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Search Results: 1 - 10 of 3248 matches for " Shih-Rung Yeh "
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Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth
Pei-I Tsai, Hsiu-Hua Kao, Caroline Grabbe, Yu-Tao Lee, Aurnab Ghose, Tzu-Ting Lai, Kuan-Po Peng, David Van Vactor, Ruth H Palmer, Ruey-Hwa Chen, Shih-Rung Yeh, Cheng-Ting Chien
Neural Development , 2008, DOI: 10.1186/1749-8104-3-26
Abstract: We have generated mutants for the Drosophila FAK gene, Fak56. Null Fak56 mutants display overgrowth of larval neuromuscular junctions (NMJs). Localization of phospho-FAK and rescue experiments suggest that Fak56 is required in presynapses to restrict NMJ growth. Genetic analyses imply that FAK mediates the signaling pathway of the integrin αPS3βν heterodimer and functions redundantly with Src. At NMJs, Fak56 downregulates ERK activity, as shown by diphospho-ERK accumulation in Fak56 mutants, and suppression of Fak56 mutant NMJ phenotypes by reducing ERK activity.We conclude that Fak56 is required to restrict NMJ growth during NMJ development. Fak56 mediates an extracellular signal through the integrin receptor. Unlike its conventional role in activating MAPK/ERK, Fak56 suppresses ERK activation in this process. These results suggest that Fak56 mediates a specific neuronal signaling pathway distinct from that in other cellular processes.Formation and stabilization of neuronal synapses demands communication between pre- and post-synaptic partners, as well as signals from the extracellular matrix (ECM). These signals can reorganize local cytoskeletal structures or be transduced into the nucleus to regulate transcription, thereby modulating neuronal plasticity [1-3]. One major receptor family for ECM signals comprises the transmembrane protein integrins, which have been shown to play critical roles in sequential steps of neuronal wiring, such as in neurite outgrowth, axon guidance, and synaptic formation and maturation [4-7]. In Drosophila, various integrin subunits have been shown to function in motor axon pathfinding and target recognition, and synaptic morphogenesis at neuromuscular junctions (NMJs) [8-10]. Mutant analyses for the integrin subunits αPS3 and βPS indicate that integrin signaling is involved in synaptic growth and arborization of larval NMJs [8-10]. Although specific ECM signals for these integrin receptors are not clear, dynamic NMJ growth is regulated
Structure and Photoluminescence Properties of Pr3+ Ion-Doped BaY2ZnO5 Phosphor Prepared Using a Sol-Gel Method?  [PDF]
Hung-Rung Shih, Mu-Tsun Tsai, Lay-Gaik Teoh, Yee-Shin Chang
Journal of Modern Physics (JMP) , 2019, DOI: 10.4236/jmp.2019.102008
Abstract: The Pr3+ ion-doped BaY2ZnO5 phosphor with the orthorhombic structure was synthesized successfully using a sol-gel method in this study. The SEM images show that the BaY2ZnO5:Pr3+ phosphor particles are aggregational but have an isotropic distribution for 2 mol% Pr3+ ions doped. Under an excitation wavelength of 311 nm, the emission bands that appear in the emission spectra are due to the 3P03H4,5,6, 1D23H4 and 3P03F2 electron transition of Pr3+ ion, and it is the same as that for solid state reaction preparation. Comparing to the solid state reaction preparation, the intensities of the 3P03H4 transition were increased by about 6.5 times for sol-gel method. The enhancement in emission intensity is because the activators have more homogeneous contribution in host for the sol-gel method preparation. In addition, the color tone did not change very obviously, which located around the green light region for Pr3+ ion concentrations increasing. The color stability is better for sol-gel method than that for the solid state reaction preparation.

Yeh Chi-shih,

金属学报 , 1977,
Conformance Test for IEDs Based on IEC 61850 Communication Protocol  [PDF]
Tzu-Han Yeh, Shih-Che Hsu, Che-Kai Chung, Ming-Shan Lin
Journal of Power and Energy Engineering (JPEE) , 2015, DOI: 10.4236/jpee.2015.34039

In this paper, a conformance test platform is built for intelligent electronic devices (IEDs) from different manufacturers based on IEC 61850 communication protocol. A conformance test of time delay of message transmission between two IEDs, made by the same or different manufacturers, is performed. The conformance test platform, as well as the test results provide a helpful reference for IEC 61850 implementation.

