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Search Results: 1 - 10 of 223769 matches for " Santagata R "
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Anti-inflammatory effects of pre-seasonal Th1-adjuvant vaccine to Parietaria judaica in asthmatics
Scichilone N,Minaldi C,Santagata R,Battaglia S
Journal of Asthma and Allergy , 2011,
Abstract: Nicola Scichilone, Chiara Minaldi, Roberta Santagata, Salvatore Battaglia, Gaetana Camarda, Vincenzo Bellia Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S.), Sezione di Pneumologia, University of Palermo, Palermo, ItalyBackground: The ultra-short course pre-seasonal allergy vaccine, containing appropriate allergoids with the adjuvant monophosphoryl lipid A (MPL), may be effective in treating allergic symptoms. Objective: To explore the timing of the immunological responses to the pre-seasonal allergy vaccine.Methods: Four subcutaneous injections of the active product (Pollinex Quattro) were administered to 20 Parietaria-sensitive intermittent asthmatics (M/F: 12/8; age: 48 ± 10 years; FEV1% predicted: 108% ± 12%) during the 6 weeks prior to the start of the pollen season. Exhaled breath condensate (EBC) was collected immediately before the first and immediately after the last injections (t1 and t2), during the pollen season (t3) and after (t4) the pollen season. EBC was analyzed to determine the levels of pH and 8-isoprostane. Ten Parietaria-sensitive asthmatics served as the untreated control group at t1 and t2.Results: Measured pH levels were 7.64 ± 0.33 at t1, 7.67 ± 0.23 at t2, 7.72 ± 0.34 at t3, and 7.82 ± 0.34 at t4 (P = 0.049 vs baseline). 8-isoprostane levels were significantly lower than baseline at each visit (mean difference from baseline, for t2: —0.77 pg, P = 0.031; for t3: —0.92 pg, P = 0.010; for t4: —0.70 pg, P = 0.048). In the control group, pH levels were 7.73 ± 0.26 at baseline and did not change after 6 weeks (7.79 ± 0.25, P = 0.33). Similarly, the concentrations of 8-isoprostane in the control group were not different from those of the study group at baseline (P = 0.86), and the levels remained unchanged after 6 weeks (P = 0.58).Conclusion: These findings show that the ultra-short course of vaccine adjuvated with MPL acutely reduces the degree of airway inflammation, as expressed by markers of oxidative stress, and suggest that this reduction is maintained during and after the pollen season.Keywords: allergen, asthma, immunotherapy, inflammation, pollen, exhaled breath condensate
Un modello per l’utilizzo del video nella formazione professionale degli insegnanti
Rossella Santagata
Form@re : Open Journal per la Formazione in Rete , 2013,
Abstract: Il video è sempre più utilizzato nella formazione professionale degli insegnanti. Le nuove tecnologie permettono un uso più flessibile ed economico del video. Questo contributo introduce un modello per la creazione di esperienze formative centrate sull’utilizzo del video e per la raccolta di dati sull’effetto del video sull’apprendimento degli insegnanti. Quattro dimensioni vengono discusse: gli obiettivi di formazione, i tipi di video da utilizzare, le guide per la visione che focalizzano l’attenzione su aspetti fondamentali del processo di insegnamento e apprendimento, e l’importanza di utilizzare strumenti di valutazione direttamente legati agli obiettivi di formazione.
A Conformational Study of Flexible Cyclic Compounds (Hydrocarbon Rings of 9-12 Members)
F. Suvire,S. Rodríguez,L. Santagata,A. Rodríguez,R. Enriz
Molecules , 2000, DOI: 10.3390/50300585
Abstract: We report here a conformational study of cyclic flexible compounds (rings with 9-12 members). Two methods of systematic search for the minima were used. The results were compared with those obtained using other exploratory methods.
