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Search Results: 1 - 10 of 11881 matches for " Shengwen;Xie "
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Photochemical characteristics of diclofenac and its photodegradation of inclusion complexes with β-cyclodextrins
Qin, Minmin;Yang, Haifeng;Chen, Shengwen;Xie, Hongyong;Guan, Jie;
Química Nova , 2012, DOI: 10.1590/S0100-40422012000300022
Abstract: diclofenac is one of most frequently detected compounds in the water cycle. in this work, the effect of initial concentration, liquid inclusion complexes with β-cyclodextrins (β-cds) on the photodegradation of diclofenac were studied. six phototransformation products were detected by hplc chromatograms. uv-absorption spectra of diclofenac and phototransformation products were determined. one of the phototransformation products was identified. the degradation followed pseudo-first-order kinetics. the experiment showed that irradiation of diclofenac in the presence of β-cds increase photodegradation rate and determined the optimal molar ratio of diclofenac to β-cds as 1:2. the reduced photohaemolytic activity of diclofenac in the presence of β-cds may be attributed to the sequestering and stabilizing of the radical intermediates and /or photoproducts by complexation.
Distribution of Miss Distance in Discrete-Time Controlled System with Noise-Corrupted State Information  [PDF]
Shengwen Xiang, Hongqi Fan, Qiang Fu
World Journal of Engineering and Technology (WJET) , 2017, DOI: 10.4236/wjet.2017.54B008
Abstract:
Miss distance is an important parameter of assessing highly maneuvering targets interception. Due to the noise-corrupted measurement and the fact that not all the state variables can be directly measured, the miss distance becomes a random variable with a priori unknown distribution. Currently, such a distribution is mainly evaluated by the method of Monte Carlo simulation. In this paper, an analytic approach is obtained in discrete-time controlled system with noise-corrupted state information. The system is subject to a bang-bang control strategy. The analytic distribution is validated through the comparison with Monte Carlo simulation.
A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors
Shengwen Li, William Loudon
Cancer Cell International , 2008, DOI: 10.1186/1475-2867-8-9
Abstract: Over 1.4 million people in the United States were diagnosed with cancer in 2007 and the national cost of the disease was over $206 billion in 2006, accounting one-thirds of healthcare dollars (total: $686 billion) spent in the U.S. [1,2]. An estimated 18,820 new cases of brain cancer was diagnosed in the United States of America in 2006, and more than 12,000 would die from the disease (data from the National Cancer Institute of the United States of America). Our current forms of therapy for these diseases are brain surgery followed by administration of toxic drugs and exposure to radiation, which lead that the patients face challenges due to both the effects of treatment and potential neurological dysfunction. Overall the cost of care per patient was $67,887 with accrued mean monthly health care costs that were 20 times higher than demographically similar individuals without cancer ($6364 vs. $277)[3].Primary malignant tumors such as high grade gliomas diffusely migrate into the brain early in the disease course, disseminating tumor microsatellites to distant regions of the central nervous system [4]. These tentacles of tumor exist interspersed between normal functional tissues. Complete surgical resection of many malignant brain tumors is not practical by virtue of their anatomical location and the relationship of this diffuse disease relative to eloquent functional tissue. Adjuvant therapies including chemotherapy and radiation therapy are often used in conjunction with surgery for many types of cancer to attempt eradication of the residual tumor [5]. In malignant brain tumors, however, combined surgical and adjuvant therapies frequently prove insufficient to eliminate neoplastic disease as a result of unique characteristics of CNS anatomy and function as well as and practical limitations concerning biological characteristics of the tumor [6]. Therefore, despite gross total surgical resection, chemotherapy and radiation therapy, neoplastic cells persist and inevit
Preparation and Characterisation of Collagen from Freshwater Fish Scales  [PDF]
Fengxiang Zhang, Anning Wang, Zhihua Li, Shengwen He, Lijun Shao
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.28112
Abstract: Acid-soluble collagen (ASC) and pepsin-solubilized collagen (PSC) were prepared from the waste freshwater carp fish scales. The results of SDS-PAGE showed that purified collagens were composed of at least two different chains which were in accordance with the type I collagen with α chain composition of (α1)2α2. Compared with the carp fish ordinary muscle type I collagen , porcine dermis type I collagen and other seawater fish collagens, freshwater carp fish scales collagen contained relative high half-cystine (Cys-s), but lower denaturation temperature(Td) than the porcine dermis type I collagen. These collagens had evident absorption at 230 nm by UV-Vis spectra. The spectrum X-ray diffraction showed that the collagen remained single-helix and tri-helix configuration with the minimum values of the repeat spacings (d) of about 4.48 Å and 11.87 Å. Therefore, to make more effective use of limited-resources, carp fish scales can be a potential resource for the extraction of type I collagen or gelatin.
