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Search Results: 1 - 10 of 7977 matches for " Seung-Tae Chung "
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CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms
Seong-Su Han, Liangping Peng, Seung-Tae Chung, Wendy DuBois, Sung-Ho Maeng, Arthur L Shaffer, Michael B Sporn, Siegfried Janz
Molecular Cancer , 2006, DOI: 10.1186/1476-4598-5-22
Abstract: Morphological features and surface marker expression of iMycEμ-2 cells were evaluated using cytological methods and FACS, respectively. mRNA expression levels of the inserted MycHis and normal Myc genes were determined by allele-specific RT-PCR and qPCR. Myc protein was detected by immunoblotting. Cell cycle progression and apoptosis were analyzed by FACS. The expression of 384 "pathway" genes was assessed with the help of Superarray? cDNA macroarrays and verified, in part, by RT-PCR.Sub-micromolar concentrations of CDDO-Im caused growth arrest and apoptosis in iMycEμ-1 and iMycEμ-2 cells. CDDO-Im-dependent growth inhibition and apoptosis were associated in both cell lines with the up-regulation of 30 genes involved in apoptosis, cell cycling, NFκB signaling, and stress and toxicity responses. Strongly induced (≥10 fold) were genes encoding caspase 14, heme oxygenase 1 (Hmox1), flavin-containing monooxygenase 4 (Fmo4), and three members of the cytochrome P450 subfamily 2 of mixed-function oxygenases (Cyp2a4, Cyp2b9, Cyp2c29). CDDO-Im-dependent gene induction coincided with a decrease in Myc protein.Growth arrest and killing of neoplastic mouse B cells and plasma cells by CDDO-Im, a closely related derivative of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid, appears to be caused, in part, by drug-induced stress responses and reduction of Myc.2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) and closely related derivatives, such as CDDO-imidazolide (CDDO-Im) [1], are novel synthetic triterpenoids that exhibit potent in vitro activity against a wide range of human cancers including lung and ovarian carcinoma [2], acute myeloid leukemia [3], cutaneous T-cell lymphoma [3], chronic lymphocytic leukemia (CLL) [4] and multiple myeloma (MM) [5]. CDDO's anti-neoplastic activity involves a complex set of biochemical pathways that can lead, depending on cell type and context, to induction of cell differentiation and apoptosis [3,5-7], inhibition of
NF-κB/STAT3/PI3K signaling crosstalk in iMycEμ B lymphoma
Seong-Su Han, Hwakyung Yun, Dong-Ju Son, Van S Tompkins, Liangping Peng, Seung-Tae Chung, Joong-Su Kim, Eun-Sung Park, Siegfried Janz
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-97
Abstract: Nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) were constitutively activated in iMycEμ mice, not only in LBLs but also in the splenic B-lymphocytes of young animals months before tumors developed. Moreover, inhibition of either transcription factor in iMycEμ-1 cells suppressed growth and caused apoptosis, and the abrogation of NF-κB activity reduced DNA binding by both STAT3 and Myc, as well as Myc expression. Inhibition of STAT3 signaling eliminated the activity of both NF-κB and Myc, and resulted in a corresponding decrease in the level of Myc. Thus, in iMycEμ-1 cells NF-κB and STAT3 are co-dependent and can both regulate Myc. Consistent with this, NF-κB and phosphorylated STAT3 were physically associated with one another. In addition, LBLs and iMycEμ-1 cells also showed constitutive AKT phosphorylation. Blocking AKT activation by inhibiting PI3K reduced iMycEμ-1 cell proliferation and caused apoptosis, via downregulation of NF-κB and STAT3 activity and a reduction of Myc levels. Co-treatment with NF-κB, STAT3 or/and PI3K inhibitors led to additive inhibition of iMycEμ-1 cell proliferation, suggesting that these signaling pathways converge.Our findings support the notion that constitutive activation of NF-κB and STAT3 depends on upstream signaling through PI3K, and that this activation is important for cell survival and proliferation, as well as for maintaining the level of Myc. Together, these data implicate crosstalk among NF-κB, STAT3 and PI3K in the development of iMycEμ B-cell lymphomas.Deregulated NF-κB activity plays a critical role in the survival and radiation resistance of tumor cells in a variety of human neoplasias including B cell lymphomas (BCLs) [1-5]. NF-κB comprises a family of transcription factors that control genes implicated in B-cell activation, proliferation and resistance to apoptosis [6]. Five known, structurally conserved members of the NF-κB/Rel family function as dimers in various combinations:
