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Search Results: 1 - 10 of 32566 matches for " Shaji John Kachanathu "
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The Effect of Longitudinal Stretching of Muscles and Nerve versus Deep Transverse Friction Massage in the Management of Patients with Carpal Tunnel Syndrome  [PDF]
Ashraf Ramadan Hafez, Aqeel Mohammed Alenazi, Shaji John Kachanathu, Abdulmohsen Meshari Alroumi, Elham Saed Mohamed
Open Journal of Therapy and Rehabilitation (OJTR) , 2014, DOI: 10.4236/ojtr.2014.24025
Abstract: Background and Purpose: Carpal tunnel syndrome (CTS) is a common source of hand numbness and pain. The goal of this study was to compare longitudinal stretching of muscles and nerve to deep transverse friction massage for decreasing pain and improving hand function in patients with chronic CTS. Subjects and Methods: Thirty patients, 25 to 40 years old, were included in this study and randomized into two groups: the first group (36.8 ± 0.262) followed a physical therapy program group receiving stretching of wrist and hand flexors in combination with ultrasound, strengthening exercises of wrist and hand flexors, and wrist splint, three sessions per week for 12 weeks; and the second group (35.9 ± 0.225) followed the physical therapy program of deep transverse friction massage on the carpal tunnel site at the wrist joint, with using ultrasonic therapy, strengthening exercises of wrist and hand flexors and wrist splint, three sessions per week for 12 weeks. Outcome measures were range of motion (ROM), pain using visual analog scale (VAS), and hand grip strength measured with a sphygmomanometer. Results: There was a significant difference in both groups in all outcome measures compared to baseline. Over stretching group showed significant difference at the end of study in terms of range of motion of wrist flexion, extension and strength of handgrip when compared to deep friction massage group P < 0.05. However, there is no significant difference between groups in pain. Discussion and Conclusion: This study showed that the effect of stretching exercises is more beneficial than deep transverse friction massage in the treatment of patients with CTS in decreasing the compression of the median nerve in the tunnel.
The Effect of Stretching Hamstring, Gastrocnemius, Iliopsoas and Back Muscles on Pain and Functional Activities in Patients with Chronic Low Back Pain: A Randomized Clinical Trial  [PDF]
Hamada E. Seif, Aqeel Alenazi, Sahar Mahmoud Hassan, Shaji John Kachanathu, Ashraf R. Hafez
Open Journal of Therapy and Rehabilitation (OJTR) , 2015, DOI: 10.4236/ojtr.2015.34019
Abstract: A back pain lasting more than 12 weeks has been defined as a chronic low back pain (LBP) [1]. More than half of people suffer from LBP [1]. The purpose of this study was to examine the effect of gastrocnemius muscle stretching in the treatment of chronic low back pain. Methods: Forty patients with chronic low back pain, ages ranging from 25 to 40 years, were recruited and divided randomly into two groups. The control group followed a physical therapy program that included stretching exercises for back, hamstring and iliopsoas muscles. Strengthening exercises for abdominal muscle and postural instructions for activities of daily living were also performed. The experimental group followed the same control-group exercises with the addition of stretching exercises for gastrocnemius muscles. The interventions for both groups consisted of three sessions per week for six weeks, each session lasting for an hour. The outcome measures were visual analog scale (VAS) for pain severity, modified fingertip to floor (FTF) for range of motion (ROM) of trunk flexion, Oswestry Disability Index (ODI), and loading X-ray to detect lumbosacral angle. Results: There was no significant difference between groups at baseline characteristics. At final follow up, the two groups were significantly different in all outcome measures in terms of pain (p < 0.01), modified FTF (p < 0.01), disability questionnaire (p < 0.01), and lumbosacral angle (p < 0.01). Conclusion: Gastrocnemius manual stretching exercise is more beneficial in reducing pain and improving functions for patients with chronic low back pain when adding to stretching exercises for hamstring, iliopsoas, and back muscles, and strengthening exercise for abdominal muscles.
