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Search Results: 1 - 10 of 6388 matches for " Seon Ae Eom1 "
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PEP-1-p18 prevents neuronal cell death by inhibiting oxidative stress and Bax expression
Duk-Soo Kim2,#, Eun Jeong Sohn1,#, Dae Won Kim1, Young Nam Kim1, Seon Ae Eom1, Ga Hyeon Yoon1, Sung-Woo Cho3, Sang-Hyun Lee1, Hyun Sook Hwang1, Yoon Shin Cho1, Jinseu Park1, Won Sik Eum1,* & Soo Young Choi1,*
BMB Reports , 2012,
Abstract: P18, a member of the INK4 family of cyclin-dependent kinaseinhibitors, is a tumor suppressor protein and plays a key cellsurvival role in a variety of human cancers. Under pathophysiologicalconditions, the INK4 group proteins participate in novelbiological functions associated with neuronal diseases andoxidative stress. Parkinson’s disease (PD) is characterized by loss ofdopaminergic neurons, and oxidative stress is important in itspathogenesis. Therefore, we examined the effects of PEP-1-p18 onoxidative stress-induced SH-SY5Y cells and in a PD mouse model.The transduced PEP-1-p18 markedly inhibited 1-methyl-4-phenylpyridinium-induced SH-SY5Y cell death by inhibiting Baxexpression levels and DNA fragmentation. Additionally, PEP-1-p18prevented dopaminergic neuronal cell death in the substantia nigraof a 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-induced PDmouse model. These results indicate that PEP-1-p18 may be auseful therapeutic agent against various diseases and is a potentialtool for treating PD.
Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein
Sun Hwa Lee1,#, Dae Won Kim1,#, Seon Ae Eom1, Se-Young Jun1, Meeyoung Park1, Duk-Soo Kim2, Hyung Joo Kwon3, Hyeok Yil Kwon4, Kyu Hyung Han1, Jinseu Park1, Hyun Sook Hwang1, Won Sik Eum1,* & Soo Young Choi1,*
BMB Reports , 2012,
Abstract: We examined that the protective effects of ANX1 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammationin animal models using a Tat-ANX1 protein. Topicalapplication of the Tat-ANX1 protein markedly inhibited TPAinducedear edema and expression levels of cyclooxygenase-2(COX-2) as well as pro-inflammatory cytokines such as interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor-alpha(TNF-α). Also, application of Tat-ANX1 protein significantlyinhibited nuclear translocation of nuclear factor-kappa B(NF-κB) and phosphorylation of p38 and extracellular signalregulatedkinase (ERK) mitogen-activated protein kinase(MAPK) in TPA-treated mice ears. The results indicate thatTat-ANX1 protein inhibits the inflammatory response byblocking NF-κB and MAPK activation in TPA-induced miceears. Therefore, the Tat-ANX1 protein may be useful as atherapeutic agent against inflammatory skin diseases.
Expression of Genes Affecting Skin Coloration and Sugar Accumulation in Apple Fruits at Ripening Stages in High Temperatures  [PDF]
Seon Ae Kim, Soon Young Ahn, Hyun Hee Han, In Chang Son, Hae Keun Yun
World Journal of Engineering and Technology (WJET) , 2015, DOI: 10.4236/wjet.2015.33B002

High temperature is one of the most important environmental factors that affect the successful cultivation of apple (Malus × domestica Borkh). The expression of genes related with anthocyanin synthesis and sugar accumulation by high temperature treatment was investigated in the fruits of “Fuji” apple at different developmental stages in different temperature conditions through real- time PCR. In the initial ripening stages in fruits, there was high expression of genes associated with fruit ripening, flavonoid compound accumulation, and coloration in high temperatures. Expression of phenylalanine ammonia-lyase, chalcone synthase, flavone 3-hydrogenase, and malate dehydrogenase genes increased gradually in initial ripening stages, while sharply reduced at 24 hr after treatment. In addition, there was no significant difference in the expression of all temperature treatments in late ripening stages. In the further work, investigation of expression levels of various genes could be conducted in the level of transcriptomes from fruits at the early stages to get meaningful information of ripening metabolism in apples in high temperatures.

