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Search Results: 1 - 10 of 120030 matches for " Shiran Wang "
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Effects of Nourishing “Yin”-Removing “Fire” Chinese Herb Mixture on the Differential Expression of GABAA Receptor α Subunits in Hypothalamus of Precocious Puberty Female Rats  [PDF]
Jing Li, Yanyan Sun, Shiran Wang, Jian Yu, Zhanzhuang Tian
Chinese Medicine (CM) , 2013, DOI: 10.4236/cm.2013.43013

GABAergic input to Gonadotropin-releasing hormone (GnRH) neurons is necessary to initiate the onset of puberty and its action mainly depends on GABAA receptor of which the subunit composition, properties and consequently function varies during this period. Nourishing “Yin”-Removing “Fire” Chinese herb mixture, a Chinese herb-based formulation, has been proved that it may retard the initiation of pubertal development in female precocious puberty rats. Our objective is to investigate the effects of Nourishing “Yin”-Removing “Fire” Chinese herb mixture on the expression of GABAA receptor α subunits in hypothalamus. Female Sprague-Dawley rats were divided into normal (N), precocious puberty model (M) induced by danazol, model exposed to saline (MS) and model exposed to Chinese herb mixture (CHM) groups. All rats were administered by the Chinese herb mixture from P15 on. Coefficients of reproductive organs and serum gonadotropins and estradiol levels in M were significantly enhanced while they were significantly decreased in CHM. The hypothalamic GnRH mRNA was also significantly increased in M and in CHM, as well as ERα mRNA. At the mean time, the hypothalamic GABAA receptor α1 and α3 subunits mRNA were more significantly

Effects of Nourishing “Yin”-Removing “Fire” Chinese Herb Mixture on the Expression of GABAB Receptors in Hypothalamus of Precocious Puberty Female Rats  [PDF]
Zhejun Chen, Zehui Meng, Shiran Wang, Liting Zhu, Zhanzhuang Tian
Chinese Medicine (CM) , 2016, DOI: 10.4236/cm.2016.72008
Abstract: Objectives: To investigate the potential role of GABAB Receptors (GABABRs) involved in the effect of Nourishing “Yin”-Removing “Fire” Chinese herb mixture (TCM) treatment on precocious puberty. Methods: Female Sprague-Dawley rats were randomly divided into four groups: normal (N), central precocious puberty (CPP) model (M), CPP fed with normal saline (S) and CPP fed with Nourishing “Yin”-Removing “Fire” Chinese herb mixture (TCM). Rats of postnatal day 5 were given a single subcutaneous injection of 240 μg danazol to establish CPP model rats. Rats of S and TCM groups were continuously administered with saline or nourishing “Yin”-removing “Fire” Chinese herb mixture since postnatal day 15. The expression of GABABRs was detected by means of real-time PCR and immunohistochemistry. Results: The expression of hypothalamic GnRH mRNA in M was significantly increased on the day of pre-puberty when compared with that of N (P < 0.01). On the day of onset-puberty, LH levels were higher in M than those in N (P < 0.01), while the serum E2 and LH levels of TCM decreased when compared with those of M (P < 0.05). On the day of pre-puberty, the number of GABAB1 receptor (GABABR1) immunoreactive cells in the arcuate nucleus (ARN) was decreased in M when compared with that of N (P < 0.05) and increased in TCM compared with that of M (P < 0.05); simultaneously, the expression of GABABR1 mRNA in hypothalamus was significantly decreased in M when compared with that of N (P < 0.01) and increased in TCM compared with that of M (P < 0.01). On the day of onset-puberty, the number of GABABR1 immunoreactive cells in medial septum (MS) was decreased in M compared with that in N (P < 0.05) and increased in TCM comparing with that of M (P < 0.05); meanwhile, the mRNA expression of GABABR1 in hypothalamus was decreased in M compared with that in N (P < 0.05), while the numbers of GABAB2 receptor (GABABR2) immunoreactive cells in the ARN, MS and diagnonal band of broca (DBB) were decreased in M when compared with those of N (P < 0.05) and increased in TCM compared with those of M (P < 0.05) on the day of onset-puberty. At the same time, the mRNA expression of GABABR2 was significantly decreased in M compared with that of N (P < 0.01). Conclusions: These results indicated that the GABABRs might
Explicit Large Time Stepping with Third-Order Exponential Time Differencing Scheme for Hypersonic Chemical Non-Equilibrium Flow  [PDF]
Shiran Dai, Songping Wu
Journal of Applied Mathematics and Physics (JAMP) , 2018, DOI: 10.4236/jamp.2018.61017
In this paper, a third-order exponential time differencing scheme, named ETDRK3, was investigated for large time stepping in the computation of hypersonic non-equilibrium flow. The second-order Harten-TVD scheme was used for the spatial discretization. The efficient implementation of the scheme with diagonalization of Jacobin matrix was established and carried out for the semi-cylindrical around flow. Current observations showed that the numerical results were in good agreement with those obtained by the classical explicit three-stage Runge-Kutta scheme (RK3) and implicit LU scheme. Efficiency assessments promised the effectiveness of the ETDRK3 scheme. The rationality of the application of this scheme was proved by its preferable accuracy and efficiency.
