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Search Results: 1 - 10 of 28391 matches for " Sang-Nam Lee "
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Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice
Charles R Farber, James Chitwood, Sang-Nam Lee, Ricardo A Verdugo, Alma Islas-Trejo, Gonzalo Rincon, Iris Lindberg, Juan F Medrano
BMC Genetics , 2008, DOI: 10.1186/1471-2156-9-34
Abstract: Through a combination of DNA microarray analysis and quantitative PCR we identified a strong expression quantitative trait locus (eQTL) regulating Scg5 expression in two mouse chromosome 2 congenic strains and three additional F2 intercrosses. More importantly, the eQTL was coincident with a body weight QTL in congenic mice and Scg5 expression was negatively correlated with body weight in two of the F2 intercrosses. Analysis of haplotype blocks and genomic sequencing of Scg5 in high (C3H/HeJ, DBA/2J, BALB/cByJ, CAST/EiJ) and low (C57BL/6J) expressing strains revealed mutations unique to C57BL/6J and possibly responsible for the difference in mRNA abundance. To evaluate the functional consequence of Scg5 overexpression we measured the pituitary levels of 7B2 protein and PCSK2 activity and found both to be increased. In spite of this increase, the level of pituitary α-MSH, a PCSK2 processing product, was unaltered.Together, these data support a role for Scg5 in the modulation of body weight.Body weight, as with all complex traits, is partially regulated by the coordinate action of individual genes. One common approach for dissecting the genetics of growth is the mapping of quantitative trait loci (QTL). In the last decade numerous human and mouse growth QTL have been identified [1]; however, while this progress is important, few if any of the loci have been unequivocally resolved to the effects of a single quantitative trait gene (QTG).Several studies involving many different mouse inbred strains have demonstrated an enrichment of growth and obesity QTL on chromosome 2 [2,3]. In our laboratory, we have developed a number of genomic resources with the goal of discerning the molecular basis of chromosome 2 QTL segregating between the C57BL/6J (B6), C57BL/6J-hg/hg (HG) and CAST/EiJ (CAST) strains [4,5]. These include two congenic strains, B6.CAST-(D2Mit329-D2Mit457)N(6) (B62D) and HG.CAST-(D2Mit329-D2Mit457)N(6) (HG2D), constructed by introgressing an identical congenic
The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients
Ji-Yoon Kim, Yeon-Sil Kim, Young-Kyoon Kim, Hyun-Jin Park, Seung-Joon Kim, Jin-Hyoung Kang, Young-Pil Wang, Hong-Seok Jang, Sang-Nam Lee, Sei-Chul Yoon
Radiation Oncology , 2009, DOI: 10.1186/1748-717x-4-59
Abstract: Thirty-four lung cancer patients who received three-dimensional conformal radiation therapy were evaluated prospectively. Serial blood samples before, at the beginning, in the middle of, at the end of RT and 2 and 4 weeks after RT were analyzed for IL-1α, IL-6, IL-10, TNF-α and TGF-β1 by performing enzyme-linked immunosorbent assay. The predictive values of dosimetric factors for RP were evaluated, too.Overall, 8 patients (23.5%) had grade ≥ 2 RP. By serial measurement of cytokines level, only the TGF-β1 level showed a correlation to the symptomatic RP. None of the other cytokines, IL-1α, IL-6, IL-10 and TNF-α level was correlated with the risk of RP. The mean pretreatment TGF-β1 level did not differ between RP and non-RP groups. However, during the period of radiation treatment, the TGF-β1 level began to increase at the end of RT in the RP group and became significantly higher 4 weeks after RT (p = 0.007). Using an ANOVA model for repeated-measures, we found significant associations between the changes of TGF-β1 during the time course of the RT and the risk of developing RP (p < 0.001). Most of the dosimetric factors showed a significant association with RP.Our results show that the changes of TGF-β1 could be correlated with RP and the incorporation of the biological parameters into the dosimetric data could be useful for predicting symptomatic RP.Increasing radiation dose and combining it with chemotherapy were found to improve the local control for lung cancer and thus improve the overall survival of lung cancer patients [1-4]. However, the tolerance of the surrounding normal tissues to radiation therapy limits the level of dose that can be delivered for the treatment of lung cancer.The risk of radiation pulmonary toxicity may increase for the following patients: patients with a poor performance status or inadequate pulmonary function, patients who undergo combined chemoradiotherapy and patients receiving an increased total radiation dose and treatment volume. Do
Does Environmental Risk Affect Human Migration Behavior?  [PDF]
Seong Nam Hwang, Sang-Woo Lee
Journal of Geographic Information System (JGIS) , 2017, DOI: 10.4236/jgis.2017.94031
Abstract: This study tests the influence of environmental risks associated with floods, hurricanes, and hazardous material releases on human migration behavior. With close attention to a function of environmental risk factors, socio-demographic attributes, hazard risk and locational attributes were measured and correlated to the standardized number of recent arrivals and long term residents at the census tract level. Two groups (i.e., recent arrivals and long-term residents) were created to compare their moving behavior. The results indicate that flood risk showed little relationship to either recent arrivals or long-term residents. These results are consistent with past research which suggests that people tend to ignore their vulnerability to natural hazards. However, both groups had negative relationships to the risk from hurricanes and hazardous material releases. This counter-intuitive result suggests that other factors, such as proximity to employment opportunities or property tax advantages, need to be examined. In particular, the recent arrivals were negatively related to chemical risk while long-term residents were positively related to chemical risks, indicating that people that just arrived and old residents are somewhat different in perceiving environmental risks. In addition, the results of this study suggest that people are objective about environmental risks in selecting their habitat. However, once the habitat is settled, people’s perception of the risks may be interfered or reduced by other factors.