Gene expression profiling: Canonical molecular changes and clinicopathological features in sporadic colorectal cancers
Jin Cheon Kim, Seon Young Kim, Seon Ae Roh, Dong-Hyung Cho, Dae Dong Kim, Jeong Hyun Kim, Yong Sung Kim
World Journal of Gastroenterology , 2008,
Abstract: AIM: To investigate alternative or subordinate pathways involved in colorectal tumorigenesis and tumor growth, possibly determining at-risk populations and predicting responses to treatment.METHODS: Using microarray gene-expression analysis, we analyzed patterns of gene expression relative to canonical molecular changes and clinicopathological features in 84 sporadic colorectal cancer patients, standardized by tumor location. Subsets of differentially expressed genes were confirmed by real-time reverse-transcript polymerase chain reaction (RT-PCR).RESULTS: The largest number of genes identified as being differentially expressed was by tumor location, and the next largest number by lymphovascular or neural invasion of tumor cells and by mismatch repair (MMR) defects. Amongst biological processes, the immune response was significantly implicated in entire molecular changes observed during colorectal tumorigenesis (P < 0.001). Amongst 47 differentially expressed genes, seven (PISD, NIBP, BAI2, STOML1, MRPL21, MRPL16, and MKKS) were newly found to correlate with tumorigenesis and tumor growth. Most location-associated molecular changes had distinct effects on gene expression, but the effects of the latter were sometimes contradictory.CONCLUSION: We show that several differentially expressed genes were associated with canonical molecular changes in sporadic colorectal cancers, possibly constituting alternative or subordinate pathways of tumorigenesis. As tumor location was the dominant factor influencing differential gene expression, location-specific analysis may identify location-associated pathways and enhance the accuracy of class prediction.
Preferred Feeding Sites and Prey of the Adult Gold-spotted Pond Frog, Rana plancyi chosenica
Eom, Junho1,Jung-Hyun Lee2,Nam-Yong Ra2,Daesik Park1*
Journal of Ecology and Field Biology , 2007,
Abstract: To determine the feeding sites preferred by adult gold-spotted pond frogs, Rana plancyi chosenica,and the foods that induce favorable growth of the frogs in the laboratory, we conducted two separate experimentsbetween 27 May and 12 July 2007 in a vivarium. In the first experiment, we counted the number of cricketseaten by four gold-spotted pond frogs in a 60 min period at four different feeding sites within the experimentalarenas: on the water surface, at the edge of a pond, and at two terrestrial sites. Adult gold-spotted pond frogsate more crickets on the water surface and at the edge of the pond than the terrestrial sites. In the secondexperiment, we measured the growth of SVL (snout-vent length) and body mass of adult gold-spotted pond frogsfed crickets, mealworms, maggots, or earthworms in individual experimental boxes over a one month period. TheSVL and body mass of the adult gold-spotted pond frogs fed crickets, mealworms, or maggots were greater thanthose of the frogs that were fed earthworms. These results indicate that providing crickets, mealworms, ormaggots on the water or at the edge of a pond should induce favorable growth of captive-reared adult goldspottedpond frogs.
Enhancement of Host Immune Responses by Oral Vaccination to Salmonella enterica serovar Typhimurium Harboring Both FliC and FljB Flagella
Jeong Seon Eom, Jin Seok Kim, Jung Im Jang, Bae-Hoon Kim, So Young Yoo, Ji Hyeon Choi, Iel-Soo Bang, In Soo Lee, Yong Keun Park
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074850
Abstract: Flagellin, the structural component of the flagellar filament in various motile bacteria, can contribute to the activation of NF-κB and proinflammatory cytokine expression during the innate immune response in host cells. Thus, flagellin proteins represent a particularly attractive target for the development of vaccine candidates. In this study, we investigated the immune response by increasing the flagella number in the iacP mutant strain and the adjuvant activity of the flagellin component FljB of Salmonella enterica serovar Typhimurium. We found that the iacP mutant strain expresses two flagellin proteins (FliC and FljB), which result in increased NF-κB-dependent gene expression in bone marrow derived macrophages. Using an oral immunization mouse model, we observed that the administration of a live attenuated S. typhimurium BRD509 strain expressing the FliC and FljB flagellins induced significantly enhanced flagellin-specific IgG responses in the systemic compartment. The mice immunized with the recombinant attenuated S. typhimurium strain that has two types of flagella were protected from lethal challenge with the Salmonella SL1344 strain. These results indicate that overexpression of flagella in the iacP mutant strain enhance the induction of an antigen-specific immune responses in macrophage cell, and both the FliC and FljB flagellar filament proteins-producing S. typhimurium can induce protective immune responses against salmonellosis.
Electrical spin injection and detection in an InAs quantum well
Hyun Cheol Koo,Hyunjung Yi,Jae-Beom Ko,Joonyeon Chang,Suk-Hee Han,Donghwa Jung,Seon-Gu Huh,Jonghwa Eom
Physics , 2006, DOI: 10.1063/1.2430688
Abstract: We demonstrate fully electrical detection of spin injection in InAs quantum wells. A spin polarized current is injected from a NiFe thin film to a two-dimensional electron gas (2DEG) made of InAs based epitaxial multi-layers. Injected spins accumulate and diffuse out in the 2DEG, and the spins are electrically detected by a neighboring NiFe electrode. The observed spin diffusion length is 1.8 um at 20 K. The injected spin polarization across the NiFe/InAs interface is 1.9% at 20 K and remains at 1.4% even at room temperature. Our experimental results will contribute significantly to the realization of a practical spin field effect transistor.
