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Search Results: 1 - 10 of 197276 matches for " Serbülent G?khan Beyaz "
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Comparison of preemptive intravenous paracetamol and caudal block in terms of analgesic and hemodynamic parameters in children
Serbülent Gkhan Beyaz
Journal of Clinical and Experimental Investigations , 2012,
Abstract: Objectives: Paracetamol has a widespread use for feverand symptomatic relief of pain in children. The aim ofthis study was to compare analgesic effects of preemptiveintravenous (i.v.) paracetamol, and caudal block withlevobupivacaine.Materials and methods: A total of 60 children with ASAI-II physical status, aged 5-15 years and undergoing inguinalhernia repair, were randomly allocated to threegroups so that each group contained 20 patients. Group Pchildren received i.v. 15mg/kg paracetamol. Group C receivedonly caudal block with levobupivacaine, and GroupPC received both i.v. paracetamol, and caudal block withlevobupivacaine. Pain level assessed by modified EasternOntario Children’s Hospital pain scale (mCHEOPs),sedation status by Ramsey sedation scale at postoperative5, 15, 30 min and 1,3, and 6th hours.Results: No significant differences were found in age,gender distribution, body weight, ASA status, type andduration of surgery between three groups (p>0.05). Althoughsignificant difference were found in mCHEOPsscores within groups by repeated measures, no differenceof pain scores was observed between three groups(p>0.05). There were no significant differences in the hemodynamicparameters (heart rate, blood pressure) bothwithin groups and between groups (p>0.05).Conclusions: Preemptive intravenous paracetamol hadsimilar analgesic effects compared with caudal block withlevobupivacaine with regard to postoperative pain scoresin children undergoing inguinal hernia repair. No hemodynamicor other adverse effects were observed withintravenous paracetamol. J Clin Exp Invest 2012; 3(2):202-208
Preemptive Analgesic Effect of Ketamine in Children with Lower Abdominal Surgery
Serbülent Gkhan Beyaz
Balkan Medical Journal , 2011,
Abstract: Objective: Preemptive analgesic effect of low dose ketamine has been supported by clinical studies in adults. The aim of this study was to evaluate the analgesic effect of ketamine applied at different times in children who underwent lower abdominal surgery.Material and Methods: A total of 90 children having ASAI-II physical status between 3 and 12 was randomly divided into three groups as pre, int and post groups. Ketamine were given to these groups in the following manner respectively; 1mg/kg intravenous ketamine before incision (pre-incisional); the same dose ketamine 10 minutes following the first incision (intraoperative); and ketamine at the end of the surgical operation (postoperative). The pain of patients was assessed by postoperative pain scale (CHIPPS) in children and infants; the sedation status of children was assessed by Ramsey’s sedation scale. The first analgesic requirement time was recorded.Results: No significant difference was found in demographic characteristics of the three groups (p>0.05). Lower CHIPPS scores were found in Group Post throughout all measurement periods (p<0.05). Group Post was found to have significantly higher sedation levels compared with the other two groups (p=0.003). Conclusion: No analgesic effect was obtained using by pre-incisional and intraoperative i.v.1mg/kg ketamine, during lower abdominal surgery in children. Further studies with different drugs are needed to clarify this topic.
Pain Management in Prostate Cancer  [PDF]
Ali Eman, Serbülent Gkhan Beyaz, Hasan Sa?lam, Mustafa Emre Gürcü
Open Journal of Urology (OJU) , 2012, DOI: 10.4236/oju.2012.223031
Abstract: Prostate cancer is the most common urogenital malignity of western communities and is the second leading cause of cancer-related deaths in this population. Pain is often due to bone metastasis in prostate cancer. For the patient diagnosed with cancer and for his family, pain is the most feared aspect of cancer following the likelihood of failure to treat and death. Quality of life is severely impaired together with complaint of pain which arises high rates as 80% in advanced stage cancers.
