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Search Results: 1 - 10 of 120048 matches for " Shixuan Wang "
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Multivariate Volatility Regulated Kelly Strategy: A Superior Choice in Low Correlated Portfolios  [PDF]
Ruanmin Cao, Zhenya Liu, Shixuan Wang, Weifeng Zhou
Theoretical Economics Letters (TEL) , 2017, DOI: 10.4236/tel.2017.75098
Abstract: We propose a Multivariate Volatility Regulated Kelly strategy, which has extra penalization on variance compared to the Kelly criterion. The objective function is constructed and solved. We show the superiority of our method in relatively low correlated portfolios, relative to the fractional Kelly and full Kelly strategies. Our strategy reduces the short-term risk without sacrificing the growth rate to invest more in risk-free assets. Simulation results and Chinese commodity future empirical results strongly support our method.
The Cytoplasmic Tail of FPC Antagonizes the Full-Length Protein in the Regulation of mTOR Pathway
Shixuan Wang, Maoqing Wu, Gang Yao, Jingjing Zhang, Jing Zhou
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095630
Abstract: FPC (fibrocystin or polyductin) is a single transmembrane receptor-like protein, responsible for the human autosomal recessive polycystic kidney disease (ARPKD). It was recently proposed that FPC undergoes a Notch-like cleavage and subsequently the cleaved carboxy(C)-terminal fragment translocates to the nucleus. To study the functions of the isolated C-tail, we expressed the intracellular domain of human FPC (hICD) in renal epithelial cells. By 3-dimensional (3D) tubulogenesis assay, we found that in contrast to tubule-like structures formed from control cells, hICD-expressing cells exclusively formed cyst-like structures. By western blotting, we showed that the Akt/mTOR pathway, indicated by increased phosphorylation of Akt at serine 473 and S6 kinase 1 at threonine 389, was constitutively activated in hICD-expressing cells, similar to that in FPC knockdown cells and ARPKD kidneys. Moreover, application of mTOR inhibitor rapamycin reduced the size of the cyst-like structures formed by hICD-expressing cells. Application of either LY294002 or wortmannin inhibited the activation of both S6K1 and Akt. Expression of full-length FPC inhibited the activation of S6 and S6 kinase whereas co-expression of hICD with full-length FPC antagonized the inhibitory effect of full-length FPC on mTOR. Taken together, we propose that FPC modulates the PI3K/Akt/mTOR pathway and the cleaved C-tail regulates the function of the full-length protein.
Proteomics Analysis of Normal and Senescent NG108-15 Cells: GRP78 Plays a Negative Role in Cisplatin-Induced Senescence in the NG108-15 Cell Line
Wei Li, Wei Wang, Yan Li, Wenwen Wang, Tian Wang, Li Li, Zhiqiang Han, Shixuan Wang, Ding Ma, Hui Wang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090114
Abstract: Accelerated senescence (ACS) leading to proliferative arrest is a physiological mechanism of the DNA damage response that occurs during tumor therapy. Our experiment was designed to detect unknown genes that may play important roles in cisplatin-induced senescence and to illustrate the related senescence mechanism. Using 2-dimension electrophoresis (2-DE), we identified 5 protein spots with different expression levels in the normal and senescent NG108-15 cells. According to MALDI-TOF MS analysis, the 5 proteins were determined to be peptidylprolyl isomerase A (PPIA), peroxiredoxin 1 (PRX1), glutathione S-transferase mu 1 (GSTM1), vimentin (VIM) and glucose-regulated protein 78 (GRP78). Then, we investigated how cisplatin-induced senescence was mediated by GRP78 in the NG108-15 cells. Knockdown of GRP78 significantly increased P53 expression in NG108-15 cells. Additionally, 2-deoxy-D-glucose (2DG)-induced GRP78 overexpression protected the NG108-15 cells from cisplatin-induced senescence, which was accompanied by the obvious suppression of P53 and p-CDC2 expression. Inhibition of Ca2+ release from endoplasmic reticulum (ER) stores was also found to be associated with the anti-senescence effect of 2DG-induced GRP78 overexpression. In conclusion, we found 5 proteins that were differentially expressed in normal NG108-15 cells and senescent NG108-15 cells. GRP78 plays an important role in cisplatin-induced senescence in NG108-15 cells, mainly through its regulation of P53 expression and ER calcium efflux.
