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Search Results: 1 - 10 of 5746 matches for " Sara Velilla "
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Oral Doxycycline Reduces Pterygium Lesions; Results from a Double Blind, Randomized, Placebo Controlled Clinical Trial
Oscar Rúa, Ignacio M. Larráyoz, María T. Barajas, Sara Velilla, Alfredo Martínez
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052696
Abstract: Purpose To determine whether oral doxycycline treatment reduces pterygium lesions. Design Double blind, randomized, placebo controlled clinical trial. Participants 98 adult patients with primary pterygium. Methods Patients were randomly assigned to receive 100 mg oral doxycycline twice a day (49 subjects), or placebo (49 subjects), for 30 days. Photographs of the lesion were taken at the time of recruitment and at the end of the treatment. Follow-up sessions were performed 6 and 12 months post-treatment. Statistical analyses for both continuous and categorical variables were applied. p values of less than 0.05 were considered to indicate statistical significance. Main Outcome Measures The primary endpoint was the change in lesion size after 30 days of treatment. Results The primary endpoint was not met for the whole population but subgroup analysis showed that doxycycline was effective in patients of Caucasian origin while other ethnicities, mostly Hispanic, did not respond to the treatment. Moreover, there was a correlation between age and better response (p = 0.003). Adverse events were uncommon, mild, and in agreement with previous reports on short doxycycline treatments. Conclusions Oral doxycycline was superior to placebo for the treatment of primary pterygia in older Caucasian patients. These findings support the use of doxycycline for pterygium treatment in particular populations. Trial Registration European Union Clinical Trials Register EudraCT 2008-007178-39
Granates metamórficos alpinos en rocas metapelíticas del grupo del Mulhacén (Sierra Nevada. SE. Espa a)
Velilla, N.
Estudios Geologicos , 1985,
Abstract: The Paleozoic, or older, basement and the Permo-Triassic cover of the Mulhacén group are made up mainly of metapelitic rocks. In these rocks the first alpine metamorphic phase (high P and low T) produced the breakdown of prealpine biotite and st aurolite porphyroblasts to form garnets and other minerals. These garnets are very rich in almandine endmember (Alm 82, Pyr 11, Gro 6, Spe 1) and they show Fe and Ca zoning , The main alpine phase of metamorphism (amphibolite facies) gave rise to a great amount of garnet of various textural and chemical types. Their compositions range between Alm 63-80 , Pyr 6-20, Gro 8-29, and Spe 0.3-4, and they are strongly, and sometimes complex.ly, zoned . The main factors controlling the chemical characteristics of garnets are discussed. Among these it can be emphasized : a) the host-rock chemistry, b) the metamorphic conditions, e) the oxidation ratio of the rock, d) the nucleation and growth processes, and e) the relationships with other Fe-Mg and /or Ca coexisting minerals. El grupo del Mulhacén está constituido mayoritariamente por rocas metapelíticas, tanto en sus tramos basales, correspondientes a un zócalo paleozoico o más antiguo, como en la cobertera permotriásica en la que presentan una notable variedad mineralógica. En este tipo de rocas, durante la primera fase de metamorfismo alpino (de alta P Y baja T), se forman granates a partir de porfiroblastos prealpinos de biotita y de estaurolita. Estos granates son muy ricos en almandino (Alm 82, Pir 11, Gro 6, Esp 1) Y están zonados respecto al Fe y al Ca. La segunda fase de metamorfismo alpino (facies anfibolitas) produce un a cristalización muy abundante de granates, con una profusión de tipos texturales y químicos. Sus composiciones están comprendidas entre los siguientes términos: Alm 63-80, Pir 6-20, Gro 8-29, Esp . 0.3-4. Presentan una marcada y, a veces, compleja zonación química. Se discuten los factores que determinan las características químicas de los granates, entre los que cabe destacar: a) composición química de la roca huésped, b) condiciones P-T del metamorfismo, e) estado de oxidación de la roca, d) proceso de nucleación y crecimiento , y e) relaciones con minerales ferromagnesianos y/o cálcicos coexistentes.
