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Search Results: 1 - 10 of 2804 matches for " Satya Prakash "
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Synthesis and Characterization of Hydroxyapatite Powder by Eggshell  [PDF]
Himanshu Khandelwal, Satya Prakash
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2016, DOI: 10.4236/jmmce.2016.42011
Abstract: Hydroxyapatite (HA) having chemical formula Ca10(PO4)6(OH)2, is the main chemical component of human bone tissue (70%). This is the reason why it has been widely engaged in the dental and non-load bearing implantations, to cope up with the bone response as a bioactive material. In this study HA powder was synthesized by wet chemical method, using phosphoric acid (H3PO4) and eggshells. The synthesized HA powder was characterized by X-ray diffraction analysis, Scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX) and Fourier transform (FT-IR) spectroscopy. The Thermos gravimetric analysis (TGA-DTA) was also carried out to evaluate the stability of the synthesized HA powder at higher temperatures. The results of the study indicate that sintered (at 900°C) HA powder resembles the feature of pure and single apatite phase having favourable Ca/P ratio ranging from 1.7 to 2.4.
Role of Post Heat Treatment of Plasma Sprayed Pure and Al2O3-TiO2 Reinforced Hydroxyapatite Coating on the Microstructure and Mechanical Properties  [PDF]
Gurbhinder Singh, Surendra Singh, Satya Prakash
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2010, DOI: 10.4236/jmmce.2010.912076
Abstract: Pure and 10 wt% 80Al2O3-20TiO2 reinforced hydroxyapatite coatings were successfully deposited on Ti6Al4V substrate by plasma spray technique for bio medical applications. Post coating heat treatment was carried out to study the effect of heat treatment on improvement in micro structure and mechanical properties of coatings. Coating was characterized by SEM/EDAX and XRD analysis. Positive impact of post coating heat treatment was observed in microstructure, surface roughness and micro hardness of both coatings.
Post Heat Treatment of Plasma Sprayed Pure and Alumina-Titania Reinforced Hydroxyapatite Coating on SS 304 Steel  [PDF]
Gurbhinder Singh, Surendra Singh, Satya Prakash
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.102012
Abstract: It has been reported by previous research work that in plasma spray process hydroxyapatite decomposes into some amorphous phases due to rapid cooling of the coated substrate during the coating process, which causes instability of coated implant. Post coating heat treatment has been expected to minimize these phases and also enhance the long term reliability of hydroxyapatite coatings on metal substrates. In this paper post coating heat treatment is carried out at different temperatures suggested by the literature to study its effect on the microstructural and mechanical properties of coating. Coated substrates were characterized by X-ray diffraction (XRD) and SEM/EDAX analysis.
High Temperature Cyclic Oxidation Behavior of Ni and Co Based Superalloys  [PDF]
Deepa Mudgal, Surendra Singh, Satya Prakash
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2012, DOI: 10.4236/jmmce.2012.113017
Abstract: High temperature oxidation causes degradation of materials in aircraft, marine, industrial and land base gas turbines. To obviate this problem, oxidation behavior of Ni and Co based superalloys viz superni 600 and superco 605 (Midhani grade) has been studied in air at 900oC. Both superalloys go through cyclic oxidation which consists of 1 hr heating in silicon carbide tube furnace followed by 20 min cooling in ambient air. Weight change was taken by a digital electronic weighing balance having accuracy of 1 mg after each cycle. Exposed alloys were characterized by XRD, FESEM and EDS. Result shows that the Co base superalloy superco 605 shows less weight gain as compare to superni 600. The oxide layer mainly contains oxides of Cr2O3, NiO and spinel NiCr2O4.
Characterization of Plasma Sprayed Hydroxyapatite Coatings on AISI 316L SS and Titanium Substrate and their Corrosion Behavior in Simulated Body Fluid  [PDF]
Manoj Mittal, S. K. Nath, Satya Prakash
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.1011079
Abstract: In order to increase the bone bioactivity of metallic implants, hydroxyapatite (HA: Ca10(PO4)2(OH)6) is often coated on their surface so that real bond with surrounding bone tissue can be formed. In present study, HA coatings were deposited on AISI 316L SS and titanium using shrouded plasma spray process. The coated specimens were subjected to X-ray diffraction (XRD) analysis, field emission scanning electron microscopy (FE-SEM/EDAX). The polarization studies in simulated body fluid (SBF) were conducted to evaluate the corrosion resistance of bare and coated specimens. It was found that the hydroxyapatite coating provided excellent corrosion resistance. The resistance to corrosion was found independent on substrates
Characterization and Corrosion Behavior of Plasma Sprayed Pure and Reinforced HA Coatings in Simulated Body Fluid  [PDF]
Gurbhinder Singh, Surendra Singh, Satya Prakash
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.109060
Abstract: To evaluate the corrosion behavior in simulated body fluid pure and 10wt% 80Al2O3-20TiO2 reinforced HA coatings were successfully deposited by atmospheric plasma spray technique on SS-304L substrate alloy. To eliminate non favorable phases on the as sprayed coatings the coatings were heat treated at 700°C and 800°C for post coating heat treatment technique. Both pure and reinforced as sprayed and post coating heat treated coatings were characterized by XRD and SEM/EDAX analysis for surface characterization and further evaluated by electrochemical test for corrosion behavior in simulated body fluids.