Association between RASSF1A Promoter Methylation and Ovarian Cancer: A Meta-Analysis
Hao Shi, Ya Li, Xiaozhong Wang, Cheng Lu, Lilan Yang, Changmei Gu, Jiaqiang Xiong, Yangxin Huang, Shixuan Wang, Meixia Lu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076787
Abstract: Background The RAS association domain family protein 1a gene (RASSF1A) is one of the tumor suppressor genes (TSG). Inactivation of RASSF1A is critical to the pathogenesis of cancer. Aberrant TSG methylation was considered an important epigenetic silencing mechanism in the progression of ovarian cancer. A number of studies have discussed association between RASSF1A promoter methylation and ovarian cancer. However, they were mostly based on a small number of samples and showed inconsist results, Therefore, we conducted a meta-analysis to better identify the association. Methods Eligible studies were identified by searching the PubMed, EMBASE, Web of Science, and CNKI databases using a systematic searching strategy. We pooled the odds ratio (ORs) from individual studies using a fixed-effects model. We performed heterogeneity and publication bias analysis simultaneously. Results Thirteen studies, with 763 ovarian cancer patients and 438 controls were included in the meta-analysis. The frequencies of RASSF1A promoter methylation ranged from 30% to 58% (median is 48%) in the cancer group and 0 to 21% (median is 0) in the control group. The frequencies of RASSF1A promoter methylation in the cancer group were significantly higher than those in the control group. The pooled odds ratio was 11.17 (95% CI = 7.51–16.61) in the cancer group versus the corresponding control group under the fixed-effects model. Conclusion The results suggested that RASSF1A promoter methylation had a strong association with ovarian cancer.
Gauge Factor and Stretchability of Silicon-on-Polymer Strain Gauges
Shixuan Yang,Nanshu Lu
Sensors , 2013, DOI: 10.3390/s130708577
Abstract: Strain gauges are widely applied to measure mechanical deformation of structures and specimens. While metallic foil gauges usually have a gauge factor slightly over 2, single crystalline silicon demonstrates intrinsic gauge factors as high as 200. Although silicon is an intrinsically stiff and brittle material, flexible and even stretchable strain gauges have been achieved by integrating thin silicon strips on soft and deformable polymer substrates. To achieve a fundamental understanding of the large variance in gauge factor and stretchability of reported flexible/stretchable silicon-on-polymer strain gauges, finite element and analytically models are established to reveal the effects of the length of the silicon strip, and the thickness and modulus of the polymer substrate. Analytical results for two limiting cases, i.e., infinitely thick substrate and infinitely long strip, have found good agreement with FEM results. We have discovered that strains in silicon resistor can vary by orders of magnitude with different substrate materials whereas strip length or substrate thickness only affects the strain level mildly. While the average strain in silicon reflects the gauge factor, the maximum strain in silicon governs the stretchability of the system. The tradeoff between gauge factor and stretchability of silicon-on-polymer strain gauges has been proposed and discussed.
Adjuvant Chemotherapy, a Valuable Alternative Option in Selected Patients with Cervical Cancer
Shuang Li, Ting Hu, Yile Chen, Hang Zhou, Xiong Li, Xiaodong Cheng, Ru Yang, Shixuan Wang, Xing Xie, Ding Ma
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073837
Abstract: Radiotherapy is the standard treatment for cervical cancer, but causes radiotherapy-induced complications. Recently, chemotherapy has been more extensively utilized. Here, we perform a large-scale comparison of chemotherapy and radiotherapy. From 2002 to 2008, 2,268 patients were grouped according to adjuvant radiotherapy or chemotherapy before and/or after surgery, and we compared the 5-year overall survival (OS) and disease-free survival (DFS) rates, recurrence rates, side effects, quality of life (QoL), and sexual activity. There were no significant differences between the treatment groups for the 5-year OS and DFS rates (OS: p = 0.053, DFS: p = 0.095), although marginally improved outcomes were observed in the chemotherapy group (OS: 86.5% vs. 82.8%; DFS: 84.5% vs. 81.4%). However, patients with early-stage disease, clinical response, and younger age had increased 5-year OS and DFS rates following chemotherapy compared to radiotherapy (p<0.05). The chemotherapy group exhibited significantly lower 5-year recurrence and distant failure rates compared to the radiotherapy group (p<0.001 and p = 0.007, respectively). Nausea and vomiting were the most frequent short-term complications of chemotherapy, whereas bowel and urinary complications were more frequent in the radiotherapy group. Compared to the chemotherapy group, patients who received radiotherapy reported a lower QoL, less frequent sexual activity, and more severe menopausal symptoms (p<0.05). Cervical cancer patients treated with chemotherapy, especially those with early-stage disease, clinical responses, and younger ages, have more positive outcomes, fewer complications, better QoL and sexual activity, suggesting that chemotherapy may be a valuable alternative option for selected patients.
