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Search Results: 1 - 10 of 2924 matches for " Seiichi Kobayashi "
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Further Stabilization and Power Density Improvement of Stack-Type Thermoelectric Power Generating Module with Biphasic Medium by Using Various Flexible Metals as Electrodes  [PDF]
Seiichi Deguchi, Shoichiro Imaizumi, Hajime Arimura, Keisuke Sawada, Noriyuki Kobayashi, Norifumi Isu, Kenji Sakai, Kentaro Kimoto
Journal of Power and Energy Engineering (JPEE) , 2018, DOI: 10.4236/jpee.2018.611007
Abstract: In order to realize further stability of a stack-type thermoelectric power generating module (i.e. no electrical connections inside), flexible materials of metal springs and/or rods having restoring forces were installed between lower-temperature-sides of thermoelectric elements. These flexible materials were expected to play three important roles of interpolating different thermal expansions of the module components, enlarging heat removal area and penetration of any media through themselves. Then, a low-boiling-point medium (i.e. NOVEC manufactured by 3M Japan Ltd.) was also applied for a high-speed direct heat removal via its phase change from the lower-temperature-sides of the thermoelectric elements in the proposing stack-type thermoelectric power generating module. No electrical disconnections inside the module were confirmed for more than 9 years of use, indicating further module stability. The power generating density was improved to about 120 mW·m-2 with SUS304 springs having 0.7 mm diameter. Increasing power generating density can be expected in terms of suitable selection of flexible metal with high Vickers hardness, cavities control on the spring surface, more vigorous multiphase flow with adding powders to the medium and optimization of the module configurations according to numerical simulations.
Piezoelectric Power Harvesting via Acoustic-Pressure Driven by Low-Speed Wind-Force with Resonating-Tube and Wind-Collector  [PDF]
Seiichi Deguchi, Hiroya Taguchi, Hajime Arimura, Noriyuki Kobayashi, Norifumi Isu, Kentaro Takagi, Tsuyoshi Inoue, Takashi Nozoe, Seigo Saito, Takahiko Sano
Journal of Power and Energy Engineering (JPEE) , 2018, DOI: 10.4236/jpee.2018.611005
Abstract: Wind-driven power harvestings attract attentions since their target wind speeds are quite low less than the so-called cut-in wind speed, which is generally recognized as around 3 m/s. The extant power harvestings driven by wind-induced-air-column-resonations (i.e. acoustic-pressures) are still lacking simplicity, scale flexibility and solid strategies for practical applications. Therefore, the piezoelectric power harvesters via acoustic-pressures driven by low-speedwind-forces with resonating-tubes and wind-collectors were invented so as to complement all the lacks. The wind-collector as well as the resonating-tube contributed to upraise the power harvesting density. The champion power harvesting density of 19.5 nW/dm2 could be procured at 2.3 m/s of an artificial wind and the optimal resonating-tube and wind-collector. Power harvesting proofs from the natural wind with low mean speeds down to about 0.6 m/s were successfully obtained. The cut-in wind speed of the prototype piezoelectric power harvester was found to be quite low as about 0.4 m/s, signifying its ubiquity. Finally, a multi-bundle pendant-type piezoelectric power harvester was specifically presented together with professing the solid and multiple strategies for practical applications.
