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Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]
Komal Mehta, Jayesh Gala, Surendra Bhasale, Sattayasheel Naik, Millind Modak, Harshad Thakur, Nivedita Deo, Mark JS Miller
BMC Complementary and Alternative Medicine , 2007, DOI: 10.1186/1472-6882-7-34
Abstract: Subjects (n = 95) were screened and randomized to receive glucosamine sulfate (n = 47, 1500 mg/day) or reparagen (n = 48, 1800 mg/day), a polyherbal consisting of 300 mg of vincaria (Uncaria guianensis) and 1500 mg of RNI 249 (Lepidium meyenii) administered orally, twice daily. Primary efficacy variable was response rate based on a 20% improvement in WOMAC pain scores. Additional outcomes were WOMAC scores for pain, stiffness and function, visual analog score (VAS) for pain, with assessments at 1, 2, 4, 6 and 8 weeks. Tolerability, investigator and subject global assessments and rescue medication consumption (paracetamol) were measured together with safety assessments including vital signs and laboratory based assays.Subject randomization was effective: age, gender and disease status distribution was similar in both groups. The response rates (20% reduction in WOMAC pain) were substantial for both glucosamine (89%) and reparagen (94%) and supported by investigator and subject assessments. Using related criteria response rates to reparagen were favorable when compared to glucosamine. Compared to baseline both treatments showed significant benefits in WOMAC and VAS outcomes within one week (P < 0.05), with a similar, progressive improvement over the course of the 8 week treatment protocol (45–62% reduction in WOMAC or VAS scores). Tolerability was excellent, no serious adverse events were noted and safety parameters were unchanged. Rescue medication use was significantly lower in the reparagen group (p < 0.01) at each assessment period. Serum IGF-1 levels were unaltered by treatments.Both reparagen and glucosamine sulfate produced substantial improvements in pain, stiffness and function in subjects with osteoarthritis. Response rates were high and the safety profile was excellent, with significantly less rescue medication use with reparagen. Reparagen represents a new natural productive alternative in the management of joint health.Current Controlled Trials ISRCTN2543
Effect of Salinity Stress on Antioxidant Defense System of Niger (Guizotia abyssinica Cass.)  [PDF]
Hemla Naik Kavya Naik, Varadahalli R. Devaraj
American Journal of Plant Sciences (AJPS) , 2016, DOI: 10.4236/ajps.2016.76093
Abstract: Salinity is one of the principal abiotic stresses that affect plant productivity by inducing osmotic stress, which in turn, causes oxidative stress. Plants respond to this oxidative stress by adjusting levels of antioxidants and associated components. 10-day old seedlings of Niger were evaluated for abiotic stress response in terms of antioxidants and antioxidant enzymes over 72 h in presence of up to 500 mM NaCl in combination with CaCl2. Stress markers: H2O2, lipid peroxidation, antioxidants; ASC and GSH and antioxidant enzymes such as POX, APX and GR were significantly elevated, while CAT was reduced. The response was concentration and time-dependent up to 300 mM NaCl and fluctuated beyond. Metabolic enzymes β-amylase and acid phosphatase exhibited moderate increase relative to controls. The parameters indicated tolerance of the plants to salinity up to 300 mM over 48 h.
Solid state fermentation of pomegranate seed for lovastatin production: a bioprocessing approach  [PDF]
Azza Naik, Smita Lele
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.35083
Abstract: This study reports lovastatin production by solid state fermentation using pomegranate seeds as a substrate. Six different fungal strains and several agro-industrial wastes were selected and screened. Various physico-chemical parameters were optimized to improve lovastatin. Moreover, chemical mutation was systematically employed to enhance lovastatin yield on selected strains. Productivity of 3 ± 0.06 mg lovastatin/gm dfm was obtained prior to optimization. One factor a time followed by Response Surface Methodology (RSM) gave 4.2 ± 0.10 mg lovastatin/gm dfm yield in an optimized setup with pomegranate seed powder (5 gms), KH2PO4 (0.1% w/v), glucose (5% w/v), moisture (60% w/w), pH 5 in a 15 days fermentation cycle. The production was further increased to 6.5 ± 0.08 mg lovastatin/gm dfm through chemical mutation of the strain. This process is simple and reproducible for the production of lovastatin using pomegranate seed as an agro-industrial waste.
