Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 3 )

2018 ( 15 )

2017 ( 15 )

2016 ( 13 )

Custom range...

Search Results: 1 - 10 of 1671 matches for " Shichun Lun "
All listed articles are free for downloading (OA Articles)
Page 1 /1671
Display every page Item
Transfer of immunoglobulins through the mammary endothelium and epithelium and in the local lymph node of cows during the initial response after intramammary challenge with E. coli endotoxin
Karin ?stensson, Shichun Lun
Acta Veterinaria Scandinavica , 2008, DOI: 10.1186/1751-0147-50-26
Abstract: The content of IgG1, IgG2, IgM, IgA and albumin (BSA) was examined in peripheral/afferent mammary lymph and lymph leaving the supramammary lymph nodes, and in blood and milk before (0 h) and during 4 hours after intramammary challenge with Esherichia coli endotoxin in 5 cows.Igs increased most rapidly in afferent lymph resulting in higher concentrations than in efferent lymph at postinfusion hour (PIH) 2, contrary to before challenge. Ig concentrations in milk were lower than in lymph; except for IgA at 0 h; and they increased more slowly. Afferent lymph:serum and efferent lymph:serum concentration ratios (CR) of Igs were similar to those of BSA but slightly lower. Milk:afferent lymph (M:A) CRs of each Ig, except for IgG2, showed strikingly different pattern than those of BSA. The M:A CR of IgG1, IgM and IgA were higher than that of BSA before challenge and the CR of IgA and IgG1 remained higher also thereafter. At PIH 2 there was a drop in Ig CRs, except for IgG2, in contrast to the BSA CR which gradually increased. The M:A CR of IgM and Ig A decreased from 0 h to PIH 4, in spite of increasing permeability.The transfer of Igs through the endothelium appeared to be merely a result of diffusion although their large molecular size may hamper the diffusion. The transfer through the epithelium and the Ig concentrations in milk seemed more influenced by selective mechanisms and local sources, respectively. Our observations indicate a selective mechanism in the transfer of IgG1 through the epithelium also in lactating glands, not previously shown; a local synthesis of IgA and possibly of IgM, released primarily into milk, not into tissue fluid; that IgG2 transfer through both barriers is a result of passive diffusion only and that the content of efferent lymph is strongly influenced by IgG1, IgM and IgA in the mammary tissue, brought to the lymph node by afferent lymph.Bovine mastitis has been extensively studied but mainly as reflected in milk and circulating blood. Inve
Rv2190c, an NlpC/P60 Family Protein, Is Required for Full Virulence of Mycobacterium tuberculosis
Geetha Parthasarathy, Shichun Lun, Haidan Guo, Nicole C. Ammerman, Deborah E. Geiman, William R. Bishai
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0043429
Abstract: Mycobacterium tuberculosis, the etiologic agent of tuberculosis (TB) possesses at least five genes predicted to encode proteins with NlpC/P60 hydrolase domains, including the relatively uncharacterized Rv2190c. As NlpC/P60 domain-containing proteins are associated with diverse roles in bacterial physiology, our objective was to characterize Rv2190c in M. tuberculosis growth and virulence. Our data indicate that lack of Rv2190c is associated with impaired growth, both in vitro and during an in vivo mouse model of TB. These growth defects are associated with altered colony morphology and phthiocerol dimycocerosate levels, indicating that Rv2190c is involved in cell wall maintenance and composition. In addition, we have demonstrated that Rv2190c is expressed during active growth phase and that its protein product is immunogenic during infection. Our findings have significant implications, both for better understanding the role of Rv2190c in M. tuberculosis biology and also for translational developments.
Successful Shortening of Tuberculosis Treatment Using Adjuvant Host-Directed Therapy with FDA-Approved Phosphodiesterase Inhibitors in the Mouse Model
Mamoudou Maiga, Nisheeth Agarwal, Nicole C. Ammerman, Radhika Gupta, Haidan Guo, Marama C. Maiga, Shichun Lun, William R. Bishai
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030749
Abstract: Global control of tuberculosis (TB), an infectious disease that claims nearly 2 million lives annually, is hindered by the long duration of chemotherapy required for curative treatment. Lack of adherence to this intense treatment regimen leads to poor patient outcomes, development of new or additional drug resistance, and continued spread of M.tb. within communities. Hence, shortening the duration of TB therapy could increase drug adherence and cure in TB patients. Here, we report that addition of the United Stated Food and Drug Administration-approved phosphodiesterase inhibitors (PDE-Is) cilostazol and sildenafil to the standard TB treatment regimen reduces tissue pathology, leads to faster bacterial clearance and shortens the time to lung sterilization by one month, compared to standard treatment alone, in a murine model of TB. Our data suggest that these PDE-Is could be repurposed for use as adjunctive drugs to shorten TB treatment in humans.
The Two-Domain LysX Protein of Mycobacterium tuberculosis Is Required for Production of Lysinylated Phosphatidylglycerol and Resistance to Cationic Antimicrobial Peptides
Erin Maloney equal contributor,Dorota Stankowska equal contributor,Jian Zhang,Marek Fol,Qi-Jian Cheng,Shichun Lun,William R. Bishai,Malini Rajagopalan,Delphi Chatterjee,Murty V. Madiraju
PLOS Pathogens , 2009, DOI: 10.1371/journal.ppat.1000534
Abstract: The well-recognized phospholipids (PLs) of Mycobacterium tuberculosis (Mtb) include several acidic species such as phosphatidylglycerol (PG), cardiolipin, phosphatidylinositol and its mannoside derivatives, in addition to a single basic species, phosphatidylethanolamine. Here we demonstrate that an additional basic PL, lysinylated PG (L-PG), is a component of the PLs of Mtb H37Rv and that the lysX gene encoding the two-domain lysyl-transferase (mprF)-lysyl-tRNA synthetase (lysU) protein is responsible for L-PG production. The Mtb lysX mutant is sensitive to cationic antibiotics and peptides, shows increased association with lysosome-associated membrane protein–positive vesicles, and it exhibits altered membrane potential compared to wild type. A lysX complementing strain expressing the intact lysX gene, but not one expressing mprF alone, restored the production of L-PG and rescued the lysX mutant phenotypes, indicating that the expression of both proteins is required for LysX function. The lysX mutant also showed defective growth in mouse and guinea pig lungs and showed reduced pathology relative to wild type, indicating that LysX activity is required for full virulence. Together, our results suggest that LysX-mediated production of L-PG is necessary for the maintenance of optimal membrane integrity and for survival of the pathogen upon infection.
Traditional Chinese Herbal Medicine for Epilepsy Treatment Should Be Administered According to the Seizure Type and Epileptic Syndrome  [PDF]
Lun Cai
Health (Health) , 2017, DOI: 10.4236/health.2017.98087
Abstract: Traditional Chinese herbal medicine (TCHM) has long been used to treat epilepsy. Although many clinical trials and animal studies have seemingly demonstrated its effect, the question of whether TCHM is efficacious in epileptic patients has not been certified because of insufficient supportive evidence. This insufficient supportive evidence stems from the fact that most of the current studies regarding TCHM for epilepsy treatment are not designed according to the different seizure types and epileptic syndromes (STESs). Here, we explore the reasons why many studies have not considered the various STESs and explain how to treat epilepsy according to the pharmacological mechanism for different STESs and exploit the advantage of TCHM for epilepsy treatment. Then, we explain how we treat epilepsy using TCHM according to the different STESs and Bian Zheng Lun Zi.
The Impact of Mouse Passaging of Mycobacterium tuberculosis Strains prior to Virulence Testing in the Mouse and Guinea Pig Aerosol Models
Paul J. Converse,Kathleen D. Eisenach,Sue A. Theus,Eric L. Nuermberger,Sandeep Tyagi,Lan H. Ly,Deborah E. Geiman,Haidan Guo,Scott T. Nolan,Nicole C. Akar,Lee G. Klinkenberg,Radhika Gupta,Shichun Lun,Petros C. Karakousis,Gyanu Lamichhane,David N. McMurray,Jacques H. Grosset,William R. Bishai
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010289
Abstract: It has been hypothesized that the virulence of lab-passaged Mycobacterium tuberculosis and recombinant M. tuberculosis mutants might be reduced due to multiple in vitro passages, and that virulence might be augmented by passage of these strains through mice before quantitative virulence testing in the mouse or guinea pig aerosol models.
Lithium secondary batteries using an asymmetric sulfonium-based room temperature ionic liquid as a potential electrolyte
ShiChun Luo,ZhengXi Zhang,Li Yang
Chinese Science Bulletin , 2008, DOI: 10.1007/s11434-007-0526-0
Abstract: A new asymmetric sulfonium-based ionic liquid, 1-butyldimethylsulfonium bis(trifluoromethylsulfonyl) imide (S114TFSI), was developed as electrolyte material for lithium secondary battery. Its cathodic potential was a little more positive against the Li/Li+, so vinylene carbonate (VC) was added into the LiTFSI/S114TFSI ionic liquid electrolyte to ensure the formation of a solid electrolyte interface (SEI), which effectively prevented the decomposition of the electrolyte. The properties of the Li/LiMn2O4 cell containing S114TFSI-based electrolyte were studied and the cycle performances were compared to those with a conventional organic electrolyte (1 mol/L LiPF6/DMC:EC=1:1(w/w)) at room temperature. Electrochemical impedance spectroscopy (EIS) and X-ray diffraction (XRD) were conducted to analyze the mechanisms affecting the cell performances at different temperatures. The lithium secondary battery system, using the above ionic liquid electrolyte material, shows good cycle performances and good safety at room temperature, and is worthwhile to further investigate so as to find out the potential application.
The Construction of Infinite Families of k-Tight Optimal Double Loop Networks

