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Search Results: 1 - 10 of 210130 matches for " Sieu L Tran "
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First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia
Li Zhou, Eve Diefenbach, Ben Crossett, Sieu L Tran, Thomas Ng, Helen Rizos, Rejane Rua, Bin Wang, Amit Kapur, Kaushal Gandhi, Bruce J Brew, Nitin K Saksena
Molecular Neurodegeneration , 2010, DOI: 10.1186/1750-1326-5-27
Abstract: Here, we have analyzed total proteins from the frontal cortex of 9 HAD and 5 HIV non-dementia patients. Using 2-Dimensional differential in-gel electrophoresis (2-DIGE) to analyze the brain tissue proteome, 76 differentially expressed proteins (p < 0.05; fold change>1.25) were identified between HAD and HIV non-dementia patients, of which 36 protein spots (based on 3D appearance of spots on the images) were chosen for the mass spectrometry analysis. The large majority of identified proteins were represented in the energy metabolic (mitochondria) and signal transduction pathways. Furthermore, over 90% of the protein candidates are common to both HAD and other non-viral neurodegenerative disease, such as Alzheimer's disease. The data was further validated using specific antibodies to 4 proteins (CA2, GS, CKMT and CRMP2) by western blot (WB) in the same samples used for 2D-DIGE, with additional confirmation by immunohistochemitsry (IHC) using frontal lobe tissue from different HAD and HIV+ non-dementia patients. The validation for all 4 antibodies by WB and IHC was in concordance with the DIGE results, lending further credence to the current findings.These results suggest not only convergent pathogenetic pathways for the two diseases but also the possibility of increased Alzheimer's disease (AD) susceptibility in HAD patients whose life expectancy has been significantly increased by highly active antiretroviral therapy.HIV-1 associated dementia (HAD) is a common complication of HIV disease with a prevalence of at least 20% in advanced HIV infection in the pre-highly active antiretroviral therapy (HAART) era [1]. Even in patients taking HAART, milder forms of cognitive impairment remain common and functionally significant [2]. The reasons for the continued presence and development of HAD and its milder forms, despite effective HAART are not clear. Furthermore, due to the longevity of HIV patients after the advent of HAART, the prevalence of HAD has increased [3]. It has
Maximum Entropy and Bayesian Inference for the Monty Hall Problem  [PDF]
Jennifer L. Wang, Tina Tran, Fisseha Abebe
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.47127
Abstract: We devise an approach to Bayesian statistics and their applications in the analysis of the Monty Hall problem. We combine knowledge gained through applications of the Maximum Entropy Principle and Nash equilibrium strategies to provide results concerning the use of Bayesian approaches unique to the Monty Hall problem. We use a model to describe Monty’s decision process and clarify that Bayesian inference results in an “irrelevant, therefore invariant” hypothesis. We discuss the advantages of Bayesian inference over the frequentist inference in tackling the uneven prior probability Monty Hall variant. We demonstrate that the use of Bayesian statistics conforms to the Maximum Entropy Principle in information theory and Bayesian approach successfully resolves dilemmas in the uneven probability Monty Hall variant. Our findings have applications in the decision making, information theory, bioinformatics, quantum game theory and beyond.
Neuromimetic Circuits with Synaptic Devices based on Strongly Correlated Electron Systems
Sieu D. Ha,Jian Shi,Yasmine Meroz,L. Mahadevan,Shriram Ramanathan
Computer Science , 2014, DOI: 10.1103/PhysRevApplied.2.064003
Abstract: Strongly correlated electron systems such as the rare-earth nickelates (RNiO3, R = rare-earth element) can exhibit synapse-like continuous long term potentiation and depression when gated with ionic liquids; exploiting the extreme sensitivity of coupled charge, spin, orbital, and lattice degrees of freedom to stoichiometry. We present experimental real-time, device-level classical conditioning and unlearning using nickelate-based synaptic devices in an electronic circuit compatible with both excitatory and inhibitory neurons. We establish a physical model for the device behavior based on electric-field driven coupled ionic-electronic diffusion that can be utilized for design of more complex systems. We use the model to simulate a variety of associate and non-associative learning mechanisms, as well as a feedforward recurrent network for storing memory. Our circuit intuitively parallels biological neural architectures, and it can be readily generalized to other forms of cellular learning and extinction. The simulation of neural function with electronic device analogues may provide insight into biological processes such as decision making, learning and adaptation, while facilitating advanced parallel information processing in hardware.
