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Search Results: 1 - 10 of 539 matches for " Shigeyuki Saitoh "
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Atherogenic lipids profile relates to postprandial hyperglycemia and hyperinsulinemia due to whole body insulin resistance in prediabetic subjects  [PDF]
Yoshinori Miyazaki, Makoto Furugen, Hiroshi Akasaka, Shigeyuki Saitoh, Tetsuji Miura
Journal of Diabetes Mellitus (JDM) , 2012, DOI: 10.4236/jdm.2012.23044
Abstract: Backgrounds: Differences in serum lipids profiles in different type of glucose intolerance are unclear. Aims: To characterize lipid profiles in different type of glucose intolerance, and to assess relationships between serum lipids profile and disturbance of glucose metabolism in prediabetic subjects. Methods: Using the measurements in medical check-up with 75 goral glucose tolerance test (OGTT), total of 620 male subjects, who are not on medications for metabolic diseases or hypertension, were divided into normal fasting glucose and glucose tolerance (NFG/ NGT), isolated impaired fasting glucose (iIFG), isolated impaired glucose tolerance (iIGT) and combined IFG and IGT (IFG/IGT) based on results of the OGTT. Results: Age and body mass index (BMI) were similar in the four groups. Matsuda index (an index of whole body insulin sensitivity) was lower in iIFG, iIGT and IFG/IGT as compared with NFG/NGT. Plasma insulin excursion during the OGTT was significantly higher in IFG/IGT versus NFG/NGT. Serum triglyceride level (TG) and TG to HDL ratio (TG/HDL) were higher in IFG/IGT versus NFG/NGT. Matsuda index was positively correlated with HDL and was inversely correlated with TG, LDL, non-HDL, TG/ HDL and LDL to HDL ratio (LDL/HDL). Backward stepwise multiple regression analysis indicated that increases in BMI, plasma insulin level at 60 min (PI60) and plasma glucose level at 120 min in the OGTT were independently associated with increases in TG and TG/HDL. Increases in BMI and PI60 were related to an increase in non-HDL and LDL/HDL and a decrease in HDL. Conclusions: These results indicate that postprandial hyperglycemia and hyperinsulinemia based on advanced insulin resistance are closely related to lipid risk factors of atherosclerotic macrovascular disease in prediabetic subjects.
Glucagon-Like Peptide-1 Secretory Function as an Independent Determinant of Blood Pressure: Analysis in the Tanno-Sobetsu Study
Mayumi Yoshihara, Hiroshi Akasaka, Hirofumi Ohnishi, Takayuki Miki, Tetsuaki Furukawa, Satoshi Yuda, Shigeyuki Saitoh, Tetsuji Miura
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0067578
Abstract: Aims Roles of glucagon-like peptide-1 (GLP-1) in extra-pancreatic tissues remain unclear. The aim of this study was to examine determinants of GLP-1 secretory function and possible contribution of GLP-1 to blood pressure (BP) regulation. Methods and Results We recruited 128 subjects who received annual examinations and 75g-oral glucose tolerance tests (OGTT) in the Tanno-Sobetsu cohort. Subjects on regular medications for cardiovascular and/or metabolic diseases were excluded, and data for the remaining 103 subjects were used for the univariate and multivariate analyses. Age, plasma glucose (PG), hemoglobin A1c (HbA1c), plasma insulin, and serum lipids were not selected as independent determinants of fasting GLP-1 level by multiple linear regression analysis. However, age and female sex were selected as independent positive determinants of the area under the curve of GLP-1 level during OGTT (AUCGLP-1), an index of GLP-1 secretory function. Multiple linear regression analysis indicated that AUCGLP-1 was an independent negative predictor of systolic BP (SBP), while AUCGLP-1 was not correlated with fasting PG or HbA1c level. In subgroup analyses using the median of AUCGLP-1 to divide the study subjects into high and low GLP-1 response groups, AUCGLP-1 was significantly correlated with both SBP and diastolic BP (r = 0.40 and 0.28, respectively) in the low GLP-1 response group but not in the high GLP-1 response group. Conclusions The results of the present study suggest that GLP-1 secretory function is involved in prevention of BP elevation and that the GLP-1 response to oral glucose rather increases with aging perhaps as an adaptive phenomenon.