The Key Factors Influencing Internet Finances Services Satisfaction: An Empirical Study in Taiwan  [PDF]
Ming-Chih Chen, Shih-Shiunn Chen, Hung-Ming Yeh, Wei-Guang Tsaur
American Journal of Industrial and Business Management (AJIBM) , 2016, DOI: 10.4236/ajibm.2016.66069
Abstract: The global innovation of information technology fundamentally reshaped the finance technology and the flourishing development over the past decade. The high coverage of both the internet network and the mobile phone has facilitated Taiwan to become one of the most potential internet finance regions. This study aims to empirically validate the technology acceptance model (TAM 3) for exploring the key factors that influence the internet finance development. SEM was adopted to investigate both the hypothesis and the path coefficient associations among the constructs and their significance. Confirmed factor analysis for the instrument validity and reliability assessment was made. Hierarchy regression was performed to test the moderator effect of experience and voluntariness. This study result found that Taiwan finance customers had high expectations of information security and preferred high technology products with complex functions. The result demonstrated that customer’s Use Behavior was influenced by Perceived of Usefulness, not Perceived of Ease of Use. The moderator effect result in Experience had a positive moderator effect on Objective Usability to Perceived Ease of Use. This research extracted the key factors that influenced the internet finance development in Taiwan for providing both local government and internet finance developing countries guidelines while concurrently developing an internet finance development strategy.
Stopband-Extended Balanced Filters Using Both λ/4 and λ/2 Sirs with Common-Mode Suppression and Improved Passband Selectivity
Shih-Cheng Lin;Chong-You Yeh
PIER , 2012, DOI: 10.2528/PIER12041403
Abstract: Benefitting from the simultaneous utilization of quarter-wave (λ/4) and half-wave (λ/2) microstrip resonators, a via-free balanced bandpass filter (BPF) with direct-coupled scheme is presented in this study. In the beginning, a single-ended filter with transmission zeros (TZs) is newly proposed and the mechanism of creating two TZs around the passband without necessitating cross couplings is adopted. The TZs can be made structure-inherent based on the coexisted out-of-phase couplings among a coupled-resonator pair. On the foundation of the presented single-ended filter, a balanced filter featuring extended differential-mode (DM) stopband, good common-mode (CM) suppression, and improved passband selectivity has been designed and implemented. The DM stopband extension is achieved by misaligning the higher-order harmonic frequencies of each resonator in the DM bisected circuit while the CM suppression is accomplished by both harmonic misalignment and careful designed coupled structure in the CM bisected circuit. Eventually, a demonstrated balanced filter centering at 1.5 GHz possesses DM stopband extended up to 8f, where f denotes the DM operation frequency, and its CM rejection ratio (CMRR) within DM passband better than 51.9 dB is attained. For measurement convenience, the DM characterizations have been accomplished by 2-port network analyzer with simple rat-race baluns and are found relatively accurate within the -15dB bandwidth of the utilized baluns.
Ultrasound Microbubble Contrast Agents for Diagnostic and Therapeutic Applications: Current Status and Future Design
Shih-Tsung Kang,Chih-Kuang Yeh
Chang Gung Medical Journal , 2012,
Abstract: U l t r a s o u n d c o n t r a s t a g e n t s a r e h i g h l y e c h o g e n i cmicrobubbles with many unique properties. Microbubbles canbasically improve the sensitivity of conventional ultrasoundimaging to the microcirculation. The resonance of microbubbles in response to an incident ultrasound pulse results in nonl ine a r ha rmoni c emi s s ion tha t s e rve s a s the s igna tur e ofmicrobubbles in microbubble-specific imaging. Inertial cavitation and destruction of microbubbles can produce a strongmechanical stress enhancing the permeability of the surrounding tissues, and can further increase the extravasation of drugsfrom the blood into the cytoplasm or interstitium. Stable cavitation by high-frequency ultrasound can also mildly increasetissue permeability without causing any damage even at a highacoustic pressure. Microbubbles can carry drugs, release themupon ultrasound-mediated microbubble destruction, and simultaneously enhance vascular permeability to increase drug deposition in tissues. Various targeting ligands can be conjugated to the surface of microbubbles to attain ligand-directed andsite-specific accumulation for targeted imaging. In addition to current developments inmicrobubble technology, this review introduces our studies of the applications of microbubble-specific imaging, ultrasound-aided drug delivery, and targeted imaging. These applications are promising but may require further improvement for clinical use.
A network flow approach to predict drug targets from microarray data, disease genes and interactome network - case study on prostate cancer
Shih-Heng Yeh, Hsiang-Yuan Yeh, Von-Wun Soo
Journal of Clinical Bioinformatics , 2012, DOI: 10.1186/2043-9113-2-1
Abstract: We integrate gene expression, disease genes and interaction networks to identify the effective drug targets which have a strong influence on disease genes using network flow approach. In the experiments, we adopt the microarray dataset containing 62 prostate cancer samples and 41 normal samples, 108 known prostate cancer genes and 322 approved drug targets treated in human extracted from DrugBank database to be candidate proteins as our test data. Using our method, we prioritize the candidate proteins and validate them to the known prostate cancer drug targets.We successfully identify potential drug targets which are strongly related to the well known drugs for prostate cancer treatment and also discover more potential drug targets which raise the attention to biologists at present. We denote that it is hard to discover drug targets based only on differential expression changes due to the fact that those genes used to be drug targets may not always have significant expression changes. Comparing to previous methods that depend on the network topology attributes, they turn out that the genes having potential as drug targets are weakly correlated to critical points in a network. In comparison with previous methods, our results have highest mean average precision and also rank the position of the truly drug targets higher. It thereby verifies the effectiveness of our method.Our method does not know the real ideal routes in the disease network but it tries to find the feasible flow to give a strong influence to the disease genes through possible paths. We successfully formulate the identification of drug target prediction as a maximum flow problem on biological networks and discover potential drug targets in an accurate manner.Cancer is extremely complex and it is viewed as a multi-stage disease caused by the accumulation of genetic alterations in tumor associated suppressor oncogenes [1]. It is a fundamental challenge in human health to understand disease mechanisms for
Schwannoma of the Penis: A Report of Two Cases
Chi-Ju Yeh,Wen-Yu Chuang,Shih-Tsung Huang,Shih-Ming Jung
Chang Gung Medical Journal , 2007,
Abstract: Schwannomas are benign nerve sheath tumors, which can occur sporadically or inpatients with neurofibromatosis. Schwannomas of the penis are extremely rare. To ourknowledge, only 18 cases of penile schwannomas have been reported previously in theEnglish-language literature. Here we report two additional cases of penile schwannomas,including one case of multiple penile schwannomas. The first patient was a 26-year-old manpresenting with a 2 x 2 cm, slowly growing, painless tumor on the dorsal penile shaft. Thesecond patient was a 41-year-old man presenting with three painless nodules measuring upto 0.9 cm on the dorsal penile shaft. Neither patient had evidence of neurofibromatosis. Bothpatients received simple tumor excision, and neither experienced tumor recurrence. Penileschwannomas tend to occur on the dorsal penile shaft, the location of the penile dorsalnerves. Notably, multiple tumors are present in 30% of penile schwannoma cases, whereasmost schwannomas at other locations present as a single tumor. Most penile schwannomaspresent as painless nodules. No reported patients had malignant transformation, but two hadtumor recurrence 4 months and 7 years after excision. Despite its rarity, schwannomasshould be included in the differential diagnoses of penile tumors. Simple excision with followup should be the treatment of choice.
Surface Detail Capturing for Realistic Facial Animation
Pei-Hsuan Tu,I-Chen Lin,Jeng-Sheng Yeh,Rung-Huei Liang,Ming Ouhyoung,

