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Search Results: 1 - 10 of 85066 matches for " Silvana Maria;Figueiró-Filho "
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Efeito diabetogênico das drogas anti-retrovirais em ratas Wistar prenhes
Figueiró-Filho, Ernesto Antonio;Duarte, Geraldo;El Beitune, Patrícia;Quintana, Silvana Maria;Marcolin, Alessandra Cristina;
Revista Brasileira de Ginecologia e Obstetrícia , 2004, DOI: 10.1590/S0100-72032004000100005
Abstract: purpose: to experimentally evaluate the diabetogenic effects of antiretroviral drugs on pregnant wistar rats and the perinatal effects on the offspring. methods: adult female pregnant wistar rats weighing 200-230 g were used. the antiretroviral drugs zidovudine (zdv), lamivudine (3tc) and nelfinavir (nfv) were used alone and in association at daily doses of ten times the dose normally used in pregnant women, proportionally to the animal's body weight. seven groups were studied, including the control. the experiment started on day 0 of pregnancy and the pregnant animals were sacrificed on day 21. the fetuses were counted and weighed. blood determinations of glucose, insulin, glucagon and lactate were performed on day 21. the retroperitoneal adipose tissue was weighed. data were analyzed statistically by student's t-test. results: the groups treated with 3tc, zdv + 3tc and zdv + 3tc + nfv showed decreasing values of maternal daily body weight gain, retroperitoneal adipose tissue weight and weight of fetuses (control group: 6.2 g; 3tc group variation: 4.1-5.6 g). the serum lactate levels were also decreased when compared to the control in these groups (control group: 5.8 mmol/ml; 3tc group variations: 3.2-3.7 mmol/ml). all antiretroviral-treated groups showed a decreasing number of fetuses when compared to the control (control group: 14.7; drug group variation: 11.1-12.7). all treated groups also showed decreasing serum values of insulin (control group: 6.2 μiu/ml; drug group variation: 2.1 to 2.7 μiu/ml) and increasing serum levels of glucagon when compared to the control (control group: 88.2 pg/ml; drug group variation: 99.7 to 120.7 pg/ml). there was no statistical significance of glucose levels when comparing treated groups to the control. conclusions: the antiretroviral drugs interfered in carbohydrate metabolism of pregnant rats and reduced the number of fetuses. 3tc caused less maternal body weight gain, decreased fetus weight and lactate and insulin levels and
HIV-1: maternal prognosis
El Beitune, Patrícia;Duarte, Geraldo;Quintana, Silvana Maria;Figueiró-Filho, Ernesto Ant?nio;
Revista do Hospital das Clínicas , 2004, DOI: 10.1590/S0041-87812004000100005
Abstract: profound modifications in the profile of patients are currently being observed within the epidemic context of aids, especially with respect to pauperization and feminization of the disease. the population most frequently affected is in the reproductive age, and among adults aged 18 to 24 years, the ratio is 1 man to 1 woman, a phenomenon occurring uniformly all over the world. one of the main challenges for hiv-1-infected pregnant women and their doctors is the effect of the interaction between hiv infection and pregnancy. the present article is a review of the literature; and its objective is to assess the influence of hiv-1 infection seen from the maternal perspective, with a discussion of immunologic function, maternal prognosis, and the hiv-abortion interface. at present, we cannot conclude that pregnancy has a short-term effect on the evolution of hiv infection, but the concomitance of hiv and pregnancy may adversely affect the prognosis of gestation, especially in view of its frequent association with increased abortion and puerperal morbidity rates.
Efeito diabetogênico das drogas anti-retrovirais em ratas Wistar prenhes
Figueiró-Filho Ernesto Antonio,Duarte Geraldo,El Beitune Patrícia,Quintana Silvana Maria
Revista Brasileira de Ginecologia e Obstetrícia , 2004,
Abstract: OBJETIVO: estudar a a o diabetogênica de drogas anti-retrovirais em ratas prenhes e o prognóstico perinatal das crias. MéTODOS: estudo com ratas fêmeas prenhes adultas da ra a Wistar, pesando entre 200-230 g. Foram testadas a azidotimidina (AZT), lamivudina (3TC) e nelfinavir (NFV), cujas dosagens foram padronizadas em 10 vezes a dose utilizada em gestantes, proporcionalmente ao peso dos animais. Foram avaliados sete grupos, incluindo o controle, contendo 10 ratas por grupo. O início do experimento foi o dia zero da prenhez e as cesarianas realizadas no 21o dia, após decapita o, sendo os fetos contados e pesados. Procedeu-se a dosagens de glicemia, insulina, glucagon e lactato no 21o dia. Avaliou-se também o peso do tecido adiposo retroperitoneal. Os dados foram analisados utilizando-se o teste t de Student para a análise estatística. RESULTADOS: os grupos tratados com 3TC, AZT + 3TC e AZT + 3TC + NFV demonstraram altera es com a redu o das médias de ganho de peso materno diário, do peso da gordura retroperitoneal e peso das crias (grupo controle: 6,2 g; grupos contendo 3TC: 4,1 a 5,6 g), bem como dos valores de lactato (grupo controle: 5,8 mmol/mL; grupos contendo 3TC: 3,2 a 3,7 mmol/mL), quando comparados ao controle. Todos os grupos tratados com drogas anti-retrovirais apresentaram redu o significativa do número de fetos por ninhada (grupo controle: 14,7; grupos medicamentos: 11,1 a 12,7) e dos valores séricos de insulinemia (grupo controle: 6,2 μUI/mL; grupos medicamentos: 2,1 a 2,7 μUI/mL) e eleva o da glucagonemia (grupo controle: 88,2 pg/mL; grupos medicamentos: 99,7 a 120,7 pg/mL). N o houve diferen as estatisticamente significantes entre o grupo controle e tratados nos valores de glicemia. CONCLUS ES: o uso de anti-retrovirais em ratas prenhes causa interferência no metabolismo glicídico dos animais durante o período de prenhez, provocando significativa redu o do número das crias. Observou-se que o uso do 3TC resultou em menor ganho de peso materno e das crias, redu o de insulina e lactato e eleva o do glucagon.
