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Search Results: 1 - 10 of 22516 matches for " Sang-Wook Kim "
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Genetic diversity, population structure and relationships in indigenous cattle populations of Ethiopia and Korean Hanwoo breeds using SNP markers
Zewdu Edea,Sang-Wook Kim,Kwan-Suk Kim
Frontiers in Genetics , 2013, DOI: 10.3389/fgene.2013.00035
Abstract: In total, 166 individuals from five indigenous Ethiopian cattle populations – Ambo (n = 27), Borana (n = 35), Arsi (n = 30), Horro (n = 36), and Danakil (n = 38) – were genotyped for 8773 single nucleotide polymorphism (SNP) markers to assess genetic diversity, population structure, and relationships. As a representative of taurine breeds, Hanwoo cattle (n = 40) were also included in the study for reference. Among Ethiopian cattle populations, the proportion of SNPs with minor allele frequencies (MAFs) ≥0.05 ranged from 81.63% in Borana to 85.30% in Ambo, with a mean of 83.96% across all populations. The Hanwoo breed showed the highest proportion of polymorphism, with MAFs ≥0.05, accounting for 95.21% of total SNPs. The mean expected heterozygosity varied from 0.370 in Danakil to 0.410 in Hanwoo. The mean genetic differentiation (FST; 1%) in Ethiopian cattle revealed that within individual variation accounted for approximately 99% of the total genetic variation. As expected, FST and Reynold genetic distance were greatest between Hanwoo and Ethiopian cattle populations, with average values of 17.62 and 18.50, respectively. The first and second principal components explained approximately 78.33% of the total variation and supported the clustering of the populations according to their historical origins. At K = 2 and 3, a considerable source of variation among cattle is the clustering of the populations into Hanwoo (taurine) and Ethiopian cattle populations. The low estimate of genetic differentiation (FST) among Ethiopian cattle populations indicated that differentiation among these populations is low, possibly owing to a common historical origin and high gene flow. Genetic distance, phylogenic tree, principal component analysis, and population structure analyses clearly differentiated the cattle population according to their historical origins, and confirmed that Ethiopian cattle populations are genetically distinct from the Hanwoo breed.
C-Rank: A Link-based Similarity Measure for Scientific Literature Databases
Seok-Ho Yoon,Sang-Wook Kim,Sunju Park
Computer Science , 2011,
Abstract: As the number of people who use scientific literature databases grows, the demand for literature retrieval services has been steadily increased. One of the most popular retrieval services is to find a set of papers similar to the paper under consideration, which requires a measure that computes similarities between papers. Scientific literature databases exhibit two interesting characteristics that are different from general databases. First, the papers cited by old papers are often not included in the database due to technical and economic reasons. Second, since a paper references the papers published before it, few papers cite recently-published papers. These two characteristics cause all existing similarity measures to fail in at least one of the following cases: (1) measuring the similarity between old, but similar papers, (2) measuring the similarity between recent, but similar papers, and (3) measuring the similarity between two similar papers: one old, the other recent. In this paper, we propose a new link-based similarity measure called C-Rank, which uses both in-link and out-link by disregarding the direction of references. In addition, we discuss the most suitable normalization method for scientific literature databases and propose an evaluation method for measuring the accuracy of similarity measures. We have used a database with real-world papers from DBLP and their reference information crawled from Libra for experiments and compared the performance of C-Rank with those of existing similarity measures. Experimental results show that C-Rank achieves a higher accuracy than existing similarity measures.
