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Search Results: 1 - 10 of 2452 matches for " Seyed Hanif Mahboobi "
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The Interaction of CRM1 and the Nuclear Pore Protein Tpr
Charles L. Zhao, Seyed Hanif Mahboobi, Ruhollah Moussavi-Baygi, Mohammad R. K. Mofrad
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093709
Abstract: While much has been devoted to the study of transport mechanisms through the nuclear pore complex (NPC), the specifics of interactions and binding between export transport receptors and the NPC periphery have remained elusive. Recent work has demonstrated a binding interaction between the exportin CRM1 and the unstructured carboxylic tail of Tpr, on the nuclear basket. Strong evidence suggests that this interaction is vital to the functions of CRM1. Using molecular dynamics simulations and a newly refined method for determining binding regions, we have identified nine candidate binding sites on CRM1 for C-Tpr. These include two adjacent to RanGTP – from which one is blocked in the absence of RanGTP – and three next to the binding region of the cargo Snurportin. We report two additional interaction sites between C-Tpr and Snurportin, suggesting a possible role for Tpr import into the nucleus. Using bioinformatics tools we have conducted conservation analysis and functional residue prediction investigations to identify which parts of the obtained binding sites are inherently more important and should be highlighted. Also, a novel measure based on the ratio of available solvent accessible surface (RASAS) is proposed for monitoring the ligand/receptor binding process.
Designing a Research Mentorship Program (RMP) to enhance research productivity at Ebne-Sina psychiatric hospital
Hamidreza Mahboobi,Mohammad Esmaeil Shahrzad,Seyed Hamzeh Seddigh,Yaghoub Hamedi
Australasian Medical Journal , 2010,
Laser Doppler Vibrometry measurements of human cadaveric tympanic membrane vibration
Jason A Beyea, Seyed Alireza Rohani, Hanif M Ladak, Sumit K Agrawal
Journal of Otolaryngology - Head and Neck Surgery , 2013, DOI: 10.1186/1916-0216-42-17
Abstract: Cadaveric human temporal bone study.Setting: Basic science laboratory.A mastoidectomy and facial recess approach was performed on four cadaveric temporal bones to obtain access to the ossicles without disrupting the TM. Ossicles were palpated to ensure normal mobility and an intact ossicular chain. Laser Doppler Vibrometry (LDV) measurements were then taken on all four TMs. LDV measurements were repeated on each TM following stapes footplate fixation, incudo-stapedial joint dislocation, and malleus head fixation.Main outcome measures: LDV measurements of TM vibration at the umbo, the lateral process of the malleus, and in each of the four quadrants of the TM.The best signal-to-noise ratios were found between 2 and 4kHz, at the umbo, the anterior superior quadrant, the anterior inferior quadrant, and the posterior inferior quadrant. Since our goal was to assess the ossicular chain, we selected the TM locations closest to the ossicular chain (the umbo and lateral process of the malleus) for further analysis. Differences could be seen between normals and the simulated ossicular pathologies, but values were not statistically significant.LDV measurements are technically challenging and require optimization to obtain consistent measurements. This study demonstrates the potential of LDV to differentiate ossicular pathologies behind an intact tympanic membrane. Future studies will further characterize the clinical role of this diagnostic modality.
The Impact of the Internet on the Doctor - Patient Relationship
Marta Marcinkiewicz,Hamidreza Mahboobi
Australasian Medical Journal , 2009,
Abstract: .
National Program for Elimination of Iodine Deficiency Disorders in Iran
Hamidreza Mahboobi,Tahereh Khorgoei
Electronic Physician , 2010,
Abstract: This is an Article in format of Letter to the Editor (LTE) and do not need an abstract.