Intolerancia glicêmica e o prognóstico perinatal em gestantes utilizando anti-retrovirais
Duarte Geraldo,El Beitune Patrícia,Figueiró-Filho Ernesto Antonio,Quintana Silvana Maria
Revista Brasileira de Ginecologia e Obstetrícia , 2004,
Abstract:
Controle de polidramnio recorrente em gestante portadora do HIV-1: relato de caso
Duarte Geraldo,Figueiró-Filho Ernesto Antonio,El Beitune Patrícia,Quintana Silvana Maria
Revista Brasileira de Ginecologia e Obstetrícia , 2004,
Abstract: A redu o da transmiss o vertical (TV) do vírus da imunodeficiência humana tipo 1 (HIV-1) utilizando a profilaxia com a zidovudina (AZT) representa significativo avan o na assistência pré-natal e obstétrica destas pacientes. Condutas obstétricas invasivas s o contra-indicadas em gestantes portadoras do HIV-1, em face do risco de aumento da taxa de TV deste vírus. Os autores relatam um caso de polidramnio recorrente em gestante portadora do HIV-1, que exigiu drenagem por amniocentese. Foram realizadas quatro pun es ao longo da gesta o, na 23a, 26a, 27a e 29a semanas, todas guiadas por ultra-sonografia, drenando, respectivamente, 1.800, 1.450, 1.700 e 1.960 mL de líquido amniótico claro em cada pun o. Com 30 semanas e 5 dias de gesta o a paciente apresentou trabalho de parto pré-termo, evoluindo para parto vaginal de recém-nato (RN) pesando 1.690 g e medindo 43 cm. O RN evoluiu com diagnóstico de nefropatia perdedora de sódio, tendo três aferi es de rea o em cadeia de polimerase para HIV-1 negativas. Os autores ilustram uma op o no manejo de situa es que envolvam gestantes portadoras do HIV-1 que necessitem de procedimentos obstétricos invasivos, utilizando AZT endovenoso (2 mg/kg) previamente ao procedimento, medida que apresentou excelente resultado no caso descrito, evitando a infec o perinatal pelo HIV-1.
HIV-1: maternal prognosis
El Beitune Patrícia,Duarte Geraldo,Quintana Silvana Maria,Figueiró-Filho Ernesto Ant?nio
Revista do Hospital das Clínicas , 2004,
Abstract: Profound modifications in the profile of patients are currently being observed within the epidemic context of AIDS, especially with respect to pauperization and feminization of the disease. The population most frequently affected is in the reproductive age, and among adults aged 18 to 24 years, the ratio is 1 man to 1 woman, a phenomenon occurring uniformly all over the world. One of the main challenges for HIV-1-infected pregnant women and their doctors is the effect of the interaction between HIV infection and pregnancy. The present article is a review of the literature; and its objective is to assess the influence of HIV-1 infection seen from the maternal perspective, with a discussion of immunologic function, maternal prognosis, and the HIV-abortion interface. At present, we cannot conclude that pregnancy has a short-term effect on the evolution of HIV infection, but the concomitance of HIV and pregnancy may adversely affect the prognosis of gestation, especially in view of its frequent association with increased abortion and puerperal morbidity rates.
Visceral Leishmaniasis (Kala-Azar) and Pregnancy
Ernesto Antonio Figueiró-Filho,Geraldo Duarte,Patrícia El-Beitune,Silvana Maria Quintana,Tamara Lemos Maia
Infectious Diseases in Obstetrics and Gynecology , 2004, DOI: 10.1080/1064744042000210384
Abstract: Objective: The aim of the present review was to close the gap in the approach to pregnant women with visceral leishmaniasis (kala-azar) by providing up-to-date information to obstetricians about physiopathology, epidemiology, vertical transmission, drugs and treatment during pregnancy.