Molecular Effects of Doxycycline Treatment on Pterygium as Revealed by Massive Transcriptome Sequencing
Ignacio M. Larráyoz, Alberto de Luis, Oscar Rúa, Sara Velilla, Juan Cabello, Alfredo Martínez
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039359
Abstract: Pterygium is a lesion of the eye surface which involves cell proliferation, migration, angiogenesis, fibrosis, and extracellular matrix remodelling. Surgery is the only approved method to treat this disorder, but high recurrence rates are common. Recently, it has been shown in a mouse model that treatment with doxycycline resulted in reduction of the pterygium lesions. Here we study the mechanism(s) of action by which doxycycline achieves these results, using massive sequencing techniques. Surgically removed pterygia from 10 consecutive patients were set in short term culture and exposed to 0 (control), 50, 200, and 500 μg/ml doxycycline for 24 h, their mRNA was purified, reverse transcribed and sequenced through Illumina’s massive sequencing protocols. Acquired data were subjected to quantile normalization and analyzed using cytoscape plugin software to explore the pathways involved. False discovery rate (FDR) methods were used to identify 332 genes which modified their expression in a dose-dependent manner upon exposure to doxycycline. The more represented cellular pathways included all mitochondrial genes, the endoplasmic reticulum stress response, integrins and extracellular matrix components, and growth factors. A high correlation was obtained when comparing ultrasequencing data with qRT-PCR and ELISA results. Doxycycline significantly modified the expression of important cellular pathways in pterygium cells, in a way which is consistent with the observed efficacy of this antibiotic to reduce pterygium lesions in a mouse model. Clinical trials are under way to demonstrate whether there is a benefit for human patients.
Escriure (correctament) per al web
Centelles Velilla, Miquel
BiD : Textos Universitaris de Biblioteconomia i Documentació , 2004,
Abstract: Es presenten els requeriments d escriptura que imposa la lectura de textos al web i les recomanacions generals per a la redacció orientada a facilitar-ne la lectura. Després d introduir el marc general de la lectura del text escrit, les tècniques i estratègies, s exposen els condicionants i les especificitats de la lectura en el web. A partir d aquests elements, es presenten una sèrie de recomanacions de bones pràctiques per a la correcta redacció al web, que s organitzen segons els tres components bàsics del text escrit: l estil o to, l estructura i la presentació (correcció ortogràfica i tipogràfica). També s introdueixen unes eines que poden ser útils per a la millora de la redacció de textos en un entorn corporatiu.The article presents the requirements of written text to be read on the web, as well as the general recommendations for editing text aimed at facilitating its reading. After introducing the overview of reading of written text, techniques, and strategies, the author turns to factors that condition reading on the web, as well as other specifics. Based on these elements, a series of recommendations is offered for good practices for writing correctly for the web, organised by the three basic components of written text: style or tone, structure, and presentation (orthographic and typographic corrections). Also introduced are tools that can be useful for improving text editing in a corporate environment.Se presentan las exigencias de escritura impuestas por la lectura de textos en páginas web y las recomendaciones generales de redacción de cara a facilitar la lectura. Después de introducir el marco general de la lectura del texto escrito, las técnicas y las estrategias, se exponen los condicionantes y especificidades de la lectura de páginas web. A partir de estos elementos se hacen una serie de recomendaciones de buenas prácticas para una correcta redacción de páginas web que se organizan según los tres componentes básicos del texto escrito: el estilo o tono, la estructura y la presentación (corrección ortográfica y tipográfica). También se ofrecen recursos que pueden resultar útiles para mejorar la redacción de textos en un entorno cooperativo.
