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Search Results: 1 - 10 of 78279 matches for " Shilin Chen "
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Phenotype prediction of nonsynonymous single nucleotide polymorphisms in human phase II drug/xenobiotic metabolizing enzymes: perspectives on molecular evolution
DaCheng Hao,PeiGen Xiao,ShiLin Chen
Science China Life Sciences , 2010, DOI: 10.1007/s11427-010-4062-9
Abstract: Nonsynonymous single nucleotide polymorphisms (nsSNPs) in coding regions can lead to amino acid changes that might alter the protein’s function and account for susceptibility to disease and altered drug/xenobiotic response. Many nsSNPs have been found in genes encoding human phase II metabolizing enzymes; however, there is little known about the relationship between the genotype and phenotype of nsSNPs in these enzymes. We have identified 923 validated nsSNPs in 104 human phase II enzyme genes from the Ensembl genome database and the NCBI SNP database. Using PolyPhen, Panther, and SNAP algorithms, 44%–59% of nsSNPs in phase II enzyme genes were predicted to have functional impacts on protein function. Predictions largely agree with the available experimental annotations. 68% of deleterious nsSNPs were correctly predicted as damaging. This study also identified many amino acids that are likely to be functionally critical, but have not yet been studied experimentally. There was significant concordance between the predicted results of Panther and PolyPhen, and between SNAP non-neutral predictions and PolyPhen scores. Evolutionarily non-neutral (destabilizing) amino acid substitutions are thought to be the pathogenetic basis for the alteration of phase II enzyme activity and to be associated with disease susceptibility and drug/xenobiotic toxicity. Furthermore, the molecular evolutionary patterns of phase II enzymes were characterized with regards to the predicted deleterious nsSNPs.
A comparison of hydrocarbons emission from engine running 85# gasoline and M-100 methanol fuel
Yao Heng,Chen Zongliang,Yu Shilin
环境科学学报(英文版) , 1994,
Abstract: Increasing global interest in methanoi fuel has led us to investigate the exhaust emissionsof its engine. Analysis of its inorganic and organic emissions. such as CO. NOx and hydrocarbons(total HC) have been widely reported. This paper presents an analysis of more than 20 kinds ofhydrocarbons in the emissions obtained from a spark-ignition Shanghai car running 85# gasoline anda comparison with emission from a Santana test car running M-100 methanol fuel. A set ofenrichment method has also been described. Test results show that at the current stage of methanolengine development the concentration of individual hydrocarbon including some poisonous substancesis lower than those of normal gasoline engine.
The Study and Applications of Sparse Methods Technology in Yunnan Mountain Substation  [PDF]
Hongliang Wang, Min Cao, Xianfu Chen, Shilin Li, Shaoquan Zhang, Xin Shen
Journal of Power and Energy Engineering (JPEE) , 2014, DOI: 10.4236/jpee.2014.24055
Abstract: As one of the divisions in China Southern Power Grid, Yunnan Power Grid Corporation has conducted research and demonstration projects on multiple smart grid technologies to improve the power system reliability, save operation cost and enhance measurement accuracy. In this paper, we will introduce The Study of Yunnan Mountain Substation Data Aggregation Technology based on Sparse Methods. Most substations are built in the mountain, the complex geological conditions and poor natural conditions put forward higher requirements on the substation running and real-time comprehensive monitoring of substation system. Processing and polymerization research of large amounts of the monitoring data and information is studied in this article. This paper introduces the sparse methods and then explains the thinning algorithm, especially new algorithm is proposed. Finally, the substation sparse method architecture is put forward and the simulation experiment was carried out to prove the feasibility and effectiveness of the proposed method.
