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Search Results: 1 - 10 of 952 matches for " Shunsuke Yasuda "
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Intramedullary Spinal Cord Metastases in Breast Cancer: Report a Case  [PDF]
Masahiro Kitada, Nana Takahashi, Shunsuke Yasuda, Satoshi Okazaki, Kei Ishibashi, Satoshi Hayashi
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.713099
Abstract: Background: Intramedullary spinal cord metastasis (ISCM) from breast cancer is a relatively rare disease. We present this disease. Case presentation: The patient was a 67-year-old woman with lung metastasis appearing 3 years after breast cancer surgery. Complete remission was achieved for the metastatic lesion with chemotherapy, but multiple cerebellar metastases were found 3 months after the completion of chemotherapy. Whole-brain irradiation was administered, resulting in symptomatic improvement. Approximately 6 months later, the patient experienced weakness in the lower extremities and difficulty walking. Magnetic resonance imaging detected a well-defined intraspinal tumor measuring 13 × 13 × 30 mm at the level of Th12-L1. After 20-Gy irradiation to the tumor, oral steroid administration, and rehabilitation, the patient regained the ability to walk. Eight months have passed, to date, since these interventions and the patient is currently receiving treatment for metastases to bones, including the spine, but is still capable of walking without difficulty. We herein report this case with a review of the relevant literature. Conclusion: ISCM in the breast cancer is relatively rare. But, it is the clinical condition which it should always place in the mind.
Clinicopathological Study of Epithelial Metaplastic Breast Cancer  [PDF]
Masahiro Kitada, Shunsuke Yasuda, Nana Takahashi, Satoshi Okazaki, Kei Ishibashi, Satoshi Hayashi
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.713100
Abstract: Introduction: Metaplastic breast cancer (MBC) is a rare pathological type with an incidence rate of not more than 1%, and has been reported to be often detected after its progression and highly malignant with a high proportion of triple negative type tumors, with poor outcomes as compared to IDC [1] [2] [3]. We analyzed clinicopathological characteristics of patients who underwent surgery for epithelial MBC at our department. Patients and Methods: From January 2000 to March 2014, a total of 2120 patients underwent surgery for breast cancer, and MBC was diagnosed in 15 of these patients. Fourteen of the 15 had epithelial MBC and were included in this study. The present study compared clinopathological characteristics of MBC with those of IDC of triple negative type (TN type group) and IDC of non-triple negative type (IDC group). Results: Breast conserving surgery was performed in 7 patients with MBC (50%), a proportion clearly lower than the 64.3% in the IDC group. The mean tumor size was 3.8 cm, which was greater than the 2.13 cm in the TN type group and the 1.7 cm in the IDC group. About nuclear grade, the proportion of grade III was 57.1%, markedly higher than the 38.6% in the TN type group and the 12.6% in the IDC group. All patients were estrogen receptor (ER) and progesterone receptor (PgR) negative; 11 patients were TN type tumors and 3 were HER2 type. Conclusion: We studied patients who underwent surgery for epithelial MBC. The examined cases showed clinopathological characteristics of the disease, including large tumors with a highly malignant nature at the initial detection, higher Ki-67 levels, ER and PgR negativity (all cases), mostly TN type, and a high recurrence rate.