The Effect of Deep Friction Massage versus Stretching of Wrist Extensor Muscles in the Treatment of Patients with Tennis Elbow  [PDF]
Sahar Mahmoud Hassan, Ashraf Ramadan Hafez, Hamada Eid Seif, Shaji John Kachanathu
Open Journal of Therapy and Rehabilitation (OJTR) , 2016, DOI: 10.4236/ojtr.2016.41004
Abstract: Overuse injuries of the elbow and forearm are very common in athletes. This study was conducted to evaluate the effect of muscle stretching and deep friction massage with using wrist joint support during management of tennis elbow. This study included forty patients with tennis elbow divided into two equal groups: the first group with a mean age 38.1 ± 0.294 followed a physical therapy program in form of deep friction massage on the proximal attachment of wrist extensor muscles, the second group with a mean age 37.6 ± 0.253, submitted to stretching exercises of wrist extensors. Both of groups submitted to ultrasonic therapy with wrist splint during treatment period, three sessions per week for six weeks. Outcome measures were universal goniometer, visual analogue scale, and squeezing sphygmomanometer. The results showed that there was a significant improvement in ROM of wrist flexion and wrist extension, and handgrip in second group and it was more than in the first group while no significant difference in pain. This study showed that stretching exercise is more beneficial in the management of patients with tennis elbow.
Kachanathu Shaji John,Verma Satish Kumar,Khanna Gulshan Lal
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: Little has been known about the response to relaxation therapies such as of Music Therapy (MT) and Mindfulness Meditation Therapy (MMT) in sports. Researchers have been performed on the psychophysiological responses of MT and MMT on normal and diseased persons, but little has been done on sports population especially in shooters during competition. The purpose of this study was to estimate the contribution of MT and MMT training on shooting performance of shooters. 165 professional male shooters age of 29.5±4.3years were examined in three groups Group A, B, and C, MT, MMT, and as a Control respectively, n= 50±3 in each group. Duration of the study was 4 weeks. Pre and post data of quantitative Performance Score (PS) were analyzed. Results of the study showed positive correlation, highly significant (p<0.0001) post-intervention PS. Ultimately resulted in reduction of competition stress level and increase in PS. Comparatively Group A an B, and group A shown marginal improvement than Group B. Whereas the Control group has been shown non-significant result compare to experimental groups (p<0.05). Study concluded that relaxation therapies such as MT and MMT interventions along with routine sports specific training may decrease Competition Stress (CS) level and will enhance sports performance and also found MT has been shown better effectiveness than MMT in 4 weeks of training.
Wiskott-aldrich syndrome
John Shaji
Indian Journal of Dermatology, Venereology and Leprology , 1992,
Abstract: An infant with Wiskott-Aldrich syndrome who presented with eczematous skin lesions, recurrent infections, and thrombocytopenia is reported. He was posted for allogenic bone marrow transplantation but died before the transplantation. Allogenic bone marrow transplantation offers excellent immunologic and haematologic reconstitution, if histocompatible sibling donor is available.
Comparative Analysis of Plyometric Training Program and Dynamic Stretching on Vertical Jump and Agility in Male Collegiate Basketball Player
John Shaji,Saluja Isha
Al Ameen Journal of Medical Sciences , 2009,
Abstract: The purpose of the study was to compare, analyze the individual and combined effect of plyometric training program and dynamic stretching on vertical jump and agility. The subjects included 45, healthy male collegiate basketball players between the ages of 18-25. All subjects were tested in the vertical jump and agility using the Sergeant Jump test and T-test respectively prior to starting the dynamic stretching and plyometric training program. The subjects then completed a four week plyometric training program and were retested. Univariate ANOVA was conducted to analyze the change scores (post – pre) in the independent variables by group (plyometric, dynamic stretching and combined) with pre scores as covariates. The Univariate ANOVA revealed a significant group effect for Sergeant Jump test F = 12.95, P = 0.000 for Dynamic stretching group, F = 12.55, P = 0.000 for Plyometric training group and F = 15.11, P = 0.000 for combined group. The combined group reveled, maximum increase in the height when compared with the pretest scores. For the T-Test agility scores a significant group effect was found F = 2.00, P = 0.043 for Plyometric training group, F = 9.14, P = 0.000 for combined group while dynamic stretching group F = 2.11, P = 0.088 reveled non significant results. The findings suggested that two days of plyometric training a week in combination with dynamic stretching for four weeks is sufficient enough to show improvements in vertical jump height and agility. The results also suggest that two days of plyometric training and dynamic stretching are equally effective in improving vertical jump height. In contrast dynamic stretching two days a week for four weeks was not sufficient enough to show improvements in agility while plyometric training was sufficient.