Ground beetle (Coleoptera: Carabidae) assemblage in the urban landscape, Korea
Jong-Kook Jung,Seung-Tae Kim,Sue-Yeon Lee,Chang-Kyu Park
Journal of Ecology and Field Biology , 2012,
Abstract: This study was conducted with the intention of clarifying the effects of land-use types on a species of ground beetle’s richness,abundance, and composition; the study focused on urban landscapes. We also selected the potential bioindicatorsclassifying land-use types; eleven sites were selected from an urban landscape in Korea. Overall, land-use types in urbanlandscapes did not appear to cause significant decrease in species richness or the abundance of total ground beetle assemblage.According to habitat preferences, several land-use types and distances from the forest significantly affectedthe species richness and abundance, while the open-habitat species were not affected by these variables. Land-use typeswere classified into two major groups, forest and non-forest areas, based on ground beetle assemblage; several indicators,such as Dolichus halensis halensis and subfamily Carabinae species, were of particular consideration. In conclusion, environmentalchange by anthropogenic disturbance can cause different effects on ground beetle assemblages, and forestspecialists can be negatively affected.
Identification of Acceptable Restoration Strategies
Seung-Tae Cha,Nam-Ho Lee,Eung-Bo Shim,Jeong-Hoon Shin
Journal of Systemics, Cybernetics and Informatics , 2008,
Abstract: In recent years, we have seen several catastrophic and cascading failures of power systems throughout the world. Power system breakup and blackouts are rare events. However, when they occur, the effects on utilities and general population can be quite severe. To prevent or reduce cascading sequences of events caused by the various reasons, KEPRI is researching ways to revolutionize innovative strategies that will significantly reduce the vulnerability of the power system and will ensure successful restoration of service to customers. This paper describes a restoration guidelines / recommendations for the KEPS simulator, which allows power system operator and planner to simulate and plan restoration events in an interactive mode. The KEPS simulator provides a list of restoration events according to the priority based on some restoration rules and list of priority loads. Further, the paper will draw on research using information from a Jeju case study.
Genetic Variation in CYP17A1 Is Associated with Arterial Stiffness in Diabetic Subjects
Soo Jin Yang,Seung-Tae Lee,Won Jun Kim,Se Eun Park,Sung Woo Park,Jong-Won Kim,Cheol-Young Park
Experimental Diabetes Research , 2012, DOI: 10.1155/2012/827172
Abstract: Hypertension and arterial stiffness are associated with an increasing risk of diabetes and cardiovascular diseases. This study aimed to identify genetic variants affecting hypertension and arterial stiffness in diabetic subjects and to compare genetic associations with hypertension between prediabetic and diabetic subjects. A total of 1,069 participants (326 prediabetic and 743 diabetic subjects) were assessed to determine the genetic variants affecting hypertension by analyzing 52 SNPs previously reported to be associated with hypertension. Moreover, the SNPs were tested for association with hemodynamic parameters related to hypertension. Out of the 52 SNPs analyzed, four SNPs including rs5326 (DRD1), rs1004467 (CYP17A1), rs2960306 (GRK4), and rs11191548 (near NT5C2) in diabetic subjects and rs1530440 (C10orf107) in prediabetic subjects showed a modest association with hypertension (, 0.0020, 0.0066, 0.0078, and 0.0015, resp; all were insignificant after Bonferroni correction). Of these SNPs, rs1004467 in CYP17A1 was significantly associated with augmentation index in diabetic subjects who were not taking antihypertensive medication (; corrected ) but not in diabetic subjects receiving antihypertensive medication. This finding suggests that certain genetic variations found in diabetic subjects may confer arterial stiffness and the development of hypertension and also be affected by antihypertensive medication.
