Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 1 )

2018 ( 4 )

2017 ( 5 )

2016 ( 10 )

Custom range...

Search Results: 1 - 10 of 514 matches for " Shinichi Inoh "
All listed articles are free for downloading (OA Articles)
Page 1 /514
Display every page Item
Simplified Bernoulli Formula to Diagnose Ischemia-Causing Stenosis at Coronary CT Angiography: Comparison with SPECT  [PDF]
Nobuo Tomizawa, Hiroaki Arakawa, Kodai Yamamoto, Shinichi Inoh, Takeshi Nojo, Sunao Nakamura
Advances in Computed Tomography (ACT) , 2019, DOI: 10.4236/act.2019.82002
Abstract: Purpose: To compare the diagnostic performance of estimated energy loss (EEL) calculated using a simplified Bernoulli formula at coronary computed tomography (CT) and single photon emission computed tomography (SPECT) to diagnose ischemia-causing stenosis by invasive fractional flow reserve (FFR). Methods: We retrospectively included 43 patients who underwent coronary CT, SPECT, and FFR measurement by catheter within 3 months. When an intermediate stenosis (40% - 70%) was present at CT, EEL was calculated using the following parameters: lesion length, diameter stenosis, minimal lumen area, and the myocardial volume. An EEL > 1.17 or diameter stenosis > 70% was determined ischemic. Stress-induced ischemia by SPECT was determined when a perfusion defect at stress was accompanied with a fill-in at rest. An FFR ≤ 0.80 or diameter stenosis >70 % was determined as ischemic by catheter. Results: A total of 26 vessels were determined as ischemic by catheter exam. The per-vessel sensitivity and specificity of EEL and SPECT were 81% vs 42% and 92% vs 91%, respectively. The accuracy of EEL to diagnose stenosis causing ischemia was significantly higher than SPECT (90% vs 81%, p = 0.04). The area under the curve of the receiver operating characteristics curve was also significantly higher for EEL than SPECT (0.86 vs 0.67, p < 0.005). Conclusions: EEL showed higher accuracy than SPECT to diagnose ischemia-causing stenosis by improving the sensitivity.
New Transfection Agents Based on Liposomes Containing Biosurfactant MEL-A
Mamoru Nakanishi,Yoshikazu Inoh,Tadahide Furuno
Pharmaceutics , 2013, DOI: 10.3390/pharmaceutics5030411
Abstract: Nano vectors are useful tools to deliver foreign DNAs, oligonucleotides, and small interfering double-stranded RNAs (siRNAs) into mammalian cells with gene transfection and gene regulation. In such experiments we have found the liposomes with a biosurfacant mannosylerythriol lipid (MEL-A) are useful because of their high transfer efficiency, and their unique mechanism to transfer genes to target cells with the lowest toxicity. In the present review we will describe our current work, which may contribute to the great advance of gene transfer to target cells and gene regulations. For more than two decades, the liposome technologies have changed dramatically and various methods have been proposed in the fields of biochemistry, cell biology, biotechnology, and so on. In addition, they were towards to pharmaceutics and clinical applications. The liposome technologies were expected to use gene therapy, however, they have not reached a requested goal as of yet. In the present paper we would like to present an approach using a biosurfactant, MEL-A, which is a surface-active compound produced by microorganisms growing on water-insoluble substrates and increases efficiency in gene transfection. The present work shows new transfection agents based on liposomes containing biosurfactant MEL-A.
Pattern of Salivary Gland Tumour in Sokoto, North-Western Nigeria  [PDF]
Daniel Aliyu, Kufre Robert Iseh, Saddiku Mallami Sahabi, Stanley Baba Amutta, Mohammed Abdullahi, Mfon Ime Inoh
International Journal of Clinical Medicine (IJCM) , 2016, DOI: 10.4236/ijcm.2016.75037
Abstract: Background: Salivary gland tumours though rare but constitute a heterogeneous group of tumours accounting for 5% of head and neck tumours with a high incidence reported in other part of the world compared with studies in Sub-saharan Africa. Aim: To describe the dermographic and histopathological patterns of salivary gland tumuors in a tertiary health institution Sokoto. Materials and Method: This was a five-year descriptive and retrospective analysis of all patients diagnosed and managed with salivary gland tumour in the department of ear, nose and throat, Usmanu Danfodiyo University Teaching Hospital Sokoto between January 2010 and December 2014. Clinical records and histopathological slides of these patients were retrieved and data extracted from the case files included patients demography, site of the tumour, and histopathological diagnosis. Data obtained were analysed using IBM-SPSS version 22. Results: A total of 103 salivary gland tumours (SGTs) during the study period. Age ranged from 1 year to 75 years with a mean age of 41.66 (±17.80) years. There was a male preponderance of 53.4% and 46.6% female with a M:F of 1.2:1. Histologically, 35 (34.0%) were benign and 68 (66.0%) were malignant lesion. Minor salivary gland 63 (61.2%) was the commonest gland involved followed by the parotid 27 (26.2%) gland. Squamous cell carcinoma (SCC) was most frequent malignant lesion and pleomorphic adenoma was the commonest benign tumour. Conclusion: Minor salivary glands of the palate are the principal site for salivary gland malignancy with male preponderance and SCC being the most frequent malignant lesion. Therefore any SGTs should raise a high index of suspicion.
Muscle endurance measurement using a progressive workload and a constant workload by maximal voluntary contraction  [PDF]
Shinichi Demura, Masakatsu Nakada
Health (Health) , 2010, DOI: 10.4236/health.2010.211186
Abstract: Muscle endurance measurement using a progressive workload method may reduce pain sensation in the subject. This study aimed to examine the relationships between force-time parameters during sustained static gripping as measured by maximal voluntary contraction (MVC) using either a progressive workload (PW) or a constant workload (CW). Sixteen subjects performed sustained static gripping with 7 gradually increasing relative demand values of 20% to 80% MVC and sustained static gripping by MVC. The staging of progressive workload was 10 s for 20% MVC, 20 s each for 30, 40, 50, 60, and 70% MVC, and 10 s for 80% MVC. The forces exerted at 120 s in the CW and PW methods were at around the 23-27% MVC level. Peak force, final force, and force during the last 30 s for the PW method evaluated muscle endurance after 1 min and showed high correlations (r = 0.746 ? 0.895). Significant correlations (r = 0.575 ? 0.605) were found between time to 40% MVC in the CW method and peak force, final force, and force in the last 30 s in the PW method group. The peak force in the PW method may be useful for evaluating muscle endurance with a short testing time and without high pain sensation.