Twisting immune responses for allogeneic stem cell therapy
Shengwen Calvin Li,Jiang F Zhong
World Journal of Stem Cells , 2009,
Abstract: Stem cell-derived tissues and organs have the potential to change modern clinical science. However, rejection of allogeneic grafts by the host’ s immune system is an issue which needs to be addressed before embryonic stem cell-derived cells or tissues can be used as medicines. Mismatches in human leukocyte class I antigens and minor histocompatibility antigens are the central factors that are responsible for various graft-versus-host diseases. Traditional strategies usually involve suppressing the whole immune systems with drugs. There are many side effects associated with these methods. Here, we discuss an emerging strategy for manipulating the central immune tolerance by naturally “ introducing” donor antigens to a host so a recipient can acquire tolerance specifically to the donor cells or tissues. This strategy has two distinct stages. The first stage restores the thymic function of adult patients with sex steroid inhibitory drugs (LHRH-A), keratinocyte growth factor (KGF), interleukin 7 (IL-7) and FMS-like tyrosine kinase 3 (FLT3). The second stage introduces hematopoietic stem cells and their downstream progenitors to the restored thymus by direct injection. Hematopoietic stem cells are used to introduce donor antigens because they have priority access to the thymus. We also review several clinical cases to explain this new strategy.
Research of Configuration on Multi-tenant
Shengwen Zhang,Zhaohui Li,Xiaoxi Chen
Information Technology Journal , 2011,
Abstract: The SaaS (Software as a Service) application model comes into being along with the expansion and convention of the network platform and its core lies in Multi-tenant application. The new software model based SaaS has a great temptation for enterprises. The new software model eases the fund pressure of enterprises virtually so that enterprises can concentrate on their own business development. However, the large customers bring the issue of individual needs. The tenants from different enterprises put forward different demands according to their own internal management way and process. How to meet the individual needs of enterprises is the main content of this study. Present study takes Dalian ted talent port for example. It mainly researched personalized configuration on data, function and interface and gave a personalized configuration way, achieving Multi-tenant application and managing these applications through personalized configuration.
SNPEVG: a graphical tool for GWAS graphing with mouse clicks
Wang Shengwen,Dvorkin Daniel,Da Yang
BMC Bioinformatics , 2012, DOI: 10.1186/1471-2105-13-319
Abstract: Background Genome-wide association studies (GWAS) using single nucleotide polymorphism (SNP) markers generate large quantities of tests results. Global and local graphical viewing of the test results is an effective approach to digest and interpret GWAS results. Results SNPEVG is a set of graphical tools for instant global and local viewing and graphing of GWAS results for all chromosomes and for each trait. The current version includes three programs, SNPEVG1, SNPEVG2 and SNPEVG3. SNPEVG1 is a graphical tool for SNP effect viewing of P-values allowing multiple traits. The total number of graphs that can be generated by one ‘Run’ is n(c + 2), where n is number of ‘traits’ with 0 < n ≤ 100, and c is the number of chromosomes. SNP effect viewing and graphing is accomplished through a user friendly graphical user interface (GUI) that provides a wide-range of options for the user to choose. The GUI can produce the Manhattan plot, the Q-Q plot of all SNP effects, and graphs for SNP effects by chromosome by clicking one command. Any or all the graphs can be saved with publication quality by clicking one command. SNPEVG2 is for the viewing and graphing of multiple traits on the same graph with options to graph any or all of the traits, customizable colors and user specified Y1 or Y2 axis for each traits. The SNPEVG3 program uses the output file of single-locus test results from the epiSNP computer package as the input file. Each chromosome figure can display three genetic effects (genotypic, additive and dominance effects), and the number of observations. Conclusions The SNPEVG package is a versatile, flexible and efficient graphical tool for rapid digestion of large quantities of GWAS results with mouse clicks.
