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Search Results: 1 - 10 of 922 matches for " Shinhiro Takeda "
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Aggressive treatment with noninvasive ventilation for mild acute hypoxemic respiratory failure after cardiovascular surgery: Retrospective observational study
Keiko Nakazato, Shinhiro Takeda, Keiji Tanaka, Atsuhiro Sakamoto
Journal of Cardiothoracic Surgery , 2012, DOI: 10.1186/1749-8090-7-41
Abstract: We retrospectively analyzed all patients admitted to the intensive care unit after cardiovascular surgery, whose oxygenation transfer (PaO2/FIO2) deteriorated mildly after extubation, and in whom NIV was initiated. A two-way analysis of variance and the Bonferroni multiple comparisons procedure, the Mann–Whitney test, Fisher’s exact test or the χ2test was performed.A total of 94 patients with AHRF received NIV, of whom 89 patients (94%) successfully avoided endotracheal intubation (successful group) and five patients required reintubation (reintubation group). All patients, including the reintubated patients, were successfully weaned from mechanical ventilation and discharged from the intensive care unit. In the successful group, PaO2/FIO2 improved and the respiratory rate decreased significantly within 1?h after the start of NIV, and the improvement in PaO2/FIO2 remained during the whole NIV period.We conclude that NIV is beneficial for mild AHRF after cardiovascular surgery when it is started within 3?h after mild deterioration of PaO2/FIO2. We also think that it is important not to hesitate before performing reintubation when NIV is judged to be ineffective.
Postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting or cardiac valve surgery: intraoperative use of landiolol
Nakanishi Kazuhiro,Takeda Shinhiro,Kim Chol,Kohda Shusuke
Journal of Cardiothoracic Surgery , 2013, DOI: 10.1186/1749-8090-8-19
Abstract: Background Landiolol hydrochloride is a new β-adrenergic blocker with a pharmacological profile that suggests it can be administered safely to patients who have sinus tachycardia or tachyarrhythmia and who require heart rate reduction. This study aimed to investigate whether intraoperative administration of landiolol could reduce the incidence of atrial fibrillation (AF) after cardiac surgery. Methods Of the 200 consecutive patients whose records could be retrieved between October 2006 and September 2007, we retrospectively reviewed a total of 105 patients who met the inclusion criteria: no previous permanent/persistent AF, no permanent pacemaker, no renal insufficiency requiring dialysis, and no reactive airway disease, etc. Landiolol infusion was started after surgery had commenced, at an infusion rate of 1 μg/kg/min, titrated upward in 3–5 μg/kg/min increments. The patients were divided into 2 groups: those who received intraoperative β-blocker therapy with landiolol (landiolol group) and those who did not receive any β-blockers during surgery (control group). An unpaired t test and Fisher’s exact test were used to compare between-group differences in mean values and categorical data, respectively. Results Seventeen of the 105 patients (16.2%) developed postoperative atrial fibrillation: 5/57 (8.8%) in the landiolol group and 12/48 (25%) in the control group. There was a significant difference between the two groups (P=0.03). The incidence of AF after valve surgery and off-pump coronary artery bypass grafting was lower in the landiolol group, although the difference between the groups was not statistically significant. Conclusions Our retrospective review demonstrated a marked reduction of postoperative AF in those who received landiolol intraoperatively. A prospective study of intraoperative landiolol for preventing postoperative atrial fibrillation is warranted.
