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Search Results: 1 - 10 of 121492 matches for " Shur-Jen Wang "
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RGD: A comparative genomics platform
Mary Shimoyama, Jennifer R Smith, Tom Hayman, Stan Laulederkind, Tim Lowry, Rajni Nigam, Victoria Petri, Shur-Jen Wang, Melinda Dwinell, Howard Jacob, RGD Team
Human Genomics , 2011, DOI: 10.1186/1479-7364-5-2-124
Abstract: The Rat Genome Database (RGD) (http://rgd.mcw.edu webcite) is recognised as the premier resource for genetic, genomic and phenotype data for the laboratory rat, Rattus norvegicus. Since 1999, RGD has provided a comprehensive catalogue of genes, quantitative trait loci (QTL) and strains, along with software tools to retrieve and display data of interest to investigators using this organism. The disease focus of these researchers often results in the use of multiple model organisms, in addition to clinical studies, in their efforts to elucidate the mechanisms and underlying genetic factors involved in human disease. To meet the needs of such users, RGD focuses its manual curation efforts on the functional, phenotype and pathway data related to specific disease areas and has integrated human and mouse data to create a comprehensive platform for comparative genomics and genetics. Several of these components are highlighted here.The wealth of data at RGD includes genes and QTLs for rat, human and mouse, as well as polymorphic markers for rat and human (Table 1). Information on inbred, outbred, mutant, congenic, consomic and other types of rat strains is also provided. A team of scientific curators validates the identity of genomic elements, provides official nomenclature and annotates these elements with functional data from published literature [1]. With more than 1.3 million published rat research papers, prioritising data for curation is a vital task, and a project approach has proved effective. Such projects revolve around gene families, molecular pathways, ultra-conserved gene sets and diseases.The disease portals (http://rgd.mcw.edu/wg/portals/ webcite) create a structure for prioritising rat data curation and integrating rat, human and mouse information, and provide a platform for researchers easily to access multiple data types related to a particular disease area (Table 2). RGD currently has portals for cardiovascular and neurological diseases, cancer, diabetes
The Rat Genome Database Curators: Who, What, Where, Why
Mary Shimoyama ,G. Thomas Hayman,Stanley J. F. Laulederkind,Rajni Nigam,Timothy F. Lowry,Victoria Petri,Jennifer R. Smith,Shur-Jen Wang,Diane H. Munzenmaier,Melinda R. Dwinell,Simon N. Twigger,Howard J. Jacob,the RGD Team
PLOS Computational Biology , 2009, DOI: 10.1371/journal.pcbi.1000582
Abstract:
Extracorporeal shockwave therapy in musculoskeletal disorders
Ching-Jen Wang
Journal of Orthopaedic Surgery and Research , 2012, DOI: 10.1186/1749-799x-7-11
Abstract: Extracorporeal shockwave therapy (ESWT) began with an incidental observation of osteoblastic response pattern during animal studies in the mid-1980 that generated an interest in the application of ESWT to musculoskeletal disorders. In the past 10 to 15 years, shockwave therapy had emerged as the leading choice in the treatment of many orthopedic disorders including proximal plantar fasciitis of the heel [1-6], lateral epicondylitis of the elbow [7-10], calcific tendinitis of the shoulder [11,12] and. non-union of long bone fracture [13-15]. More recently, the use of ESWT had expanded to the treatment of patellar tendinopathy (jumper's knee) and Achilles tendinopathy [16-19], and avascular necrosis of the femoral head [20-22]. ESWT has gained significant acceptance from Europe (Germany, Austria, Italy and others) to South America (Brazil, Columbia, Argentina and others), Asia (Korea, Malaysia, Taiwan and others) and North America (Canada and USA), and this had led to the change of European Society for Musculoskeletal Shockwave Therapy to International Society for Musculoskeletal Shockwave Therapy (ISMST) in 2000. In USA, FDA (Food and Drug Administration) first approved the specific shockwave device, OssaTron (High Medical Technology, Lengwil, Switzerland, now Sanuwave/Alpharetta, GA) for the treatment of proximal plantar fasciitis in 2000 and lateral epicondylitis of the elbow in 2003. FDA also approved Epos (Dornier Medical System, Kennesaw, GA) for the treatment of plantar fasciitis and Sonocur (Siemens Medical Systems, Iselin, NJ) for the treatment of lateral epicondylitis of the elbow in 2002, Orthospec (Medispec, Germantown, MD) and Orbasone (Orthometrix, White Plains, NY) for the treatment of plantar fasciitis in 2005. In the meantime, many off-label uses of ESWT were also studied including calcific tendinitis of the shoulder, patellar tendinopathy, Achilles tendinopathy, and non-union of long bone fracture, avascular necrosis of the femoral head and others. T
