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Search Results: 1 - 10 of 401240 matches for " Santica M. Marcovina "
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Levels of Cholesterol in Small LDL Particles Predict Atherosclerosis Progression and Incident CHD in the HDL-Atherosclerosis Treatment Study (HATS)
Paul T. Williams, Xue-Qiao Zhao, Santica M. Marcovina, B. Greg Brown, Ronald M. Krauss
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056782
Abstract: Objective Test whether angiographically-documented changes in percent stenosis and clinical endpoints (coronary-related deaths, myocardial infarctions, stroke, revascularization for worsening ischemia) in the HDL-Atherosclerosis Treatment Study (HATS) were attributable to specific LDL-subclasses. Methods Gradient gel electrophoresis of on-study LDL-subclass cholesterol concentrations were measured in 32 placebo, 33 simvastatin-niacin, 38 antioxidant, and 39 simvastatin-niacin & antioxidant treated participants. The prespecified primary end point was the mean change per patient from the initial arteriogram to the final arteriogram in the percent stenosis caused by the most severe lesion in each of the nine proximal coronary segments. Results The change in the percent stenosis of the most severe proximal lesions increased in association with higher concentrations of the small LDL subfractions LDL-IIIb (24.2–24.6 nm) and LDL-IVa (23.3–24.1 nm) before (both P = 0.002) and after (P = 0.01 and P = 0.03 respectively) adjustment for treatment group and on-study HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations. The associations appeared specific to lesions with <30% baseline stenosis. When adjusted for age, sex, baseline BMI and cigarette use, the odds for primary clinical endpoints (death from coronary causes, nonfatal myocardial infarction, stroke, or revascularization for worsening ischemia) were significantly greater in subjects with higher on-study LDL-IIIb levels both before (P = 0.01) and after (P = 0.03) adjustment for treatment group and the standard lipid values. Conclusions Plasma LDL-IIIb cholesterol concentrations were related to changes in coronary artery stenosis and cardiovascular events in patients with coronary artery disease and low HDL-cholesterol. Trial Registration ClinicalTrials.gov NCT00000553
Buffy coat specimens remain viable as a DNA source for highly multiplexed genome-wide genetic tests after long term storage
Josyf C Mychaleckyj, Emily A Farber, Jessica Chmielewski, Jamie Artale, Laney S Light, Donald W Bowden, Xuanlin Hou, Santica M Marcovina
Journal of Translational Medicine , 2011, DOI: 10.1186/1479-5876-9-91
Abstract: We isolated DNA from 120 Action to Control Cardiovascular Risk in Diabetes (ACCORD) clinical trial buffy coats sampling a range of storage times up to 9 years and other factors that could influence DNA yield. We performed TaqMan SNP and GWA genotyping to test whether the DNA retained integrity for high quality genetic analysis.We tested two QIAGEN automated protocols for DNA isolation, preferring the Compromised Blood Protocol despite similar yields. We isolated DNA from all 120 specimens (yield range 1.1-312 ug per 8.5 ml ACD tube of whole blood) with only 3/120 samples yielding < 10 ug DNA. Age of participant at blood draw was negatively associated with yield (mean change -2.1 ug/year). DNA quality was very good based on gel electrophoresis QC, TaqMan genotyping of 6 SNPs (genotyping no-call rate 1.1% in 702 genotypes), and excellent quality GWA genotyping data (maximum per sample genotype missing rate 0.64%).When collected as a long term clinical trial or biobank specimen for DNA, buffy coats can be stored for up to 9 years in a -80degC frozen state and still produce high yields of DNA suitable for GWA analysis and other genetic testing.The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial is registered with ClinicalTrials.gov, number NCT00000620.Clinical trials and prospective observational cohort studies are complex to design and costly to implement, hence there is a strong desire to maximize overall clinical and scientific return on investment. A common strategy is to include blood specimen collection at a baseline or early participant study visit to enable future ancillary studies or analysis of secondary biomarker outcomes. The blood specimens may be processed to produce aliquots of sera, plasma, or blood cell pack that are stored frozen for future use. For genetics studies, DNA is more stable under long-term freezer storage, but in many existing or completed studies, the study protocol required the extraction and storage of buffy coats (aliqu
Study of Duct Characteristics Deduced from Low Latitude Ground Observations of Day-Time Whistler at Jammu  [PDF]
M. Altaf, M. M. Ahmad
International Journal of Astronomy and Astrophysics (IJAA) , 2013, DOI: 10.4236/ijaa.2013.33032
Abstract:

Propagation characteristics of low latitude whistler duct characteristics have been investigated based on day-time measurements at Jammu. The morphogical characteristics of low latitude whistlers are discussed and compared with characteristics of middle and high latitude whistlers. The Max. electron density (Nm) at the height of the ionosphere obtained from whistler dispersion comes out to be higher than that of the background which is in accordance with the characteristics of whistler duct. The equivalent width is found to be close to the satellite observations and the characteristics of whistler duct in low latitude ionosphere are similar to those in middle and high latitude ionosphere. The width of ducts estimated from the diffuseness of the whistler track observed during magnetic storm is found to lie in the range of 50 - 200 Km.

Review Article: Immobilized Molecules Using Biomaterials and Nanobiotechnology  [PDF]
Magdy M. M. Elnashar
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2010, DOI: 10.4236/jbnb.2010.11008
Abstract: Immobilized molecules using biomaterials and nanobiotechnology is a very interesting topic that touching almost all aspects of our life. It uses the sciences of biology, chemistry, physics, materials engineering and computer science to develop instruments and products that are at the cutting edge of some of today’s most promising scientific frontiers. In this review article, the author based on his experience in this arena has tried to focus on some of the supports for im-mobilization; the most important molecules to be immobilized such as DNA, cells, enzymes, metals, polysaccharides, etc and their applications in medicine, food, drug, water treatment, energy and even in aerospace. He specified a special section on what is new in the arena of supports and technologies used in enzyme immobilization and finally a recommendation by the author for future work with a special attention to up-to-date references.
Using of the generalized special relativity (GSR) in estimating the neutrino masses to explain the conversion of electron neutrinos  [PDF]
M. H. M. Hilo
Natural Science (NS) , 2011, DOI: 10.4236/ns.2011.34044
Abstract: In this work the Generalized Special Relativity (GSR) is utilized to estimate masses of some elementary particles such as, neutrinos. These results are found to be in conformity with experimental and theoretical data. The results obtained may explain some physical phenomena, such as, conversion of neutrinos from type to type when solar neutrino reaches the Earth.
Postischemic Lower Extremity Wounds Treated with and without Negative Pressure Dressing  [PDF]
Naz?mmü?
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.37075
Abstract: Background: Vacuum-assisted dressing is a noninvasive closure system of the wound, which makes localized and controlled negative pressure. Its mechanical tension reduces edema, stimulates granulation tissue formation and angiogenesis, and prepares the wound bed for closure. In this study, a patient has been presented, who suffered from serious lower extremity wounds due to arterial emboli, one of her wounds has been treated with vacuum-assisted dressing and the other with conventional dressing to evaluate the efficacy of vacuum-assisted dressing in acute ischemic wounds. Methods: A 65-year-old female patient was admitted to the emergency clinic, due to complaint of severe pain in her right lower extremity which suggested an acute arterial occlusion. She immediately underwent an embolectomy operation; however, a few days later, severe ischemia on the leg and foot became appearant. All of the necrosis was sharply debrided under sterile conditions in the operating room, and then lower leg wound was covered with vacuum-assisted dressing, also calcaneal wound was dressed with silver sulphadiazine. Results: Eighteen days after the first dressing with negative pressure, distal leg wound became ready for closure, whereas, enough granulation tissue over the calcaneal area developed merely thirty-four days later. Calcaneal wound closed spontaneously within fifty-three days. Conclusions: When dealing with this experience, using the negative pressure dressing in patient with severe lower limb wounds following arterial emboli, accelerates wound healing by means of developing the granulation tissue, and rapidly prepares the wound for closure, so it may reduce the risk of amputation.
Laplace Transform Method for Unsteady Thin Film Flow of a Second Grade Fluid through a Porous Medium  [PDF]
M. Ali, M. Awais
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.53017
Abstract:

In this article, we have effectively used the Numerical Inversion of Laplace transform to study the time-dependent thin film flow of a second grade fluid flowing down an inclined plane through a porous medium. The solution to the governing equation is obtained by using the standard Laplace transform. However, to transform the obtained solutions from Laplace space back to the original space, we have used the Numerical Inversion of Laplace transform. Graphical results have been presented to show the effects of different parameters involved and to show how the fluid flow evolves with time.