Changes in Electrocardiogram Findings during Treatment with Gonadotropin-Releasing Hormone Agonist and Surgical Castration for Prostate Carcinoma  [PDF]
Hasan Sa?lam, Akif ?akar, Osman K?se, ?ükrü Kumsar, Salih Budak, Serbülent Gkhan Beyaz, ?ztu? Adsan
Open Journal of Urology (OJU) , 2012, DOI: 10.4236/oju.2012.223029
Abstract: Purpose: To investigate electrocardiogram (ECG) changes after complete androgen blockade (CAB) achieved by either surgical or medical castration and compare the outcomes of the groups. Methods: Sixty-three consecutive men (between 58 - 86 years of age) requiring CAB for prostate cancer were enrolled in the study. Patients with diabetes mellitus, an additional malignancy, coronary heart disease, atrial fibrillation, heart failure or a medical history of cardiac event in the last 12 months were excluded from the study. Additionally, those who were taking medicine affecting heart rate were excluded. The participants were divided into two groups according to their modality of castration. The first group consisted of 35 patients who received bilateral orchiectomy plus anti-androgen medication. The second group contained 28 patients who accepted gonadotropin-releasing hormone (GnRH) plus anti-androgen therapy. After complete examinations and biochemical tests, the ECG leads of the patients were obtained conveniently. This was then repeated at three- and six-month visits. ECG findings (including heart rate, PR, QRS, QT, corrected QT (QTc) intervals and QT dispersion (QTd)) were recorded and analysed statistically. The groups were then compared in terms of pre- and post-treatment ECG outcomes. Results: Both groups revealed similarly lower heart rate and prolonged PR, QRS, QT, corrected QTc and QTd by the end of six months. By the end of three months, all variables had changed significantly in the orchiectomy group, whereas in the GnRH group, they had not. Conclusion: CAB may result in lower heart rate and prolonged QT, a condition associated with fatal cardiac arrhythmia and sudden death. Therefore, patients receiving CAB should be monitored closely for cardiac adverse effects.
Thoracal paravertebral block for breast surgery
Serbülent Gkhan Beyaz,Tolga Erg?nen?,Fatih Alt?ntoprak,Ali Fuat Erdem
Dicle Medical Journal , 2012,
Abstract: Thoracic paravertebral block (TPVB) is an alternativemethod to general anesthesia because of provides a safeanesthesia with balanced hemodynamic response, allowspostoperative pain control by means of catheter and haslow side effect profile. TPVB performed safely for the patientsundergoing breast cancer surgery with the samereason, has used in too few center instead of general anesthesia.This technique provides an adequate anesthesiafor the patients undergoing breast surgery and in additionprovides stable hemodynamic status with unilateralsomatic and sympathetic blockade, near-perfect controlof postoperative pain, minimal nausea and vomiting rate,early discharge and low cost. For this reason, thoracicparavertebral block which is a standard method in breastsurgeries for some centers should be known by all anesthesiologists.We believe that, thoracic paravertebralblock is a method can be applied instead of general anesthesia.Key words: Paravertebral block, thoracic, breast surgery,regional anesthesia
Complete atrioventricular block in a child with normal cardiac functions
S. Gkhan BEYAZ,Yusuf AKDO?AN,Orhan TOKG?Z
Dicle Medical Journal , 2009,
Abstract: Complete atrioventricular block is a rare complication in noncardiac operations of children, though it is life threatening. Complete atrioventicular block may occur secondary to many causes and it does not response to medical treatments. An 11 years-old girl was brought to our hospital with fever and abdominal pain finally diagnosed as acute appendicitis. Anamnesis, physical examination, laboratory findings and radiological findings were found to be normal. After anesthesia induction, the mask ventilation has been applied. Intubation was performed after giving muscle relaxants. After first surgical incision multiple arrhythmias were monitored. Cardiac arrhythmias continue long time and complete A-V block developed. Arrhythmias did not respond to medical treatment. The patient showed no hemodynamic instability and she awakened after completion of surgical operation. She was sent to intensive care unit because of complete A-V block. Pacemaker was not applied because of not having any symptom. A patient who was diagnosed as congenital complete AV block has been followed up with regular intervals.
Toxic reaction related to high dose lidocaine secondary to intravenous regional anesthesia
Orhan Tokg?z,S.Gkhan Beyaz,Zülfü Ar?kano?lu
Journal of Clinical and Experimental Investigations , 2010,
Abstract: Lidocaine can be seen systemic intoxication, central nervous system (CNS) and cardiovascular toxicities, due to its common usage and broad safety margin.Lidocaine overdose has been reported with convulsion, cardiac collapse and coma. In present case, a patient underwent surgical excision of wrist mass who erroneously received 1200 mg 10% lidocaine instead of 225 mg 2% dose. Interestingly, the case shows only some mild CNS side effects without any serious adverse effect.