Trends in breastfeeding and complementary feeding practices in Pakistan, 1990-2007
Hafsa Hanif
International Breastfeeding Journal , 2011, DOI: 10.1186/1746-4358-6-15
Abstract: Estimates on the various indicators for infant and young child feeding proposed by WHO were analyzed in light of the Pakistan Demographic and Health Surveys (1990-91 and 2006-07) and several other national studies conducted since 1995.Nearly half the core and optional indicators have improved over the years, though modestly; the others have demonstrated no statistically significant improvement over the years. Of the five indicators required in the WHO tool for the assessment of infant and young child feeding, introduction of complementary foods, bottle-feeding, and early initiation of breastfeeding, stand in the poor category, while exclusive breastfeeding and duration of breastfeeding fall in the fair category, suggesting an overall poor status.There is considerable scope to improve breastfeeding and complementary feeding in Pakistan. Further programs should focus on improving the following indicators that have shown no significant development: early initiation of breastfeeding, exclusive breastfeeding under six months, continued breastfeeding at two years, age appropriate feeding, and bottle feeding. Effective implementation of interventions that are known to improve breastfeeding practices is imperative, as is further research to yield data that can lead future endeavors.Breastfeeding and complementary feeding practices have long been demonstrated to have significant implications for maternal and child health. Healthy breastfeeding practices reduce child mortality and morbidity, and improve immunity in children, besides being essential for their optimal growth and development [1]. In mothers, breastfeeding is associated with enhanced emotional attachment to the infant, reduced risk of breast and endometrial cancer, increased duration of post partum amenorrhea, and consequent birth spacing, as well as several other health benefits [1]. The World Health Organization recommends that infants be exclusively breastfed for the first six months, followed by breastfeeding
Risk and Return under Shari’a Framework: An Attempt to Develop Shari’a Compliant Asset Pricing Model (SCAPM)
Muhammad Hanif
Pakistan Journal of Commerce and Social Sciences , 2011,
Abstract: A speedy emerging area of finance is the Shari’a compliant financial system. In first decade of 21st century Islamic financing has shown tremendous increase and global volume has reached to US $ 1,041 billion by the end of 2009. Being financial intermediaries Islamic Financial Institutions (IFIs) have shown commendable progress in deposit collection under profit and loss sharing schemes however investment avenues are limited in comparison of conventional banks. Although a large number of financing modes are available to IFIs, yet maintenance of required liquidity is serious issue because money market and capital market is dominated by interest based instruments and conventional practices (some are clearly prohibited by Shari’a). Recently Al-meezan Investment Management Ltd. (AIML) has started screening of Shari’a compliant stocks on KSE, and provided an avenue for Shari’a Compliant Investors/IFIs to invest in equities. This study is conducted to understand conventional asset pricing models, document any mismatching with Shari’a financial system, and suggest amendments if required. Findings suggest existing models of equity pricing (CAPM, APT/MFM) are very much practicable under Shari’a framework with slight modification of risk free return because under Shari’a frame work risk free returns do not exist.
The Professional Medical Journal , 2002,
Abstract: In acute appendicitis role of single dose metronidazole, as prophylaxis still needs appreciation where there is nocomplication such as perforation or abscess formation. A prospective study of fifty patients is presented who presented withacute appendicitis in the Department of accident and emergency Mayo Hospital, Lahore. They were divided into twogroups A & B, 25 patients in each group. Group A was given single dose of metronidazole as prophylaxis preoperatively.Patients in group B received three doses of metronidazole: one preoperatively and two postoperatively. Results were samein both groups, with no postoperative wound infection or intraperitoneal sepsis. Single dose metronidazole proved to be aseffective as three doses for prophylaxis in appendicectomy.
Muhammad Hanif
The Professional Medical Journal , 1998,
Abstract: In this study 30 patients presenting with blunt abdominal trauma were included. The clinical diagnosis atthe time of presentation was doubtful regarding the decision of exploratory laparotomy. Both DPL(Diagnostic peritoneal lavage) and USG (Ultrasound abdomen) were done in each patient. In 26 patients(86.66%) the above two investigations were, conclusive of the intra abdominal injury. They ruled out anyinjury in 17 patients. DPL was true positive in 10 patients, true negative in 18 patients., false positive in 2and false negative in non of the patients. Similarly USG was true positive in 9, false positive in 1, truenegative in 19 and false negative in non of the patients. So the sensitivity, specificity and diagnostic accuracyfor DPL were 100%, 90% and 93.33% while of USG were 90%, 95% and 93.33% respectively. These resultsshows that both DPL and USG are complementary to each other. Although DPL has got higher sensitivitybut it is less specific, so the diagnostic accuracy of the two investigations is same.
Indian Involvement in Afghanistan in the Context of the South Asian Security System
Melanie Hanif
Journal of Strategic Security , 2010,
Abstract: This article focuses on the regional requirements for a pacification of Afghanistan. For this purpose, Afghanistan is analytically "reframed" as part of South Asia. The hypothesis is that India is the only regional actor that might possess both the incentives and the capabilities to deal with the negative security externalities emanating from Afghanistan.In South Asia, material characteristics such as the delineation of the region and its power polarity are unclear. India's role within the region is even more controversial. By examining India's role within its security environment, this paper will suggest how this lack of clarity could be remedied. In light of the disputes between India and Pakistan and between Pakistan and Afghanistan, India's involvement in the Afghan conflict is probably the most critical test case for India's leadership potential. The following section elaborates a theoretical framework based on Regional Security Complex Theory (RSCT) and the concept of regional hegemony as one form of regional order.
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