Generalized Inversions of Hadamard and Tensor Products for Matrices  [PDF]
Saburou Saitoh
Advances in Linear Algebra & Matrix Theory (ALAMT) , 2014, DOI: 10.4236/alamt.2014.42006
Abstract:
We shall give natural generalized solutions of Hadamard and tensor products equations for matrices by the concept of the Tikhonov regularization combined with the theory of reproducing kernels.
Efficacy of static magnetic field for pain of adjuvant arthritis rats  [PDF]
Shigeyuki Kanai, Norimasa Taniguchi
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.324067
Abstract: Rats suffering from adjuvant arthritis (AA) were used to examine the effect of a static magnetic field (SMF) upon pain relief. Rats were divided into SMF- treated AA rats, non-SMF treated AA rats and control rats. Following SMF stimulation, we measured blood flow volume in the paw and then reactive speed response to thermal stimulation. The AA groups exhibited significantly lower blood volume and reactivity to thermal stimulation compared to the control group. Compared to non-SMF, SMF exhibited increased blood flow volume in both the tail and paw, along with an increased reactive speed response to thermal stimulation. Our findings suggest that an improved of blood flow and reactive speed response, induced by SMF, appears to be effective for the relief of pain induced by chronic inflammation.
On the Relationship between Estimate and Its t Value  [PDF]
Yuji Matsuoka, Shigeyuki Hamori
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.51001
Abstract: It is generally believed that the signs of the estimated coefficient and its t value should be the same. This paper, however, shows that there may be an inconsistency in the signs of the estimated coefficient and its t value when we use the group mean dynamic OLS estimator developed by Pedroni (2001).
Circulating Levels of Fatty Acid-Binding Protein Family and Metabolic Phenotype in the General Population
Shutaro Ishimura, Masato Furuhashi, Yuki Watanabe, Kyoko Hoshina, Takahiro Fuseya, Tomohiro Mita, Yusuke Okazaki, Masayuki Koyama, Marenao Tanaka, Hiroshi Akasaka, Hirofumi Ohnishi, Hideaki Yoshida, Shigeyuki Saitoh, Tetsuji Miura
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081318
Abstract: Objective Fatty acid-binding proteins (FABPs) are a family of 14-15-kDa proteins, and some FABPs have been to be used as biomarkers of tissue injury by leak from cells. However, recent studies have shown that FABPs can be secreted from cells into circulation. Here we examined determinants and roles of circulating FABPs in a general population. Methods From the database of the Tanno-Sobetsu Study, a study with a population-based cohort design, data in 2011 for 296 subjects on no medication were retrieved, and FABP1~5 in their serum samples were assayed. Results Level of FABP4, but not the other isoforms, showed a gender difference, being higher in females than in males. Levels of all FABPs were negatively correlated with estimated glomerular filtration rate (eGFR), but a distinct pattern of correlation with other clinical parameters was observed for each FABP isoform; significant correlates were alanine aminotransferase (ALT), blood pressure (BP), and brain natriuretic peptide (BNP) for FABP1, none besides eGFR for FABP2, age, BP, and BNP for FABP3, age, waist circumference (WC), BP, BNP, lipid variables, high-sensitivity C-reactive protein (hsCRP), and HOMA-R for FABP4, and age, WC, BP, ALT, BNP, and HOMA-R for FABP5. FABP4 is the most strongly related to metabolic markers among FABPs. In a multivariate regression analysis, FABP4 level was an independent predictor of HOMA-R after adjustment of age, gender, WC, BP, HDL cholesterol, and hsCRP. Conclusions Each FABP isoform level showed a distinct pattern of correlation with clinical parameters, although levels of all FABPs were negatively determined by renal function. Circulating FABP4 appears to be a useful biomarker for detecting pre-clinical stage of metabolic syndrome, especially insulin resistance, in the general population.
Matrices and Division by Zero z/0 = 0  [PDF]
Tsutomu Matsuura, Saburou Saitoh
Advances in Linear Algebra & Matrix Theory (ALAMT) , 2016, DOI: 10.4236/alamt.2016.62007
Abstract: In this paper, a new viewpoint of the division by zero z/0 = 0 in matrices is introduced and the results will show that the division by zero is our elementary and fundamental mathematics. New and practical meanings for many mathematical and physical formulas for the denominator zero cases may be given. Furthermore, a new space idea for the point at infinity for the Eucleadian plane is also introduced.
