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Search Results: 1 - 10 of 79188 matches for " Shin-Da Lee "
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Granulocyte Colony-Stimulating Factor Activating HIF-1α Acts Synergistically with Erythropoietin to Promote Tissue Plasticity
Shih-Ping Liu,Shin-Da Lee,Hsu-Tung Lee,Demeral David Liu,Hsiao-Jung Wang,Ren-Shyan Liu,Shinn-Zong Lin,Woei-Cherng Shyu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010093
Abstract: Stroke and peripheral limb ischemia are serious clinical problems with poor prognosis and limited treatment. The cytokines erythropoietin (EPO) and granulocyte-colony stimulating factor (G-CSF) have been used to induce endogenous cell repair and angiogenesis. Here, we demonstrated that the combination therapy of EPO and G-CSF exerted synergistic effects on cell survival and functional recovery from cerebral and peripheral limbs ischemia. We observed that even under normoxic conditions, G-CSF activates hypoxia-inducible factor-1α (HIF-1α), which then binds to the EPO promoter and enhances EPO expression. Serum EPO level was significantly increased by G-CSF injection, with the exception of Tg-HIF-1α+f/+f mice. The neuroplastic mechanisms exerted by EPO combined with G-CSF included enhanced expression of the antiapoptotic protein of Bcl-2, augmented neurotrophic factors synthesis, and promoted neovascularization. Further, the combination therapy significantly increased homing and differentiation of bone marrow stem cells (BMSCs) and intrinsic neural progenitor cells (INPCs) into the ischemic area. In summary, EPO in combination with G-CSF synergistically enhanced angiogenesis and tissue plasticity in ischemic animal models, leading to greater functional recovery than either agent alone.
Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats
Mallikarjuna Korivi,Chien-Wen Hou,Chih-Yang Huang,Shin-Da Lee,Ming-Fen Hsu,Szu-Hsien Yu,Chung-Yu Chen,Yung-Yang Liu,Chia-Hua Kuo
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/932165
Abstract: Despite regular exercise benefits, acute exhaustive exercise elicits oxidative damage in liver. The present study determined the hepatoprotective properties of ginsenoside-Rg1 against exhaustive exercise-induced oxidative stress in rats. Forty rats were assigned into vehicle and ginsenoside-Rg1 groups (0.1 mg/kg bodyweight). After 10-week treatment, ten rats from each group performed exhaustive swimming. Estimated oxidative damage markers, including thiobarbituric acid reactive substance (TBARS) (67%) and protein carbonyls (56%), were significantly (<0.01) elevated after exhaustive exercise but alleviated in ginsenoside-Rg1 pretreated rats. Furthermore, exhaustive exercise drastically decreased glutathione (GSH) content (~79%) with concurrent decreased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities. However, these changes were attenuated in Rg1 group. Additionally, increased xanthine oxidase (XO) activity and nitric oxide (NO) levels after exercise were also inhibited by Rg1 pretreatment. For the first time, our findings provide strong evidence that ginsenoside-Rg1 can protect the liver against exhaustive exercise-induced oxidative damage.
Enhanced Differentiation of Three-Gene-Reprogrammed Induced Pluripotent Stem Cells into Adipocytes via Adenoviral-Mediated PGC-1α Overexpression
Pin-I Huang,Yueh-Ching Chou,Yuh-Lih Chang,Yueh Chien,Kuan-Hsuan Chen,Wen-Shin Song,Chi-Hsien Peng,Chin-Hong Chang,Shin-Da Lee,Kai-Hsi Lu,Yi-Jen Chen,Chia-Hua Kuo,Chuan-Chih Hsu,Hsin-Chen Lee,Ming-Chi Yung
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12117554
Abstract: Induced pluripotent stem cells formed by the introduction of only three factors, Oct4/Sox2/Klf4 (3-gene iPSCs), may provide a safer option for stem cell-based therapy than iPSCs conventionally introduced with four-gene iPSCs. Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) plays an important role during brown fat development. However, the potential roles of PGC-1α in regulating mitochondrial biogenesis and the differentiation of iPSCs are still unclear. Here, we investigated the effects of adenovirus-mediated PGC-1α overexpression in 3-gene iPSCs. PGC-1α overexpression resulted in increased mitochondrial mass, reactive oxygen species production, and oxygen consumption. Microarray-based bioinformatics showed that the gene expression pattern of PGC-1α-overexpressing 3-gene iPSCs resembled the expression pattern observed in adipocytes. Furthermore, PGC-1α overexpression enhanced adipogenic differentiation and the expression of several brown fat markers, including uncoupling protein-1, cytochrome C, and nuclear respiratory factor-1, whereas it inhibited the expression of the white fat marker uncoupling protein-2. Furthermore, PGC-1α overexpression significantly suppressed osteogenic differentiation. These data demonstrate that PGC-1α directs the differentiation of 3-gene iPSCs into adipocyte-like cells with features of brown fat cells. This may provide a therapeutic strategy for the treatment of mitochondrial disorders and obesity.