Effective Use of Sugammadex for Incomplete Pyridostigmine Reversal of Muscle Relaxation by Rocuronium: A Case Report  [PDF]
Hee Jong Lee, Kyo Sang Kim, Ji Seon Jeong, Sung Hwan Choi, Kyu Nam Kim
Open Journal of Anesthesiology (OJAnes) , 2013, DOI: 10.4236/ojanes.2013.39083
Abstract:

Anticholinesterase does not allow adequate reversal of the deep neuromuscular blockade (NMB) achieved using high doses of relaxants. A 71-year-old female patient (weight 70 kg, height 169 cm) was scheduled for a transurethral resection of a bladder tumor under general anesthesia. We administered rocuronium 30 mg (0.43 mg/kg) for tracheal intubation due to an estimated short surgical time. During the operation, an additional rocuronium 10 mg was injected. The surgical procedure ended abruptly 10 minutes after receiving the last dose of rocuronium. At the end of surgery, the patient received pyridostigmine as a reversal. However, residual NMB persisted, and neuromuscular monitoring did not show the expected degree of recovery. Sugammadex 2 mg/kg was used, and the patient experienced complete reversal from NMB in just 2 min.

Effect of Spinless Impurities on Reduction of $T_c$ in High $T_c$ Superconductors
In-Ho Lee,Sang Boo Nam
Physics , 2001,
Abstract: The notion of a finite pairing interaction energy range suggested by Nam, results in some states at the Fermi level not participating in pairings when there are scattering centers such as impurities. The fact that not all states at the Fermi level participate in pairing is shown to suppress $T_c$ in an isotropic superconductor and destroy superconductivity. We have presented quantitative calculations of $T_c$ reduced via spinless impurities, in good agreements with data of Zn-doped YBCO and LSCO, respectively. It is not necessary to have the anisotropic order parameter, to account for the destruction of superconductivity via non-magnetic impurities.
Watermarking Algorithms for 3D NURBS Graphic Data
Lee Jae Jun,Cho Nam Ik,Lee Sang Uk
EURASIP Journal on Advances in Signal Processing , 2004,
Abstract: Two watermarking algorithms for 3D nonuniform rational B-spline (NURBS) graphic data are proposed: one is appropriate for the steganography, and the other for watermarking. Instead of directly embedding data into the parameters of NURBS, the proposed algorithms embed data into the 2D virtual images extracted by parameter sampling of 3D model. As a result, the proposed steganography algorithm can embed information into more places of the surface than the conventional algorithm, while preserving the data size of the model. Also, any existing 2D watermarking technique can be used for the watermarking of 3D NURBS surfaces. From the experiment, it is found that the algorithm for the watermarking is robust to the attacks on weights, control points, and knots. It is also found to be robust to the remodeling of NURBS models.
Calculation of Magnetic Penetration Depth Length $λ(T)$ in High Tc Superconductors
Jae-Weon Lee,In-Ho Lee,Sang Boo Nam
Physics , 2001,
Abstract: The notion of a finite pairing interaction energy range via Nam, results in the incomplete condensation in which not all states participate in pairings. Thestates not participating in pairings are shown to yield the lowenergy states responsible for the linear T dependence ofsuperelectron density at low T in a s-wave superconductor. Wepresent extensive quantitative calculations of $\lambda$(T) forall T ranges, in good agreements with experiments. It is notnecessary to have nodes in the order parameter, to account for thelinear T dependence of $\lambda$(T) at low T in high Tc superconductors.