A New Record of Salvia Species (Lamiaceae) for Iran
Navaz Kharazian,Behrouz Shiran
International Journal of Botany , 2008,
Abstract: Salvia moorcroftiana Wall. ex Benth. is reported as a new record of Salvia L. species for the first time from Iran, East of Chaharmahal va Bakhtiari province, South of Shahr-e-Kord, toward Tang-e-Sayad. The morphological characters of this species have been described and designed in details.
Petrogenesis of Quaternary Shoshonitic Volcanism in NE Iran (Ardabil): Implication for Postcollisional Magmatism
Habib Shahbazi Shiran
Journal of Geological Research , 2013, DOI: 10.1155/2013/735498
Abstract: Trachyandesites, trachytes, andesites, and pyrocalstic rocks, with shoshonitic signature, are the main Quaternary volcanic rocks in the Sabalan region (Ardabil). Plagiocalse, K-feldspar, biotite associated with clinopyroxene, and glass are the main constituents of these lavas. Plagioclases are andesine to labradorite while clinopyroxenes have augitic composition. The Sabalan volcanic rocks show enrichment in LREEs (relative to HREEs) and are characterized by enrichment in LILEs and depletion in HFSEs. Petrological observations, along with rare earth and trace elements geochemistry, suggest shoshonitic signature for Sabalan lavas. This signature highlights derivation from a subduction-related source. The Sabalan volcanic rocks are isotopically characterized by derivation from an enriched mantle source with a tendency to plot in the fields defined by island-arc basalts (IAB) and OIBs (in εNd versus 87Sr/86Sr diagram). The geochemical and isotopic characteristics of the Sabalan lavas suggest that their magma has been issued via low degree partial melting of a subduction-metasomatized continental lithospheric mantle. The formation of these lavas is related to slab steepening and breakoff in a postcollisional regime. 1. Introduction Cenozoic magmatism is well known from the peri-Arabic region, north of the Bitlis-Zagros Suture Zone (Figure 1), and ranges in age from Eocene to Plio-Quaternary. The timing of the eruptions and pooling the plutons mostly coincides with and postdates a series of continental collisional events in the northern Bitlis-Zagros Suture Zone region [1, 2]. The Eocene magmatism in the peri-Arabic region (both in the Urumieh-Dokhtar magmatic belt and south of the Anatolian block) is calc-alkalic to shoshonitic, which resulted from subduction of the Neotethyan Ocean beneath the central Iranian and Anatolian blocks. The Plio-Quaternary (and Quaternary) alkaline-ultrapotassic magmatism occupies most of the Turkish-Iranian high plateau (NW Iran and NE Turkey) and is mostly characterized by within-plate and/or subduction-related geochemical characteristics [3–5]. The geochemical variations of late Cenozoic lavas indicate a progression from calc-alkaline to alkaline compositions with time [2]. Figure 1: Simplified tectonic map of the eastern Mediterranean-Persian Gulf region showing the active plate boundaries and post-collisional volcanic rocks in the Peri-Arabian region modified after [ 6]. Abbreviation: PSF = Pampak-Sevan Fault; EKP = Erzurum-Kars Plateau; EAF = East Anatolian Fault; IAESZ = Izmir-Ankara-Erzincan Suture Zone; EF = Ecemis
Exponentiated Weibull Power Series Distributions and its Applications
Eisa Mahmoudi,Mitra Shiran
Statistics , 2012,
Abstract: In this paper we introduce the exponentiated Weibull power series (EWPS) class of distributions which is obtained by compounding exponentiated Weibull and power series distributions, where the compounding procedure follows same way that was previously carried out by Roman et al. (2010) and Cancho et al. (2011) in introducing the complementary exponential-geometric (CEG) and the two-parameter Poisson-exponential (PE) lifetime distributions, respectively. This distribution contains several lifetime models such as: exponentiated weibull-geometric (EWG), exponentiated weibull-binomial (EWB), exponentiated weibull-poisson (EWP), exponentiated weibull-logarithmic (EWL) distributions as a special case. The hazard rate function of the EWPS distribution can be increasing, decreasing, bathtub-shaped and unimodal failure rate among others. We obtain several properties of the EWPS distribution such as its probability density function, its reliability and failure rate functions, quantiles and moments. The maximum likelihood estimation procedure via a EM-algorithm is presented in this paper. Sub-models of the EWPS distribution are studied in details. In the end, Applications to two real data sets are given to show the flexibility and potentiality of the EWPS distribution.