Use of Solid-Supported Reagents towards Synthesis of 2-Arylbenzoxazole, 3, 5-Diarylisoxazole and 1, 3, 5-Triarylpyrazole  [PDF]
Sneha Naik, Vidya Desai
Green and Sustainable Chemistry (GSC) , 2013, DOI: 10.4236/gsc.2013.31001

Herein we report a convenient and efficient synthesis of 2-Arylbenzoxazole from the Schiff’s bases of 2-Aminophenol, 3, 5-Diarylisoxazole from α, β-unsaturated ketoxime and 1,3,5-Triarylpyrazole from 2-pyrazoline and N-Arylhydrazone by using milder, less toxic and less expensive-NBS-SiO2, KMnO4-Al2O3, PCC-SiO2 and ACC-Al2O3 as solid-supported oxidizing agents at room temperature. Within the framework of Green Chemistry, the use of solid supported reagents has many advantages such as 1) they are easy to remove from reactions by filtration 2) excess reagents can be used to drive the reaction without introducing any difficulties in purification 3) such solid-supported reagents react differently, mostly more selectively, than their unbound counterparts and 4) toxic, noxious and explosive chemicals are handled more safely when contained on solid support.

Room-Temperature Humidity Sensing Using Graphene Oxide Thin Films  [PDF]
Gautam Naik, Sridhar Krishnaswamy
Graphene (Graphene) , 2016, DOI: 10.4236/graphene.2016.51001
Abstract: In this article, we report on a room-temperature humidity sensing device using graphene oxide (GO) thin films synthesized by chemical exfoliation. Changes in the device conductivity are measured for varying relative humidity in the experimental chamber. Experiments are carried out for relative humidity varying from 30% to 95%. We observe a difference in the results obtained for low relative humidity (<50%) and high relative humidity (>50%), and propose a sensing mechanism to explain this difference. Although the sensor exhibits some hysteresis at high relative humidities, a method to “reset” the sensor is also proposed. The sensing device has high sensitivity and fast response time.
Photoreduction and Thermal Properties of Graphene-Based Flexible Films  [PDF]
Gautam Naik, Sridhar Krishnaswamy
Graphene (Graphene) , 2017, DOI: 10.4236/graphene.2017.62003
Abstract: In the present study, we report on an efficient method for large-area photoreduction of graphene oxide flexible films. The laser-based reduction can be carried out in situ and can be tuned to attain the properties required. A systematic study has been conducted to evaluate the variation of the degree of reduction with the actual reduction temperature, which is measured using an infrared thermal camera. Local reduction temperature is varied up to 350°C, and the degree of reduction is measured using the C/O ratio. The C/O ratio is increased from 2:1 for graphene oxide to 10:1 for reduced graphene oxide. This high degree of reduction is observed at low temperatures, and also in a short period of time. Thermal conductivity properties calculated using the temperature distribution shows the in-plane thermal conductivities of graphene oxide and reduced graphene oxide are a few orders of magnitude lower than single layer graphene. This can be attributed to oxygen-defect scattering, and also due to the heat conduction through the thickness of the sample by way of contact between adjacent flakes. This photoreduction method provides a way for roll-to-roll scalable production of graphene-based flexible films.
Simulation Study of Active Noise Control in Wind Turbines Using FxLMS Adaptation Algorithm  [PDF]
Soumya Roy, Pratik Naik
Journal of Power and Energy Engineering (JPEE) , 2017, DOI: 10.4236/jpee.2017.58006
Abstract: Utility scale wind turbines produce a significant amount of noise which has been identified as one of the most critical challenges to the widespread use of wind energy. Aerodynamic noise caused primarily by the interaction of the boundary layer and (or) the upstream atmospheric turbulence with the trailing edge of the blade has been identified as the most dominant source of noise in wind turbines. The authors here propose an active noise control system based on the FxLMS algorithm which can achieve suppression of noise from a modern wind turbine. Two types of noise sources have been simulated: monopole and dipole. The results of the active noise control algorithm are validated with simulations in MATLAB. The agreement between the results shows the far impact of active noise control techniques will have in future wind turbines.
