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Search Results: 1 - 10 of 59853 matches for " Shi-Jian Ding "
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Proteomic Analysis of the Organ of Corti Using Nanoscale Liquid Chromatography Coupled with Tandem Mass Spectrometry
Hong Peng,Miao Liu,Jason Pecka,Kirk W. Beisel,Shi-Jian Ding
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13078171
Abstract: The organ of Corti (OC) in the cochlea plays an essential role in auditory signal transduction in the inner ear. For its minute size and trace amount of proteins, the identification of the molecules in pathophysiologic processes in the bone-encapsulated OC requires both delicate separation and a highly sensitive analytical tool. Previously, we reported the development of a high resolution metal-free nanoscale liquid chromatography system for highly sensitive phosphoproteomic analysis. Here this system was coupled with a LTQ-Orbitrap XL mass spectrometer to investigate the OC proteome from normal hearing FVB/N male mice. A total of 628 proteins were identified from six replicates of single LC-MS/MS analysis, with a false discovery rate of 1% using the decoy database approach by the OMSSA search engine. This is currently the largest proteome dataset for the OC. A total of 11 proteins, including cochlin, myosin VI, and myosin IX, were identified that when defective are associated with hearing impairment or loss. This study demonstrated the effectiveness of our nanoLC-MS/MS platform for sensitive identification of hearing loss-associated proteins from minute amount of tissue samples.
Entropy majorization, thermal adiabatic theorem, and quantum phase transitions
Shi-Jian Gu
Physics , 2009,
Abstract: Let a general quantum many-body system at a low temperature adiabatically cross through the vicinity of the system's quantum critical point. We show that the system's temperature is significantly suppressed due to both the entropy majorization theorem in quantum information science and the entropy conservation law in adiabatic processes. We take the one-dimensional transverse-field Ising model and spinless fermion system as concrete examples to show that the inverse temperature might become divergent around their critical points. Since the temperature is a measurable quantity in experiments, our work, therefore, provides a practicable proposal to detect quantum phase transitions.
Fidelity susceptibility and quantum adiabatic condition in thermodynamic limits
Shi-Jian Gu
Physics , 2009, DOI: 10.1103/PhysRevE.79.061125
Abstract: In this work, we examine the validity of quantum adiabatic theorem in thermodynamic systems. For a $d$-dimensional quantum many-body system, we show that the duration time $\tau_0$ required by its ground-state adiabatic process does not depend on the microscopic details, but the scaling dimension of the fidelity susceptibility $d_a$. Our result, therefore, provides a quantitative time scale of the quantum adiabatic theorem in thermodynamic systems. The quantum adiabatic theorem might be violated in case that the scaling dimension of the fidelity susceptibility is larger than the system's real dimension ($d_a>d$).
Density-functional fidelity approach to quantum phase transitions
Shi-Jian Gu
Physics , 2008, DOI: 10.1088/0256-307X/26/2/026401
Abstract: We propose a new approach to quantum phase transitions in terms of the density-functional fidelity, which measures the similarity between density distributions of two ground states in parameter space. The key feature of the approach, as we will show, is that the density-functional fidelity can be measured easily in experiments. Both the validity and versatility of the approach are checked by the Lipkin-Meshkov-Glick model and the one-dimensional Hubbard model.
Super Mario's prison break -- a proposal of object-intelligent-feedback-based classical Zeno and anti-Zeno effects
Shi-Jian Gu
Physics , 2009, DOI: 10.1209/0295-5075/88/20007
Abstract: Super Mario is imprisoned by a demon in a finite potential well. He can escape from the well with the help of a flight of magic stairs floating in the space. However, the hateful demon may occasionally check his status. At that time, he has to make a judgement of either jumping to the inside ground immediately in order to avoid the discovery of his escape intention, or speeding up his escape process. Therefore, if the demon checks him too frequently such that there is no probability for him to reach the top of the barrier, he will be always inside the well, then a classical Zeno effect occurs. On the other hand, if the time interval between two subsequent checks is large enough such that he has a higher probability of being beyond the demon's controllable range already, then the demon's check actually speeds up his escape and a classical anti-Zeno effect takes place.
Fidelity approach to quantum phase transitions
Shi-Jian Gu
Physics , 2008, DOI: 10.1142/S0217979210056335
Abstract: We review briefly the quantum fidelity approach to quantum phase transitions in a pedagogical manner. We try to relate all established but scattered results on the leading term of the fidelity into a systematic theoretical framework, which might provide an alternative paradigm for understanding quantum critical phenomena. The definition of the fidelity and the scaling behavior of its leading term, as well as their explicit applications to the one-dimensional transverse-field Ising model and the Lipkin-Meshkov-Glick model, are introduced at the graduate-student level. In addition, we survey also other types of fidelity approach, such as the fidelity per site, reduced fidelity, thermal-state fidelity, operator fidelity, etc; as well as relevant works on the fidelity approach to quantum phase transitions occurring in various many-body systems.
Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274
Jinxuan Hou, Jixin Dong, Lijun Sun, Liying Geng, Jing Wang, Jialin Zheng, Yan Li, Julia Bridge, Steven H Hinrichs, Shi-Jian Ding
Journal of Translational Medicine , 2011, DOI: 10.1186/1479-5876-9-64
Abstract: The expression level of phosphorylated c-Met in RMS cell lines (RD, CW9019 and RH30) and tumor tissues was assessed by phospho-RTK array and immunohistochemistry, respectively. The inhibition effects of SU11274 on RMS cells were studied with regard to intracellular signaling, cell proliferation, cell cycle and cell migration.A high level of phosphorylated c-Met was detected in 2 alveolar RMS cell lines (CW9019 and RH30) and 14 out of 24 RMS tissue samples, whereas relatively low levels of phospho-c-Met were observed in the embryonic RMS cell line (RD). The small molecule SU11274 could significantly reduce the phosphorylation of c-Met, resulting in inhibition of cell proliferation, G1 phase arrest of cell cycle and blocking of cell migration in CW9019 and RH30 cell lines.These results might support the role of c-Met in the development and progression of RMS. Furthermore, the inhibitor of c-Met, SU11274, could be an effective targeting therapy reagent for RMS, especially alveolar RMS.Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in childhood, accounting for up to 50% of all soft tissue sarcomas [1]. While in adults, RMS represents about 15-20% of all soft tissue sarcomas [2]. There are two main histologically distinct subtypes of RMS: embryonal RMS (ERMS) and alveolar RMS (ARMS) [3]. ERMS is composed of spindle-shaped cells with a stromal rich appearance and occurs mainly in the head and neck region. It is the most frequently diagnosed variant with a generally good prognosis and presents early with an onset around the age of 2-5 years [3,4]. In contrast, ARMS consists of small, round, densely packed cells and occurs more often in the trunk and extremities. ARMS is primarily diagnosed in adolescents and is associated with a poor prognosis as patients often present with metastatic disease [5]. Chemotherapy is the most common therapeutic option for RMS. The regimens are typically based on variations of the well-established vincristine, actinomycin D and cyc
Chaos Control in Random Boolean Networks by Reducing Mean Damage Percolation Rate

JIANG Nan,CHEN Shi-Jian,

中国物理快报 , 2011,
Spectral function and fidelity susceptibility in quantum critical phenomena
Shi-Jian Gu,Wing Chi Yu
Physics , 2014, DOI: 10.1209/0295-5075/108/20002
Abstract: In this paper, we derive a simple equality that relates the spectral function $I(k,\omega)$ and the fidelity susceptibility $\chi_F$, i.e. $% \chi_F=\lim_{\eta\rightarrow 0}\frac{\pi}{\eta} I(0, i\eta)$ with $\eta$ being the half-width of the resonance peak in the spectral function. Since the spectral function can be measured in experiments by the neutron scattering or the angle-resolved photoemission spectroscopy(ARPES) technique, our equality makes the fidelity susceptibility directly measurable in experiments. Physically, our equality reveals also that the resonance peak in the spectral function actually denotes a quantum criticality-like point at which the solid state seemly undergoes a significant change.
Many-body reduced fidelity susceptibility in Lipkin-Meshkov-Glick model
Jian Ma,Xiaoguang Wang,Shi-Jian Gu
Physics , 2009, DOI: 10.1103/PhysRevE.80.021124
Abstract: We study the reduced fidelity susceptibility $\chi_{r}$ for an $M$-body subsystem of an $N$-body Lipkin-Meshkov-Glick model with $\tau=M/N$ fixed. The reduced fidelity susceptibility can be viewed as the response of subsystem to a certain parameter. In noncritical region, the inner correlation of the system is weak, and $\chi_{r}$ behaves similar with the global fidelity susceptibility $\chi_{g}$, the ratio $\eta=\chi_{r}/\chi_{g}$ depends on $\tau$ but not $N$. However, at the critical point, the inner correlation tends to be divergent, then we find $\chi_{r}$ approaches $\chi_{g}$ with the increasing the $N$, and $\eta=1$ in the thermodynamic limit. The analytical predictions are perfect agreement with the numerical results.
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