Successful Magnetic Resonance Imaging-Guided Focused Ultrasound Surgery for Recurrent Uterine Fibroid Previously Treated with Uterine Artery Embolization
Sang-Wook Yoon,Kyoung Ah Kim,Sang Heum Kim,Jong Tae Lee
Obstetrics and Gynecology International , 2010, DOI: 10.1155/2010/351273
Abstract: A 45-year-old premenopausal woman was referred to our clinic due to recurring symptoms of uterine fibroids, nine years after a uterine artery embolization (UAE). At the time of screening, the patient presented with bilateral impairment and narrowing of the uterine arteries, which increased the risk of arterial perforation during repeated UAE procedures. The patient was subsequently referred for magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) treatment. Following the treatment, the patient experienced a significant improvement in symptoms (symptom severity score was reduced from 47 to 12 by 1 year post-treatment). MR images at 3 months showed a 49% decrease in fibroid volume. There were no adverse events during the treatment or the follow-up period. This case suggests that MRgFUS can be an effective treatment option for patients with recurrent fibroids following previous UAE treatment. 1. Introduction Uterine leiomyoma (fibroid) is the most common reproductive tract tumor in women of reproductive age. Fibroids have been clinically identified in at least 25% of women [1], and pathological analysis suggests that the prevalence of fibroids may be as high as 77% [2]. Symptomatic fibroids can significantly affect quality of life (QOL) and can result in heavy and prolonged menstrual flow, urinary frequency, pelvic pain, abdominal pressure, infertility, and dyspareunia [3–5]. Surgical treatments for uterine fibroids include hysterectomy and myomectomy [6]. Minimally invasive or noninvasive treatments include uterine artery embolization (UAE), magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS), and hormonal therapy [6–9]. Each of these treatment options, which require minimal or no hospitalization, enables women to preserve their uteri [10] and usually minimize complications, recovery time, and treatment costs [11, 12]. UAE is a minimally invasive, image-guided therapy, in which the blood supply to the uterine fibroid is blocked by catheterization, and the ischemic necrosis of the fibroids is induced by the insertion of embolic particles [13]. The embolic particles are usually composed of polyvinyl alcohol, tris-acryl, or gelatin sponge material. MRgFUS is a noninvasive treatment in which ultrasound energy, focused on the fibroid in multiple focal spots, raises the temperature of tissue within the focal zone and causes coagulative necrosis. MRI guides and monitors the procedure, thereby providing closed loop anatomical and thermal feedback [9]. Several measures are used to assess the efficacy of these minimally invasive
Contrast-Enhanced Dynamic MR Imaging of Uterine Fibroids as a Potential Predictor of Patient Eligibility for MR Guided Focused Ultrasound (MRgFUS) Treatment for Symptomatic Uterine Fibroids
Sang-Wook Yoon,Chan Lee,Kyoung Ah Kim,Sang Heum Kim
Obstetrics and Gynecology International , 2010, DOI: 10.1155/2010/834275
Abstract: Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a non-invasive treatment approach for symptomatic uterine fibroids. One imaging characteristic considered in selecting patients who may benefit from MRgFUS of their uterine fibroids is the signal intensity of the fibroid compared with surrounding myometrium on T2-weighted MR images. Previous reports suggest that hyper-intense fibroids are less amenable to MRgFUS compared with iso- or hypo-intense fibroids. In this case study, we utilized contrast-enhanced dynamic MR imaging to further characterize the vascularity of a hyper-intense fibroid. Based on the results of dynamic T1-weighted contrast-enhanced images, we assumed that the hyper-intense appearance resulted from high fluid content rather than high vascularity and predicted that the fibroid would respond to MRgFUS. The patient underwent the MRgFUS without complication and reported significant decrease in fibroid symptoms at 3 and 12 months post-treatment. This case suggests that pre-treatment dynamic contrast-enhanced imaging used in conjunction with T2-weighted imaging may improve the criteria for selecting uterine fibroids amenable to treatment with MRgFUS, potentially leading to improved patient outcomes. 1. Introduction Uterine fibroids are the most common tumors of the female reproductive tract. Fibroids have been identified clinically in at least 25% of women [1], and pathological analyses suggest that the prevalence of fibroids may be as high as 77% [2]. Although most fibroids are asymptomatic, approximately 25% are associated with symptoms that can have a significant impact on patient’s quality of life, including prolonged or excessive menstrual bleeding, pelvic pain or bulkiness, dyspareunia, increased urinary frequency, and infertility [3]. Several options, each with varying degrees of invasiveness, are available for treatment of symptomatic uterine fibroids. These include among others, hysterectomy, myomectomy (abdominal or laparoscopic), uterine artery embolization, MR-guided Focused Ultrasound (MRgFUS), and hormonal therapy [4], which also is sometimes provided as an adjuvant to other therapies. Each of the treatments has its own benefits and disadvantages. For example, the benefit of hysterectomy is that the removal of the uterus is 100% effective in alleviating fibroid-related symptoms [5]. However, the procedure is invasive, requires general or epidural anesthesia, and typically involves several weeks of postoperative recovery time during which patients may be limited from engaging in daily activities, including work.