Effect of past and present lifestyle habits and nutrition on calcaneal quantitative osteo-sono index in pre- and post-menopausal females  [PDF]
Masakatsu Nakada, Shinichi Demura
Health (Health) , 2010, DOI: 10.4236/health.2010.22019
Abstract: This study is examined the effect of past and present lifestyle habits and nutrition on the os-teo-sono assessment index (OSI) in pre- and post-menopausal females. The subjects were 200 premenopausal females (38.8±10.3years) and 156 postmenopausal females (59.2±5.9 ye- ars). BMD (Body mineral density) was estimated by right-calcaneal OSI using an ultrasonic transmission method with an AOS-100 device (ALOKA). The number of postmenopau- sal fe-males in the close examination and guidance required groups (80 cases: 51.3 %) (OSI < 2.428) was significantly higher than that of premeno-pausal females (44 cases: 22.0 %) (χ2=33.105: P<0.000). In premenopausal females, the proportion of subjects that had not taken vitamin D in the past (in junior high school and high school) was significantly higher in the close examination- guidance required group (OSI < 2.428) than in the normal group (OSI ≧ 2.428). However, in postmenopausal females, there was no signifi-cant difference in past and present lifestyle habits and nutrition between the close exami-nation-guidance required group and the normal group. In premenopausal females, it was deter-mined that the intake of vitamin D during pu-berty increased the absorption of calcium sig-nificantly.
The effect of past and present lifestyle, nutrition habits, and gender on bone mineral density  [PDF]
Masakatsu Nakada, Shinichi Demura
Health (Health) , 2010, DOI: 10.4236/health.2010.27109
Abstract: This study aimed to examine the gender and age differences of the quantitative osteo-sono assessment index (OSI) and the effects of the past and present lifestyle and nutrition habits on OSI in adult males and females from 20 to 70 years of age. The subjects were 155 males (20- 79 years) and 399 females (20-78 years). The bone mass was estimated by the right-calcaneal OSI using an ultrasonic transmission method with an AOS-100 device (ALOKA). The frequency of tests for OSI in women tended to increase rapidly in the 50-70 age group requiring close examination or guidance. In 50-70 year- old females, the proportion of dairy products and vitamin D intake in the past (junior high school and high school days) was significantly lower in the group requiring close examination or guidance (OSI < 2.428) than in the normal group (OSI ≧ 2.428). That is, there was insufficient calcium intake (through dairy products) and vitamin D intake, which is instrumental in calcium absorption, (through fish, chicken eggs, and fungi) during puberty, when bone mass increases with skeletal growth. In conclusion, the number in the group requiring close examination or guidance was high for 50-70 year-old males and females. The OSI decreases rapidly in females after their 50s and the number in the group requiring close examination or guidance increased rapidly.
Gender differences and laterality in maximal handgrip strength and controlled force exertion in young adults  [PDF]
Hiroshi Kubota, Shinichi Demura
Health (Health) , 2011, DOI: 10.4236/health.2011.311115
Abstract: This study examines gender differences and laterality in maximal handgrip strength and controlled force exertion (CFE) in young adults. The subjects were 75 healthy young males (mean age 19.6 ± 1.6 yrs.) and 50 healthy young females (mean age 20.9 ± 1.9 yrs.). Maximal handgrip strength was measured twice. The subjects performed the CFE test three times after one practice trial. They matched their handgrip strengths to the demand values, which constantly changed and ranged from 5 to 25% of maximal handgrip strength. The difference between the demand value and the grip exertion value was used as an estimate of CFE. Maximal handgrip strength was significantly larger in males than in females in both the dominant and non-dominant hands, and was significantly larger in the dominant hand in both males and females. Insignificant gender differences were found in CFE of both hands. CFE was significantly superior in the dominant hand in both genders. In conclusions, gender differences are present in maximal handgrip strength of the dominant and non-dominant hands in young adults, but not in CFE of both hands. Laterality exists in maximal handgrip strength and in CFE for both genders.
The Effects of Knee Joint Pain and Disorders on Knee Extension Strength and Walking Ability in the Female Elderly  [PDF]
Hiroki Sugiura, Shinichi Demura
Advances in Physical Education (APE) , 2012, DOI: 10.4236/ape.2012.24024
Abstract: This study examines the differences in leg strength and walking ability among groups with different knee problems. The participants were 328 elderly females (60 - 94 years old; mean age 76.1 years; SD = 6.2) who were classified into three groups: those without knee pain or a knee disorder, those with knee pain, and those with a knee disorder. The subjects took knee extension strength and 12 meter maximum effort walk tests. Knee extension strength was significantly lower in the groups with knee pain and a knee disorder than in the group without pain or a knee disorder. Walking speed was significantly slower in the group with a knee disorder than in the other two groups. In conclusion, the female elderly with knee pain or a knee disorder are inferior in knee extension strength and walking ability. In addition, the elderly with a knee disorder are inferior in walking ability to the elderly with knee pain.
Combined effects of knee extension strength, visual acuity, and knee-joint pain on older women’s gait  [PDF]
Tomohiro Demura, Shinichi Demura
Health (Health) , 2013, DOI: 10.4236/health.2013.53060