Anti-inflammatory effects of pre-seasonal Th1-adjuvant vaccine to Parietaria judaica in asthmatics
Scichilone N, Minaldi C, Santagata R, Battaglia S, Camarda G, Bellia V
Journal of Asthma and Allergy , 2011, DOI: http://dx.doi.org/10.2147/JAA.S17784
Abstract: nti-inflammatory effects of pre-seasonal Th1-adjuvant vaccine to Parietaria judaica in asthmatics Original Research (3568) Total Article Views Authors: Scichilone N, Minaldi C, Santagata R, Battaglia S, Camarda G, Bellia V Published Date March 2011 Volume 2011:4 Pages 19 - 25 DOI: http://dx.doi.org/10.2147/JAA.S17784 Nicola Scichilone, Chiara Minaldi, Roberta Santagata, Salvatore Battaglia, Gaetana Camarda, Vincenzo Bellia Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S.), Sezione di Pneumologia, University of Palermo, Palermo, Italy Background: The ultra-short course pre-seasonal allergy vaccine, containing appropriate allergoids with the adjuvant monophosphoryl lipid A (MPL), may be effective in treating allergic symptoms. Objective: To explore the timing of the immunological responses to the pre-seasonal allergy vaccine. Methods: Four subcutaneous injections of the active product (Pollinex Quattro) were administered to 20 Parietaria-sensitive intermittent asthmatics (M/F: 12/8; age: 48 ± 10 years; FEV1% predicted: 108% ± 12%) during the 6 weeks prior to the start of the pollen season. Exhaled breath condensate (EBC) was collected immediately before the first and immediately after the last injections (t1 and t2), during the pollen season (t3) and after (t4) the pollen season. EBC was analyzed to determine the levels of pH and 8-isoprostane. Ten Parietaria-sensitive asthmatics served as the untreated control group at t1 and t2. Results: Measured pH levels were 7.64 ± 0.33 at t1, 7.67 ± 0.23 at t2, 7.72 ± 0.34 at t3, and 7.82 ± 0.34 at t4 (P = 0.049 vs baseline). 8-isoprostane levels were significantly lower than baseline at each visit (mean difference from baseline, for t2: —0.77 pg, P = 0.031; for t3: —0.92 pg, P = 0.010; for t4: —0.70 pg, P = 0.048). In the control group, pH levels were 7.73 ± 0.26 at baseline and did not change after 6 weeks (7.79 ± 0.25, P = 0.33). Similarly, the concentrations of 8-isoprostane in the control group were not different from those of the study group at baseline (P = 0.86), and the levels remained unchanged after 6 weeks (P = 0.58). Conclusion: These findings show that the ultra-short course of vaccine adjuvated with MPL acutely reduces the degree of airway inflammation, as expressed by markers of oxidative stress, and suggest that this reduction is maintained during and after the pollen season.
Interferometric length metrology for the dimensional control of ultra-stable Ring Laser Gyroscopes
J. Belfi,N. Beverini,D. Cuccato,A. Di Virgilio,E. Maccioni,A. Ortolan,R. Santagata
Physics , 2014, DOI: 10.1088/0264-9381/31/22/225003
Abstract: We present the experimental test of a method for controlling the absolute length of the diagonals of square ring laser gyroscopes. The purpose is to actively stabilize the ring cavity geometry and to enhance the rotation sensor stability in order to reach the requirements for the detection of the relativistic Lense-Thirring effect with a ground-based array of optical gyroscopes. The test apparatus consists of two optical cavities 1.32 m in length, reproducing the features of the ring cavity diagonal resonators of large frame He-Ne ring laser gyroscopes. The proposed measurement technique is based on the use of a single diode laser, injection locked to a frequency stabilized He-Ne/Iodine frequency standard, and a single electro-optic modulator. The laser is modulated with a combination of three frequencies allowing to lock the two cavities to the same resonance frequency and, at the same time, to determine the cavity Free Spectral Range (FSR). We obtain a stable lock of the two cavities to the same optical frequency reference, providing a length stabilization at the level of 1 part in $10^{11}$, and the determination of the two FSRs with a relative precision of 0.2 ppm. This is equivalent to an error of 500 nm on the absolute length difference between the two cavities.
Optimization of the geometrical stability in square ring laser gyroscopes
R. Santagata,A. Beghi,J. Belfi,N. Beverini,D. Cuccato,A. Di Virgilio,A. Ortolan,A. Porzio,S. Solimeno
Physics , 2014, DOI: 10.1088/0264-9381/32/5/055013
Abstract: Ultra sensitive ring laser gyroscopes are regarded as potential detectors of the general relativistic frame-dragging effect due to the rotation of the Earth: the project name is GINGER (Gyroscopes IN GEneral Relativity), a ground-based triaxial array of ring lasers aiming at measuring the Earth rotation rate with an accuracy of 10^-14 rad/s. Such ambitious goal is now within reach as large area ring lasers are very close to the necessary sensitivity and stability. However, demanding constraints on the geometrical stability of the laser optical path inside the ring cavity are required. Thus we have started a detailed study of the geometry of an optical cavity, in order to find a control strategy for its geometry which could meet the specifications of the GINGER project. As the cavity perimeter has a stationary point for the square configuration, we identify a set of transformations on the mirror positions which allows us to adjust the laser beam steering to the shape of a square. We show that the geometrical stability of a square cavity strongly increases by implementing a suitable system to measure the mirror distances, and that the geometry stabilization can be achieved by measuring the absolute lengths of the two diagonals and the perimeter of the ring.
