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Search Results: 1 - 10 of 12976 matches for " Sheila Aparecida Coelho;Chamone "
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Disease progression after R-CHOP treatment associated with the loss of CD20 antigen expression
Bellesso, Marcelo;Xavier, Flavia Dias;Costa, Renata Oliveira;Pereira, Juliana;Siqueira, Sheila Aparecida Coelho;Chamone, Dalton Alencar Fischer;
Revista Brasileira de Hematologia e Hemoterapia , 2011, DOI: 10.5581/1516-8484.20110036
Abstract: a case of a follicular lymphoma transformed into a cd20+ is described which progressed with the loss of cd20 expression after 8 cycles of r-chop. this phenomenon is not a rare event and has shown poor prognosis. our purposes are to describe this event and suggest biopsy in relapsed or progressive disease.
Bcl-2 protein frequency in patients with high-risk diffuse large B-cell lymphoma
Hallack Neto, Abrah?o Elias;Siqueira, Sheila Aparecida Coelho;Dulley, Frederico Luiz;Chauobah, Alfredo;Belesso, Marcelo;Saboia, Rosaura;Ruiz, Milton Artur;Chamone, Dalton Alencar Fischer;Pereira, Juliana;
Sao Paulo Medical Journal , 2010, DOI: 10.1590/S1516-31802010000100004
Abstract: context and objective: gene expression and immunohistochemical profiling of diffuse large b-cell lymphoma (dlbcl) have revealed important prognostic subgroups: germinal center b-cell-like (gcb-like) dlbcl and activated b cell-like (abc-like) dlbcl. although few reports on high-risk dlbcl are available, the prognosis for the gcb-like subgroup has been shown to be better than that of the abc-like subgroup. the role of bcl-2 as a predictor of survival in dlbcl cases is unclear and its expression varies between the two subgroups of dlbcl. in this study, we analyzed the frequency and prognostic impact of bcl-2 protein expression in high-risk dlbcl cases. design and setting: retrospective cohort study among dlbcl patients treated at hospital das clínicas, faculdade de medicina da universidade de s?o paulo (hc-fmusp). methods: the prognostic impact of the expression of the proteins cd10, bcl-6, mum1 (multiple myeloma oncogene-1) and bcl-2 on high-risk dlbcl cases was evaluated by means of immunohistochemistry. seventy-three patients aged 18-60 years were evaluated for all these markers. results: twenty-four cases (32.9%) were gcb-like and 49 (67.1%) were abc-like, with no difference regarding complete remission, disease-free survival or overall survival rates. twenty-seven patients (37%) showed bcl-2 expression, which was the only independent factor predicting a worse prognosis for overall survival according to multivariate analysis. conclusion: bcl-2 protein was expressed in 37% of the high-risk dlbcl patients, without any difference between the abc-like dlbcl and gcb-like dlbcl cases.
Compara??o de três protocolos distintos para extra??o de RNA de amostras fixadas em formalina e emblocadas em parafina
Gouveia, Gisele Rodrigues;Ferreira, Suzete Cleusa;Sabino, Ester Cerdeira;Siqueira, Sheila Aparecida Coelho;Pereira, Juliana;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2011, DOI: 10.1590/S1676-24442011000600012
Abstract: introduction: formalin fixed paraffin embedded (ffpe) tissues are an important sample source for retrospective studies. despite its ability to preserve proteins and cell morphology, formalin hinders molecular biology tests once it fragments and chemically modifies nucleic acids, particularly rna. objective: to compare the efficiency of three different rna extraction protocols for gene expression analysis of ffep tissues. material and methods: rna was extracted from ffpe samples of human lymph by means of ambion and arcturus bioscience kits and the classical trizol method. after extraction, rna was quantified and tested for amplification through real time polymerase chain reaction (rt-pcr) using glyceraldehydes-3 phosphate dehydrogenase (gapdh) endogenous gene primers. discussion/conclusion: all the protocols produced sufficient and adequate amounts of total rna. however, only protocols using arcturus and ambion kits generated suitable rna for pcr amplification.
