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Search Results: 1 - 10 of 132525 matches for " Segura-Ibarra V "
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The physiology of cardiovascular disease and innovative liposomal platforms for therapy
Ruiz-Esparza GU,Flores-Arredondo JH,Segura-Ibarra V,Torre-Amione G
International Journal of Nanomedicine , 2013,
Abstract: Guillermo U Ruiz-Esparza,1,3 Jose H Flores-Arredondo,2 Victor Segura-Ibarra,3 Guillermo Torre-Amione,2,3 Mauro Ferrari,1 Elvin Blanco,1,* Rita E Serda1,3,* 1Methodist Hospital Research Institute, 2Methodist DeBakey Heart and Vascular Center, Methodist Hospital, Houston, TX, USA; 3Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico *Senior authors Abstract: Heart disease remains the major cause of death in males and females, emphasizing the need for novel strategies to improve patient treatment and survival. A therapeutic approach, still in its infancy, is the development of site-specific drug-delivery systems. Nanoparticle-based delivery systems, such as liposomes, have evolved into robust platforms for site-specific delivery of therapeutics. In this review, the clinical impact of cardiovascular disease and the pathophysiology of different subsets of the disease are described. Potential pathological targets for therapy are introduced, and promising advances in nanotherapeutic cardiovascular applications involving liposomal platforms are presented. Keywords: liposomes, cardiovascular disease, therapeutics, nanoparticles, nanomedicine
The physiology of cardiovascular disease and innovative liposomal platforms for therapy
Ruiz-Esparza GU, Flores-Arredondo JH, Segura-Ibarra V, Torre-Amione G, Ferrari M, Blanco E, Serda RE
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S30599
Abstract: iology of cardiovascular disease and innovative liposomal platforms for therapy Review (1238) Total Article Views Authors: Ruiz-Esparza GU, Flores-Arredondo JH, Segura-Ibarra V, Torre-Amione G, Ferrari M, Blanco E, Serda RE Published Date February 2013 Volume 2013:8 Pages 629 - 640 DOI: http://dx.doi.org/10.2147/IJN.S30599 Received: 01 October 2012 Accepted: 06 November 2012 Published: 11 February 2013 Guillermo U Ruiz-Esparza,1,3 Jose H Flores-Arredondo,2 Victor Segura-Ibarra,3 Guillermo Torre-Amione,2,3 Mauro Ferrari,1 Elvin Blanco,1,* Rita E Serda1,3,* 1Methodist Hospital Research Institute, 2Methodist DeBakey Heart and Vascular Center, Methodist Hospital, Houston, TX, USA; 3Escuela de Medicina y Ciencias de la Salud, Instituto Tecnológico y de Estudios Superiores de Monterrey, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico *Senior authors Abstract: Heart disease remains the major cause of death in males and females, emphasizing the need for novel strategies to improve patient treatment and survival. A therapeutic approach, still in its infancy, is the development of site-specific drug-delivery systems. Nanoparticle-based delivery systems, such as liposomes, have evolved into robust platforms for site-specific delivery of therapeutics. In this review, the clinical impact of cardiovascular disease and the pathophysiology of different subsets of the disease are described. Potential pathological targets for therapy are introduced, and promising advances in nanotherapeutic cardiovascular applications involving liposomal platforms are presented.
Effect of Cyclooxygenase-2 Blockade on Renal Hypertrophy Development during Early Diabetes Mellitus  [PDF]
Beatriz Vázquez-Cruz, Josseline Rangel-Veladiz, David Segura-Cobos, Pedro López-Sánchez, Maximiliano Ibarra-Barajas, Dante Amato
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.43042
Abstract:

Diabetes mellitus is the leading cause of diabetic nephropathy; the early phase of diabetes is associated with kidney growth and hyperfiltration; several factors modulate these changes, among them, prostaglandins and angiotensin II. Previous studies have shown that cyclooxygenase-2 is implicated in experimental models of diabetes. The aim of this work was to study the effect of celecoxib treatment on renal hypertrophy development in early diabetes mellitus. In our rats with early streptozotocin-induced diabetes there was renal hypertrophy, and increased renal expression of cyclooxygenase-2, AT1 receptor, and transforming growth factor-β1. Treatment with the selective cyclooxygenase-2 inhibitor celecoxib reduced the urinary excretion of prostaglandins such as prostaglandin E2, 6-keto prostaglandin F1α, and thromboxane B2. Kidney hypertrophy was reversed by the treatment, and the renal expression of cyclooxygenase-2, AT1 receptor, and transforming growth factor-β1 decreased. The renoprotective effects of celecoxib were independent of the changes in plasma glucose levels. These results confirm that cyclooxygenase-2 inhibition in rats with streptozotocin-induced diabetes decrease renal hypertrophy; this effect in turn, may be mediated by reduction of the expression of AT1 receptors and transforming growth factor-b1 in the kidney.