BRAF V600E Mutations Are Common in Pleomorphic Xanthoastrocytoma: Diagnostic and Therapeutic Implications
Dora Dias-Santagata,Quynh Lam,Kathy Vernovsky,Natalie Vena,Jochen K. Lennerz,Darrell R. Borger,Tracy T. Batchelor,Keith L. Ligon,A. John Iafrate,Azra H. Ligon,David N. Louis,Sandro Santagata
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017948
Abstract: Pleomorphic xanthoastrocytoma (PXA) is low-grade glial neoplasm principally affecting children and young adults. Approximately 40% of PXA are reported to recur within 10 years of primary resection. Upon recurrence, patients receive radiation therapy and conventional chemotherapeutics designed for high-grade gliomas. Genetic changes that can be targeted by selective therapeutics have not been extensively evaluated in PXA and ancillary diagnostic tests to help discriminate PXA from other pleomorphic and often more aggressive astrocytic malignancies are limited. In this study, we apply the SNaPshot multiplexed targeted sequencing platform in the analysis of brain tumors to interrogate 60 genetic loci that are frequently mutated in 15 cancer genes. In our analysis we detect BRAF V600E mutations in 12 of 20 (60%) WHO grade II PXA, in 1 of 6 (17%) PXA with anaplasia and in 1 glioblastoma arising in a PXA. Phospho-ERK was detected in all tumors independent of the BRAF mutation status. BRAF duplication was not detected in any of the PXA cases. BRAF V600E mutations were identified in only 2 of 71 (2.8%) glioblastoma (GBM) analyzed, including 1 of 9 (11.1%) giant cell GBM (gcGBM). The finding that BRAF V600E mutations are common in the majority of PXA has important therapeutic implications and may help in differentiating less aggressive PXAs from lethal gcGBMs and GBMs.
Native defects in ultra-high vacuum grown graphene islands on Cu(111)
S. M. Hollen,S. J. Tjung,K. R. Mattioli,G. A. Gambrel,N. M. Santagata,E. Johnston-Halperin,J. A. Gupta
Physics , 2015,
Abstract: We present a scanning tunneling microscopy (STM) study of native defects in graphene islands grown by ultra-high vacuum (UHV) decomposition of ethylene on Cu(111). We characterize these defects through a survey of their apparent heights, atomic-resolution imaging, and detailed tunneling spectroscopy. Bright defects that occur only in graphene regions are identified as C site point defects in the graphene lattice and are most likely single C vacancies. Dark defect types are observed in both graphene and Cu regions, and are likely point defects in the Cu surface. We also present data showing the importance of bias and tip termination to the appearance of the defects in STM images and the ability to achieve atomic resolution. Finally, we present tunneling spectroscopy measurements probing the influence of point defects on the local electronic landscape of graphene islands.
Measuring general relativity effects in a terrestrial lab by means of laser gyroscopes
N Beverini,M Allegrini,A Beghi,J Belfi,B. Bouhadef,M Calamai,G Carelli,D Cuccato,A Di Virgilio,E Maccioni,A Ortolan,A. Porzio,R Santagata,S Solimeno,A Tartaglia
Physics , 2013, DOI: 10.1088/1054-660X/24/7/074005
Abstract: GINGER is a proposed tridimensional array of laser gyroscopes with the aim of measuring the Lense-Thirring effect, predicted by the General Relativity theory, in a terrestrial laboratory environment. We discuss the required accuracy, the methods to achieve it, and the preliminary experimental work in this direction.
A ring-lasers array for fundamental physics
A. Di Virgilio,M. Allegrini,A. Beghi,J. Belfi,N. Beverini,F. Bosi,B. Bouhadef,M. Calamai,G. Carelli,D. Cuccato,E. Maccioni,A. Ortolan,G. Passeggio,A. Porzio,M. L. Ruggiero,R. Santagata,A. Tartaglia
Physics , 2014, DOI: 10.1016/j.crhy.2014.10.005
Abstract: After reviewing the importance of light as a probe for testing the structure of space-time, we describe the GINGER project. GINGER will be a three-dimensional array of large size ring-lasers able to measure the de Sitter and Lense-Thirring effects. The instrument will be located at the underground laboratory of GranSasso, in Italy. We describe the preliminary actions and measurements already under way and present the full road map to GINGER. The intermediate apparatuses GP2 and GINGERino are described. GINGER is expected to be fully operating in few years.
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