Structural versus electronic distortions of symmetry-broken IrTe$_2$
Hyo Sung Kim,Tae-Hwan Kim,Junjie Yang,Sang-Wook Cheong,Han Woong Yeom
Physics , 2014, DOI: 10.1103/PhysRevB.90.201103
Abstract: We investigate atomic and electronic structures of the intriguing low temperature phase of IrTe2 using high-resolution scanning tunneling microscopy and spectroscopy. We confirm various stripe superstructures such as $\times$3, $\times$5, and $\times$8. The strong vertical and lateral distortions of the lattice for the stripe structures are observed in agreement with recent calculations. The spatial modulations of electronic density of states are clearly identified as separated from the structural distortions. These structural and spectroscopic characteristics are not consistent with the charge-density wave and soliton lattice model proposed recently. Instead, we show that the Ir (Te) dimerization together with the Ir 5d charge ordering can explain these superstructures, supporting the Ir dimerization mechanism of the phase transition.
A Community-Based Sampling Method Using DPL for Online Social Network
Seok-Ho Yoon,Ki-Nam Kim,Sang-Wook Kim,Sunju Park
Computer Science , 2011,
Abstract: In this paper, we propose a new graph sampling method for online social networks that achieves the following. First, a sample graph should reflect the ratio between the number of nodes and the number of edges of the original graph. Second, a sample graph should reflect the topology of the original graph. Third, sample graphs should be consistent with each other when they are sampled from the same original graph. The proposed method employs two techniques: hierarchical community extraction and densification power law. The proposed method partitions the original graph into a set of communities to preserve the topology of the original graph. It also uses the densification power law which captures the ratio between the number of nodes and the number of edges in online social networks. In experiments, we use several real-world online social networks, create sample graphs using the existing methods and ours, and analyze the differences between the sample graph by each sampling method and the original graph.
Prediction of Risk Factors for Coronary Heart Disease Using Framingham Risk Score in Korean Men
Jae-Hong Ryoo, Soo Hyun Cho, Sang-Wook Kim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045030
Abstract: Background Currently, there is sparse data available on the relationship between coronary heart disease (CHD) and its risk factors estimated by the Framingham Risk Score (FRS) in Korea. This is particularly true when looking at risk factors of CHD associated with the FRS after adjustment for other covariates especially in healthy subjects. Methodology/Principal Findings We conducted a prospective cohort study to examine the association between the risk factors of CHD and the risk for CHD estimated by FRS in 15,239 men in 2005 and 2010. The FRS is based on six coronary risk factors: gender, age, total cholesterol, high-density lipoprotein (HDL)-cholesterol, systolic blood pressure (BP), and smoking habit. Multiple linear regression analysis was used to analyze the relationships between the FRS and risk factors for CHD. This study reported that apolipoproetein B (apoB), apoA-I, apoB/apoA-I, alcohol intake, log-transformed TG, log-transformed hsCRP, LDL-cholesterol, hypertension, diabetes, regular exercise, and BMI were significantly associated with the FRS. Above all, the partial R-square of apoB was 14.77%, which was overwhelmingly bigger than that of other variables in model V. This indicated that apoB accounted for 14.77% of the variance in FRS. Conclusion/Significance In this study, apoB was found to be the most important determinant for the future development of CHD during a 5-year follow-up in healthy Korean men.