Aspirin Has Antitumor Effects via Expression of Calpain Gene in Cervical Cancer Cells
Sang Koo Lee,Min Seon Park,Myeong Jin Nam
Journal of Oncology , 2008, DOI: 10.1155/2008/285374
Abstract: Aspirin and other nonsteroidal anti-inflammatory drugs show efficacy in the prevention of cancers. It is known that they can inhibit cyclooxygenases, and some studies have shown that they can induce apoptosis. Our objective in this study was to investigate the mechanism by which aspirin exerts its apoptosis effects in human cervical cancer HeLa cells. The effect of aspirin on the gene expression was studied by differential mRNA display RT-PCR. Among the isolated genes, mu-type calpain gene was upregulated by aspirin treatment. To examine whether calpain mediates the antitumor effects, HeLa cells were stably transfected with the mammalian expression vector pCR3.1 containing mu-type calpain cDNA (pCRCAL/HeLa), and tumor formations were measured in nude mice. When tumor burden was measured by day 49, HeLa cells and pCR/HeLa cells (vector control) produced tumors of 2126 mm3 and 1638 mm3, respectively, while pCRCAL/HeLa cells produced markedly smaller tumor of 434 mm3 in volume. The caspase-3 activity was markedly elevated in pCRCAL/HeLa cells. The increased activity levels of caspase-3 in pCRCAL/HeLa cells, in parallel with the decreased tumor formation, suggest a correlation between caspase-3 activity and calpain protein. Therefore, we conclude that aspirin-induced calpain mediates an antitumor effect via caspase-3 in cervical cancer cells.
Delayed Presentation of Renocolic Fistula at 4 Months after Blunt Abdominal Trauma
Sang Don Lee,Tae Nam Kim,Hong Koo Ha
Case Reports in Medicine , 2011, DOI: 10.1155/2011/103497
Abstract: Causes of previously reported reno-colic fistulas included primary renal and colonic pathologic states involving infectious, malignant or other inflammatory processes. However, reno-colic fistula after renal injury is extremely uncommon. We report an unusual delayed presentation of reno-colic fistula that occurred at 4 months later after blunt abdominal trauma.
Effect of Weld Properties on the Crush Strength of the PWR Spacer Grid
Kee-nam Song,Sang-hoon Lee
Science and Technology of Nuclear Installations , 2012, DOI: 10.1155/2012/540285
Abstract: Mechanical properties in a weld zone are different from those in the base material because of different microstructures. A spacer grid in PWR fuel is a structural component with an interconnected and welded array of slotted grid straps. Previous research on the strength analyses of the spacer grid was performed using base material properties owing to a lack of mechanical properties in the weld zone. In this study, based on the mechanical properties in the weld zone of the spacer grid recently obtained by an instrumented indentation technique, the strength analyses considering the mechanical properties in the weld zone were performed, and the analysis results were compared with the previous research. 1. Introduction A PWR fuel assembly consists of spacer grids, fuel rods, a top nozzle, a bottom nozzle, guide tubes, and an instrumentation tube as shown in Figure 1. Among them, the spacer grid is a structural component which is an interconnected array of slotted grid straps and is welded at intersections to form an egg-crate structure. From a structural point of view, the spacer grid is required to have enough crush strength under lateral loads so that nuclear fuel rods are maintained in a coolable geometry, allowing control rods to be inserted [1]. The capacity of a spacer grid to resist lateral loads is usually characterized in terms of its crush strength, and it was reported [2] that the lateral crush strength of the spacer grid is closely related with the welding quality of the spacer grid. Figure 1: PWR fuel assembly and spacer grid. Welding is a very convenient and widely used method to join simple metallic parts with a complicated structure by the use of adhesive and cohesive attractive forces between metals [3]. Microstructures in the weld zone, including a weld (or fusion zone) and a heat affected zone (HAZ), are different from that in a base material, as shown in Figure 2 [3]. Consequently, the mechanical properties in the weld zone are different from those in the base material to some extent. When a welded structure is loaded, the mechanical behavior of the welded structure might be different from the case of a structure with homogeneous mechanical properties. Nonetheless, mechanical properties in the welded structure have been neglected in many structural analyses [4–7] of spacer grids due to a lack of mechanical properties in the weld zone. Usually, the general way to obtain the mechanical properties in the weld zone is by taking tensile test specimens in the fusion zone and HAZ, and by performing a standard tensile test. However, when the
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