Recent Advancements in Targeted Delivery of Therapeutic Molecules in Neurodegenerative Disease - Spinocerebellar Ataxia - Opportunities and Challenges
Satya Prakash and Meenakshi Malhotra
Drug Target Insights , 2012,
Abstract: Drug discovery and its methodologies have been very effective in terms of treating cancers and immunological disorders but have not been able to stop genetic diseases as most of the drugs target at the protein level. They merely mitigate the symptoms of the disease. Spinocerebellar ataxia is a neurological genetic disorder that is caused by the formation of an abnormal protein. There have been several reports on ataxic drug development but actual clinical treatment is yet to be achieved. Oligonucleotide therapy called sequence specific siRNA mediated gene silencing has evolved with promising results. This approach emphasizes on suppressing the expression of the diseased gene at mRNA level. However, there is a limitation in delivery of siRNA to the target site. Several methods have been developed over the last decade to enhance the target specific delivery of DNA, siRNA, protein and small drug molecules for therapeutic purpose with less or no side effects. This review discusses the latest upcoming technologies in the field that focus on a number of nonviral nanocarriers for targeted delivery. In this review, we explore the promise and potential of novel therapeutics with interest on ataxia therapy.
CREATININE CLEARANCE AS A MARKER FOR DIAGNOSING THE SEVERITY OF PREECLEMPSIA
Satya Prakash* and Neha Sharma
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: Background: For many years, creatinine clearance has become increasingly popular because of several advantages. The major error arises in clearance test when the timing of urine collection is inaccurate and the bladder is incompletely empty. Aim: In view of the aforementioned controversial literature, it was decided to evaluate the relation-ship between the renal changes (creatinine clearance) in pre-eclamptic, eclamptic, preeclamptic toxeaemic, non-pregnant and normal pregnant women. Setting and Design: The present investigations were undertaken to study creatinine clearance in normal non-pregnant women, pregnant women in different trimesters, Preeclamptic toxaemic patients and eclamptic patients, between the age group 25-32 years admitted in Rajendra Institute of Medical Sciences, Ranchi during the period from June 2008 to September 2009.Methods and Material: Control group consisted of 15 normal non-pregnant women, 10 cases in first trimester, 30 cases in 2nd trimester, 20 cases in 3rd trimester, 60 cases of Preeclamptic toxaemia and 20 cases of eclampsia. Creatinine clearance measurements were done by enzymatic method and modified Jaffe’s kinetic method.Statical Analysis: Statistical analysis was performed using GraphPad Prism version 5.00 for Windows, GraphPad software, San Diego, CAUSA, www.graphpad.com.Results: Creatinine clearance, in normal non-pregnant cases, the mean was 102.63 ml/min. In eclamptic cases, the mean found was around 71.98 ml/min. The difference between group is highly significant except when control and mild cases were compared (p>0.005).Conclusions: Clearance fall gradually in cases from mild to severe. However, it is a good index to gauge the renal status in these patients.
Network Security
Satya Prakash,Aradhana Jyotsana
International Journal of Scientific Research Engineering & Technology (IJSRET) , 2012,
Abstract: Our goal is here to give you the terminology, the wordsthat your customers are going to want to know andwant to be able to converse with. The Internet is awonderful tool but security is very important for it.Meteoric growths like that of Cisco from now here to amulti-billion dollar company in a decade would not bepossible without leveraging the tools available with theinternet and intranet. But without well definedsecurity, the Internet can be a dangerous place. Thegood news is that the tools are available to make theInternet a safe place for your business. Some peoplethink that only large sites are hacked. In reality, evensmall company sites are hacked. There’s a falseimpression from many small company owners that,"Hey, who would want to break into my company?I’m nobody. I’m not a big corporation like IBM or thePentagon or something like that, so why wouldsomebody want to break into my company?" Thereality is that even small companies are hacked intovery, very often.
Recent Advancements in Targeted Delivery of Therapeutic Molecules in Neurodegenerative Disease - Spinocerebellar Ataxia - Opportunities and Challenges
Satya Prakash,Meenakshi Malhotra
Drug Target Insights , 2008,
Abstract: Drug discovery and its methodologies have been very effective in terms of treating cancers and immunological disorders but have not been able to stop genetic diseases as most of the drugs target at the protein level. They merely mitigate the symptoms of the disease. Spinocerebellar ataxia is a neurological genetic disorder that is caused by the formation of an abnormal protein. There have been several reports on ataxic drug development but actual clinical treatment is yet to be achieved. Oligonucleotide therapy called sequence specific siRNA mediated gene silencing has evolved with promising results. This approach emphasizes on suppressing the expression of the diseased gene at mRNA level. However, there is a limitation in delivery of siRNA to the target site. Several methods have been developed over the last decade to enhance the target specific delivery of DNA, siRNA, protein and small drug molecules for therapeutic purpose with less or no side effects. This review discusses the latest upcoming technologies in the field that focus on a number of nonviral nanocarriers for targeted delivery. In this review, we explore the promise and potential of novel therapeutics with interest on ataxia therapy.
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