Clinical, Pathological and Surgical Risk Factors Associated with Craniopharyngioma Recurrence: A Literature Review  [PDF]
James Lubuulwa, Zhuang Miao, Shengwen Liu, Juan Chen, Sheng Wang, Wei Jiang, Kai Shu, Ting Lei
Open Journal of Modern Neurosurgery (OJMN) , 2019, DOI: 10.4236/ojmn.2019.91008
Abstract: Objective: This review article attempts to examine and provide an overview of the risk factors associated with craniopharyngioma recurrence. Methods: A literature review of articles relating to the recurrences of craniopharyngioma and the clinical, molecular prognostic indicators of recurrence and treatment outcomes was performed retrospectively. Results: A total of 107 studies which described specific risk factors related to craniopharyngioma recurrence were identified which included but not limited to 54 retrospective case series, 7 systematic reviews, 21 laboratory reports, 13 case reports and 12 literature reviews. Conclusion: Based on the evidence identified in this review, the risk factors for recurrence in craniopharyngioma management are interrelated in a complex way, and surgery with or without adjuvant radiotherapy is reported to be of long-term benefit, but a disparity in findings suggests no definitive consensus on the risk factors of craniopharyngioma recurrence. More high-quality research is needed.
Inhibition of nucleotide excision repair by arsenic
Shengwen Shen,Chuan Wang,Michael Weinfeld,X. Chris Le
Chinese Science Bulletin , 2013, DOI: 10.1007/s11434-012-5439-x
Abstract: Inhibition of DNA repair is one proposed mechanism for the co-mutagenicity/co-carcinogenicity of arsenic. This review summarizes the current literature on the effects of arsenic compounds on nucleotide excision repair (NER). Several possible mechanisms for the observed NER inhibition have been proposed. Modulation of the expression of NER proteins has been considered to be one possibility of impairing the NER process. However, data on the effects of arsenic on the expression of NER proteins remain inconsistent. It is more likely that arsenic inhibits the induction of accessory or other key proteins involved in cellular control of DNA repair pathways, such as p53. For example, arsenic affects p53 phosphorylation and p53 DNA binding activity, which could regulate NER through transcriptional activation of downstream NER genes. Although it is important to study possible direct inactivation of NER proteins by arsenic binding, indirect inactivation of proteins having thiol residues critical to their function or zinc finger proteins cannot be negated. For example, nitric oxide (NO) induced in arsenic-treated cells serves as a specific inhibitor of NER, possibly through NO-induced S-nitrosylation of proteins related to DNA repair. Poly(ADP-ribose) polymerase-1, a zinc finger protein implicated in both NER and base excision repair (BER), deserves special attention because of its involvement in NO production and its broad range of protein substrates including many repair enzymes.
Effect of sample stratification on dairy GWAS results
Ma Li,Wiggans George R,Wang Shengwen,Sonstegard Tad S
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-536
Abstract: Background Artificial insemination and genetic selection are major factors contributing to population stratification in dairy cattle. In this study, we analyzed the effect of sample stratification and the effect of stratification correction on results of a dairy genome-wide association study (GWAS). Three methods for stratification correction were used: the efficient mixed-model association expedited (EMMAX) method accounting for correlation among all individuals, a generalized least squares (GLS) method based on half-sib intraclass correlation, and a principal component analysis (PCA) approach. Results Historical pedigree data revealed that the 1,654 contemporary cows in the GWAS were all related when traced through approximately 10–15 generations of ancestors. Genome and phenotype stratifications had a striking overlap with the half-sib structure. A large elite half-sib family of cows contributed to the detection of favorable alleles that had low frequencies in the general population and high frequencies in the elite cows and contributed to the detection of X chromosome effects. All three methods for stratification correction reduced the number of significant effects. EMMAX method had the most severe reduction in the number of significant effects, and the PCA method using 20 principal components and GLS had similar significance levels. Removal of the elite cows from the analysis without using stratification correction removed many effects that were also removed by the three methods for stratification correction, indicating that stratification correction could have removed some true effects due to the elite cows. SNP effects with good consensus between different methods and effect size distributions from USDA’s Holstein genomic evaluation included the DGAT1-NIBP region of BTA14 for production traits, a SNP 45kb upstream from PIGY on BTA6 and two SNPs in NIBP on BTA14 for protein percentage. However, most of these consensus effects had similar frequencies in the elite and average cows. Conclusions Genetic selection and extensive use of artificial insemination contributed to overlapped genome, pedigree and phenotype stratifications. The presence of an elite cluster of cows was related to the detection of rare favorable alleles that had high frequencies in the elite cluster and low frequencies in the remaining cows. Methods for stratification correction could have removed some true effects associated with genetic selection.
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