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Search Results: 1 - 10 of 2541 matches for " Seiya Yoshida "
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Successful adjuvant bi-weekly gemcitabine chemotherapy for pancreatic cancer without impairing patients’ quality of life
Toyama Yoichi,Yoshida Seiya,Saito Ryota,Kitamura Hiroaki
World Journal of Surgical Oncology , 2013, DOI: 10.1186/1477-7819-11-3
Abstract: Background Although adjuvant gemcitabine (GEM) chemotherapy for pancreatic cancer is standard, the quality of life (QOL) in those patients is still impaired by the standard regimen of GEM. Therefore, we studied whether mild dose-intensity adjuvant chemotherapy with bi-weekly GEM administration could provide a survival benefit with acceptable QOL to the patients with pancreatic cancer. Methods After a phase I trial, an adjuvant bi-weekly 1,000 mg/m2 of GEM chemotherapy was performed in 58 patients with pancreatic cancer for at least 12 courses (Group A). In contrast, 36 patients who declined the adjuvant bi-weekly GEM chemotherapy underwent traditional adjuvant 5FU-based chemotherapy (Group B). Careful periodical follow-ups for side effects of GEM and disease recurrence, and assessment of patients’ QOL using the EORTC QOL questionnaire (QLQ-C30) and pancreatic cancer-specific supplemental module (QLQ-PAN26) were performed. Retrospectively, the degree of side effects, patients’ QOL, compliance rate, disease-free survival (DFS), and overall survival (OS) in Group A were compared with those in Group B. Results No severe side effects (higher than Grade 2 according to the common toxicity criteria of ECOG) were observed, except for patients in Group B, who were switched to the standard GEM chemotherapy. Patients’ QOL was better in Group A than B (fatigue: 48.9 ± 32.1 versus 68.1 ± 36.3, nausea and vomiting: 26.8 ± 20.4 versus 53.7 ± 32.6, diarrhea: 21.0 ± 22.6 versus 53.9 ± 38.5, difficulty gaining weight: 49.5 ± 34.4 versus 67.7 ± 40.5, P < 0.05). Compliance rates in Groups A and B were 93% and 47%. There was a significant difference in the median DFS between both groups (Group A : B =12.5 : 6.6 months, P < 0.001). The median OS of Group A was prolonged markedly compared with Group B (20.2 versus 11.9 months, P < 0.005). For OS between both groups, univariate analysis revealed no statistical difference in 69-year-old or under females, and T1–2 factors, moreover, multivariate analysis indicated three factors, such as bi-weekly adjuvant GEM chemotherapy, T2 or less, and R0. Conclusions Adjuvant chemotherapy with bi-weekly GEM offered not only the advantage of survival benefits but the excellent compliance with acceptable QOL for postoperative pancreatic cancer patients.
ExonMiner: Web service for analysis of GeneChip Exon array data
Kazuyuki Numata, Ryo Yoshida, Masao Nagasaki, Ayumu Saito, Seiya Imoto, Satoru Miyano
BMC Bioinformatics , 2008, DOI: 10.1186/1471-2105-9-494
Abstract: We have developed ExonMiner that is the first all-in-one web service for analysis of exon array data to detect transcripts that have significantly different splicing patterns in two cells, e.g. normal and cancer cells. ExonMiner can perform the following analyses: (1) data normalization, (2) statistical analysis based on two-way ANOVA, (3) finding transcripts with significantly different splice patterns, (4) efficient visualization based on heatmaps and barplots, and (5) meta-analysis to detect exon level biomarkers. We implemented ExonMiner on a supercomputer system in order to perform genome-wide analysis for more than 300,000 transcripts in exon array data, which has the potential to reveal the aberrant splice variations in cancer cells as exon level biomarkers.ExonMiner is well suited for analysis of exon array data and does not require any installation of software except for internet browsers. What all users need to do is to access the ExonMiner URL http://ae.hgc.jp/exonminer webcite. Users can analyze full dataset of exon array data within hours by high-level statistical analysis with sound theoretical basis that finds aberrant splice variants as biomarkers.It is reported that some splicing isoform-specific transcriptional regulations are related to disease [1,2]. To find disease specific transcriptional regulations, detection of disease specific splice variations is the first step. However, conventional microarrays that produce gene-level information are not suitable for this purpose. On the other hand, Affymetrix Human Exon 1.0 ST Array can measure exon-level expression profiles that are suitable to find differentially expressed exons in genome-wide scale. Affymetrix exon array can measure the transcript levels of more than 1,000,000 exons with 300,000 transcripts by about 6,500,000 probes.We have developed a supercomputer-based web service named ExonMiner to analyze exon array datasets for detecting genes that are spliced into different isoforms in two type