Exponentiated Weibull-Geometric Distribution and its Applications
Eisa Mahmoudi,Mitra Shiran
Statistics , 2012,
Abstract: In this paper a new lifetime distribution, which is called the exponentiated Weibull-geometric (EWG) distribution, is introduced. This new distribution obtained by compounding the exponentiated Weibull and geometric distributions. The EWG distribution includes as special cases the generalized exponential-geometric (GEG), complementary Weibull-geometric (CWG), complementary exponential-geometric (CEG), exponentiated Rayleigh-geometric (ERG) and Rayleigh-geometric (RG) distributions. The hazard function of the EWG distribution can be decreasing, increasing, bathtub-shaped and unimodal among others. Several properties of the EWG distribution such as quantiles and moments, maximum likelihood estimation procedure via an EM-algorithm, R\'{e}nyi and Shannon entropies, moments of order statistics, residual life function and probability weighted moments are studied in this paper. In the end, we give two applications with real data sets to show the flexibility of the new distribution.
AFLP markers for the assessment of genetic diversity in european and North American potato varieties cultivated in Iran
Saeed Tarkesh Esfahani,Behrouz Shiran,Ghlolamreza Balali
Crop Breeding and Applied Biotechnology , 2009,
Abstract: Information about the genetic diversity of potato germplasm in Iran is important for variety identification andto enhance the classification of germplasm collections and exploit them in breeding programs and for the development andintroduction of new varieties. AFLP fingerprinting was applied to a group of cultivated potato varieties to find if there is anygeographical differentiation in potato diversity from Europe and North America. The high level of polymorphism within potatovarieties and the high number of variety-specific bands suggest that AFLPs are powerful markers for diversity analysis inpotato varieties. No region-specific AFLP markers were found (present in varieties from the same origin and absent inothers). The UPGMA dendrogram revealed four distinct clusters corresponding almost to the geographical origin of thevarieties. However, the bootstrap support for branches was rather weak. No clusters clearly distinguished varieties fromEurope and North America. Varieties from the same geographical origins however tended to group together within eachcluster. The mean similarity and the UPGMA dendrogram both suggest that North American varieties have nearly identicalgenetic diversity to European varieties. The results of AMOVA revealed large within-region variations which accounted for94.5% of the total molecular variance. The between-region variation, although accounting for only 5.5% of the total variation,was statistically significant. AFLP technology was successfully used to evaluate diversity between different geographicalgroups of potatoes and is recommended for potato genetic studies.
Genetic Variation in Iranian Mints on the Bases of RAPD Analysis
Soheila Momeni,Behrouz Shiran,Khorshid Razmjoo
Pakistan Journal of Biological Sciences , 2006,
Abstract: In the present study, the genetic diversity and taxonomic relationships between 17 accessions of four Mentha species were examined using RAPD markers and analysed the data by both similarity methods and principal coordinate analysis. Out of 70 primers, provided reproducible results. A total of 608 reliable and polymorphic RAPD bands were detected which used to estimate genetic similarity among pair-wise combinations of accessions. High genetic diversity was found within Mentha accessions. Jaccard`s similarity value ranged from 0.13 to 0.69, with mean of 0.25, which reflects a rather high genetic variability among the accessions evaluated. The result indicated that RAPD as a molecular marker was useful for detecting the genetic variation among the accessions. According to our analysis, M. piperita14 is about 0.45 similar to M. spicata10 are clustered in the same group. The clustering between these two accessions is in agreement with the earlier observations.
Lumbosacral epidural lipomatosis due to prolonged steroid intake causing cauda equina syndrome
Mahmood Nabil,Shetty Shiran,Andrews Sajan
Neurology India , 2010,
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