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Search Results: 1 - 10 of 192 matches for " Sheetal Bhan "
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Dose-Dependent Activation of Putative Oncogene SBSN by BORIS
Daria Gaykalova, Rajita Vatapalli, Chad A. Glazer, Sheetal Bhan, Chunbo Shao, David Sidransky, Patrick K. Ha, Joseph A. Califano
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040389
Abstract: Testis-specific transcription factor BORIS (Brother of the Regulator of Imprinted Sites), a paralog and proposed functional antagonist of the widely expressed CTCF, is abnormally expressed in multiple tumor types and has been implicated in the epigenetic activation of cancer-testis antigens (CTAs). We have reported previously that suprabasin (SBSN), whose expression is restricted to the epidermis, is epigenetically derepressed in lung cancer. In this work, we establish that SBSN is a novel non-CTA target of BORIS epigenetic regulation. With the use of a doxycycline-inducible BORIS expressing vector, we demonstrate that relative BORIS dosage is critical for SBSN activation. At lower concentrations, BORIS induces demethylation of the SBSN CpG island and disruption and activation of chromatin around the SBSN transcription start site (TSS), resulting in a 35-fold increase in SBSN expression in the H358 human lung cancer cell line. Interestingly, increasing BORIS concentrations leads to a subsequent reduction in SBSN expression via chromatin repression. In a similar manner, increase in BORIS concentrations leads to eventual decrease of cell growth and colony formation. This is the first report demonstrating that different amount of BORIS defines its varied effects on the expression of a target gene via chromatin structure reorganization.
Geological Behaviours in Urban Areas for Surface Runoff and Recharge  [PDF]
Sheetal Sharma
Open Journal of Soil Science (OJSS) , 2017, DOI: 10.4236/ojss.2017.78014
Abstract: Urbanization is rapidly growing all over the world affecting life styles and environment to a large scale. The most challenging impacts that can be observed are the reducing water levels and increasing surface flows in form of flash floods. Urban sprawl has converted hectares of agriculture and forest land into developed surfaces which have zero infiltration resulting in increased flow of precipitation. Apart from sealed land surfaces, the ignorance of soil behavior also leads to added surface flows and unnatural infiltration into soil. Incompatibility of urban planning and functions with the natural environment is becoming vast. Changes in land patterns due to Build up, pavements, roads and similar land cover affect surface water flow seriously. Wise use of modern means and best technologies available are not in use resulting in a huge gap between basic knowledge of natural processes and its requirement for balanced development having minimum impact on water recharge. Present paper is a research on various soil groups and urban water sheds for impacts of increasing Build up on runoff and behavior of soil under developed conditions. The method adopted was to analyze Build up from 1971 to 2014 using ArcGis 9.3 and hydrological modeling using SWMM software for resulting runoff in 40 years of urbanization. Results were compared for different soil groups to observe best conditions for suitable Build up on soil groups for sustainable development.
Integrative Discovery of Epigenetically Derepressed Cancer Testis Antigens in NSCLC
Chad A. Glazer,Ian M. Smith,Michael F. Ochs,Shahnaz Begum,William Westra,Steven S. Chang,Wenyue Sun,Sheetal Bhan,Zubair Khan,Steven Ahrendt,Joseph A. Califano
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008189
Abstract: Cancer/testis antigens (CTAs) were first discovered as immunogenic targets normally expressed in germline cells, but differentially expressed in a variety of human cancers. In this study, we used an integrative epigenetic screening approach to identify coordinately expressed genes in human non-small cell lung cancer (NSCLC) whose transcription is driven by promoter demethylation.
Should Health Professionals Allow Reporters Inside Hospitals and Clinics at Times of Natural Disasters?
Anant Bhan
PLOS Medicine , 2005, DOI: 10.1371/journal.pmed.0020177
Abstract:
Should health professionals allow reporters inside hospitals and clinics at times of natural disasters?
Bhan Anant
PLOS Medicine , 2005,
Abstract:
Tackling polyauthoritis giftosa
Bhan Anant
Indian Journal of Dermatology, Venereology and Leprology , 2010,
Abstract:
Obituary: Professor Arun Kumar Gupta
Bhan Surya
Indian Journal of Orthopaedics , 2008,
Abstract:
Substance abuse among medical professionals: A way of coping with job dissatisfaction and adverse work environments?
Bhan Anant
Indian Journal of Medical Sciences , 2009,
Abstract:
Media management during disasters might also require protecting patient privacy and rights
Bhan Anant
Indian Journal of Medical Sciences , 2009,
Abstract:
Off-pump bi-directional Glenn shunt: How I do it?
Bhan Anil
Annals of Pediatric Cardiology , 2008,
Abstract:
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