Genetic Variation in CYP17A1 Is Associated with Arterial Stiffness in Diabetic Subjects
Soo Jin Yang,Seung-Tae Lee,Won Jun Kim,Se Eun Park,Sung Woo Park,Jong-Won Kim,Cheol-Young Park
Journal of Diabetes Research , 2012, DOI: 10.1155/2012/827172
Abstract: Hypertension and arterial stiffness are associated with an increasing risk of diabetes and cardiovascular diseases. This study aimed to identify genetic variants affecting hypertension and arterial stiffness in diabetic subjects and to compare genetic associations with hypertension between prediabetic and diabetic subjects. A total of 1,069 participants (326 prediabetic and 743 diabetic subjects) were assessed to determine the genetic variants affecting hypertension by analyzing 52 SNPs previously reported to be associated with hypertension. Moreover, the SNPs were tested for association with hemodynamic parameters related to hypertension. Out of the 52 SNPs analyzed, four SNPs including rs5326 (DRD1), rs1004467 (CYP17A1), rs2960306 (GRK4), and rs11191548 (near NT5C2) in diabetic subjects and rs1530440 (C10orf107) in prediabetic subjects showed a modest association with hypertension ( , 0.0020, 0.0066, 0.0078, and 0.0015, resp; all were insignificant after Bonferroni correction). Of these SNPs, rs1004467 in CYP17A1 was significantly associated with augmentation index in diabetic subjects who were not taking antihypertensive medication ( ; corrected ) but not in diabetic subjects receiving antihypertensive medication. This finding suggests that certain genetic variations found in diabetic subjects may confer arterial stiffness and the development of hypertension and also be affected by antihypertensive medication. 1. Introduction Hypertension is a major health concern that is increasing worldwide [1] and is associated with an increasing risk of developing diabetes and kidney and cardiovascular diseases [2, 3]. The etiology of hypertension is complex in that both genetic and environmental factors influence its development. So far, enormous efforts have been made to identify common genetic variants affecting hypertension by conducting several large-scale genomewide association (GWA) studies including the Wellcome Trust Case Control Consortium (WTCCC) study and the Framingham Heart Study 100K Project [4–7]. However, to our knowledge, no studies have reported a genetic association with hypertension relating to diabetes. Given that numerous genes are known to be associated with hypertension and the prevalence of hypertension in diabetic subjects is relatively high, it is likely that allele variations for multiple genes previously reported to be associated with hypertension may also influence the development of hypertension in the diabetic population. In addition, it is possible that there will be different patterns of association with developing hypertension
A case of long survival in poorly differentiated small cell carcinoma of the pancreas
Min Sung Chung, Tae Kyung Ha, Kyeong Geun Lee, Seung Sam Paik
World Journal of Gastroenterology , 2008,
Abstract: Small cell carcinoma (SCC) of the pancreas is rare. It has similar histological features to pulmonary small cell carcinoma and is equally aggressive. Most patients with SCC in the pancreas reported in case studies died within 1 year after diagnosis. We present a case of unusually long-term survival after surgery and combined chemotherapy for SCC of the pancreas. A 62-year-old woman presented with epigastric pain and jaundice. Computed tomography revealed dilated common bile duct caused by external compression of the mass in the pancreatic head. Exploratory laparotomy and pancreaticoduodenectomy (PPPD) was performed with histopathological analysis confirming a primary small cell carcinoma of the pancreas. After an uneventful postoperative recovery, the patient was treated with 6 cycles of combined chemotherapy consisting of cisplatin and ectoposide. During the follow-up, there was no evidence of recurrence and the patient has remained in a good health condition for 36 mo since the diagnosis.
Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides
Eun Mi Lee,Seung Sik Lee,Byung Yeoup Chung,Jae-Young Cho,In Chul Lee,So Ra Ahn,Soo Jeung Jang,Tae Hoon Kim
Molecules , 2010, DOI: 10.3390/molecules15118251
Abstract: Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-b-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1–5 showed potent inhibitory effects on pancreatic lipase, with IC50 values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 mM.
Elucidating Interactions and Conductivity of Newly Synthesised Low Bandgap Polymer with Protic and Aprotic Ionic Liquids
Pankaj Attri, Seung-Hyun Lee, Sun Woo Hwang, Joong I. L. Kim, Sang Woo Lee, Gi-Chung Kwon, Eun Ha Choi, In Tae Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068970
Abstract: In this paper, we have examined the conductivity and interaction studies of ammonium and imidazolium based ionic liquids (ILs) with the newly synthesised low bandgap polymer (Poly(2-heptadecyl-4-vinylthieno[3,4-d]t?hiazole)(PHVTT)). Use of low bandgap polymers is the most suitable way to harvest a broader spectrum of solar radiations for solar cells. But, still there is lack of most efficient low bandgap polymer. In order to solve this problem, we have synthesised a new low bandgap polymer and investigated its interaction with the ILs to enhance its conductivity. ILs may undergo almost unlimited structural variations; these structural variations have attracted extensive attention in polymer studies. The aim of present work is to illustrate the state of art progress of implementing the interaction of ILs (protic and aprotic ILs) with newly synthesised low bandgap polymer. In addition to this, our UV-Vis spectroscopy, confocal Raman spectroscopy and FT-IR spectroscopy results have revealed that all studied ILs (tributylmethylammonium methyl sulfate ([N1444][MeSO4] from ammonium family) and 1-methylimidazolium chloride ([Mim]Cl, and 1-butyl-3-methylimidazolium chloride ([Bmim]Cl from imidazolium family) have potential to interact with polymer. Our semi empirical calculation with help of Hyperchem 7 shows that protic IL ([Mim]Cl) interacts strongly with the low bandgap polymer through the H-bonding. Further, protic ILs shows enhanced conductivity than aprotic ILs in association with low bandgap polymer. This study provides the combined effect of low bandgap polymer and ILs that may generate many theoretical and experimental opportunities.
Gadolinium Enhanced 3D Proton Density Driven Equilibrium MR Imaging in the Evaluation of Cisternal Tumor and Associated Structures: Comparison with Balanced Fast-Field-Echo Sequence
Sung Jun Ahn, Mi Ri Yoo, Sang Hyun Suh, Seung-Koo Lee, Kyu Sung Lee, Eun Jin Son, Tae-Sub Chung
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0103215
Abstract: Objectives Although Gadolinium enhanced bFFE is commonly used to evaluate cisternal tumors, banding artifact may interrupt interpretation and adjacent nerve and vessels differentiation is known to be difficult. We analyzed the qualities of Gd enhanced 3D PDDE in the evaluation of cisternal tumors, comparing with bFFE. Material and Methods Forty five cisternal tumors (33 schwannoma and 12 meningioma) on both bFFE and PDDE were retrospectively reviewed. For quantitative analysis, contrast ratios of CSF to tumor and tumor to parenchyma (CRC/T and CRT/P) on both sequences were compared by paired t-test. For qualitative analysis, the readers gauged the qualities of the two MR sequences with respect to the degree of demarcating cisternal structures (tumor, basilar artery, AICA, trigeminal nerve, facial nerve and vestibulocochlear nerve). Results In quantitative analysis, CRC/T and CRT/P on 3D PDDE was significantly lower than that of 3D bFFE (p<0.01). In qualitative analysis, basilar artery, AICA, facial nerve and vestibulocochlear nerves were significantly better demarcated on 3D PDDE than on bFFE (p<0.01). The degree of demarcation of tumor on 3D PDDE was not significantly different with that on 3D bFFE (p = 0.13). Conclusion Although the contrast between tumor and the surrounding structures are reduced, Gd enhanced 3D PDDE provides better demarcation of cranial nerves and major vessels adjacent to cisternal tumors than Gd enhanced bFFE
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