Fatal outcome in bronchus-associated lymphoid tissue lymphoma
Mattedi, Romulo Loss;Bernardi, Fabiola del Carlo;Bacchi, Carlos Eduardo;Siqueira, Sheila Aparecida Coelho;Mauad, Thais;
Jornal Brasileiro de Pneumologia , 2007, DOI: 10.1590/S1806-37132007000400021
Abstract: primary pulmonary lymphoma is rare. the most common histological type is the bronchus-associated lymphoid tissue lymphoma. this type of lymphoma has an indolent course and excellent response to therapy. one-third of all cases are diagnosed incidentally. however, due to the rarity of this disease, little is known about its natural history in terms of dissemination and evolution. herein, we report the unusual case of a 61-year-old man who refused treatment after being diagnosed with bronchus-associated lymphoid tissue lymphoma and died 2 years later from massive lung infiltration without dissemination to other organs.
Disseminated neuroendocrine neoplasm with undetected primary tumor
Frederico Becker Ribeiro,Sheila Aparecida Coelho Siqueira,Marianne Castro Gon?alves,Anderson da Costa Lino Costa
Autopsy and Case Reports , 2012,
Abstract: Since the 19th century, neuroendocrine neoplasms (NEN) have been identified. Right up to the present day, the nomenclature is still under debate reflecting the heterogeneity of these tumors. Although some of them are slow growing, some can be fearfully aggressive and may develop in almost any organ of the abdomen, thorax, neck, skin, and gonads. The most commonly observed sites of NEN are the lung and the gastroenteropancreatic system (GEP), where more than 50 entities have been observed. In case of a NEN of unknown primary tumor, the histopathological diagnostic workup includes immunohistochemistry for chromogranin A and synaptophysin, followed by specific tissue markers. Clinical presentation is very diverse, depending on the primary site and functionality of the tumor. In the case of the GEP-NEN, the main symptoms are abdominal pain, diarrhea, weight loss, gastrointestinal bleeding, or bowel obstruction. The presence of neuropsychiatric symptoms is not insignificant in this group of tumors. The authors report a case of a 51-year-old man who sought medical attention because of a three-month history of a consumptive disease. The diagnostic workup disclosed a diffuse nodular infiltration of the lungs, hypokalemia, and hypercalcemia in a cachectic patient. The clinical investigation could not proceed because of an infectious intercurrence, which led to the fatal outcome. Autopsy findings showed a diffuse metastatic NEN. The primary tumoral site could not be demonstrated with the available immunohistochemical panel.
Rosai - Dorfman disease: a rare entity diagnosed at autopsy
Jo?o da Costa Veloso Neto,Sheila Aparecida Coelho Siqueira,Maria Claudia Nogueira Zerbini
Autopsy and Case Reports , 2013,
Abstract: Rosai-Dorfman disease (RDD) or Sinus histiocytosis with massive lymphadenopathy is a rare and benign histiocytic proliferative disorder first described by Juan Rosai and Ronald Dorfman in 1969, whose etiology remains unknown. Since then, many cases were reported in the literature. The disease primarily involves the lymph nodes, and is characterized by painless, bilateral cervical lymphadenopathy accompanied by fever, night sweats, malaise and weight loss, reason why many patients are clinically misdiagnosed as malignant lymphoma. In some cases, extranodal involvement may be present. Leukocytosis, elevated erythrocyte sedimentation rate, and hypergamaglobulinemia are often present. The authors report a case of a 52-year-old female patient admitted to the hospital with the diagnosis of pneumonia and progressed to multiple organs failure and death. During the hospitalization an attempt to diagnose a lymphoproliferative disease trough an axillary lymph node biopsy was disappointing. The autopsy was crucial for the diagnosis, illustrating a severe and unusual presentation of Rosai-Dorfman disease.
