with the adapted high risk. we verified that the overall survival and disease-free survival were influenced by the clinic stage, ldh value and patients performance status. we recommend the regular use of ipi in the treatment of the patients with dlbcl in our institution.
In vitro cytotoxicity of the LDE: daunorubicin complex in acute myelogenous leukemia blast cells
Dorlhiac-Llacer P.E.,Marquezini M.V.,Toffoletto O.,Carneiro R.C.G.
Brazilian Journal of Medical and Biological Research , 2001,
Abstract: Acute myelogenous leukemia (AML) blast cells show high-affinity degradation of low-density lipoprotein (LDL), suggesting an increased expression of cellular LDL receptors. LDE is a lipid microemulsion easily synthesized in vitro which is known to mimic the metabolic pathway of LDL. We used LDE as a carrier for daunorubicin and assayed the cytotoxicity of the complex using AML blast cells since RT-PCR analysis showed that AML cells express LDL receptor mRNA. The LDE:daunorubicin complex killed 46.7% of blast cells and 20.2% of normal bone marrow cells (P<0.001; Student t-test). Moreover, this complex destroyed AML blast cells as efficiently as free daunorubicin. Thus, LDE might be a suitable carrier of chemotherapeutic agents targeting these drugs to neoplastic cells and protecting normal tissues.
In vitro cytotoxicity of the LDE: daunorubicin complex in acute myelogenous leukemia blast cells
Dorlhiac-Llacer, P.E.;Marquezini, M.V.;Toffoletto, O.;Carneiro, R.C.G.;Maranh?o, R.C.;Chamone, D.A.F.;
Brazilian Journal of Medical and Biological Research , 2001, DOI: 10.1590/S0100-879X2001001000004
Abstract: acute myelogenous leukemia (aml) blast cells show high-affinity degradation of low-density lipoprotein (ldl), suggesting an increased expression of cellular ldl receptors. lde is a lipid microemulsion easily synthesized in vitro which is known to mimic the metabolic pathway of ldl. we used lde as a carrier for daunorubicin and assayed the cytotoxicity of the complex using aml blast cells since rt-pcr analysis showed that aml cells express ldl receptor mrna. the lde:daunorubicin complex killed 46.7% of blast cells and 20.2% of normal bone marrow cells (p<0.001; student t-test). moreover, this complex destroyed aml blast cells as efficiently as free daunorubicin. thus, lde might be a suitable carrier of chemotherapeutic agents targeting these drugs to neoplastic cells and protecting normal tissues.
Estudo de grupos sangüíneos em doadores de sangue caucasóides e negróides na cidade de S?o Paulo
Novaretti, Marcia C. Z.;Dorlhiac-Llacer, Pedro E.;Chamone, Dalton A.F.;
Revista Brasileira de Hematologia e Hemoterapia , 2000, DOI: 10.1590/S1516-84842000000100004
Abstract: despite the fact mulattos (individuals resulting from admixture of caucasian and black individuals) represent one of the most common racial mixed individuals not only in brazil but in many other countries, there is little information regarding the distribution of blood groups among them. we studied 2,462 blood donors classified as caucasian, mulattos e blacks according to their anthropological characteristics as well as to their ancestry information. phenotype frequencies were studied in the abo, mns, p, rh, lutheran, kell, lewis, duffy e kidd blood group systems. we did not find significant statistically difference between blacks and mulattos for the majority of the blood groups systems here reported, excepting of p1 positive, dccee, le(a-b-), js(a+b+), js(a-b+), fy(a-b-), fy(a+b+) e fy(a-b+). on the other he there was a significant difference between caucasian and blacks for the following red blood cells phenotypes: a, b, m+n-s+s-, m+n-s-s+, p1 positivo, ddccee, dccee, dccee, dccee, dccee, k+k+, k-k+, kp(a-b+), kp(a+b+), js(a-b+), js(a+b-), le(a-b+), le(a-b-), fy(a-b+), fy(a+b+), fy(a-b-), jk(a+b-), jk(a+b+) e jk(a-b+). conclusion: as expected, the results for the mulattos group were intermediate between caucasian and blacks, with strong negroid influence.
Controle de qualidade interno de regentes em imunohematologia: aspectos práticos
Novaretti, Marcia C. Z.;Bueno, Valdecir J.;Dorlhiac-Llacer, Pedro E.;Chamone, Dalton A. F.;
Revista Brasileira de Hematologia e Hemoterapia , 2002, DOI: 10.1590/S1516-84842002000400005
Abstract: one of the main objectives of transfusion medicine is to promote safe transfusion. continuous improvement involves the standardization of techniques used for quality control of reagents, adequate equipment evaluation and its maintenance and staff training. quality control of reagents is critical for achieving reliable results in immunohematological testing. in brazil, as far as we know, there are no minimum requirements for immunohematological reagent guidelines. this paper has the purpose of describing practical aspects of quality control in imunohematology, as well as providing information on the most common immunohematological reagents available on the brazilian market.
Controle de qualidade interno de regentes em imunohematologia: aspectos práticos
Novaretti Marcia C. Z.,Bueno Valdecir J.,Dorlhiac-Llacer Pedro E.,Chamone Dalton A. F.
Revista Brasileira de Hematologia e Hemoterapia , 2002,
Abstract: A hemoterapia tem buscado incessantemente o aumento da seguran a transfusional. Para tanto tem envolvido, dentre outros, a padroniza o de testes que comprovem a qualidade dos reagentes utilizados nos servi os hemoterápicos, as análises, o uso e a manuten o de equipamentos apropriados e treinamento de funcionários. O controle de qualidade é essencial e indispensável para a obten o de resultados confiáveis nos ensaios para os quais se destinam. Até o momento, n o há descri o pré-estabelecida dos requisitos mínimos para os reagentes utilizados nos testes imuno-hematológicos pelo Ministério da Saúde. Este trabalho tem por objetivo apresentar os aspectos práticos que envolvem o controle de qualidade em imuno-hematologia, além de informa es básicas sobre os principais reagentes imuno-hematológicos disponíveis no mercado brasileiro.