Surgical Treatment of Idiopathic Multiple Pulmonary Arteriovenous Malformation Identified at the Onset of Cerebral Infarction: A Case Report  [PDF]
Masahiro Kitada, Shunsuke Yasuda, Nana Takahashi, Satoshi Okazaki, Kei Ishibashi, Satoshi Hayashi, Yoshinobu Ohsaki
Open Journal of Respiratory Diseases (OJRD) , 2017, DOI: 10.4236/ojrd.2017.72007
Abstract: Pulmonary arteriovenous malformation (PAVM), which is asymptomatic in most cases, is often identified in patients with central nervous system disorders such as brain abscesses and/or cerebral infarctions. We have reported a patient with idiopathic multiple PAVM identified at the onset of cerebral infarction. A 69-year-old woman visited the Department of Neuropathic Internal Medicine at our hospital with chief complaints of numbness in her left hand and a feeling of weakness. The patient was given a diagnosis of subacute cerebral infarction. Multiple old lacunar infarctions were also observed in the deep white matter of the left frontal lobe. Chest computed tomography showed multiple nodular structures, mainly in the right lower lung field (S8), as well as continuous arteries and veins at the site; thus, the patient was finally diagnosed with multiple PAVM. Right lower thoracoscopic lobectomy was performed, as is typical surgical practice in such cases. The patient had a favorable postoperative course, and had no recurrence of cerebral infarction. Although the patient’s lesions were mainly restricted to S8, the fact that there were multiple lesions deemed a lobectomy as the appropriate course of treatment. This case emphasizes that attention should be paid to cases of multiple PAVM since cerebral infarction may arise from the disease.
Clinicopathological Study of Neuroendocrine Carcinoma of the Breast  [PDF]
Masahiro Kitada, Shunsuke Yasuda, Masahiro Abe, Nana Takahashi, Satoshi Okazaki, Kei Ishibashi, Satoshi Hayashi
Journal of Cancer Therapy (JCT) , 2017, DOI: 10.4236/jct.2017.88069
Abstract: Introduction: Neuroendocrine carcinoma (NEC) occurs mostly in the digestive organs, such as the pancreas and gastrointestinal tract, and the lungs. Primary NEC of the breast is a rare entity. There are not many studies on this disease, and this study was carried out in order to know the clinical pathology of this disease. Methods: Of 2354 patients who underwent surgery for breast cancer in our hospital during the period from January 2000 to July 2015, 8 (0.34%) were pathologically diagnosed with NEC of the breast. This study is retrospectively registered. Result: The histological types were small cell carcinoma in one patient and invasive ductal carcinoma (IDC) with neuroendocrine differentiation in the remaining 7. The mean patient age was slightly higher than that of patients with usual IDC. On pathological examination, the NEC tumors were more hormone dependent and often HER2 negative, as compared to usual IDC, though there was no significant difference in nuclear grade. The patients with NEC of the breast showed positivity for neuroendocrine markers on immunohistological staining, and had favorable outcomes. Conclusion: NEC of the breast is rare, and there is no established consensus regarding the pathological significance, prognosis, and treatment method. Further accumulation of cases is necessary.
Should We Overlook All Altruistic Behavior by Politicians?  [PDF]
Shunsuke Sekiguchi
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.33023

Not all policies benefit their intended targets even though they are motivated by political altruism. This paper analyzes how the frequency of altruistic behavior changes depending on whether consumers (i.e., the electorate) or producers (i.e., politicians) bear the responsibility. It compares the strict liability rule, which means the altruist must bear all damages, with the no liability rule, which means the recipient must bear all damages. It finds that under the no liability rule, if politicians are altruist, the frequency of altruistic behavior is less than under the strict liability rule. Therefore, the paper shows that if politicians were altruists, they would prefer the strict liability rule.

Instability in the Hotelling’s Non-Price Spatial Competition Model  [PDF]
Yosuke Yasuda
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.33A002

This note analyzes a slightly modified Hotelling model in which two firms are allowed to choose multiple store locations. Each firm can endogenously choose the number of stores while opening a store incurs a set-up cost. We show that the principle of minimum differentiation, i.e., both firms open a store each on the center, never holds when the set-up cost is decreasing in the number of stores. Under general cost functions that include non-linear and asymmetric set up costs, we characterize the conditions under which the principle holds. General payoff functions that are non-linear in the market share are also considered.