Castleman disease: an uncommon diagnosis in pediatrics
Paula Martinez Vianna,Paulo Galluzzi Pastore,Lilian Cristofani,Sheila Aparecida Coelho Siqueira
Autopsy and Case Reports , 2012,
Abstract: First described by Dr. Benjamin Castleman in 1956, Castleman disease is an uncommon disease of an etiology that is not yet thoroughly known. Three distinct histological subtypes have already been described: hyaline-vascular-, plasma cell-, and human herpes virus 8-associated variant, clinically distinguished in multi or unicentric types. Castleman disease is occasionally diagnosed in children, but more often in young adults, with no gender predominance. The symptoms are rather heterogeneous, varying from an asymptomatic mass in the unicentric Castleman disease type, to life-threatening systemic inflammatory state with systemic symptoms in the multicentric Castleman disease type. The authors report a case of a 15-year-old boy who sought medical attention due to a cervical tumor mass, without systemic symptoms. Pathology exam of the excised mass diagnosed a very typical example of the hyaline-vascular unicentric type of Castleman disease.
Estudo manométrico do es?fago distal de gatos anestesiados com tiopental sódico
Santos, Carlos Eduardo Meirelles dos;Henry, Maria Aparecida Coelho de Arruda;Rahal, Sheila Canevesse;Lerco, Mauro Masson;
Acta Cirurgica Brasileira , 2004, DOI: 10.1590/S0102-86502004000300009
Abstract: purpose: to obtain the normality standard of the lower esophageal sphincter (les) of cats anesthetized with tiopental and at analysing the practical viability of the anesthetic use in felines esophagus motor activity investigation. methods: manometric studies of les were performed in 12 cats anestetized with tiopental with perfusion reading in three radial channels. les pressures and lengths were measured. results: the mean values of les pressure and lengths were 33,52 ± 12,42 mmhg and 1,6 ± 0,4 cm respectively. conclusion: a les reference value for felines pressure and length was determined. acommodation and return were comfortable for the animals with the use of sodic tiopental as an anesthetic agent.
Abdominal mycobacterial infection in acquired immunodeficiency syndrome patients
Guidugli, Ruggero Bernardo;Siqueira, Sheila Aparecida Coelho;Senise, Jorge de Figueiredo;Silva, Anderson José da;Hamrick, Paul;Figueiroa, Nancy Rezende;
Sao Paulo Medical Journal , 1995, DOI: 10.1590/S1516-31801995000300003
Abstract: the authors studied 12 patients with aids and abdominal mycobacteriosis hospitalized in the hospital ipiranga (s?o paulo, brazil), from june 1989 to january 1992. diagnosis was confirmed by the histopathological examination of organ specimens collected during laparotomy, which, in most cases, was carried out due to an emergency situation. observations included perforation of the ileum, seropurulent fluid involved and bloked by viscera, epiploon, and fibrin. hepatoesplenomegaly was present in all patients and generalized granulomatous peritonitis was observed in more than 50%. a patient died in the immediate post-op period, four after an average period of 55 days in the hospital. a patient evolved with stercoral fistula and asked to be discharged. six patients were discharged after an average hospitalization period of 27 days. the authors stress that in developing regions where tuberculosis incidence is high, a patient with aids and a painful and irritative abdominal picture should always lead to the hypothesis of mycobacteriosis.
Estudo manométrico do es fago distal de gatos anestesiados com tiopental sódico
Santos Carlos Eduardo Meirelles dos,Henry Maria Aparecida Coelho de Arruda,Rahal Sheila Canevesse,Lerco Mauro Masson
Acta Cirurgica Brasileira , 2004,
Abstract: OBJETIVO: Obter o padr o de normalidade da press o e comprimento do esfíncter inferior do es fago (EIE) em gatos anestesiados com tiopental e analisar a viabilidade prática do anestésico para uso neste tipo de investiga o sobre atividade motora do es fago de felinos. MéTODOS: Em 12 gatos anestesiados com tiopental sódico foram realizados estudos manométricos do EIE, com leitura por perfus o em três canais radiais. Foram avaliadas as press es e comprimentos do EIE. RESULTADOS: Os valores médios da press o e comprimento do EIE foram 33,52 ± 12,42 mmHg e 1,6 ± 0,4 cm, respectivamente. CONCLUS O: Foi possível estabelecer valor de referência para a press o e comprimento do EIE de felinos, com uma conten o e retorno confortáveis para o animal, utilizando o tiopental sódico como agente anestésico.
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