Los programas de Fuentes y servicios de información en las escuelas norteamericanas de Biblioteconomía y Documentación
Centelles Velilla, Miquel
BiD : Textos Universitaris de Biblioteconomia i Documentació , 2000,
Abstract: S'estableix una relació entre els cursos bàsics de treball de referència, impartits en les escoles de Biblioteconomia i Documentació nord-americanes, i les assignatures Serveis d'informació i Serveis i fonts d'informació presents en els plans d'estudis de la Diplomatura en Biblioteconomia i Documentació de la Universitat de Barcelona durant la dècada dels noranta. Es presenta una revisió de la literatura recent sobre la naturalesa i les tendències del curs bàsic esmentat, i s'analitzen els programes corresponents a aquesta assignatura que s'imparteixen a les millors escoles dels Estats Units d'Amèrica.
Informe del BOBCATSSS 2004 Symposium Library and Information in Multicultural Societies (Riga, Letònia, 26-28 de gener de 2004)
Centelles Velilla, Miquel
BiD : Textos Universitaris de Biblioteconomia i Documentació , 2004,
Els programes de Fonts i serveis d'informació a les escoles nord-americanes de Biblioteconomia i Documentació
Centelles Velilla, Miquel
BiD : Textos Universitaris de Biblioteconomia i Documentació , 2000,
Abstract: S'estableix una relació entre els cursos bàsics de treball de referència, impartits en les escoles de Biblioteconomia i Documentació nord-americanes, i les assignatures Serveis d'informació i Serveis i fonts d'informació presents en els plans d'estudis de la Diplomatura en Biblioteconomia i Documentació de la Universitat de Barcelona durant la dècada dels noranta. Es presenta una revisió de la literatura recent sobre la naturalesa i les tendències del curs bàsic esmentat, i s'analitzen els programes corresponents a aquesta assignatura que s'imparteixen a les millors escoles dels Estats Units d'Amèrica.
Aula virtual y presencial en aprendizaje de comunicación audiovisual y educación Virtual and Real Classroom in Learning Audiovisual Communication and Education
Josefina Santibá?ez Velilla
Comunicar , 2010, DOI: 10.3916/c35-2010-03-12
Abstract: El modelo mixto de ense anza-aprendizaje pretende utilizar las tecnologías de la información y de la comunicación (TIC) para garantizar una formación más ajustada al Espacio Europeo de Educación Superior (EEES). Se formularon los siguientes objetivos de investigación: Averiguar la valoración que hacen los alumnos de Magisterio del aula virtual WebCT como apoyo a la docencia presencial, y conocer las ventajas del uso de la WebCT y de las TIC por los alumnos en el estudio de caso: Valores y contravalores transmitidos por series televisivas visionadas por ni os y adolescentes . La investigación se realizó con una muestra de 205 alumnos de la Universidad de La Rioja que cursaban la asignatura de Tecnologías aplicadas a la Educación . Para la descripción objetiva, sistemática y cuantitativa del contenido manifiesto de los documentos se ha utilizado la técnica de análisis de contenido cualitativa y cuantitativa. Los resultados obtenidos demuestran que las herramientas de comunicación, contenidos y evaluación son valoradas favorablemente por los alumnos. Se llega a la conclusión de que la WebCT y las TIC constituyen un apoyo a la innovación metodológica del EEES basada en el aprendizaje centrado en el alumno. Los alumnos evidencian su competencia audiovisual en los ámbitos de análisis de valores y de expresión a través de documentos audiovisuales en formatos multimedia. Dichos alumnos aportan un nuevo sentido innovador y creativo al uso docente de series televisivas. The mixed model of Teaching-Learning intends to use Information and Communication Technologies (ICTs) to guarantee an education more adjusted to European Space for Higher Education (ESHE). The following research objectives were formulated: 1) To find out the assessment made by teacher-training college students of the virtual classroom WebCT as an aid to face-to-face teaching. 2) To know the advantages of the use of WebCT and ICTs by students in the case study: Values and counter-values transmitted by television series for children and teenagers . The research has been carried out using a sample of 205 students of the University of La Rioja who attended a course in Technologies Applied to Education. The technique of qualitative and quantitative content analysis has been used to provide an objective, systematic and quantitative description of the different documents content. The results obtained show that the communication, content and assessment tools of WebCT are favourably assessed by the students. We have reached the conclusion that WebCT and ICTS constitute an aid to ESHE methodological inno