On Utilization of K-Means for Determination of q-Parameter for Tsallis-Entropy-Maximized-FCM  [PDF]
Makoto Yasuda
Journal of Software Engineering and Applications (JSEA) , 2017, DOI: 10.4236/jsea.2017.107033
Abstract: In this paper, we consider a fuzzy c-means (FCM) clustering algorithm combined with the deterministic annealing method and the Tsallis entropy maximization. The Tsallis entropy is a q-parameter extension of the Shannon entropy. By maximizing the Tsallis entropy within the framework of FCM, membership functions similar to statistical mechanical distribution functions can be derived. One of the major considerations when using this method is how to determine appropriate q values and the highest annealing temperature, Thigh?, for a given data set. Accordingly, in this paper, a method for determining these values simultaneously without introducing any additional parameters is presented. In our approach, the membership function is approximated by a series of expansion methods and the K-means clustering algorithm is utilized as a preprocessing step to estimate a radius of each data distribution. The results of experiments indicate that the proposed method is effective and both q and Thigh can be determined automatically and algebraically from a given data set.
R & D-Based Growth Model with Nominal Wage Stickiness  [PDF]
Shunsuke Shinagawa, Tomohiro Inoue
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.65089
Abstract: In this study, we introduce nominal wage stickiness into an endogenous growth model based on R & D. This study examines how money growth affects long-run economic growth. We find that there exists a unique balanced growth path for sufficiently high rates of money growth, and that the economy exhibits sustained growth based on sustained R & D. Faster money growth results in greater employment and faster economic growth along such a balanced growth path. Furthermore, under some parameter restrictions, no balanced growth path exists for low rates of money growth; the economy is trapped in a steady state without long-run growth. These results suggest that money growth may be an important factor for long-run economic growth.
Simple HPLC Analysis of Hinokitiol in Skin Lotion with Visible Light Detection after Pre-Column Dabsylation  [PDF]
Yasuhiko Higashi, Shunsuke Tohda
American Journal of Analytical Chemistry (AJAC) , 2017, DOI: 10.4236/ajac.2017.85026
Abstract: Hinokitiolis frequently added to personal care products as an antibacterial agent. We previously established an HPLC-UV method for determination of hinokitiol in skin lotion after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole. However, the labeling reagent is expensive, and derivatives of degradation products of parabens, which may be added to skin lotion as general preservatives, interfered with the peak of the hinokitiol derivative. In this study, the concentration of hinokitiol in skin lotions was determined by HPLC with a visible light detector (450 nm) after pre-column derivatization with 4-(dimethylamino)azobenzene-4’-sulfonyl chloride (Dabsyl-Cl), a more economical reagent. A standard curve was obtained after derivatization with Dabsyl-Cl in borate buffer (pH 9.5) at 55°C for 10 min. The retention time of Dabsyl-hinokitiol was 6.8 min. The calibration plot was linear in the range of 1.25 to 40 μg/mL with a r2 value of 0.9991, and the lower limit of quantification and detection were 0.60 μg/mL (absolute amount of 0.86 ng/20μL injection, signal-to-noise ratio of 10:1) and 0.18 μg/mL (absolute amount of 0.26 ng/20μL injection, signal-to-noise ratio of 3:1), respectively. The coefficient of variation was less than 8.8%. Seven Dabsyl-paraben derivatives showed little interference with the peak of Dabsyl-hinokitiol. The developed system was used to determine the content of hinokitiol in two skin lotions. Addition-recovery tests gave satisfactory results.
Bromination of Pd Compounds during Thermal Decomposition of Tetrabromobisphenol A  [PDF]
Shunsuke Kuzuhara, Ayaka Sano
Engineering (ENG) , 2018, DOI: 10.4236/eng.2018.104013
Abstract: We conducted thermal tests using the reagent tetrabromobisphenol A (TBBPA) and various Pd compounds to study the chemical forms of Pd obtained during the pyrolytic and oxidative decomposition of TBBPA. Thermal testing was conducted in an electric furnace at temperatures of 280°C - 800°C in an Ar or Ar-O2 (5%) atmosphere for a heating period of 40 min. Scanning electron microscopy-energy dispersive X-ray spectroscopy results revealed that Pd bromide was formed in the mixture of TBBPA and PdO after heating to 450°C in the Ar atmosphere. In addition, thermogravimetry-differential thermal analysis showed that as the heating temperature was increased from 350°C to 730°C, weight loss occurred at a nearly constant rate, indicating that Pd bromide decomposed in this temperature range.
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