Optimal Execution in Illiquid Market with the Absence of Price Manipulation  [PDF]
Seiya Kuno, Masamitsu Ohnishi
Journal of Mathematical Finance (JMF) , 2015, DOI: 10.4236/jmf.2015.51001
Abstract: This article shows the execution performance of the risk-averse institutional trader with constant absolute risk aversion (CARA) type utility by using the condition of no price manipulation defined in the risk neutral sense. From two linear price impact models both satisfying that condition, we have derived the unique explicit optimal execution strategy calculated backwardly with dynamic programming equations. And our study shows that the optimal execution strategy exists in the static class. The derived solution can be decomposed into mainly two components, each giving an explanation of the property of optimal execution volume. Moreover we propose two conditions in order to compare the performance of these two price models, and illustrate that the performances of the two models are surprisingly different under certain conditions.
Possibility of sandwiched liver surgery with molecular targeting drugs, cetuximab and bevacizumab on colon cancer liver metastases: a case report
Yoichi Toyama, Takuro Ushigome, Kazuhiro Watanabe, Hiroaki Kitamura, Shinji Onda, Ryota Saito, Seiya Yoshida, Hidejiro Kawahara, Satoru Yanagisawa, Katsuhiko Yanaga
World Journal of Surgical Oncology , 2012, DOI: 10.1186/1477-7819-10-129
Pancreatic Stellate Cells (PSCs) express Cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs
Seiya Yoshida, Michael Ujiki, Xian-Zhong Ding, Carolyn Pelham, Mark S Talamonti, Richard H Bell, Woody Denham, Thomas E Adrian
Molecular Cancer , 2005, DOI: 10.1186/1476-4598-4-27
Abstract: COX-2 expression was evaluated by immunostaining and western blotting. Proliferation of PSCs was determined by thymidine incorporation and cell counting.COX-2 was found to be constitutively expressed in PSCs, and COX-2 protein was up-regulated by PANC-1 CM. Moreover, the induction of COX-2 by PANC-1 CM was prevented by U0126, an extracellular signal-regulated kinase (ERK) 1/2 inhibitor suggesting that activation of ERK 1/2 is needed for stimulation of COX-2. Finally, NS398, a selective COX-2 inhibitor, reduced the growth of PSCs by PANC-1 CM, indicating that activation of COX-2 is required for cancer stimulated PSC proliferation.The results suggest that COX-2 may play an important role in the regulation of PSC proliferation in response to pancreatic cancer.Vitamin A-containing cells were first reported in 1982 by Watari et al. in vitamin A loaded mice using fluorescence and electron microscopy [1]. This cell type was subsequently identified by electron microscopy in normal rat and human pancreatic tissues [2]. These cells were identified as pancreatic stellate cells (PSCs) by Apte et al and Bachem et al in 1998 [3,4]. In the normal pancreas, stellate cells are quiescent and can be identified by the presence of vitamin A-containing lipid droplets in the cytoplasm. In response to pancreatic injury or inflammation, PSCs are transformed ("activated") from quiescent phenotypes into highly proliferative myofibroblast-like cells which express the cytoskeletal protein α-smooth muscle actin (α-SMA), and produce type I collagen and other extracellular matrix components. Many of the morphological and metabolic changes associated with the activation of PSCs in animal models of fibrosis also occur when these cells are cultured on plastic in serum-containing medium.Activated PSCs have also been implicated in the deposition of extracellular matrix components in pancreatic adenocarcinoma [5]. In patients with pancreatic cancer, an intense, interstitial, fibrillar staining for PSCs
Optimal Off-Exchange Execution with Closing Price  [PDF]
Seiya Kuno, Masamitsu Ohnishi, Peilu Shimizu
Journal of Mathematical Finance (JMF) , 2017, DOI: 10.4236/jmf.2017.71003
Abstract: The purpose of this paper is to examine whether the closing price guaranteed execution is possible contract, and if possible, how an institutional investor who affects the security price allocates execution volumes to both traditional trading and off-exchange (over-the-counter, OTC) trading venues. With a generalized price model at the traditional venue which considers the permanent impact effect explicitly, we derive an optimal execution strategy in the traditional trading venue and the allocation of the order volume to both venues in the framework of dynamic programming. By proving that an optimal execution strategy is in the static class, we further show that the closing price guaranteed contract may be established and the trading volume at the time of agreement of the contract can be controlled. Moreover, by some numerical examples, we illustrate a possibility for the institutional investor to manipulate the market in order to seek a profit under some trading situation.