Predicting survival outcomes using subsets of significant genes in prognostic marker studies with microarrays
Shigeyuki Matsui
BMC Bioinformatics , 2006, DOI: 10.1186/1471-2105-7-156
Abstract: We develop a methodology for predicting survival outcomes using subsets of significant genes in prognostic marker studies with microarrays. Key components in this methodology include building prediction models, assessing predictive performance of prediction models, and assessing significance of prediction results. As particular specifications, we assume Cox proportional hazard models with a compound covariate. For assessing predictive accuracy, we propose to use the cross-validated log partial likelihood. To assess significance of prediction results, we apply permutation procedures in cross-validated prediction. As an additional key component peculiar to prognostic prediction, we also consider incorporation of standard prognostic factors. The methodology is evaluated using both simulated and real data.The developed methodology for prognostic prediction using a subset of significant genes can provide new insights based on predictive capability, possibly incorporating standard prognostic factors, in selecting a fraction of relevant genes for subsequent studies.Genetic markers hold great promise for refining our ability to establish precise prognostic prediction for diseases. The development of comprehensive, gene expression microarray technology has allowed the selection of relevant marker genes from a large pool of candidate genes in early-phased, developmental prognostic marker studies for various cancers including diffuse large B-cell lymphoma [1], follicular lymphoma [2], acute myeloid leukemia [3], lung adenocarcinoma [4], and metastatic kidney cancer [5]. The selected genes will be further investigated in subsequent studies using technically simpler, but more reliable assays such as multiplexed quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) in formalin-fixed, paraffin-embedded tissue sections for routine clinical use [6,7]. Accordingly, the primary task in early-phased prognostic marker studies with microarrays would be to select a small f
Very Large-Scale Integrated Processor
Shigeyuki Takano
International Journal of Networking and Computing , 2013,
Abstract: In the near future, improvements in semiconductor technology will allow thousands of resources to be implementable on chip. However, a limitation remains for both single large-scale processors and many-core processors. For single processors, this limitation arises from their design complexity, and regarding the many-core processors, an application is partitioned to several tasks and these partitioned tasks are mapped onto the cores. In this article, we propose a dynamic chip multiprocessor (CMP) model that consists of simple modules (realizing a low design complexity) and does not require the application partitioning since the scale of the processor is dynamically variable, looking like up or down scale on demand. This model is based on prior work on adaptive processors that can gather and release resources on chip to dynamically form a processor. The adaptive processor takes a linear topology that realizes a locality based placement and replacement using processing elements themselves through a stack shift of information on the linear topology of the processing element array. Therefore, for the scaling of the processor, a linear topology of the interconnection network has to support the stack shift before and after the up- or down-scaling. Therefore, we propose an interconnection network architecture called a dynamic channel segmentation distribution (dynamic CSD) network. In addition the linear topology must be folded on-chip into two-dimensional plane. We also propose a new conceptual topology and its cluster which is a unit of the new topology and is replicated on the chip. We analyzed the cost in terms of the available number of clusters (adaptive processors with a minimum scale) and delay in Manhattan-distance of the chip, as well as its peak Giga-Operations per Second (GOPS) across the process technology scaling.
Importance of Perturbed Gravitational Potentials in Differentially Rotating Newtonian Stars
Shigeyuki Karino
Physics , 2003, DOI: 10.1046/j.1365-8711.2003.06649.x
Abstract: It is usually believed that the Cowling approximation can give satisfactory solutions if the stars %are highly compressible have soft equations of state and/or if the strongly general relativistic stars are treated in the case of rigid rotation. Since, however, there have been no systematic studies about the accuracy of the Cowling approximation for differentially rotating compressible stars, we investigate eigenfrequencies and eigenfunctions of the oscillation modes in {\it rapidly} and {\it differentially} rotating compressible stars by employing the exact method including full-perturbations and the Cowling approximation. We have found that the Cowling approximation for f-mode oscillations is not a good approximation in rapidly and differentially rotating stars, although rapid rotation makes this approximation better for rigidly rotating stars. This result suggests that we must be careful when we apply the Cowling approximation to differentially rotating stars even in the framework of general relativity. On the other hand, the approximation will work well for r-modes even if the star is rotating differentially. Therefore, the Cowling approximation can be used as a strong tool for the investigation of r-mode oscillations in the general relativistic framework that it is difficult to compute including the perturbations of gravity.
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