Estudo de grupos sangüíneos em doadores de sangue caucasóides e negróides na cidade de S o Paulo
Novaretti Marcia C. Z.,Dorlhiac-Llacer Pedro E.,Chamone Dalton A.F.
Revista Brasileira de Hematologia e Hemoterapia , 2000,
Abstract: Apesar do fato de que o grupo de mulatos representa um dos mais comuns grupos raciais encontrados n o só no Brasil, mas em vários outros países, existe pouca informa o sobre a distribui o dos grupos sangüíneos nestes indivíduos. Foram estudados 2.462 doadores de sangue classificados como caucasóides, mulatos e negros conforme suas características antropológicas, bem como pela suas informa es sobre seus ancestrais. Foram estudadas as freqüências fenotípicas para os sistemas de grupos sangüíneos ABO, Rh, P, Kell, Rh, Lutheran, Lewis, Duffy e Kidd. N o foram encontradas diferen as estatisticamente significativas entre negros e mulatos para a maioria dos sistemas de grupos sangüíneos por nós estudados, com exce o dos seguintes fenótipos: P1 positivo, Dccee, Le(a-b-), Js(a+b+), Js(a-b+), Fy(a-b-), Fy(a+b+) e Fy(a-b+). Por outro lado foi observada uma diferen a estatisticamente significante entre caucasóides e negróides para os seguintes fenótipos eritrocitários: A, B, M+N-S+s-, M+N-S-s+, P1 positivo, ddccee, Dccee, Dccee, DCCee, DccEe, K+k+, K-k+, Kp(a-b+), Kp(a+b+), Js(a-b+), Js(a+b-), Le(a-b+), Le(a-b-), Fy(a-b+), Fy(a+b+), Fy(a-b-), Jk(a+b-), Jk(a+b+) e Jk(a-b+). Os resultados encontrados para o grupo mulato foram intermediários entre caucasóides e negros, com forte influência negróide.
Impacto da recusa de candidatos à doa??o de sangue devido aos critérios para preven??o da doen?a de Creutzfeldt-Jacob e sua variante
Almeida Neto, Cesar;Mendrone Júnior, Alfredo;Vieira, Anésio;Dorlhiac-Llacer, Pedro E.;Chamone, Dalton AF;
Revista Brasileira de Hematologia e Hemoterapia , 2005, DOI: 10.1590/S1516-84842005000200010
Abstract: creutzfeldt-jakob disease (cjd) and its variant (vcjd) are degenerative and fatal neurological diseases with a long incubation period. recent studies have described a potential association between vcjd and blood transmission. the aim of this study is to evaluate the impact of the deferral criteria for cjd and vcjd in our institution since their implementation in 2001. based on scientific data, we have adopted deferral criteria for the prevention of cjd and vcjd through blood transfusion since 2001. blood donors are deferred if they spent more than 6 months cumulatively in the united kingdom from january 1, 1980 through december 31, 1996, 10 years cumulatively in france, portugal, or the irish republic since 1980, received human pituitary-derived growth hormone or corneal transplants or had one or more blood relatives with familial cjd. the deferral rate concerning these criteria was retrospectively evaluated for all blood donation candidates from january 2001 to december 2004. a total of 1,015,587 pre-donation interviews were evaluated. the deferral rate for cjd and vcjd was 0.049% in 2001, 0.051% in 2002, 0.092% in 2003 and 0.098% in 2004, denoting a permanent deferral of 726 (0.068%) blood donors. the most frequent deferral reasons for cjd and vcjd was spending more than 6 months cumulatively in the united kingdom from 1980 to 1996 (0.025%) followed by corneal transplants (0.019%) and use of pituitary-derived human growth hormone (0.014%). the number of deferrals related to cjd and its variant was very low at our center. it is feasible to support the "precautionary principle" for cjd and vcjd at our center without jeopardizing blood supply.
Comparison of catheter-related infection risk in two different long-term venous devices in adult hematology-oncology patients
Pracchia, Luís Fernando;Dias, Lúcia Cristina Santos;Dorlhiac-Llacer, Pedro Enrique;Chamone, Dalton de Alencar Fisher;
Revista do Hospital das Clínicas , 2004, DOI: 10.1590/S0041-87812004000500012
Abstract: purpose: infection is the leading complication of long-term central venous catheters, and its incidence may vary according to catheter type. the objective of this study was to compare the frequency and probability of infection between two types of long-term intravenous devices. methods: retrospective study in 96 onco-hematology patients with partially implanted catheters (n = 55) or completely implanted ones (n = 42). demographic data and catheter care were similar in both groups. infection incidence and infection-free survival were used for the comparison of the two devices. results: in a median follow-up time of 210 days, the catheter-related infection incidence was 0.2102/100 catheter-days for the partially implanted devices and 0.0045/100 catheter-days for the completely implanted devices; the infection incidence rate was 46.7 (ci 95% = 6.2 to 348.8). the 1-year first infection-free survival ratio was 45% versus 97%, and the 1-year removal due to infection-free survival ratio was 42% versus 97% for partially and totally implanted catheters, respectively (p <.001 for both comparisons). conclusion: in the present study, the infection risk was lower in completely implanted devices than in partially implanted ones.
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