AutoGPA: An Automated 3D-QSAR Method Based on Pharmacophore Alignment and Grid Potential Analysis
Naoyuki Asakawa,Seiichi Kobayashi,Junichi Goto,Noriaki Hirayama
International Journal of Medicinal Chemistry , 2012, DOI: 10.1155/2012/498931
Abstract: 3D-QSAR approach has been widely applied and proven to be useful in the case where no reliable crystal structure of the complex between a biologically active molecule and the receptor is available. At the same time, however, it also has highlighted the sensitivity of this approach. The main requirement of the traditional 3D-QSAR method is that molecules should be correctly overlaid in what is assumed to be the bioactive conformation. Identifying an active conformation of a flexible molecule is technically difficult. It has been a bottleneck in the application of the 3D-QSAR method. We have developed a 3D-QSAR software named AutoGPA especially based on an automatic pharmacophore alignment method in order to overcome this problem which has discouraged general medicinal chemists from applying the 3D-QSAR methods to their “real-world” problems. Applications of AutoGPA to three inhibitor-receptor systems have demonstrated that without any prior information about the three-dimensional structure of the bioactive conformations AutoGPA can automatically generate reliable 3D-QSAR models. In this paper, the concept of AutoGPA and the application results will be described. 1. Introduction There are two major types of in silico drug discovery techniques: structure-based and ligand-based techniques. Quantitative structure-activity relationship (QSAR) approach only based on biological activities and chemical structures of a series of molecules with the modest biological activities is one of the ligand-based techniques. The QSAR approach explicitly considering three-dimensional shape of molecules is called 3D-QSAR. The CoMFA method proposed by Cramer et al. [1] is one of the 3D-QSAR approaches which has been widely applied and proven that the 3D-QSAR approach is better than the traditional QSAR one. The CoMFA method is based on the idea that biological activity can be analyzed by relating the shape-dependent steric and electrostatic field of molecules to their biological activity. The results of a 3D-QSAR depend on a number of factors, each of which must be carefully considered. One of the most important considerations involves the selection of biologically active conformations and their alignment prior to the analysis. This may be relatively straightforward when one is working with a congeneric series of compounds that all have some key structural features that can be overlaid. For example, the original CoMFA paper [1] examined a series of steroid molecules which can be overlaid easily using the rigid steroid nucleus. In most cases, however, molecules of interest for
Direct Production of High Pressure Hydrogen at Great Rate from Glycerol/Water/Metal Mixture  [PDF]
Seiichi Deguchi, Norifumi Isu, Noriyuki Kobayashi, Hajime Ohtani
Green and Sustainable Chemistry (GSC) , 2016, DOI: 10.4236/gsc.2016.63013
Abstract: One of the key issues facing the global society today is to find renewable and sustainable energy sources. Hydrogen has gained much attention in recent years since it is one of fuels for fuel cells. It emits no carbon dioxide when it is used and so on. In this study, a great rate production of high pressure hydrogen rich gas from glycerol/water/metal mixtures was developed since glycerol has become one of the enormous industrial by-products, especially from biodiesel processing plants. It was found that cobalt was the optimum metal additive among tested metals of aluminum, cobalt, magnesium and nickel in terms of a hydrogen producing rate, a hydrogen partial pressure and a conversion ratio from 50 mol% glycerol/water mixtures under an operating temperature of 723 K. Concretely, hydrogen rich gas with concentration about 64%H2 and high partial pressure about 4 MPaN,H2 could be produced at the great producing rate of 42.9 LN,H2 dm-2min-1 and high conversion ratio about 60%H2. All the produced hydrogen rich gases from glycerol/water/metal mixtures were by no means inferior to pure hydrogen as a fuel for the polymer elec-trolyte fuel cell.
Design of RLS Wiener Smoother and Filter for Colored Observation Noise in Linear Discrete-Time Stochastic Systems  [PDF]
Seiichi Nakamori
Journal of Signal and Information Processing (JSIP) , 2012, DOI: 10.4236/jsip.2012.33041
Abstract: Almost estimators are designed for the white observation noise. In the estimation problems, rather than the white observation noise, there might be actual cases where the observation noise is modeled by the colored noise process. This paper examines to design a new estimation technique of recursive least-squares (RLS) Wiener fixed-point smoother and filter for colored observation noise in linear discrete-time wide-sense stationary stochastic systems. The observation y(k) is given as the sum of the signal z(k)=Hx(k) and the colored observation noise vc(k). The RLS Wiener estimators explicitly require the following information: 1) the system matrix for the state vector x(k); 2) the observation matrix H; 3) the variance of the state vector x(k); 4) the system matrix for the colored observation noise vc(k); 5) the variance of the colored observation noise; 6) the input noise variance in the state equation for the colored observation noise.
Piezoelectric Power Harvesting Process via Phase Changes of Low-Boiling-Point Medium Together with Water for Recovering Low-Temperature Heats  [PDF]
Seiichi Deguchi, Akinori Miyajima, Hajime Arimura, Haruna Banno, Noriyuki Kobayashi, Norifumi Isu, Kentaro Takagi, Tsuyoshi Inoue, Takashi Nozoe, Seigo Saito, Takahiko Sano
Journal of Power and Energy Engineering (JPEE) , 2018, DOI: 10.4236/jpee.2018.611006
Abstract: Low-temperature thermal energy conversions down to exergy zero to electric power must contribute energy sustainability. That is to say, reinforcements of power harvesting technologies from extremely low temperatures less than 373 K might be at least one of minimum roles for the current generations. Then, piezoelectric power harvesting process for recovering low-temperature heats was invented by using a unique biphasic operating medium of an underlying water-insoluble/low-boiling-point medium (i.e. NOVEC manufactured by 3M Japan Ltd.) in small quantity and upper-layered water in large quantity. The higher piezoelectric power harvesting densities were naturally revealed with an increase in heating temperatures. Excessive cooling of the operating medium deteriorated the power harvesting efficiency. The denser operating medium was surpassingly helpful to the higher piezoelectric power harvesting density. Concretely, only about 5% density increase of main operating medium (i.e. water with dissolving alum at 0.10 mol/dm3) came to the champion piezoelectric power harvesting density of 92.6 pW/dm2 in this study, which was about 1.4 times compared to that with the original biphasic medium of pure water together with a small quantity of NOVEC.