Antiretroviral therapy during pregnancy and early neonatal life: consequences for HIV-exposed, uninfected children
El Beitune, Patrícia;Duarte, Geraldo;Quintana, Silvana Maria;Figueiró-Filho, Ernesto A.;Marcolin, Alessandra Cristina;Abduch, Renata;
Brazilian Journal of Infectious Diseases , 2004, DOI: 10.1590/S1413-86702004000200004
Abstract: women have emerged as the fastest growing human immunodeficiency virus (hiv) infected population worldwide, mainly because of the increasing occurrence of heterosexual transmission. most infected women are of reproductive age and one of the greatest concerns for both women and their physicians is that more than 1,600 infants become infected with hiv each day. almost all infections are a result of mother-to-child transmission of hiv. with the advent of combination antiretroviral therapies, transmission rates lower than 2% have been achieved in clinical studies. antiretroviral compounds differ from most other new pharmaceutical agents in that they have become widely prescribed in pregnancy in the absence of proof of safety. we reviewed antiretroviral agents used in pregnant women infected with human immunodeficiency virus, mother-to-child transmission, and their consequences for infants.
Effect of antiretroviral drugs on maternal CD4 lymphocyte counts, HIV-1 RNA levels, and anthropometric parameters of their neonates
El Beitune, Patrícia;Duarte, Geraldo;Machado, Alcyone Artioli;Quintana, Silvana Maria;Figueiró-Filho, Ernesto A.;Abduch, Renata;
Clinics , 2005, DOI: 10.1590/S1807-59322005000300005
Abstract: purpose: to study the effect of antiretroviral drugs administered during pregnancy on cd4 lymphocyte counts and hiv-1 rna levels of pregnant women and on the anthropometric parameters of their neonates. methods: a prospective study was conducted on 57 pregnant women and their neonates divided into 3 groups: zdv group, hiv-infected mothers taking zidovudine (n = 20); triple therapy (tt) group, mothers taking zidovudine + lamivudine + nelfinavir (n = 25), and control group, normal women (n = 12). cd4 lymphocyte counts and hiv-1 rna levels of pregnant women were analyzed during two periods of pregnancy. the perinatal prognosis took into account preterm rates, birth weight, intrauterine growth restriction, perinatal death, and vertical transmission of hiv-1. data were analyzed statistically using the nonparametric chi-square, mann-whitney, friedman, kruskal-wallis, and wilcoxon matched pairs tests, with the level of significance set at p <.05. results: the major maternal demographic and anthropometric data were homogeneous for the various groups. hiv-1 viral burden, which was initially elevated, median of 14,370 copies/ml, was significantly reduced in the tt group, reaching 40 copies/ml. with respect to t-cd4+ lymphocyte counts, there was a significant recovery in group tt at the end of pregnancy, this value being significantly different from that for the zdv group (p =.0052). there was no difference between groups regarding gestation length, apgar scores, or neonatal anthropometric classification. there was no case of vertical hiv-1 transmission. conclusions: the results obtained for the present series demonstrate the efficiency and suggest safety of the use of antiretroviral drugs during pregnancy as revealed by anthropometric parameters of the neonate.
O uso de anti-retrovirais em gestantes modifica o perfil lipídico?
El Beitune, Patrícia;Duarte, Geraldo;Santos, José Ernesto dos;Quintana, Silvana Maria;Figueiró-Filho, Ernesto Antonio;Marcolin, Alessandra Cristina;
Revista Brasileira de Ginecologia e Obstetrícia , 2003, DOI: 10.1590/S0100-72032003000800008
Abstract: purpose: to investigate the effect of antiretroviral drugs on the lipid metabolism in hiv-infected pregnant women. methods: a prospective study was conducted on 57 pregnant women. the women were divided into three groups: zdv group, consisting of 20 hiv-infected women taking zdv; tt group, consisting of 25 hiv-1-infected women on triple antiretroviral treatment (zdv + 3tc + nfv), and control group, consisting of 12 pregnant women considered to be normal from a clinical and laboratory viewpoint. demographic and anthropometric data were homogeneous. patients with a personal and family history of hyperlipidemia were excluded. blood samples were obtained for the determination of fasting lipids (total cholesterol, ldl and hdl, and triglycerides) at four periods during pregnancy (1st = 14-20 weeks; 2nd = 21-26 weeks; 3rd = 27-32 weeks and 4th = 33-38 weeks). data were analyzed statistically using the nonparametric c2, friedman and kruskal-wallis tests . results: the use of antiretroviral drugs during pregnancy induced no difference in total or hdl cholesterol but caused an increase from 76.5 and 84 mg/dl to 96 and 105 mg/dl in the concentration of the ldl fraction along gestation in zdv and tt groups, respectively (p<0.01). a positive significant association was observed between triglycerides and viral burden in the zdv group (r: 0.534; p=0.015). conclusion: antiretroviral agents during pregnancy increase serum ldl-colesterol levels. the risk of pregnancy regarding potentiation of long-term antiretroviral effects on lipid metabolism, remains to be established.
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