The purpose of this study was to examine the combined effects of knee extension strength (KES), visual acuity (VA), and knee joint pain (KP) on gait in 212 older women. Including, walking speed, cadence, were selected as gait parameters. Knee extension strength was measured by isometric knee extension strength, while knee joint pain and decreased visual acuity were evaluated by subjective judgment. The combine effect of KP and KES factors was examined. Stance time was significantly longer in persons with both-KP than in persons with no KP. In addition, people with superior KES had significantly greater values in walking speed, cadence, and step length, and lower values in stance time and walking angle than those with inferior KES. Furthermore, double support time showed that persons with both-KP have significantly greater values than persons with no or one-KP in the inferior KES group. Also, persons with the inferior KES had significantly greater values in persons with both-KP. The combine effect of KES and VA factors was examined. There are significant differences between the superior and the inferior KES groups. In conclusion, the elderly with both the factors of decreasing KES and both-KP, as compared to the elderly with just one of those factors, have markedly different gait properties.

Relationship between Abdominal Strength Measured by a Newly Developed Device and Abdominal Muscle Thickness  [PDF]
Takanori Noguchi, Shinichi Demura
Advances in Physical Education (APE) , 2014, DOI: 10.4236/ape.2014.42010

Although measurement of abdominal strength is important for evaluating trunk myofunction, adequate devices for these measurements have not been developed. As a consequence, the relationships between abdominal strength and abdominal muscle thickness have also not been determined. This study aimed to develop a new device for measuring abdominal strength and to examine the relationship between abdominal muscle strength and thickness. The subjects in the study included 50 young males (age, 19.1 ± 0.32 years; height, 171.0 ± 6.55 cm; weight, 69.5 ± 12.15 kg). The measurement of abdominal flexion strength had high reliability with an intra-class correlation coefficient (ICC) >0.9. The thickness of the rectus abdominis muscle was measured under two conditions using an ultrasound imaging method; relaxation and strength exertion. Abdominal muscle thickness was significantly thicker during exertion than during relaxation. Abdominal flexion strength showed a significant correlation with muscle thickness during both relaxation (r = 0.69) and strength exertion (r = 0.71). No significant difference was found between these correlation coefficients. In conclusion, the values of abdominal strength determined by our newly-developed measuring device had high reliability, with abdominal flexion strength showing a relatively close relationship with the thickness of the rectus abdominis during strength exertion and relaxation.

Page 1 /514
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.