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Search Results: 1 - 10 of 5687 matches for " Sara Plebani "
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Enzymes and muscle diseases
M. Plebani
Reumatismo , 2011, DOI: 10.4081/reumatismo.2001.158
Abstract: Skeletal muscle disorders may result in release of muscle enzymes into the circulation and give increased serum enzyme activity. A variety of enzymes routinely determined in the clinical laboratory may be elevated, but creatine kinase is the enzyme present in the highest concentration in muscle, and in every variety of muscle disease is the serum enzyme which shows the greatest incidence and degree of elevation. Aspartate aminotransferase is the enzyme associated most significantly with inflammation. A diagnostic algorithm based on the combined measurement of creatine kinase, aspartate aminotransferase and aldolase has been found to discriminate muscular distrophies from polymyositis and other myopathies. This combination of laboratory tests has diagnostic application and thus allows the clinician to better select patients who need to have a skeletal muscle biopsy as a diagnostic procedure.
Incontro SELL: un bilancio sulle digital libraries consortili dell’Europa meridionale
Marta Plebani
Bollettino del CILEA , 2006, DOI: 10.1472/bc.v102i0.1265
Abstract: Il 5 maggio 2006 si è tenuto a Salonicco, Grecia, il sesto incontro annuale di SELL (Southern European Libraries Link). I consorzi partecipanti all’iniziativa appartengono a Portogallo, Spagna, Italia, Grecia, Turchia. L’obiettivo principale dell’iniziativa è condividere esperienze e iniziative dei consorzi per superare la condizione di “gruppi d’acquisto” e offrire alle biblioteche aderenti servizi a valore aggiunto. I temi principali affrontati durante l’incontro 2006 sono stati: prestito interbibliotecario e copyright, politica europea sulle digital libraries e questioni amministrative per la gestione di un consorzio. The 6th annual SELL (Southern European Libraries Link) meeting took place on May the 5th 2006 in Thessaloniki, Greece. Countries belonging to SELL with their library consortia are: Portugal, Spain, Italy, Greece, Turkey. The overall aim of the meeting is to share similar experiences and efforts to develop consortia that go beyond the “buying club” status, offering additional services to their libraries. The main themes discussed during the 2006 meeting are: copyright and libraries, interlibrary loan, EU policy on digital libraries and administration issues.
ICOLC 2006: Overview della conferenza
Marta Plebani
Bollettino del CILEA , 2007, DOI: 10.1472/bc.v105i0.1320
Abstract: L'articolo rende conto degli interventi più significativi del convegno ICOLC 2006, svoltosi a Roma dal 12 al 14 ottobre. This articles reports on the main topics dealt during the ICOLC 2006 conference, held in Rome on 12-14 October.
IV Convegno Internet Document Delivery: NILDE nel contesto delle trattative consortili per l’acquisizione delle risorse elettroniche
Marta Plebani
Bollettino del CILEA , 2006, DOI: 10.1472/bc.v102i0.1266
Abstract: Questo articolo è un resoconto del IV Convegno sull’Internet Document Delivery, tenutosi a Napoli il 18-19 maggio 2006. Argomento del convegno il servizio NILDE, fornito agli enti accademici italiani per il prestito interbibliotecario automatizzato. Dal punto di vista del CILEA, un’opportunità per migliorare la contrattazione dei consorzi italiani con gli editori di risorse elettroniche, studiando la clausola contrattuale che permette l’utilizzo di software specifici per l’Inter Library Loan. This article tells about the IV Internet Document Delivery Conference, held in Naples on May 18th and 19th 2006. Main topic of the conference is the analysis and cooperative development of the NILDE service, used by many Italian academic institutions for Interlibrary Loan. From the CILEA consortium perspective, the conference is an opportunity to evaluate the legal clauses within agreements signed with electronic content publishers regarding use of specific sofwares for Inter Library Loan.