TCMGIS-II based prediction of medicinal plant distribution for conservation planning: a case study of Rheum tanguticum
Hua Yu, Caixiang Xie, Jingyuan Song, Yingqun Zhou, Shilin Chen
Chinese Medicine , 2010, DOI: 10.1186/1749-8546-5-31
Abstract: Native habitats were determined by specimen examination. An improved version of GIS-based program for the distribution prediction of traditional Chinese medicine (TCMGIS-II) was employed to integrate national geographic, climate and soil type databases of China. Grid-based distance analysis of climate factors was based on the Mikowski distance and the analysis of soil types was based on grade division. The database of resource survey was employed to assess the reliability of prediction result.A total of 660 counties of 17 provinces in China, covering a land area of 3.63 × 106 km2, shared similar ecological factors with those of native habitats appropriate for R. tanguticum growth.TCMGIS-II modeling found the potential habitats of target medicinal plants for their conservation planning. This technology is useful in conservation planning and regional management of medicinal plant resources.More than one-tenth of plant species are used in drugs and health products [1]. The demand for herbal drugs and health products is steadily growing [2]. Thus, many medicinal herbs are threatened by overexploitation, habitat destruction and lack of proper cultivation practices. Some wild species are disappearing at alarming rates [3,4]. Rheum tanguticum Maxim. ex Balf (Dahuang) is one of those species. R. tanguticum belongs to the family Polygonaceae and is a high-altitude perennial herb sensitive to high temperature, mainly found in the alpine regions of temperate and subtropical Asia, especially in Southwest and Northwest China (e.g. Sichuan, Gansu and Qinghai) [5,6]. As a source for rhubarb according to the Chinese Pharmacopoeia and a purgative and anti-inflammatory agent [7], R. tanguticum has been overexploited, suffering from replant diseases, inadequate seed dispersal, low reproductive efficiency and narrow distribution and habitat fragmentation, leading to its declines in the wild resources [6,8].In-situ conservation, which considered as the method of conserving endangered sp
Mapping the potential distribution of high artemisinin-yielding Artemisia annua L. (Qinghao) in China with a geographic information system
Linfang Huang, Caixiang Xie, Baozhong Duan, Shilin Chen
Chinese Medicine , 2010, DOI: 10.1186/1749-8546-5-18
Abstract: The Geographic Information System for traditional Chinese medicine (TCM-GIS) was developed and used to map the potential geographic distribution of A. annua L.Climatic, edaphic and topographic characteristics of A. annua L. microhabitats in Youyang County were mapped to find distribution patterns. The maps identified that certain habitats in the Chongqing region and some potential regions, especially in Guizhou Province, possess similarity indices of ≥98%. In particular, high quality microhabitats A. annua L. were found in the Wuling mountains region.The present study demonstrates a GIS approach to predict potential habitats for A. annua L. TCM-GIS is a powerful tool for assessing bioclimatic suitability for medicinal plants.Artemisia annua L. (Qinghao, Annual Wormwood) is a strongly fragrant, annual herbaceous plant used in Chinese medicine [1]. A. annua L. is the only natural botanical source for artemisinin (Qinghaosu) [2,3] and a potential source for essential oils for the perfume industry [4]. A. annua L. is now cultivated in China, Vietnam, India, Romania, Kenya and Tanzania [5]. Artemisinin, an endoperoxide sesquiterpene lactone in the aerial parts of A. annua L., is more efficacious, faster and less toxic than chloroquine in treating malaria. In addition, artemisinin is a potent anti-cancer agent, a possible antibacterial agent as well as a natural pesticide [6,7]. Chemical and biological synthesis of artemisinin is still under development due to poor yields [8-11]. Therefore, wild or cultivated A. annua L. is a major source for artemisinin [2,3,12].The artemisinin content is highly dependent on plant ecotypes, ecological interactions, seasonal and geographic variations [13-18]. In fact, artemisinin is absent in some A. annua L. Artemisinin was first isolated in China and some Chinese germplasm has relatively higher artemisinin levels than those of Europe, North America, East Africa and Australia [2,13,16,17,19,20]. In Youyang County, Chongqing, China, the h
A 2 Gb/s optical receiver with monolithically integrated MSM photodetector in standard CMOS process
XinDong Xiao,ShiLin Zhang,LuHong Mao,Sheng Xie,Yan Chen
Chinese Science Bulletin , 2011, DOI: 10.1007/s11434-011-4482-3
Abstract: A monolithically standard complementary-metal-oxide-semiconductor (CMOS) optical receiver with a metal-semiconductor-metal (MSM) photodetector is presented in this paper. An active-feedback transimpedance amplifier (TIA) with negative Miller capacitance is used to increase the bandwidth of the receiver. The MSM photodetector with high responsivity provides higher sensitivity for the optical receiver. The optical receiver implemented in chartered 0.35 μm process achieves a 1.7 GHz bandwidth due to the low capacitance of the MSM photodetector. 2 Gb/s optical data are successfully transmitted with a bit-error rate of 10 9 at an optical power of 15 dBm. The power consumption of the receiver is 94 mW under a single 3.3 V supply.