YANG Shichun,

系统科学与数学 , 2008,
Abstract: Double loop network is an important topological structure in computer networks and communication. Based on the theory of L-shaped tile, utilizing Chinese remainder theorem and some property of quadratic congruence, a method to construction of k-tight optimal infinite families of double loop networks is given, and the method is different from that in references. It is proved that there exist some k-tight optimal infinite families of double loop networks for every k > 0, where n(t)=3t^{2}+At+B for some B>(k+1)^{2}, A =1,3,5, and the infinite families are infinitesimal for every B. By using this method, we obtain some new k-tight optimal infinite families of double loop networks.

LI Shichun,

材料研究学报 , 1998,
Abstract: The Zn-5Al eutectic alloy is superplastically deformed in an electric field of 0.3MV.m-1,and displays the negative electroplasticity The effect of electric field on the strain rate is relative to the effect of the surface charges on the voids on the sudece. The electric field produces inductive charges on the sudece of the specimen, which produce5 voids in the sudece and decreases the strain rate of the alloy in deformation.

Sun Shichun,

海洋科学 , 1995,
Abstract: Procephalathrix arenarius, Cerebratulina natans, Iwatanemertes piperatus, Quasilineus sinicus, and Panti- nonemertes mortoni are reported from Taiwan Strait for the first time in this paper, all but Iwatanemertes piperatus which was alredy known from Riukiu Islands, are new records of East China Sea.
Page 1 /1671
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.