Cambios en la epidemiología de las hepatitis virales en Chile y consideraciones en estrategias de prevención
Ibarra V,Humberto;
Revista médica de Chile , 2007, DOI: 10.4067/S0034-98872007000200013
Abstract: the social and sanitary changes that chile is experiencing will change the epidemiologic profile of viral hepatitis. virus a hepatitis will displace to older ages, and immunization plans with specific vaccines should be considered. the real prevalence of hepatitis b may be higher, due to an underreporting of the disease. the education and vaccination of high risk groups should be reinforced. e virus hepatitis requires more research in risk groups and in certain animal species consumed by humans. c virus hepatitis is the greatest challenge as it causes chronic liver disease and is the main cause for liver transplantation
Cambios en la epidemiología de las hepatitis virales en Chile y consideraciones en estrategias de prevención The changing epidemiology of viral hepatitis in Chile
Humberto Ibarra V
Revista médica de Chile , 2007,
Abstract: The social and sanitary changes that Chile is experiencing will change the epidemiologic profile of viral hepatitis. Virus A hepatitis will displace to older ages, and immunization plans with specific vaccines should be considered. The real prevalence of hepatitis B may be higher, due to an underreporting of the disease. The education and vaccination of high risk groups should be reinforced. E virus hepatitis requires more research in risk groups and in certain animal species consumed by humans. C virus hepatitis is the greatest challenge as it causes chronic liver disease and is the main cause for liver transplantation
FRW barotropic zero modes: Dynamical systems observability
H. C. Rosu,V. Ibarra-Junquera
Physics , 2006,
Abstract: The dynamical systems observability properties of barotropic bosonic and fermionic FRW cosmological oscillators are investigated. Nonlinear techniques for dynamical analysis have been recently developed in many engineering areas but their application has not been extended beyond their standard field. This paper is a small contribution to an extension of this type of dynamical systems analysis to FRW barotropic cosmologies. We find that determining the Hubble parameter of barotropic FRW universes does not allow the observability, i.e., the determination of neither the barotropic FRW zero mode nor of its derivative as dynamical cosmological states. Only knowing the latter ones correspond to a rigorous dynamical observability in barotropic cosmology
PI-controlled bioreactor as a generalized Lienard system
V. Ibarra-Junquera,H. C. Rosu
Physics , 2005, DOI: 10.1016/j.compchemeng.2006.05.023
Abstract: It is shown that periodic orbits can occur in Cholette's bioreactor model working under the influence of a PI-controller. We find a diffeomorphic coordinate transformation that turns this controlled enzymatic reaction system into a generalized Lienard form. Furthermore, we give sufficient conditions for the existence and uniqueness of limit cycles in the new coordinates. We also perform numerical simulations illustrating the possibility of the existence of a local center (period annulus). A result with possible practical applications is that the oscillation frequency is a function of the integral control gain parameter
Study of the Pelagic Fish Environmental and Behavioral Adaptation to Strong Physicochemical Changes Induced by ENSO in Peruvian Waters (1997-1998)
Marceliano Segura,Arnaud Bertrand,Luis Vásquez
Investigaciones Marinas , 2002,
Abstract:
Inferring mixed-culture growth from total biomass data in a wavelet approach
V. Ibarra-Junquera,P. Escalante-Minakata,J. S. Murguia-Ibarra,H. C. Rosu
Physics , 2005, DOI: 10.1016/j.physa.2006.03.015
Abstract: It is shown that the presence of mixed-culture growth in batch fermentation processes can be very accurately inferred from total biomass data by means of the wavelet analysis for singularity detection. This is accomplished by considering simple phenomenological models for the mixed growth and the more complicated case of mixed growth on a mixture of substrates. The main quantity provided by the wavelet analysis is the Holder exponent of the singularity that we determine for our illustrative examples. The numerical results point to the possibility that Holder exponents can be used to characterize the nature of the mixed-culture growth in batch fermentation processes with potential industrial applications. Moreover, the analysis of the same data affected by the common additive Gaussian noise still lead to the wavelet detection of the singularities although the Holder exponent is no longer a useful parameter
Análisis de Regresión Logística para datos Correlacionados utilizando tres procedimientos del sistema Estadístico SAS
Segura Correa,José Candelario; Solis Calderón,José de Jesús; Segura Correa,Víctor Manuel;
Revista Científica , 2006,
Abstract: the objective of this study was to compare the results of logistic regressions for correlated data obtained by using three procedures of the statistical analysis system package (sas). information from a cross sectional study on infectious bovine rhinotracheitis in yucatan state, mexico, was used; where the sampling unit was the herd and the unit of interest was the animal. data were analyzed by using the logistic, genmod and nlmixed procedures of the sas. the logistic model used included the risk factors: herd size (£75, 76-147, 148-261, 262-480 animals) and stage of life (growth, development and production). the odd ratios (or) and 95% confidence intervals (ci95) were obtained. also the or and ci95 for the risk factors were estimated using ordinary logistic regression as a reference. the ors for herd size £75, 76-147, 148-261 y 262-480 animals, using logistic, genmod and nlmixed procedures were: 0.34, 0.68, 0.62 and 1; 0.34, 0.63, 0.63 and 1; and 0.29, 0.62, 0.57 and 1, respectively; and for the animals in the stage of growth, development and production were: 0.12, 0.15 and 1; 0.15, 0.17 and 1; and 0.12, 0.14 and 1, respectively. the narrower ci95 were for the ors from the ordinary logistic regression and the widest for the or obtained using the nlmixed procedure. in conclusion, the three procedures adjusted for herd effect, being the most precise those of the nlmixed procedure.
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