Sustainable Utilization of Chinese Material Medicine Resources

Chen Shilin,Guo Baolin,

世界科学技术-中医药现代化 , 2004,
Abstract: The sustainable utilization of resources refers that utilization is high efficient, reproducible and withpreservation. As to Chinese material medicine resource, a kind of biollgical resource, protecting biological diversity and preserving ecological equilibrium should be taken account of In this paper, around the conception mentioned above and considering the principle and important mission in Developing Program for Modernization of Chinese Medicine , the imperative works or research directions to be paid close attention for sustainable utilization of Chinese material medicine were approached. They were: 1) carrying out resource investigation, establishing prediction system for the endangered wild resources to ensure the sustainable provision of medicine materials; 2) enhancing the studies on germplasm resource, selecting and using good germplasm; 3) controlling the collection of wild resources, carrying out the studies on wild tendering; 4) carrying out the studies on introduction and domestication for wild species; 5) establishing germplasm storehouses and gardens to preserve germplasm resources; 6) carrying out the studies on substitutes for rare and endangered resources; 8) improving utilizing quality and efficiency of resources by high techniques, encouraging comprehensive utilization; 9)producing directly active compounds by new techniques; 10)enhancing the studies on cultivating techniques, achieving the standardized cultivation and production in a large scale; enhancing breeding new varieties.
Processing Technology Investigation of Loquat (Eriobotrya japonica) Leaf by Ultra-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry Combined with Chemometrics
Labin Wu, Xue Jiang, Linfang Huang, Shilin Chen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064178
Abstract: Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) and multivariate statistical analysis were used to investigate the processing technology of Loquat (Eriobotrya japonica) leaf (pipaye, PPY). The differences in samples processed using different methods were revealed by unsupervised principal component analysis (PCA). In the scores plot of PCA, honey-processed PPY (PPPY), crude PPY (CPPY), and heated PPY (HPPY) were clearly discriminated. Furthermore, samples processed at different temperatures could also be distinguished; indeed, our PCA results demonstrated the importance of temperature during processing. Two unique marker ions were found to discriminate between PPPY and CPPY by orthogonal partial least squares discriminant analysis (OPLS-DA), which could be used as potential chemical markers. The method was further confirmed by a verification test with commercial PPY. The orthogonal array experiment revealed an optimized processing condition with 50% honey at 140°C for 20 min after 4 h of moistening time, a process that provides significant information for standardized production.
Understanding the Molecular Mechanism of Interventions in Treating Rheumatoid Arthritis Patients with Corresponding Traditional Chinese Medicine Patterns Based on Bioinformatics Approach
Miao Jiang,Cheng Lu,Gao Chen,Cheng Xiao,Qinglin Zha,Xuyan Niu,Shilin Chen,Aiping Lu
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/129452
Abstract: Better effectiveness would be achieved when interventions are used in treating patients with a specific traditional Chinese medicine (TCM) pattern. In this paper, the effectiveness in treating rheumatoid arthritis (RA) patients in a randomized clinical trial as reanalyzed after the patients were classified into different TCM patterns and the underlying mechanism of how the TCM pattern influences the clinical effectiveness of interventions (TCM and biomedicine therapy) was explored. The pharmacological networks of interventions were builtup with protein and protein interaction analyses based on all the related targeted proteins obtained from PubChem. The underlying mechanism was explored by merging the pharmacological networks with the molecular networks of TCM cold and hot patterns in RA. The results show that the TCM therapy is better in treating the RA patients with TCM hot pattern, and the biomedical therapy is better in the RA patients with cold pattern. The pharmacological network of TCM intervention is merged well with the molecular network of TCM hot pattern, and the pharmacological network of biomedical therapy is merged well with the network of cold pattern. The finding indicates that molecular network analysis could give insight into the full understanding of the underlying mechanism of how TCM pattern impacts the efficacy.
FastUniq: A Fast De Novo Duplicates Removal Tool for Paired Short Reads
Haibin Xu, Xiang Luo, Jun Qian, Xiaohui Pang, Jingyuan Song, Guangrui Qian, Jinhui Chen, Shilin Chen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052249
Abstract: The presence of duplicates introduced by PCR amplification is a major issue in paired short reads from next-generation sequencing platforms. These duplicates might have a serious impact on research applications, such as scaffolding in whole-genome sequencing and discovering large-scale genome variations, and are usually removed. We present FastUniq as a fast de novo tool for removal of duplicates in paired short reads. FastUniq identifies duplicates by comparing sequences between read pairs and does not require complete genome sequences as prerequisites. FastUniq is capable of simultaneously handling reads with different lengths and results in highly efficient running time, which increases linearly at an average speed of 87 million reads per 10 minutes. FastUniq is freely available at http://sourceforge.net/projects/fastuniq?/.
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