Structural features of the nucleotide sequences of virus and organelle genomes  [PDF]
Masaharu Takeda
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.411089
Abstract: The four nucleotides (bases), A, T (U), G and C in small genomes, virus DNA/RNA, organelle and plastid genomes were also arranged sophisticatedly in the structural features in a single-strand with 1) reverse-complement symmetry of base or base sequences, 2) bias of four bases, 3) multiple fractality of the distribution of each four bases depending on the distance in double logarithmic plot (power spectrum) of L (the distance of a base to the next base) vs. P (L) (the probability of the base-distribution at L), although their genomes were composed of low numbers of the four bases, and the base-symmetry was rather lower than the prokaryotic-and the eukaryotic cells. In the case of the genomic DNA composed of less than 10,000 nt, it was better than to be partitioned at 10 of the L-value, and the structural features for the biologically active genomic DNA were observed as the large genomes. As the results, the base sequences of the genomic DNA including the genomic-RNA might be universal in all genomes. In addition, the relationship between the structural features of the genome and the biological complexity was discussed.
How is the biological information arranged in genome?  [PDF]
Masaharu Takeda
American Journal of Molecular Biology (AJMB) , 2012, DOI: 10.4236/ajmb.2012.23019
Abstract: The four nucleotides (bases), A. T. G and C were sophisticatedly arranged in the structural features in a single-strand of genomic DNA, 1) reverse-complement symmetry of base or base sequences, 2) bias of four bases, 3) multiple fractality of the distribution of each four bases depending on the distance in double logarithmic plot (power spectrum) of L (the distance of a base to the next base) vs. P(L) (the probability of the base-distribution at L), regardless species, forms, genome-sizes and GC-contents. In small genomes such as viruses and plasmids, the multiple fractality might be occasionally hard to distinguish clearly with the power-low-tail region (multi-fractal dimension) because of the low base numbers. In this review article, the author showed that 1) the structural features for the biologically active genomic DNA were observed all living cells including the organelle- and the viralgenome, 2) the potentiality of a new analytical method of the genome structure based on the appearance frequency, Sequence Spectrum Method (SSM) could be analyzed DNA, RNA and protein on genome, 3) the structural features of genome might be related the biological complexity. These findings might be useful extremely to understand the living cells, and the entire genome as a “field” of biological information should need to analyze.
Identification of the interactive region by the homology of the sequence spectrum  [PDF]
Masatoshi Nakahara, Masaharu Takeda
Journal of Biomedical Science and Engineering (JBiSE) , 2010, DOI: 10.4236/jbise.2010.39117
Abstract: The base sequence in genome was governed by some fundamental principles such as reverse-complement symmetry, multiple fractality and so on, and the analytical method of the genome structure, the “Sequence Spectrum Method (SSM)”, based on the structural features of genomic DNA faithfully visualized these principles. This paper reported that the sequence spectrum in SSM closely reflected the biological phenomena of protein and DNA, and SSM could identify the interactive region of protein-protein and DNA-protein uniformly. In order to investigate the effectiveness of SSM we analyzed the several protein-protein and DNA-protein interaction published primarily in the genome of Saccharomyces cerevisiae. The method proposed here was based on the homology of sequence spectrum, and it advantageously and surprisingly used only base sequence of genome and did not require any other information, even information about the amino-acid sequence of protein. Eventually it was concluded that the fundamental principles in genome governed not only the static base sequence but also the dynamic function of protein and DNA.
Characterization of the sequence spectrum of DNA based on the appearance frequency of the nucleotide sequences of the genome——A new method for analysis of genome structure  [PDF]
Masatoshi Nakahara, Masaharu Takeda
Journal of Biomedical Science and Engineering (JBiSE) , 2010, DOI: 10.4236/jbise.2010.34047
Abstract: The nucleotide (base) sequence of the genome might reflect biological information beyond the coding sequences. The appearance frequencies of successive base sequences (key sequences) were calculated for entire genomes. Based on the appearance frequency of the key sequences of the genome, any DNA sequences on the genome could be expressed as a sequence spectrum with the adjoining base sequences, which could be used to study the corresponding biological phenomena. In this paper, we used 64 successive three- base sequences (triplets) as the key sequences, and determined and compared the spectra of specific genes to the chromosome, or specific genes to tRNA genes in Saccharomyces cerevisiae, Schizosaccharomyces pombe and Escherichia coli. Based on these analyses, a gene and its corresponding position on the chromosome showed highly similar spectra with the same fold enlargement (approximately 400-fold) in the S. cerevisiae, S. pombe and E. coli genomes. In addition, the homologous structure of genes that encode proteins was also observed with appropriate tRNA gene(s) in the genome. This analytical method might faithfully reflect the encoded biological information, that is, the conservation of the base sequences was to make sense the conservation of the translated amino acids sequence in the coding region, and might be universally applicable to other genomes, even those that consisted of multiple chromosomes.