Fulminant myocarditis managed with pulsatile extracorporeal life support; use of Twin Pulse Life support (T-PLS?)
Eun Cho, Joonhwa Hong, Hyun Kang, Ju Choe, Sang-Wook Kim
Journal of Cardiothoracic Surgery , 2011, DOI: 10.1186/1749-8090-6-159
Abstract: We report on two cases of fulminant myocarditis. They developed profound hypoxemia, acidosis, pulmonary edema, and oliguria. T-PLS?(Twin Pulse Life support, New heart bio.BHK, Seoul, Korea) was used in order to prevent further deterioration. Both patients recovered well from fulminant myocarditis with T-PLS support. Echocardiograms showed normal ejection fraction after recovery. Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.A 32-year-old woman without previous medical history was referred to the emergency department with dizziness for one day. On admission, the vital signs were unstable, with a blood pressure of 70/40 mmHg, heart rate of 91 beats/min, and body temperature of 35.4°C. White blood cell count was 16,470 109/L and troponin I was 2.563 ng/mL. Arterial blood gas analysis showed metabolic acidosis. EKG demonstrated sinus tachycardia. Hemodynamic status showed rapid deterioration during the subsequent hours. Systolic blood pressure was below 90 mmHg, with a heart rate faster than 100 beats/min. Urine output decreased, too. Hypoxemia did not resolve with supplementary oxygen. Echocardiogram showed a left ventricular ejection fraction of 21% with global hypokinesia. She was admitted to the intensive care unit (ICU) with a diagnosis of probable viral myocarditis. Ventilator therapy was initiated. She developed atrial fibrillation with rapid ventricular response. Hemodynamic status showed further worsening. Urine output further decreased and she developed hypoxemia with pulmonary edema, lactic acidosis. On the second day of admission, we decided to place the patient on a T-PLS. A 17 French femoral venous and a 14 French arterial cannula were inserted percutaneously. The pump was started with a flow of 2.13 L/min/m2, a pump rate of 47/min, and 100% oxygen at 4 L/min. The membrane oxygenator was replaced
catena-Poly[[bis(dimethylammonium) [cadmate(II)-bis(μ-1,1′:4′,1′′-terphenyl-3,3′′-dicarboxylato)]] dimethylformamide disolvate]
Sang-Wook Park,Ja-Min Gu,Youngmee Kim,Seong Huh
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536810051366
Abstract: In the title compound, {(C2H8N)2[Cd(C20H12O4)2]·2C3H7NO}n, the CdII ion lies on a twofold rotation axis and is in a distorted octahedral CdO6 environment, defined by four O atoms of two μ2-coordinated 1,1′:4′,1′′-terphenyl-3,3′′-dicarboxylate (DCT) ligands and two O atoms of two μ1-coordinated DCT ligands. Both types of DCT ligands act as bridging, forming a one-dimensional polymeric structure propagating parallel to [10overline1].
A Linear-Time Approximation of the Earth Mover's Distance
Min-Hee Jang,Sang-Wook Kim,Christos Faloutsos,Sunju Park
Computer Science , 2011,
Abstract: Color descriptors are one of the important features used in content-based image retrieval. The Dominant Color Descriptor (DCD) represents a few perceptually dominant colors in an image through color quantization. For image retrieval based on DCD, the earth mover's distance and the optimal color composition distance are proposed to measure the dissimilarity between two images. Although providing good retrieval results, both methods are too time-consuming to be used in a large image database. To solve the problem, we propose a new distance function that calculates an approximate earth mover's distance in linear time. To calculate the dissimilarity in linear time, the proposed approach employs the space-filling curve for multidimensional color space. To improve the accuracy, the proposed approach uses multiple curves and adjusts the color positions. As a result, our approach achieves order-of-magnitude time improvement but incurs small errors. We have performed extensive experiments to show the effectiveness and efficiency of the proposed approach. The results reveal that our approach achieves almost the same results with the EMD in linear time.
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