The Esr Test: An Old Test With New Contents
Elisa Piva, Mario Plebani
Journal of Medical Biochemistry , 2010, DOI: 10.2478/v10011-010-0035-6
Abstract: The erythrocyte sedimentation rate (ESR) remains one of the most widely used laboratory tests. Its clinical usefulness and interpretation are in the monitoring of inflammatory diseases, in particular rheumatoid arthritis, temporal arteritis and polymyalgia rheumatica. At present, the reference method for measuring the ESR proposed by the International Committee for Standardization in Haematology (ICSH) utilizes EDTA-anticoagulated-undiluted blood to perform the test using the method described by Westergren in 1921. Current interest in the methodology focuses on the development of an automated closed system that allows the determination of the sedimentation rate with selected working methods, using a single sample for more than one haematological test, improving the bio-hazardous aspects of the testing procedures. As a consequence, standardization becomes necessary. ESR results should be reliable, despite the increased number of different methods and testing variables. Control materials and External Quality Assurance Schemes are now available, and should be used. In conclusion, innovative techniques may improve the appropriateness and usefulness of ESR in clinical practice, but in addition, they need to guarantee the traceability of results in comparison to the reference method in order to ensure comparability of results among different clinical laboratories.
Cytokines and Exocrine Pancreatic Cancer: Is There a Link?
Basso D,Plebani M
JOP Journal of the Pancreas , 2000,
Convegno ICOLC 2004: I consorzi europei oltre i semplici gruppi d’acquisto
Silvia Corbetta,Marta Plebani
Bollettino del CILEA , 2005, DOI: 10.1472/bc.v95idicembre.1162
Abstract: Barcellona, Convegno ICOLC 2004: rapporto dettagliato delle tematiche consortili legate alle biblioteche digitali.
Treatment-Seeking Alcohol and Cocaine Dependent Individuals with High BMIs and below Average Fitness Levels  [PDF]
Jennifer G. Plebani
Open Access Library Journal (OALib Journal) , 2015, DOI: 10.4236/oalib.1101588
Abstract: Participation in sports and exercise has been shown to help prevent the development of substance use and abuse among adolescents. The protective mechanisms may involve mood, self-efficacy or simply the incompatibility between peak athletic performance and acute intoxication. In addition, prior research has found that aerobic exercise is useful for reducing tension and stress during recovery from substance use disorders (Read & Brown, 2003). However, fitness and exercise levels among substance-dependent individuals have not yet been examined. As such, we chose to characterize baseline exercise and fitness levels for individuals entering outpatient substance abuse treatment as a prelude to examining activity, weight and other health changes during outpatient treatment. The NASA/Johnson Space Center Physical Activity Rating (PA-R) scale was developed to provide an estimate of a participant’s fitness level using a self-reported regular physical activity, along with height, weight, age and gender (George et al., 1997). The PA-R was administered to 109 consecutively screened treatment-seeking individuals with cocaine, alcohol, or combined cocaine and alcohol (CAD) dependence. Additional data on height and weight, gender and race were gathered. Overall, fitness levels were below average for all subjects, and mean BMI was 29.24, with 43 (39.45%) subjects classified as obese, 44 (40.37%) as overweight and only 22 (20.18%) as normal weight. PA-R findings indicate that fitness levels for participants were average or below. Taken together, findings indicate that there is substantial room for improving fitness and exercise among treatment-seeking substance-dependent subjects.