An Integral Collocation Approach Based on Legendre Polynomials for Solving Riccati, Logistic and Delay Differential Equations  [PDF]
M. M. Khader, A. M. S. Mahdy, M. M. Shehata
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.515228
Abstract:

In this paper, we propose and analyze some schemes of the integral collocation formulation based on Legendre polynomials. We implement these formulae to solve numerically Riccati, Logistic and delay differential equations with variable coefficients. The properties of the Legendre polynomials are used to reduce the proposed problems to the solution of non-linear system of algebraic equations using Newton iteration method. We give numerical results to satisfy the accuracy and the applicability of the proposed schemes.

ДОСЛ ДЖЕННЯ АНАЛ ТИЧНОГО МЕТОДУ ОЦ НЮВАННЯ ЙМОВ РНОСТ ПОТЕНЦ ЙНО КОНФЛ КТНИХ СИТУАЦ Й В ПОВ ТРЯНОМУ РУС The study of the analytical method of evaluating the probability of potential conflict situations in air traffic Исследование аналитического метода оценки вероятности потенциально конфликтных ситуаций в воздушном движении
В.M. Василь?в
Proceedings of National Aviation University , 2007,
Abstract: Розглянуто застосування запропонованого ран ше методу оц нювання ймов рност потенц йних конфл кт в для системи керування пов тряним рухом. Досл джено властивост методу, наведено проанал зовано результати комп’ютерного моделювання. Application of the method of potential conflicts probability evaluation offered before for air traffic control system is considered. The properties of the method are investigated, results of computer modeling are represented and analyzed. Рассмотрено применение предложенного ранее метода оценки вероятности потенциальных конфликтов для системы управления воздушным движением. Исследованы свойства метода, приведены и проанализированы результаты компьютерного моделирования.
МОДЕЛЮВАННЯ ТА УПРАВЛ ННЯ В БРОАКУСТИЧНИМ ВИПРОМ НЮВАННЯМ ОДНОР ДНО ПЛАСТИНИ П Д Д Ю ЗОВН ШН Х КОНЦЕНТРОВАНИХ СИЛ Modeling and management vibroacoustic emission homogeneous plate under the action of external forces concentrated Моделирование и управление виброакустическим излучением однородной пла
В.M. Макаренко
Proceedings of National Aviation University , 2009,
Abstract: Подано модель проведено досл дження акустичного випром нювання та поперечного руху прямокутно пластини. Розв’язок отримано на основ р внянь класично теор коливань пластини. Розглянуто в броакустичне випром нювання пластин з в льно обпертими граничними умовами. Як зовн шн збудження використано концентрован гармон чн сили. Встановлено законом рност зм ни звукового випром нювання залежно в д параметр в зовн шн х збуджень. Для перев рки анал тичого п дходу, використаного для розрахунк в, виконано експеримент. Власн частоти коливань в льно пластини, отриман анал тично, сп вв дносяться з результатами експерименту з малою похибкою. The model of rectangular plate acoustic radiation and transverse motion were presented, and its investigation was performed. The solution is received based on classisal plate theory. Vibration response and sound radiation of plates with simply-supported boundary conditions was discussed. Concentrated harmonic forces are used as an external excitation. The general confirmities to the law have been established for the changes of sound radiation, depending on the parameters of external excitations. An experiment was performed for justification of analytical approach, which is used for computations. Eigenfrequencies of free plate oscillations, which are received analytically, are in good agreement with experimental results. Представлены модель и проведены исследования акустического излучения и поперечного движения прямоугольной пластины. Решен
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