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Search Results: 1 - 10 of 228952 matches for " Sara R. Guariglia "
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Increasing Maternal or Post-Weaning Folic Acid Alters Gene Expression and Moderately Changes Behavior in the Offspring
Subit Barua, Kathryn K. Chadman, Salomon Kuizon, Diego Buenaventura, Nathan W. Stapley, Felicia Ruocco, Umme Begum, Sara R. Guariglia, W. Ted Brown, Mohammed A. Junaid
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101674
Abstract: Background Studies have indicated that altered maternal micronutrients and vitamins influence the development of newborns and altered nutrient exposure throughout the lifetime may have potential health effects and increased susceptibility to chronic diseases. In recent years, folic acid (FA) exposure has significantly increased as a result of mandatory FA fortification and supplementation during pregnancy. Since FA modulates DNA methylation and affects gene expression, we investigated whether the amount of FA ingested during gestation alters gene expression in the newborn cerebral hemisphere, and if the increased exposure to FA during gestation and throughout the lifetime alters behavior in C57BL/6J mice. Methods Dams were fed FA either at 0.4 mg or 4 mg/kg diet throughout the pregnancy and the resulting pups were maintained on the diet throughout experimentation. Newborn pups brain cerebral hemispheres were used for microarray analysis. To confirm alteration of several genes, quantitative RT-PCR (qRT-PCR) and Western blot analyses were performed. In addition, various behavior assessments were conducted on neonatal and adult offspring. Results Results from microarray analysis suggest that the higher dose of FA supplementation during gestation alters the expression of a number of genes in the newborns’ cerebral hemispheres, including many involved in development. QRT-PCR confirmed alterations of nine genes including down-regulation of Cpn2, Htr4, Zfp353, Vgll2 and up-regulation of Xist, Nkx6-3, Leprel1, Nfix, Slc17a7. The alterations in the expression of Slc17a7 and Vgll2 were confirmed at the protein level. Pups exposed to the higher dose of FA exhibited increased ultrasonic vocalizations, greater anxiety-like behavior and hyperactivity. These findings suggest that although FA plays a significant role in mammalian cellular machinery, there may be a loss of benefit from higher amounts of FA. Unregulated high FA supplementation during pregnancy and throughout the life course may have lasting effects, with alterations in brain development resulting in changes in behavior.
A multisource approach for coastline mapping and identification of shoreline changes
A. Guariglia,A. Buonamassa,A. Losurdo,R. Saladino
Annals of Geophysics , 2006, DOI: 10.4401/ag-3155
Abstract: Coastal dynamics are driven by phenomena of exogenous and endogenous nature. Characterizing factors that influence their equilibrium and continuous monitoring are fundamental for effective environmental planning and management of coastal areas. In order to monitor shoreline changes, we developed a methodology based on a multisource and multitemporal approach. A database, related to the Ionian coast of Basilicata region (about 50 km), was implemented by using cartographic data (IGMI data), satellite imagery (SPOT-PX/XS, Landsat-TM, Corona) and aerial data covering the period form 1949 to 2001. In particular, airborne data (1 m spatial resolution) were acquired during a specific campaign we performed in 2000 and 2001. To obtain the best performance from the available data, we applied a data fusion procedure on visible and thermal information. Different algorithms were tested, such as band ratios and clustering for extracting the coastline. The best results from multispectral data were obtained using a threshold algorithm we devised by exploiting the green, red and NIR bands, whereas for panchromatic data we selected clustering as the more suitable method. Moreover, a GPS survey was performed to evaluate the influence of tidal effects.
Diálogos na disserta??o escolar: um estudo sobre os enunciados de senso comum e de polêmica
Guariglia, Rinaldo;
Bakhtiniana: Revista de Estudos do Discurso , 2012, DOI: 10.1590/S2176-45732012000100006
Abstract: this paper examines two dialogical categories of the scholarly argumentative text: consensual one (common sense enunciates) and polemical one (opposed to common sense contents). three dialogical matrices are investigated: the dialogue between subject-producer and other social voices, and text-proposal, and interlocutor-examiner. these dialogues insert a set of textual and discursive properties which are consensual category manifestations or polemical ones in accordance with the argumentative arrangement of text. among the dialogical properties are wholeness enunciates, argumentative-descriptive enunciates, strict logical reasoning, breakage of textproposal, interrogative-rhetoric enunciates and paraphrases from the text-proposal.
Justicia global: Número especial
Osvaldo Guariglia
Revista Latinoamericana de Filosofía , 2007,
Abstract:
Patricio Garrahan: (1938-2011)
Osvaldo Guariglia
Revista Latinoamericana de Filosofía , 2011,
Abstract:
Diálogos na disserta o escolar: um estudo sobre os enunciados de senso comum e de polêmica / Dialogues at the scholarly argumentative text: an analysis of consensual and polemical enunciates
Rinaldo Guariglia
Bakhtiniana: Revista de Estudos do Discurso , 2012,
Abstract: Este estudo examina duas categorias dialógicas regidas pela argumenta o nas reda es argumentativas escolares, que respondem pela propaga o de sentidos do senso comum (categoria de consenso) e de sentidos que se contrap em ao senso comum (categoria de polêmica). Há três matrizes dialógicas observadas em reda es escolares: os diálogos do sujeito-produtor com outras vozes sociais, com a proposta de reda o e, principalmente, com o interlocutor-examinador. Esses diálogos inserem um conjunto de propriedades que ora s o manifesta es da categoria consensual ora da polêmica, e est o de acordo com o exercício argumentativo do texto. Entre as propriedades dialógicas est o a aplica o de no es generalizantes, a organiza o de enunciados descritivos, a observa o de um raciocínio lógico formalizado, o rompimento com a proposta de reda o, a inser o de enunciados interrogativo-retóricos e o uso de paráfrases extraídas da proposta.This paper examines two dialogical categories of the scholarly argumentative text: consensual one (common sense enunciates) and polemical one (opposed to common sense contents). Three dialogical matrices are investigated: the dialogue between subject-producer and other social voices, and text-proposal, and interlocutor-examiner. These dialogues insert a set of textual and discursive properties which are consensual category manifestations or polemical ones in accordance with the argumentative arrangement of text. Among the dialogical properties are wholeness enunciates, argumentative-descriptive enunciates, strict logical reasoning, breakage of text-proposal, interrogative-rhetoric enunciates and paraphrases from the text-proposal.