Graphs and projective plaines in 3-manifolds
Wolfgang Heil,Seiya Negami
International Journal of Mathematics and Mathematical Sciences , 1986, DOI: 10.1155/s0161171286000698
Abstract: Proper homotopy equivalent compact P2-irreducible and sufficiently large 3-manifolds are homemorphic. The result is not known for irreducible 3-manifolds that contain 2-sided projective planes, even if one assumes the Poincar conjecture. In this paper to such a 3-manifold M is associated a graph G(M) that specifies how a maximal system of mutually disjoint non-isotopic projective planes is embedded in M, and it is shown that G(M) is an invariant of the homotopy type of M. On the other hand it is shown that any given graph can be realized as G(M) for infinitely many irreducible and boundary irreducible M.
Eigen Vector Descent and Line Search for Multilayer Perceptron
Seiya Satoh,Ryohei Nakano
Lecture Notes in Engineering and Computer Science , 2012,
Noncommutative Monopole at the Second Order in θ
Seiya Goto,Hiroyuki Hata
Physics , 2000, DOI: 10.1103/PhysRevD.62.085022
Abstract: We study the noncommutative U(2) monopole solution at the second order in the noncommutativity parameter \theta^{ij}. We solve the BPS equation in noncommutative super Yang-Mills theory to O(\theta^2), transform the solution to the commutative description by the Seiberg-Witten (SW) map, and evaluate the eigenvalues of the scalar field. We find that, by tuning the free parameters in the SW map, we can make the scalar eigenvalues precisely reproduce the configuration of a tilted D-string suspended between two parallel D3-branes. This gives an example of how the ambiguities inevitable in the higher order SW map are fixed by physical requirements.
Nitroxide-Mediated Photo-Controlled/Living Radical Polymerization of Methacrylic Acid  [PDF]
Eri Yoshida
Open Journal of Polymer Chemistry (OJPChem) , 2013, DOI: 10.4236/ojpchem.2013.31004

The photo-controlled/living radical polymerization of methacrylic acid (MAA) was performed at room temperature by irradiation with a high-pressure mercury lamp using azo initiators and 4-methoxy-2,2,6,6-tetramethylpiperidine-1-oxyl as the mediator in the presence of (4-tert-butylphenyl)diphenylsulfonium triflate (tBuS) as the accelerator. Whereas the bulk polymerization yielded polymers with a bimodal molecular weight distribution in both the absence and presence of tBuS, the solution polymerization in methanol produced unimodal polymers with the molecular weight distribution of 2.0 - 2.3 in the presence of tBuS. The molecular weight distribution of the resulting poly (MAA) decreased with an in- crease in tBuS. The dilution of the monomer concentration also reduced the molecular weight distribution. The use of the initiator with a low 10-h half-life temperature also effectively controlled the molecular weight. The livingness of the polymerization was confirmed by obtaining linear increases in the first-order conversion versus time, the molecular weight versus the conversion, and the molecular weight versus the reciprocal of the initiator concentration.

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