Liberalist Variation in Taiwan: Four Democratization Orientations
Hung-jen Wang
Journal of Current Chinese Affairs , 2012,
Abstract: In this paper I analyse how Taiwanese liberalist scholars have discursively and operationally shaped the meanings of Taiwanese democratization via a mix of liberal values and nationalist concerns. I will argue that a valid understanding of democratization in Taiwan has never emerged in a way that adequately responds to a liberalist perspective of the country’s ongoing political development. Instead, such an understanding has been subjectively influenced by liberal intellectuals writing on the subject. In other words, current discourses in Taiwan represent efforts on the part of scholars to manage connections between liberalist values and nationalist concerns rather than shared views regarding facts emerging from Taiwanese democratization. In this paper I discuss four types of liberalist orientations to Taiwanese democratization – universal, moderate, pragmatic and nationalist – in the contexts of national-identity constraints, a balance between liberal values and national identity, and flexibility regarding liberalist and nationalist concerns. I conclude that democratization research in Taiwan reflects an aspect of knowledge production formulated by the relationship between the researcher and the subject under study.
Injuries to the Posterior Cruciate Ligament and Posterolateral Instabilities of the Knee
Ching-Jen Wang
Chang Gung Medical Journal , 2002,
Abstract: Unlike anterior cruciate ligament (ACL) injury, disability from isolated posterior cruciateligament (PCL) injury varies from no interference with life style to severe impairment ofdaily activities. Therefore, management of isolated PCL injuries remains controversial.High-energy vehicular accidents often cause more-serious PCL injuries, while less-severeinjuries result from low-energy trauma including sports. The natural history and prognosis ofPCL injury are correlated with the type and extent of instability and the development ofdegenerative changes in the knee. Indications for surgery include pain and instability of theknee.Arthroscopic single-bundle PCL reconstruction improved the function and stability ofthe knee with 77.4% satisfactory results in medium-term follow-up. Complete restoration ofligament stability was achieved in only 52% of knees, while 1/3 of the knees showed mildand 9.7% showed moderate residual ligament laxity. The incidence of degenerative changeswas 52%, and the rate was correlated with duration of injury and severity of ligament laxity.Therefore, the significance of PCL injury has been overly simplified, and the functional disabilityof knees with PCL injury underestimated. Early surgical reconstruction of knees withgrade III PCL injury is recommended.PCL injury is frequently associated with multiple ligamentous injuries. Combined PCLand posterolateral instabilities are serious knee injuries and frequently result in severe functionaldisability due to pain, instability, and degenerative changes in the knee. Unlike isolatedPCL injury, there is a consensus of opinion that surgical reconstruction is indicated inknees with combined PCL and posterolateral instabilities. Commonly employed methods ofreconstruction of the posterolateral corner include popliteus reconstruction, lateral collateralreconstruction or advancement, and a combination of the two. Combined arthroscopic PCLreconstruction and posterolateral reconstruction achieved 64% satisfactory (24% excellentand 40% good) and 36% unsatisfactory (24% fair and 12% poor) results over an average of32 months of follow-up. Complete restoration of ligament stability was noted in only 44%of knees. The incidence of degenerative changes was 44%, and the rate was correlated withduration from injury to surgery and severity of ligament laxity. Despite the fact that currentlyemployed surgical techniques only achieve modest success in restoration of ligament stability,early surgical reconstruction in knees with combined PCL and posterolateral instabilitiesachieved the best clinical results and a
A Generalized Closed Form For Triangular Matrix Powers
Walter Shur
Mathematics , 2013,
Abstract: This paper shows how to obtain a simple closed form for the elements of a triangular matrix raised to the nth power.