A Method to Determine the Margins of High Sea Ice Concentration Using AMSR-E Passive Microwave Imagery  [PDF]
Shugang Zhang, Shixuan Liu, Shuwei Zhang, Shizhe Chen
Journal of Geoscience and Environment Protection (GEP) , 2017, DOI: 10.4236/gep.2017.56003
The margin of the sea ice with high sea ice concentration is a principal feature in microwave image and a hotspot in image recognition. A method for determining the margins is developed using the feature of dual-polarized brightness temperatures at 36.5 GHz and a new parameter (contrast ratio) is used in this paper. For the microwaves, the ratio of the horizontal-polarized emissivity to the vertical-polarized emissivity is approximately equal to the ratio between horizontal-polarized and vertical-polarized brightness temperatures of sea surface, which called as the dual-polarized emissivity ratio in this study. It is found that the dual-polarized emissivity ratio of sea ice with nearly 100% sea ice concentration in Arctic at 36.5 GHz band has a value ranged between 0.92 and 0.96, as shown by satellite-observed data in figure of horizontal-po-larized brightness temperature versus vertical-polarized brightness temperature. From open water to sea ice covered area, the contrast-ratio can show the changing features of the dual-polarized brightness temperature at 36.5 GHz. The contrast ratio rapidly changes at the ice margins and its gradient appears an extreme value when the ratio changes around 0.92. This extreme value is examined by the ice concentration calculated by the MODIS data. And the results indicate that the threshold ratio coincides with the contour line of 96% sea ice concentration. So the parameter of contrast ratio could be used to determine the position of margins in microwave image.
Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2
Yulan Liu, Ling Xi, Guoning Liao, Wei Wang, Xun Tian, Beibei Wang, Gang Chen, Zhiqiang Han, Mingfu Wu, Shixuan Wang, Jianfeng Zhou, Gang Xu, Yunping Lu, Ding Ma
BMC Cancer , 2007, DOI: 10.1186/1471-2407-7-22
Abstract: PCDGF/GEP expression level in three human ovarian cancer cell lines of different invasion potential were detected by RT-PCR and western blot. Effects of inhibition of PCDGF expression on cell proliferation and invasion capability were determined by MTT assay and Boyden chamber assay. Expression levels of cyclin D1 and CDK4 and MMP-2 activity were evaluated in a pilot study.PCDGF mRNA and protein were expressed at a high level in SW626 and A2780 and at a low level in SKOV3. PCDGF expression level correlated well with malignant phenotype including proliferation and invasion in ovarian cancer cell lines. In addition, the proliferation rate and invasion index decreased after inhibition of PCDGF expression by antisense PCDGF cDNA transfection in SW626 and A2780. Furthermore expression of CyclinD1 and CDK4 were downregulated and MMP-2 was inactivated after PCDGF inhibition in the pilot study.PCDGF played an important role in stimulating proliferation and promoting invasion in ovarian cancer. Inhibition of PCDGF decreased proliferation and invasion capability through downregulation of cyclin D1 and CDK4 and inactivation of MMP-2. PCDGF could serve as a potential therapeutic target in ovarian cancer.PC cell-derived growth factor (PCDGF), also called epithelin/granulin precursor (GEP), is an 88-kDa secreted glycoprotein purified from the conditioned medium of the highly malignant mouse teratoma-derived cell line PC for its ability to stimulate proliferation in an autocrine fashion [1]. In teratoma cells, PCDGF expression was shown to be essential for tumorigenicity [2]. High levels of PCDGF expression are found in rapidly proliferating cells, such as skin cells, deep crypts of gastrointestinal tract, and immune cells. On the other hand, low levels of PCDGF expression are found in cells that are not mitotically active, such as muscle and liver cells [3,4]. Overexpression of PCDGF has been linked to the growth and tumorigenicity of human breast carcinomas and to the acquisitio