Efficacy of Bortezomib as First-Line Treatment for Patients with Multiple Myeloma
Utkarsh Painuly and Shaji Kumar
Clinical Medicine Insights: Oncology , 2012, DOI: 10.4137/CMO.S7764
Abstract: Recent years have seen a dramatic change in the approach towards diagnosing and treating Multiple Myeloma. Newer and more target specific approach to treatment has prolonged the survival for patients with multiple myeloma. The proteasome inhibitors make an important class of anti-myeloma drugs that disrupts the proteolytic machinery of the tumor cells preferentially, enhancing their susceptibility to apoptosis. Bortezomib, in particular has shown significant clinical efficacy in myeloma treatment. It is the most commonly used proteasome inhibitor and has been tested to be effective in prolonging the overall survival in several trials. Its combinations with cyclophosphamide and dexamethasone are the treatment of choice for standard risk patients following the mSMART guidelines. The success with its lower dosage in elderly and its proven efficacious subcutaneous usage makes Bortezomib a useful agent for maximizing patient compliance and minimizing therapy related toxicity and costs. This review discusses several trials where Bortezomib has been used as a single/combination agent for front-line treatment of multiple myeloma.
Pharmacy Education: It’s Challenges
Jessy Shaji,Vikrant Chadawar
Pharmaceutical Reviews , 2007,
Abstract: The Profession of Pharmacy has made significant progress in the last one decade. The present article introduces the current status of pharmaceutical education in India as well as in the overseas specially USA and Canada.To confront the new challenges we suggests necessity to revamp the Pharma Education that is mainly related to regulatory bodies, Industry–Institute Interaction, different teaching technologies along with collaboration with foreign Pharmacy Institutes and Distance education. By overcoming these problems we involve in the commitment for upgrading the education through modernizing Pharmaceutical culture.Introduction: -The Pharmacy education in our country has witnessed tremendous expansion in last one decade. However, the standard in education have been eroded by rising tides of mediocrity. There is an urgent need to initiate an academic exercise aimed at attaining revamping of curriculum, keeping in pace with current and emerging trends in the field of pharmacy, Unfortunately all these years, enough emphasis was not laid on strengthening the components of Community Pharmacy, Hospital and Clinical pharmacy, while designing curriculum at diploma and degree levels of teaching. Even, the curriculum of industrial pharmacy covered in B.Pharm at some universities is outdated. We have to strike balance between patient and industry oriented courses and bring out very effective and rewarding curriculum for our graduate course of pharmacy. The proposed AICTE syllabus for B.Pharm framed after in depth deliberations is a step in the right direction.
Shaji Jessy,Shinde Amol
International Research Journal of Pharmacy , 2012,
Abstract: The purpose of present work is to develop aceclofenac microspheres for floating pulsatile release intended for chronopharmacotheraphy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. The floating pulsatile microspheres were prepared by emulsion solvent diffusion technique. A 32 factorial design was employed to study the effect of independent variables, drug to polymer ratio and stirring speed, on dependent variables, particle size and drug entrapment efficiency. The best batch exhibited a high entrapment efficiency of 90.1% and mean particle size 118.66 μm. Polymers used for the preparation were Eudragit L100 and Eudragit S100 which gets solubilized at pH above 6 and 7 respectively. The floating microsphere provides two phase release pattern with initial lag time during floating in acidic medium followed by rapid release in phosphate buffer. This approach suggested the use of floating pulsatile microsphere as promising drug delivery for site and time specific release of aceclofenac for chronotheraphy of rheumatoid arthritis.
Protein and peptide drug delivery: Oral approaches
Shaji Jessy,Patole V
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: Till recent, injections remained the most common means for administering therapeutic proteins and peptides because of their poor oral bioavailability. However, oral route would be preferred to any other route because of its high levels of patient acceptance and long term compliance, which increases the therapeutic value of the drug. Designing and formulating a polypeptide drug delivery through the gastro intestinal tract has been a persistent challenge because of their unfavorable physicochemical properties, which includes enzymatic degradation, poor membrane permeability and large molecular size. The main challenge is to improve the oral bioavailability from less than 1% to at least 30-50%. Consequently, efforts have intensified over the past few decades, where every oral dosage form used for the conventional small molecule drugs has been used to explore oral protein and peptide delivery. Various strategies currently under investigation include chemical modification, formulation vehicles and use of enzyme inhibitors, absorption enhancers and mucoadhesive polymers. This review summarizes different pharmaceutical approaches which overcome various physiological barriers that help to improve oral bioavailability that ultimately achieve formulation goals for oral delivery.
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