The Last Digit of $\binom{2n}{n}$ and $\sum\binom{n}{i}\binom{2n-2i}{n-i}$
Walter Shur
Mathematics , 2013,
Abstract: Let $f_{n}=\sum_{i=0}^n \binom{n}{i}\binom{2n-2i}{n-i}$, $g_{n}= \sum_{i=1}^n \binom{n}{i}\binom{2n-2i}{n-i}$. Let $\{a_k\}_{k=1}$ be the set of all positive integers n, in increasing order, for which $\binom{2n}{n}$ is not divisible by 5, and let $\{b_k\}_{k=1}$ be the set of all positive integers n, in increasing order, for which $g_n$ is not divisible by 5. This note finds simple formulas for $a_k$, $b_k$, $\binom{2n}{n}\ mod\ 10$, $ f_{n}\ mod\ 10$, and $ g_{n}\ mod\ 10$.
A Universal Closed Form For Square Matrix Powers
Walter Shur
Mathematics , 2015,
Abstract: This note presents a simple, universal closed form for the powers of any square matrix. A diligent search of the internet gave no indication that the form is known.
Thrombotic thrombocytopenic purpura in a patient with interferon treated hepatitis C successfully treated with Rituximab
Nishant Poddar,Jen C. Wang
Hematology Reports , 2013, DOI: 10.4081/hr.2013.e2
Abstract: Thrombotic thrombocytopenic purpura (TTP) is a life threatening condition associated with formation of platelet thrombi. Deficiency of ADAM TS 13 with presence of inhibitory anti-ADAM TS 13 Immunoglobulin G antibody is seen in patients with acquired TTP. TTP in patients on interferon therapy for chronic hepatitis C has rarely been reported. Furthermore, successful treatment of an initial episode of acute refractory acquired TTP, in a patient of chronic hepatitis C during interferon therapy with Rituximab, has not been previously reported. Here we describe a case of acute refractory acquired TTP associated with pegylated interferon therapy for her chronic hepatitis C infection. Initially refractory to plasmapheresis and steroids, she was successfully treated with Rituximab and plasmaphersis without any evidence of reactivation of hepatitis.
Effects on Strengths of Cement Mortar When Using Incinerator Bottom Ash as Fine Aggregate  [PDF]
Min-Jen Yang, Hong-Yu Wang, Hong-Yu Wang
World Journal of Engineering and Technology (WJET) , 2014, DOI: 10.4236/wjet.2014.23B007
Abstract:

The main purpose of this paper is to study the feasibility of using the Incinerator bottom ash fine aggregate to replace natural fine aggregate in the cement mortar products. The research adopts high cement content mortar to conduct the experiment, in which the weight ratio of cement/aggregate is 1/2. The experiment uses Incinerator bottom ash fine aggregates, which passes through #16 sieve, and natural sand of the same size as the aggregate, and separates mortar specimens in- to two main categories based on different W/C ratio. Moreover, different proportions of furnace slag and F-class are used to replace a portion of cement so as to explore the influence on strength of Incinerator bottom ash aggregates mortar by adding the two admixtures. The study shows that, based on the 1:2 cement/aggregate weight ratio, Incinerator bottom ash fine aggregates mortar, unit weight around 1.8 g/cm3, is 20% lighter natural fine aggregate mortar, unit weight around 2.2 g/cm3. The Incinerator bottom ash fine aggregates mortar can only reach 60%-70% the compressive strength of natural fine aggregates mortar. Direct tensile strength and flexural tensile strength tests are 15% and 30% of compressive strength respectively, due to the irregular strength development, which does not follow general concepts, such as low W/C ratio and mineral admixtures will not necessarily help in strength development in Incinerator bottom ash fine aggregates mortar.

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