Guide to Threshold Selection for Motif Prediction Using Positional Weight Matrix
Youlian Pan,Sieu Phan
Lecture Notes in Engineering and Computer Science , 2008,
Abstract:
Threshold for Positional Weight Matrix
Yunlian Pan,Sieu Phan
Engineering Letters , 2008,
Abstract:
Hepatitis B Virus Screening Patterns amongst Physicians in Hawaii: Changes in a Decade  [PDF]
Chuong T. Tran, Krista K. Kiyosaki, Linda L. Wong
Open Journal of Gastroenterology (OJGas) , 2015, DOI: 10.4236/ojgas.2015.510023
Abstract: Purpose: Hawaii had the highest incidence of liver cancer in the US and had a unique patient population with many immigrants from the Pacific and Asia where Hepatitis B virus (HBV) was endemic. HBV screening in high risk populations was a recommended measure of preventative medicine, thus we sought to examine physician screening patterns for HBV in Hawaii. Methods: We retrospectively analyzed billing claims from 1999 to 2009 from the largest healthcare coverage provider in the state of Hawaii. We identified all patients (>18 years) who underwent HBV screening based on Current Procedural Terminology (CPT) billing codes. We collected data on age, gender and specialty of physicians ordering the screening tests. Analysis was done in 2013 and 2014. Results: Of an estimated 700,000 covered lives, 125,576 patients underwent HBV screening. We stratified the patients into two eras from 1999-2004 (N = 52,245) and 2005-2009 (N = 73,331) to examine temporal trends. In the first era, 30,975 women (59.3%) underwent HBV screening, compared to 49,950 women (69.1%) screened in the 2005-2009 era. There absolute number of tests increased, but the proportion done by primary care MDs decreased from 55.6% to 44.9%. OB/GYN screened 15.6% in the early era and 26.9% in later era. Conclusions: There was an increase in women aged 18 - 40 years screened in the 2005-2009 era compared to 1999-2004, most likely due to OB/GYN physicians’ screening of prenatal women. Physician education on HBV vaccination/treatment or appropriate referral should include OB/GYN as well as primary care physicians.
Vietnamese Immigrants in Brisbane, Australia: Perception of Parenting Roles, Child Development, Child Health, Illness, and Disability, and Health Service Utilisation
Uyen N. T. L. Tran
International Journal of Population Research , 2012, DOI: 10.1155/2012/932364
Abstract: The limited research into Vietnamese immigrants suggests that this group may have different perceptions relating to parenting roles, child development, child health, illness, and disability, and differing patterns of health service utilisation. The author conducted a pilot study exploring how Vietnamese immigrants differ from Anglo-Australian in relation to these issues. The pilot, utilising a mixed quantitative and qualitative method, was conducted in Brisbane, Australia, with subjects being existing clients of a health centre. Two focus group discussions were conducted and a structured questionnaire developed from the discussions. Vietnamese immigrants in contrast to Australian-born Caucasians regard the general practitioner as the main health care provider and were less satisfied with English-speaking health services. This study highlights potentially important health-related issues for children of Vietnamese immigrants living in Brisbane, the importance of further research in this area, and the methodological challenges faced when conducting research into Vietnamese immigrants. 1. Introduction The literature indicates reduced access to health services and disparate health outcomes in people from culturally and linguistically diverse backgrounds (CLDBs) living in Western countries [1, 2]. Low socioeconomic status, which is more prevalent in people from CLDB, accounts for some but not all of the disparate outcomes [3–5]. With Australia’s increasingly cultural and linguistically diverse society, in particular a growing Asian population, health outcomes and health service utilisation of this population is an issue of great relevance to Australian practitioners and policy-makers. Even though commonalities may exist between CLDB populations, further exploration regarding poor health outcomes and access to health services demonstrate the importance of specific factors that are unique