Oral Rg1 supplementation strengthens antioxidant defense system against exercise-induced oxidative stress in rat skeletal muscles
Szu-Hsien Yu, Hui-Yu Huang, Mallikarjuna Korivi, Ming-Fen Hsu, Chih-Yang Huang, Chien-Wen Hou, Chung-Yu Chen, Chung-Lan Kao, Ru-Ping Lee, Shin-Da Lee, Chia-Hua Kuo
Journal of the International Society of Sports Nutrition , 2012, DOI: 10.1186/1550-2783-9-23
Abstract: Forty weight-matched rats were evenly divided into control (N?=?20) and Rg1 (N?=?20) groups. Rg1 was orally administered at the dose of 0.1?mg/kg bodyweight per day for 10-week. After this long-term Rg1 administration, ten rats from each group performed an exhaustive swimming, and remaining rats considered as non-exercise control. Tibialis anterior (TA) muscles were surgically collected immediately after exercise along with non-exercise rats.Exhaustive exercise significantly (p<0.05) increased the lipid peroxidation of control group, as evidenced by elevated malondialdehyde (MDA) levels. The increased oxidative stress after exercise was also confirmed by decreased reduced glutathione to oxidized glutathione ratio (GSH/GSSG ratio) in control rats. However, these changes were completely eliminated in Rg1 group. Catalase (CAT) and glutathione peroxidase (GPx) activities were significantly (p<0.05) increased by Rg1 in non-exercise rats, while no significant change after exercise. Nevertheless, glutathione reductase (GR) and glutathione S-transferase (GST) activities were significantly increased after exercise in Rg1 group.This study provide compelling evidences that Rg1 supplementation can strengthen antioxidant defense system in skeletal muscle and completely attenuate the membrane lipid peroxidation induced by exhaustive exercise. Our findings suggest that Rg1 can use as a nutraceutical supplement to buffer the exhaustive exercise-induced oxidative stress.
Dynamics of Phase Transitions Induced by a Heat Bath
Da-Shin Lee,Daniel Boyanovsky
Physics , 1993, DOI: 10.1016/0550-3213(93)90004-9
Abstract: We study the non-equilibrium dynamics of a symmetry restoring phase transition in a scalar field theory, the ``system'', linearly coupled to another scalar field taken as a ``heat bath''. The ``system'' is initially in an ordered low temperature phase, and the heat bath is at a temperature close to the critical temperature for the system. We estimate the time at which the phase transition to the disordered (symmetric) phase takes place. We derive, and integrate the one-loop effective equations of motion for the order parameter that include the effects of the heat bath. A semiclassical Langevin equation is derived and it is found that it contains a non-dissipative, non-Markovian kernel, the noise term is colored and correlated on time scales determined by the temperature of the heat bath. The range of validity of the Langevin equation and a consistent procedure to incorporate corrections are discussed.
Primordial Magnetic Fields from Dark Energy
Da-Shin Lee,Wolung Lee,Kin-Wang Ng
Physics , 2001, DOI: 10.1016/S0370-2693(02)02264-5
Abstract: Evidences indicate that the dark energy constitutes about two thirds of the critical density of the universe. If the dark energy is an evolving pseudo scalar field that couples to electromagnetism, a cosmic magnetic seed field can be produced via spinoidal instability during the formation of large-scale structures.
Fluctuations of Quantum Radiation Pressure in Dissipative Fluid
Chun-Hsien Wu,Da-Shin Lee
Physics , 2003, DOI: 10.1016/j.physleta.2003.09.039
Abstract: Using the generalized Langevin equations involving the stress tensor approach, we study the dynamics of a perfectly reflecting mirror which is exposed to the electromagnetic radiation pressure by a laser beam in a fluid at finite temperature. Based on the fluctuation-dissipation theorem, the minimum uncertainty of the mirror's position measurement from both quantum and thermal noises effects including the photon counting error in the laser interferometer is obtained in the small time limit as compared with the "standard quantum limit". The result of the large time behavior of fluctuations of the mirror's velocity in a dissipative environment can be applied to the laser interferometer of the ground-based gravitational wave detector.
Influence on electron coherence from quantum electromagnetic fields in the presence of conducting plates
Jen-Tsung Hsiang,Da-Shin Lee
Physics , 2005, DOI: 10.1103/PhysRevD.73.065022
Abstract: The influence of electromagnetic vacuum fluctuations in the presence of the perfectly conducting plate on electrons is studied with an interference experiment. The evolution of the reduced density matrix of the electron is derived by the method of influence functional. We find that the plate boundary anisotropically modifies vacuum fluctuations that in turn affect the electron coherence. The path plane of the interference is chosen either parallel or normal to the plate. In the vicinity of the plate, we show that the coherence between electrons due to the boundary is enhanced in the parallel configuration, but reduced in the normal case. The presence of the second parallel plate is found to boost these effects. The potential relation between the amplitude change and phase shift of interference fringes is pointed out. The finite conductivity effect on electron coherence is discussed.
Out-of-equilibrium Photon Production from Disoriented Chiral Condensates
Da-Shin Lee,Kin-Wang Ng
Physics , 2000, DOI: 10.1016/S0370-2693(00)01089-3
Abstract: We study the production of photons through the non-equilibrium relaxation of a disoriented chiral condensate. We propose that to search for non-equilibrium photons in the direct photon measurements of heavy-ion collisions can be a potential test of the formation of disoriented chiral condensates.
Photon Production of Axionic Cold Dark Matter
Da-Shin Lee,Kin-Wang Ng
Physics , 1999, DOI: 10.1103/PhysRevD.61.085003
Abstract: Using the non-equilibrium quantum field theory, photon production from the coherently oscillating axion field in a flat Robertson-Walker cosmology is re-examined. First neglecting the Debye screening of the baryon plasma to photons, we find that the axions will dissipate into photons via spinodal instability in addition to parametric resonance. As a result of the pseudo-scalar nature of the axion-photon coupling, we observe a circular polarization asymmetry in the produced photons. However, these effects are suppressed to an insignificant level in the expanding universe. We then briefly discuss a systematic way of including the plasma effect which can further suppress the photon production. We note that the formalism of the problem can be applied to any pseudo-scalar field coupled to photon in a thermal background in a general curved spacetime.
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