Interferon gamma Profile in Egyptian Infants with Respiratory Syncytial Virus bronchiolitis
Maha E. Omran1, Mohamed AE. Fahmy2, Manal M. Zaher3
Egyptian Journal of Hospital Medicine , 2008,
Abstract: Viral bronchiolitis is one of the leading causes for hospitalization of infants in the world and causes an estimated one million deaths per year worldwide. Respiratory syncytial virus (RSV) is associated with the majority of cases. During the last few years it has become increasingly clear that T cells contribute to the abnormal regulation of the immune response in viral diseases since these cells are potent producers of a large variety of cytokines. It was reported that cord blood interferon gamma (IFN-) responses were inversely related to the frequency of viral respiratory infections. To ascertain whether RSV infection promotes a different IFN- profile to that induced by other respiratory infections, thirty-two infants with severe bronchiolitis were enrolled in this study. RSV-IgM was detected by immunofluorescent technique in 23/32 patients. Serum IFN- levels in RSV+ infants were significantly lower than RSV- (p < 0.001). In vitro stimulation of peripheral blood cells followed by flow cytometery combined with intracellular cytokine staining revealed that both CD4+ and CD8+ cells contribute in IFN- production. The percentage of CD4+ cells producing IFN- in RSV+ was significantly lower (P < 0.05) than those in RSV-, while the difference in % of CD8+ between RSV+ and RSV- was non significant. Our conclusions are that RSV infection is associated with severe decreased IFN- responses. Both CD4+ and CD8+ cells contribute in IFN- production during RSV bronchiolitis. RSV infection promotes a different IFN- profile from that induced by other respiratory infections.
Lymphopenia is an important prognostic factor in peripheral T-cell lymphoma (NOS) treated with anthracycline-containing chemotherapy
Yu Ri Kim, Jin Seok Kim, Soo Jeong Kim, Hyun Ae Jung, Seok Jin Kim, Won Seog Kim, Hye Won Lee, Hyeon Seok Eom, Seong Hyun Jeong, Joon Seong Park, June-Won Cheong, Yoo Hong Min
Journal of Hematology & Oncology , 2011, DOI: 10.1186/1756-8722-4-34
Abstract: A total of 118 patients with PTCL-NOS treated with anthracycline-containing chemotherapy from 4 Korean institutions were included.Thirty-six patients (30.5%) had a low absolute lymphocyte count (ALC, < 1.0 × 109/L) at diagnosis. Patients with lymphopenia had shorter overall survival (OS) and progression-free survival (PFS) rates compared with patients with high ALCs (P = 0.003, P = 0.012, respectively). In multivariate analysis, high-intermediate/high-risk International Prognostic Index (IPI) scores and lymphopenia were both associated with shorter OS and PFS. Treatment-related mortality was 25.0% in the low ALC group and 4.8% in the high ALC group (P = 0.003). In patients considered high-intermediate/high-risk based on IPI scores, lymphopenia was also associated with shorter OS and PFS (P = 0.002, P = 0.001, respectively).This study suggests that lymphopenia could be an independent prognostic marker to predict unfavorable OS and PFS in patients with PTCL-NOS treated with anthracycline-containing chemotherapy and can be used to further stratify high-risk patients using IPI scores.Peripheral T-cell lymphomas (PTCL) account for approximately 12% to 15% of all non-Hodgkin's lymphomas in Western countries and 15% to 20% in Asian countries [1,2]. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is the most common heterogeneous subgroup of PTCL because it includes lymphomas with no definitive clinical or biologic profile and it cannot be classified into a specific subtype [3]. PTCL-NOS is a highly aggressive lymphoma with a poor response to conventional chemotherapy and a 5-year overall survival (OS) of about 25% to 45% [4]. Anthracycline-containing chemotherapy, such as CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) or CHOP-like regimens, are considered to be standard therapy for PTCL-NOS, although remission rates are less than satisfactory [1]. More intensive regimens, such as hyper-CVAD (hyperfractionated cyclophosphamide, vincristine,
Effect of Insulated Oblique Plates on Heat Transfer and Recirculating Flow in a Channel  [PDF]
Yinxiao Zhan, Tae Seon Park
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.26048

Flow and heat transfer characteristics of a channel with oblique plates which are mounted periodically on the channel wall have been numerically investigated in a laminar range. The main objective of the present study is to find the effect of the tilt angle of oblique plate on pressure drop and heat transfer characteristics in unsteady states. To get the different conditions of the heat transfer and flow evolution, two key parameters of the Reynolds number and the tilt angle of oblique plate are considered. At Re=200,600, the tilt angles are changed for the range of 50° - 130°. The computational results show that the heat transfer and pressure drop are strongly dependent on the tile angle and Reynolds number. When the flows are unsteady, the tilt angle has an important role in the heat transfer enhancement. Oscillatory structures induce the better mixing of the thermal field and promote the wall heat transfer. For a constant plate length, the wall heat trans- fer is maximized near the 90° - 100°. This is strongly coupled with the variations of flow mixing induced by the oblique plate.

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