计算机科学技术学报 , 2004,
Abstract: In this paper, a facial animation system is proposed for capturing both geometrical information and illumination changes of surface details, called expression details, from video clips simultaneously, and the captured data can be widely applied to different 2D face images and 3D face models. While tracking the geometric data, we record the expression details by ratio images. For 2D facial animation synthesis, these ratio images are used to generate dynamic textures. Because a ratio image is obtained via dividing colors of an expressive face by those of a neutral face, pixels with ratio value smaller than one are where a wrinkle or crease appears. Therefore, the gradients of the ratio value at each pixel in ratio images are regarded as changes of a face surface, and original normals on the surface can be adjusted according to these gradients. Based on this idea, we can convert the ratio images into a sequence of normal maps and then apply them to animated 3D model rendering. With the expression detail mapping, the resulted facial animations are more life-like and more expressive. Pei-Hsuan Tu is currently a software engineer at Cyber-Link Corporation. She received the B.S. degree in computer science from “National Chung-Cheng University” in 2001, and M.S. degree in computer science from “National Taiwan University” in 2003. Her research interests include computer graphics and image processing. She is a member of IEEE and IEEE Computer Society. I-Chen Lin received the B.S. and Ph.D. degrees in computer science from “National Taiwan University”. His research interests include computer graphics, computer animation and motion tracking. He is a member of ACM SIGGRAPH, IEEE, and IEEE Computer Society. Jeng-Sheng Yeh received a B.S. degree in computer science from “National Taiwan University” and is currently a Ph.D. candidate in “National Taiwan University”. His research interests include computer graphics, computer user interface, and 3D protein retrieval. He is a member of ACM SIGGRAPH. Rung-Huei Liang is a post doctoral researcher at the Communication and Multimedia Laboratory at “National Taiwan University”. His research interests include facial/gesture recognition and virtual reality applications. He received the B.S. and Ph.D. degrees in computer science from “National Taiwan University”. Ming Ouhyoung is a professor of Dept. Computer Science and Information Engineering at “National Taiwan University”. His research interests include computer graphics, virtual reality, and multimedia systems. He received the B.S. and M.S. degrees in electrical engineering from “National Taiwan University” and a Ph.D. degree in computer science from the University of North Carolina at Chapel Hill. He is a member of IEEE and ACM.
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