A Novel, Non-canonical Splice Variant of the Ikaros Gene Is Aberrantly Expressed in B-cell Lymphoproliferative Disorders
Daria Capece, Francesca Zazzeroni, Maria Michela Mancarelli, Daniela Verzella, Mariafausta Fischietti, Ambra Di Tommaso, Rita Maccarone, Sara Plebani, Mauro Di Ianni, Alberto Gulino, Edoardo Alesse
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068080
Abstract: The Ikaros gene encodes a Krüppel-like zinc-finger transcription factor involved in hematopoiesis regulation. Ikaros has been established as one of the most clinically relevant tumor suppressors in several hematological malignancies. In fact, expression of dominant negative Ikaros isoforms is associated with adult B-cell acute lymphoblastic leukemia, myelodysplastic syndrome, acute myeloid leukemia and adult and juvenile chronic myeloid leukemia. Here, we report the isolation of a novel, non-canonical Ikaros splice variant, called Ikaros 11 (Ik11). Ik11 is structurally related to known dominant negative Ikaros isoforms, due to the lack of a functional DNA-binding domain. Interestingly, Ik11 is the first Ikaros splice variant missing the transcriptional activation domain. Indeed, we demonstrated that Ik11 works as a dominant negative protein, being able to dimerize with Ikaros DNA-binding isoforms and inhibit their functions, at least in part by retaining them in the cytoplasm. Notably, we demonstrated that Ik11 is the first dominant negative Ikaros isoform to be aberrantly expressed in B-cell lymphoproliferative disorders, such as chronic lymphocytic leukemia. Aberrant expression of Ik11 interferes with both proliferation and apoptotic pathways, providing a mechanism for Ik11 involvement in tumor pathogenesis. Thus, Ik11 could represent a novel marker for B-cell lymphoproliferative disorders.
Pancreatic Tumors and Immature Immunosuppressive Myeloid Cells in Blood and Spleen: Role of Inhibitory Co-Stimulatory Molecules PDL1 and CTLA4. An In Vivo and In Vitro Study
Daniela Basso, Paola Fogar, Massimo Falconi, Elisa Fadi, Cosimo Sperti, Chiara Frasson, Eliana Greco, Domenico Tamburrino, Sara Teolato, Stefania Moz, Dania Bozzato, Michela Pelloso, Andrea Padoan, Giuseppe De Franchis, Elisa Gnatta, Monica Facco, Carlo-Federico Zambon, Filippo Navaglia, Claudio Pasquali, Giuseppe Basso, Gianpietro Semenzato, Sergio Pedrazzoli, Paolo Pederzoli, Mario Plebani
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054824
Abstract: Background Blood and spleen expansion of immature myeloid cells (IMCs) might compromise the immune response to cancer. We studied in vivo circulating and splenic T lymphocyte and IMC subsets in patients with benign and malignant pancreatic diseases. We ascertained in vitro whether pancreatic adenocarcinoma (PDAC)-associated IMC subsets are induced by tumor-derived soluble factors and whether they are immunosuppressive focusing on the inhibitory co-stimulatory molecules PDL1 and CTLA4. Methodology and Principal Findings 103 pancreatic and/or splenic surgical patients were enrolled including 52 PDAC, 10 borderline and 10 neuroendocrine tumors (NETs). Lymphocytes and IMCs were analysed by flow cytometry in blood, in spleen and in three PDAC cell conditioned (CM) or non conditioned PBMC. PDL1 and CTLA4 were studied in 30 splenic samples, in control and conditioned PBMC. IMCs were FACS sorted and co-coltured with allogenic T lymphocytes. In PDAC a reduction was found in circulating CD8+ lymphocytes (p = 0.004) and dendritic cells (p = 0.01), which were reduced in vitro by one PDAC CM (Capan1; p = 0.03). Blood myeloid derived suppressive cells (MDSCs) CD33+CD14?HLA-DR? were increased in PDAC (p = 0.022) and were induced in vitro by BxPC3 CM. Splenic dendritic cells had a higher PDL1 expression (p = 0.007), while CD33+CD14+HLA-DR? IMCs had a lower CTLA4 expression (p = 0.029) in PDAC patients. In vitro S100A8/A9 complex, one of the possible inflammatory mediators of immune suppression in PDAC, induced PDL1 (p = 0.018) and reduced CTLA4 expression (p = 0.028) among IMCs. IMCs not expressing CTLA4 were demonstrated to be immune suppressive. Conclusion In PDAC circulating dendritic and cytotoxic T cells are reduced, while MDSCs are increased and this might favour tumoral growth and progression. The reduced CTLA4 expression found among splenic IMCs of PDAC patients was demonstrated to characterize an immune suppressive phenotype and to be consequent to the direct exposure of myeloid cells to pancreatic cancer derived products, S100A8/A9 complex in particular.
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