Expression of CD133 and Extracellular Matrix Molecules in Malignant Brain Tumors  [PDF]
Seiichi Yoshida, Toshiro Koike
Neuroscience & Medicine (NM) , 2011, DOI: 10.4236/nm.2011.24052
Abstract: Background: CD133 could be characterized as a “stem-like” cell subpopulation and an invasive tumor phenotype. The objectives of this study were to investigate the relationship of CD133 and other remodeling factors such as matrix metalloproteinases (MMP) in the brain tumors. Methods: Tumors from 13 patients with brain tumors (8 lung cancer metastasis, 3 breast cancer metastasis, 2 gliomas) were studied to investigate the expression-patterns of CD133, EGFR, MT1-MMP, and MMP7 using the immunostaining and RT-PCR analysis. Results: EGFR immunostaining was detected in 75% (6/8) and 67% (1/3) of brain metastasis from lung adenocarcinoma and breast cancer, respectively. MT1-MMP immunostaining was also detected in 73% (8/11) of these brain metastasis. CD133 was not detected in these 13 patients. EGFR immunostaining was detected in 75% (6/8) and 67% (1/3) of brain metastasis from lung adenocarcinoma and breast cancer, respectively. MT1-MMP immunostaining was also detected in 73% (8/11) of these brain metastasis. CD133 was not detected in these 13 patients. Conclusions: The expression of CD133 indicates a marker for brain tumor initiating.
RLS Wiener Smoother for Colored Observation Noise with Relation to Innovation Theory in Linear Discrete-Time Stochastic Systems
Seiichi Nakamori
International Journal of Information Technology and Computer Science , 2013,
Abstract: Almost estimators are designed for the white observation noise. In the estimation problems, rather than the white observation noise, there might be actual cases where the observation noise is colored. This paper, from the viewpoint of the innovation theory, based on the recursive least-squares (RLS) Wiener fixed-point smoother and filter for the colored observation noise, newly proposes the RLS Wiener fixed-interval smoothing algorithm in linear discrete-time wide-sense stationary stochastic systems. The observation y(k) is given as the sum of the signal z(k)=Hx(k) and the colored observation noise (v_c)(k). The RLS Wiener fixed-interval smoother uses the following information: (a) the system matrix for the state vector x(k); (b) the observation matrix H; (c) the variance of the state vector; (d) the system matrix for the colored observation noise (v_c)(k); (e) the variance of the colored observation noise; (f) the input noise variance in the state equation for the colored observation noise.
On ±-convex functions of order 2
Seiichi Fukui
International Journal of Mathematics and Mathematical Sciences , 1997, DOI: 10.1155/s0161171297001051
Abstract: In 1969 Mocanu [1] introduced and studied a new class of analytic functions consisting of ±-convex functions. Many mathematicians have studied and shown the properties of this class. Now we will define new classes like that Mocanu class and then investigate and give some results. The class of ±-convex functions of order 2 partially includes Mocanu's class.
Low-Temperature Excess Heat Capacity of Potassium Germanate Glasses
Seiichi Mamiya
Modern Applied Science , 2013, DOI: 10.5539/mas.v7n5p22
Abstract: Low-temperature heat capacity of potassium germanate glasses (xK2O?(100-x)GeO2; x=0.0, 10.1, 19.0, 28.2, 39.0) (x indicates K2O mol% content) has been measured in the temperature range from 2 to 50 K with K2O content. From a result of the heat capacity Cp, it has been found that an excess heat capacity is not caused by a regular thermal motion but an interaction. In addition, it has also been found that a relationship between a maximum of reduced excess heat capacity CpT -3max and elastic modulus is dual. Moreover, a ‘hole’ model of liquid theory was applied to explain the formation of resonant mechanism. This model leads us to an idea that the excess heat capacity is described by degree of freedom of reallocated-and-isolated-structural units. Consequently, we conclude that the excess heat capacity is caused by the reallocated-main-network structure containing holes resonant with the reallocated-and-isolated-microstructural units.
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