Mechanism of Generation and Collapse of a Longitudinal Vortex System Induced around the Leading Edge of a Delta Wing  [PDF]
Shigeru Ogawa, Jumpei Takeda
Open Journal of Fluid Dynamics (OJFD) , 2015, DOI: 10.4236/ojfd.2015.53028
Abstract: The purpose of the paper is to clarify the mechanism of generation and collapse of a longitudinal vortex system induced around the leading edge of a delta wing. CFD captured well characteristics of flow structure of the vortex system. It is found that the vortex system has a cone-shaped configuration, and both rotational velocity and vorticity have their largest values at the tip of the vortex and reduce downstream along the vortical axis. This resulted in inducing the largest negative pressure at the tip of the delta wing surface. The collapse of the vortex system was also studied. The system can still remain until the tip angle of 110 degrees. However, between 110 degrees and 120 degrees, the system becomes unstable. Over 120 degrees, the characteristics of the vortex are considered to have converted from the longitudinal vortex to the transverse one.
Factors Related to Nocturia in Elderly People Living in Local Remote Area in Japan  [PDF]
Yuko Takeda, Mitsumi Ono, Hideyuki Kanda, Sachiko Hara, Keiko Takeda
Health (Health) , 2017, DOI: 10.4236/health.2017.94047
The elderly people are prone to be affected by quality of life (QOL) by nocturia becoming the multiple times. A purpose of this study was to determine it about a factor associated with the night urination. This survey was conducted in 2015 as a cross-sectional study. Anonymous, self-administered questionnaires were used to prevent individuals from being identified. The analysis subjects were 699 elderly people with the nocturia which belonged to club of the aged 65 years or older. Those with nocturia were placed in the Nocturia-1 group if they reported experiencing nocturia once per night or in the Nocturia- ≥ 2 group if they reported experiencing nocturia two or more times per night. We analyzed the relationships between the characteristics, lower urinary tract symptoms, and opportunities to go outdoors in the Nocturia-1 and Nocturia- ≥ 2 groups based on sex using the χ2 test. In addition, to investigate the factors that influence the change from nocturia once per night to two or more times per night, we performed logistic regression analysis using the χ2 test on the characteristics and lower urinary tract symptoms that showed significant differences separately for men and women. Among the men, factors with a significant positive relation-ship were age, diabetes mellitus, lower back pain, daytime frequency, and urinary urgency. Among the women, factors with a significant positive relationship were age, requiring support 1-requiring long-term care 2, urinary urgency, and feeling of incomplete emptying. It was suggested that the life of elderly people improved by nocturia not increasing.
Insight into Glutamate Excitotoxicity from Synaptic Zinc Homeostasis
Atsushi Takeda
International Journal of Alzheimer's Disease , 2011, DOI: 10.4061/2011/491597
Abstract: Zinc is released from glutamatergic (zincergic) neuron terminals in the hippocampus, followed by the increase in Zn2
Political Ecological Economics: An Emerging Transdisciplinary Approach to Sustainability
Louise Takeda
The Interdisciplinary Journal of International Studies , 2003,
Abstract: Serious attempts to come to terms with the issues underlying the current environmental crisis is calling into question some very basic assumptions within the mainstream traditions of economics and development. This article explores some of the insights which are arising from a combination of the fields of ecological economics and political ecology. The aim in combining these two fields is to facilitate an inquiry into the political processes and institutions involved in questions of unequal ecological flows and distribution.
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