El múltiple Aristóteles. Una visión de la filosofía práctica aristotélica desde la problemática contemporánea
Guariglia, Osvaldo
Isegoría , 1990,
Abstract: Not available El presente trabajo intenta transmitir las sutiles uniones de la problemática filosófica contemporánea con la filosofía práctica aristotélica, cuyos temas continúan siendo fundamentalmente los temas actuales de discusión. En la teoría de la acción, dentro del horizonte wittgensteiniano, las aporías suscitadas por la concepción pictórica de la proposición en su relación con el mundo, al abordar hechos tales como el deseo, la voluntad y la acción, reciben importante ayuda de la filosofía práctica aristotélica para explicar las macro-acciones, como las que protagonizamos en nuestra vida cotidiana de relación, frente a otras corrientes que pretenden, mediante reducciones, sustracciones y otros modos de seccionamiento artificlal, aislar una especie de micro-elemento, la acción básica, directamente impenetrable a toda forma de comprensión. Por otra parte, la reactualización -acaso menos feliz- de la ética institucional de Aristóteles pone el acento en una cuestión irresuelta de toda moral universalista: su corporización en las estructuras del mundo de la vida . El modelo aristotélico tiene la ventaja sobre los otros -neohegelianos, comunitarios, etc.-, de trazar transparentemente el entrecruzamiento entre sistemas de acción colectiva, normas consuetudinarias y formas de organización social y política (las famosas constituciones), sin partir de ninguna posición filosófico-histórica previamente tomada.
La Democracia en América Latina: la alternativa entre populismo y democracia deliberativa
Guariglia, Osvaldo
Isegoría , 2011,
Abstract: In Politics VI 2, 1317b 1-17, Aristotle defines democracy as follows: the aim of democracy is, ideally, freedom from any interference of government, and, failing that, such freedom as comes from alternation of ruling and being ruled. It contributes, in this way, to a general system of liberty based on equality . Historically, this normative model shaped two possible political regimes, v. gr., popular or extreme democracy, based on direct participation of all citizens, as in Athens, and a mixed constitution containing oligarchic as well as democratic features, called republican in the roman tradition since Cicero. Modern democracy was the heir of both these Ancient regimes, tempered by the new conception of individual rights belonging to Modern thought from Hugo Grotius to the Universal Declaration of Human Rights. The representative constitution was, thus, the modern solution to the conflict between government of the majority and government of the laws. Since their Independence in the 19th century, Latin American democracies suffer from the unresolved tension between populism and the liberal constitutional regime. The neo-populism that grew in the last years of 20th century appears as a response and defiance to democracy’s unfulfilled promises. Against defenders of authoritarian populism, such as Ch. Mouffe and E. Laclau, I argue that deliberative democracy is a better response to them. En Política VI 2, 1317b 1-17, Aristóteles define así la democracia: el rasgo esencial de la democracia es el vivir como se quiere sin ninguna interferencia y de aquí vino el de no ser gobernado, si es posible por nadie, y si no, por turnos. Esta característica contribuye a un sistema general de la libertad fundada en la igualdad . Este modelo normativo dio lugar, históricamente, a dos posibles regímenes políticos, la democracia popular o extrema, basada en la participación directa de todos los ciudadanos, como en Atenas, y una constitución mixta que tenía rasgos tanto democráticos como oligárquicos, llamada república en la tradición romana desde Cicerón. La democracia moderna es la heredera de ambos regímenes, moderada por la nueva concepción de los derechos individuales que son propios del pensamiento moderno desde Hugo Grotius hasta la Declaración Universal de los Derechos Humanos. La constitución representativa fue, así, la solución moderna al conflicto entre gobierno de la mayoría y gobierno de las leyes. Desde su Independencia en el siglo XIX, las democracias de América Latina sufren por la tensión no resuelta entre populismo y constitución liberal democrá
Qué nos pueden ense ar los estoicos sobre el valor de los valores?
Guariglia, Osvaldo
Isegoría , 2001,
Abstract: Not Available No Disponible
Identidad, autonomía y concepciones de la buena vida
Guariglia, Osvaldo
Isegoría , 1999,
Abstract: Not available La modernidad establece las condiciones para un nuevo tipo de sujeto: aquel que se determina a sí mismo y que debe buscar su propia identidad en su historia y en la vida compartida con otros sujetos autónomos. Para ello es central la concepción de autonomíaautonomía a), postulada, y una autonomía b), realizada. En el otro extremo se analiza el concepto de autenticidad, que se ha solido contrastar con el de autonomía como un ideal alternativo de autorrealización. Se intenta demostrar que tanto el ideal filosófico de autonomía b) como el ideal post-romántico de autenticidad dan ambos por supuesta la vigencia de la autonomia a) como soporte y al mismo tiempo carácter distintivo de la identidad del sujeto moderno.
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