Investigation of Associations between Obesity and LEP G2548A and LEPR 668A/G Polymorphisms in a Turkish Population
Server ?ah?n,Ayd?n Rüstemo?lu,Ak?n Tekcan,Türker Ta?liyurt,Hasan Güven,Serbülent Y???t
Disease Markers , 2013, DOI: 10.1155/2013/216279
Abstract: Objective. Obesity is a complex heterogeneous disease that is caused by genes, environmental factors, and the interaction between the two. The leptin (LEP) and leptin receptor (LEPR) genes have been evaluated for polymorphisms that could potentially be related to the pathophysiology of obesity and its complications. The aim of this study was to investigate the role of LEP G2548A and LEPR 668A/G polymorphisms in the pathogenesis of obesity. Subjects. The study included 127 patients with obesity and 105 healthy controls. Polymerase chain reaction and restriction fragment length analysis for LEP G2548A and LEPR 668A/G polymorphisms were applied. Results. There was no statistically significant difference in the genotype frequencies of the LEP gene polymorphism between patients and control groups ( ). We found a difference in the LEPR genotypes between patients and controls, but this was not statistically significant ( ). Additionally, we found an increased risk of obesity in the LEP/LEPR GG/GG combined genotype ( ). Conclusion. Our findings indicate that the LEP G2548A polymorphism is not a relevant obesity marker and that the LEPR 668A/G polymorphism may be related to obesity in a Turkish population. Further researches with larger patient population are necessary to ascertain the implications of LEP and LEPR polymorphisms in obesity. 1. Introduction Obesity is a complex heterogeneous disease that is caused by genes, environmental factors, and the interaction between the two [1]. Obesity is also a multifactorial condition, and many endocrine and inflammatory pathways are involved in its development and in obesity-related diseases [2]. Excess weight in obesity may come from muscles, bone, fat, and/or body water, but obesity specifically refers to having an abnormally high proportion of total body fat [3]. The World Health Organization defines “overweight” as a body mass index (BMI) of 25 or more and “obesity” as a BMI of 30 or more [4]. The prevalence of obesity has been stated as being near epidemic size [1–3, 5–7], and obesity has been associated with type II diabetes, hypertension, coronary artery disease, stroke, and many forms of cancer [8, 9]. Therefore, it is important that the underlying pathophysiology of obesity-related diseases is understood. Obesity results from the combined effects of genes, lifestyle, and the interactions of these factors [10], and both familial and nonfamilial factors play an important role in its development [1]. A genetic predisposition to obesity has been reported as a major risk factor for individuals [7]. With the
Assessment of patients treated with semitendinosus and gracilis autograft reconstruction because of neglected patellar tendon rupture
Erdem Edipo?lu,Mustafa Gkhan Bilgili,Halil Nadir ?ne?,lent Tanr?verdi
Medical Journal of Bakirk?y , 2013,
Abstract: Objective: Assessment of patients with neglected patellar tendon ruptures treated with semitendinosus and gracilis autograft reconstruction Material and Methods: We assessed 6 patients with neglected patellar tendon ruptures treated with semitendinosus and gracilis autograft reconstruction retrospectively. Lysholm score, physical examination, muscle strength and range of movement (ROM) were evaluated. Results: 6 patients were included in the study. All patients were female. The mean age was 57.1 (49-62). The mean time between the injury and presentation was 12.8 months (11-15). The mean follow up time was 17.8 months (11-26). The mean Lysholm score was 82. ROM was between 0-110° with 5/5 muscle strength. Conclusion: The use of a semitendinosus and gracilis autograft for neglected patellar tendon ruptures reduces donor site morbidity, avoid specific risks related to allografts and does not require surgical revision to remove materials used to protect the reconstructed tendon.
Association of an Epidermoid Tumour with Ipsilateral Aneurysms of Middle Cerebral Artery Bifurcation and Anterior Communicating Artery
Gkhan KURT,Berker CEM?L,lent ?EL?K,Necdet ?EV?KER
Journal of Neurological Sciences , 2010,
Abstract: By this case report the authors are aimed to describe an unusual case of epidermoid tumour associated with ipsilateral two cerebral aneurysms. Radiological and clinical findings of a 45 year old male patient are described. Investigation of the patient revealed a right temporal lobe tumour and ipsilateral two aneurysms. The patient is treated with micro-neurosurgery successfully. Both the tumour and the right MCA aneurysm are interfereted in the same session. His pathological diagnose was epidermoid tumour. Togetherness of epidermoid tumours and cerebral aneurysms is a very rare entity. Further studies are needed to demonstrate the exact pathological and genetic mechanisms.
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