Variations in Functional and Anatomical Outcomes and in Proliferative Vitreoretinopathy Rate along a Prospective Collaborative Study on Primary Rhegmatogenous Retinal Detachments: The Retina 1 Project—Report 4
J. Carlos Pastor,Itziar Fernández,Rosa M. Coco,María R. Sanabria,Enrique Rodríguez de la Rúa,Rosa M. Pi?on,Vicente Martinez,Anna Sala-Puigdollers,José M. Gallardo,Sara Velilla
ISRN Ophthalmology , 2012, DOI: 10.5402/2012/206385
Abstract: Purpose. To analyse variations in the anatomical and functional outcomes and in proliferative vitreoretinopathy (PVR) rate of a prospective multicentric study that was primarily designed for identification of clinical risk factors for PVR. Methods. 1,046 retinal detachment (RD) cases were analysed. Cases were divided into two series based upon variation in PVR rate determined by logistic regression analysis. Series 1 (S1) included RD treated during 2004-2005 ( ) and Series 2 (S2) during 2006–2008 ( ). Pre-, intra-, and postoperative characteristics were recorded. Results. There were few differences in the preoperative characteristics. S2 had more vitrectomies and scleral bands and fewer explants and associated cataract extractions than S1. Anatomic reattachment improved from 87.9% to 92.9% in S1 and S2, respectively, ( ). Visual acuity at 3 months ≥20/40 increased from 36.5% of S1 to 44.2% in S2 ( ). PVR rate diminished from 14.1% in S1 to 8.1% in S2 ( ). Centres with higher rates of PVR in S1 showed the greatest reductions in S2. Conclusion. An improvement in anatomical and functional outcome and PVR rate occurred in participating centres cannot be attributed to the learning curve of surgeons. We speculated that it could be an effect of their participation in the study. 1. Introduction In 2005, after a retrospective case-controlled study involving five clinical centres, we developed a formula to estimate the risk of proliferative vitreoretinopathy (PVR) onset after rhegmatogenous retinal detachment (RD) surgery [1]. Even though the sensitivity and specificity values of that formula were higher than other predictive formulas [2], it was not considered appropriate for routine clinical use. Thus the Retina 1 project was designed to improve that predictive formula by increasing the sample. This project consisted of a prospective study involving 17 centres in Spain and Portugal that collected pre-, intra-, and postoperative data for consecutive, noncomplicated RDs for over 1,000 cases between 2004 and 2008. Statistical analysis of the collected data performed after closing the recruitment period revealed an inflexion point indicating a significant reduction in PVR rate at the end of 2005. Careful analysis of the pre- and post-2005 data also showed improvements in reattachment rate which could not be attributed to differences in preoperative and intraoperative characteristics. Thus, we hypothesized that active collaborative participation of surgeons in the project might have had a positive influence in their outcomes. Although the main purpose of the Retina
Homotopy Perturbation Method for Solving Moving Boundary and Isoperimetric Problems  [PDF]
Sara Ghaderi
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.35062
Abstract: In this paper, homotopy perturbation method is applied to solve moving boundary and isoperimetric problems. This method does not depend upon a small parameter in the equation. homotopy is constructed with an imbedding parameter p, which is considered as a “small parameter”. Finally, we use combined homotopy perturbation method and Green’s function method for solving second order problems. Some examples are given to illustrate the effectiveness of methods. The results show that these methods provides a powerful mathematical tools for solving problems.
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