Anti-Tumor Effects of the Peptide TMTP1-GG-D(KLAKLAK)2 on Highly Metastatic Cancers
Xiangyi Ma, Ling Xi, Danfeng Luo, Ronghua Liu, Shu Li, Yan Liu, Liangsheng Fan, Shuangmei Ye, Wanhua Yang, Shuhong Yang, Li Meng, Jianfeng Zhou, Shixuan Wang, Ding Ma
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042685
Abstract: The treatment of cancer such as oligonucleotides or peptides requires efficient delivery systems. A novel peptide, TMTP1, previously derived and identified in our laboratory showed remarkable ability to target highly metastatic tumors both in vitro and in vivo, even at the early stage of occult metastasis foci. TMTP1 moderately inhibited tumor cell viability, although not enough to deem it an efficient killer of tumor cells. In this study, we sought to enhance the anti-tumor activity of TMTP1. To do this, we fused it to an antimicrobial peptide, D(KLAKLAK)2, and termed the resulting peptide TMTP1-DKK. We found that TMTP1-DKK could trigger rapid apoptosis in human prostate and gastric cancer cells through both the mitochondrial-induced apoptosis pathway and the death receptor pathway. Furthermore, direct injection of TMTP1-DKK into mice with prostate and gastric xenograft cancers resulted in reduction of tumor volumes and a significant delay in tumor progression and metastasis in vivo. These results suggest that TMTP1-DKK may serve as a powerful therapeutic agent for metastatic tumors.
A Preliminary Research on the Reason of a Sharp Turn from Drought to Flood in the Middle and Lower Reaches of the Yangtze River in Late Spring and Early Summer of 2011

FENG Guolin,YANG Hanwei,ZHANG Shixuan,WANG Kuo,SHEN Baizhu,

大气科学 , 2012,
Abstract: Using some kinds of meteorological factors data provided by NCEP/NCAR NOAA and National Climate Center (NCC), and NOAA-Hysplit model to preliminarily analyze characteristics of precipitation and mechanism of a sharp turn from drought to flood in the middle and lower reaches of the Yangtze River in the early summer of 2011, the authors establish a synoptic concept model and conclude that: 1) The most serious sharp turn from drought to flood occurred in the middle and lower reaches of the Yangtze River, especially in the region of (27oN-32oN, 110oE-120oE), in the 1st pentad in June (around 3 June);2) analysis of sea surface temperature (SST) anomaly and the singular value decomposition (SVD) between SST and precipitation shows that the variance contribution of this sharp turn is smaller and it is an anomalous event, whose early signals exist in the equatorial middle an eastern Pacific and the equatorial Indian Ocean;3) analysis of vorticity low frequency oscillation and 10-30 d stable component indicates that dynamic mechanism across the Pacific Ocean has a great influence on precipitation in the middle and lower reaches of the Yangtze River in June, and the stable circulation in middle and high latitude areas provides a large scale circulation background field;4) before the sharp turn, there existed a stronger La Ni?a in the equatorial middle an eastern Pacific, and the equatorial Indian Ocean was controlled by negative SST anomaly on a large scale, influenced by the both, the western Pacific subtropical high was abnormally eastward, the Walker circulation was stronger, and the Hadley circulation over the Indian Ocean was weaker. All of those leaded to the lack of water vapor transport from southwest and southeast, thus a serious and sustained drought occurred in the middle and lower reaches of the Yangtze River. As the SST anomaly in both the oceans weakened, the western Pacific subtropical high suddenly extended westward and became stable (in the 1st pentad in June), the Walker circulation became weak, and the Hadley circulation over the Indian Ocean became stronger. Matching with the stable circulation on a large scale in middle and high latitude areas, it resulted in continuous converging of cold and warm air and vast precipitation over the middle and lower reaches of the Yangtze River. Finally, the sharp turn happened.
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