to individual communities. During this study, staff at Inala Community Health’s Department of Child, Youth and Family Health indicated possible deficits in the delivery of health services to families from CLDB, especially those from a Vietnamese background. Staff believed that these deficits may be related to different cultural perceptions held by parents about children’s health, development, and the role of parenting. A greater understanding of cultural values and beliefs of people from CLDB, which underlie health behaviour, is essential if appropriate health services are to be provided. A significant amount of the immigrant health research emanates from the United States of
Luminal-B breast cancer and novel therapeutic targets
Ben Tran, Philippe L Bedard
Breast Cancer Research , 2011, DOI: 10.1186/bcr2904
Abstract: The National Cancer Institute defines personalized medicine as 'a form of medicine that uses information about a person's genes, proteins, and environment to prevent, diagnose, and treat disease' [1]. Personalized cancer medicine has existed in breast cancer since the late 1980s when benefits of tamoxifen were found to be limited to patients with tumors expressing estrogen receptors (ERs) [2]. This personalized treatment has advanced further in recent times through the discovery of erbB2/HER2 gene amplification and its subsequent targeted treatments such as trastuzumab and lapatinib [3,4].Until very recently, personalized cancer medicine in breast cancer relied on only two predictive markers, ER and erbB2/HER2. The advent of gene expression profiling, however, has led to a paradigm shift in breast cancer medicine. Breast cancer is now recognized not as a single disease with variable morphology, but as at least four molecularly distinct neoplastic disorders: basal-like breast cancer, HER2-positive breast cancer, luminal-A breast cancer, and luminal-B breast cancer [5-8]. Although the immediate additional clinical value of this molecular classification is limited by its close correlation to traditional methods of testing for ER and HER2, the identification of genetic aberrations that underlie molecularly distinct subclasses of breast cancer has revealed new therapeutic targets and has reshaped breast cancer clinical trial design.The subtypes most in need of therapeutic advances are basal-like breast cancer and luminal-B breast cancer, where therapeutic resistance is common and where advances in molecular profiling have identified promising new therapeutic targets. In the present review article, we discuss the definition of luminal-B breast cancer, the clinical behavior and pathological features of luminal-B breast cancer, and emerging molecular targets for improved therapy (see Table 1 for a summary).Microarray technology has enabled better understanding of cancer bio
Prolexbase: a multilingual relational dictionary of Proper Names Prolexbase. Un dictionnaire relationnel multilingue de noms propres
Micka?l Tran,Denis Maurel
Traitement Automatique des Langues , 2007,
Abstract: This paper presents the modelling of Proper Name domain defined by the Prolex project. This modelling is based on two main concepts: the Conceptual Proper Name and the Prolexeme. The Conceptual Proper Name do not represents the referent, but a point of view on this referent. It has a specific concept in each language, the Prolexeme, that is a structured family of lexemes. Around them, we have defined other concepts and relations (synonymy, meronymy, accessibility, eponymy...). Each Conceptual Proper Name is an hyponym of a type and an existence within an ontology.
$τ\to πK ν$ Decay and $πK$ Scattering
L. Beldjoudi,Tran N. Truong
Physics , 1994, DOI: 10.1016/0370-2693(95)00158-H
Abstract: Using chiral low energy theorems and elastic unitarity assumption, the $\tau\to\pi K \nu $ decay is investigated. The vector and scalar $\pi K$ form factors are calculated. It is found that the $\pi K$ spectrum is dominated by the $K^*$ resonance. By measuring the forward-backward asymmetry, it is shown that the S wave $\pi K$ phase shift can be determined near the $K^{*}$ resonance region. The calculated branching ratio and resonance parameters are in good agreement with experiments.
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