Analysis of Use and Outcomes of Peripherally Inserted Central Catheter (PICC-Line) in Hemato-Oncological Patients  [PDF]
Sulav Sapkota, Radheshyam Naik
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.91005
Abstract: Aims: To audit the use and outcomes of using PICC lines in hemato-oncological patients. Objectives: To study the demographics of patients: ?studying the use of PICC line in hemato-oncological patients; studying the rate of complications in PICC line; studying the cause of early removal of PICC line. Methods: All PICCs inserted in adult hemato-oncological patients in Hematology and Medical Oncology Department of Health Care Global (HCG) Hospital were studied prospectively, as per the proforma, till PICCs were removed or patient expired and the pattern of complications were noted. Results: Eighty-four PICCs were inserted over a period of initial nine months and followed for a total of 1 year with three months post insertion duration for a total of 10,868 catheter-days (mean of 129 days i.e. 4.3 months, range: 1 to 288 days). The most common indication for PICC was chemotherapy (100%). Among them
A Study of 63 Cases of Mouth Neoplasms in Arecanut Growing Belt of Sullia
Naik SM,Naik SS
Iranian Journal of Cancer Prevention , 2012,
Abstract: Background: Betel nut and betel quid chewing are from major etiological factorfor oral cancer. They also increase the risk of systemic diseases such as asthma,diabetes mellitus, metabolic syndrome, myocardial infarction, hypertension, andother cardiovascular diseases.Methods: Sixty three patients of oral cancer in our institution during Jan. 2007 toMay 2011 were included in our study. This study included 14 cases of lipcarcinoma, 41 cases of buccal mucosa carcinoma, 7 cases of tongue carcinoma,and 1 case of carcinoma of upper alveolus. Duration of use of betel quid, panmasala, and gutkha were studied as well as management.Results: All patients in our study have been chewing betel-quid for 6-31 years(mean19.42 years). All of them quit betel quid and used easily availablepanmasala and gutkha for 4-13 years (mean 8.28 years). Nine cases of lipcarcinoma, 13 cases of buccal mucosa carcinoma and 3 cases of tongue carcinomawere treated with surgery. Seven cases of lip carcinoma, 30 cases of buccalmucosa carcinoma and 5 cases of tongue carcinoma were treated with postoperative or palliative radiotherapy.Conclusion: Betel nut chewing with or without tobacco and lime are proven to becarcinogens in human. Direct relationship between oral cancer and betel quid,gutkha, and panmasala use has been shown in our study. As betel quid,panmasala and gutkha chewing were proven to be carcinogens, a permanent banon manufacturing and sale of these products should be implemented.
Sarendib’s Sorrow: Sri Lanka’s Continued Conflict
Abhayraj Naik
Socio-Legal Review , 2010,
Abstract: In this article, the author studies the conflict in Sri Lanka, and identifies and describes two sources of its intractability: fractured fronts and maximalist goals. The article seeks to reveal that while the Sri Lankan government’s recent military onslaught against the LTTE has been surprisingly successful, history is clear that a meaningful solution to the conflict in Sri Lanka will be found not on the battlefield but in the hearts and minds of the Sri Lankan people. The causes of the conflict are several – an analysis of these sources of intractability involves both a backward looking appreciation of the events, perspectives and trends that fractured a nation as well as a forward looking transformative outlook towards a shared deliberative reality. The author believes that while the current military success against the LTTE coincides with a wave of collective Sri Lankan anguish at the country’s grim predicament. For several reasons, the present represents a potential moment of critical realignment in Sri Lanka. An analysis of the institutional, historical and ideological bases of the conflict indicates different channels that the public sphere will have to simultaneously destroy and create if such a critical realignment is to be serendipitously realised.
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