Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 14 )

2018 ( 7 )

2017 ( 10 )

2016 ( 23 )

Custom range...

Search Results: 1 - 10 of 1612 matches for " Samir Shehata "
All listed articles are free for downloading (OA Articles)
Page 1 /1612
Display every page Item
The Effect of Hypofractionated Radiotherapy on Tumor Control and Survival in Patients with High-Risk Breast Cancer  [PDF]
Aiat Morsy, Sara H. Hammouda, Samir Shehata
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.101007
Abstract: BACKGROUND Adjuvant radiotherapy is given following surgery in breast cancer patients. Hypofractonated radiotherapy can significantly reduce the waiting time for radiotherapy, working load on machines, patient visits to radiotherapy departments and medical costs. Material and Methods 244 patients with high-risk breast cancer (stage IIB, stage III and stage IA with any of the following criteria: lymphovascular invasion, hormonal receptor negative, young age) who underwent Breast conservative surgery (BCS) or Modified radical mastectomy (MRM) were enrolled in this study. All patients received adjuvant radiotherapy with different hypofractionation schedules either 3900 cGY/13 fractions or 4240 cGY/16 fractions or 4005 cGY/15 fractions using linear accelerator with 6 MV photon beam. Lateral/Medial tangential and Ipsilateral supraclavicular fields were employed and the ipsilateral axilla was also irradiated if required to the same dose with posteroanterior field. Patients were followed every 3 mons for the first 2 years and every 6 mons thereafter. Outcomes were analyzed in terms of tumor control and survival. Results 244 patients with high-risk breast cancer requiring postoperative radiotherapy to the intact breast or chest wall were treated. The mean age was 48 years (range 28 - 69 years). The 5-year locoregional free survival of all patients was 93.8% the local relapse reported in 15 patients (6.2%) 7 patients at site of operated scar & 8 patients at the regional lymph nodes. The median follow up period was 75 months ranged from 49 to 102 months. Distant metastasis free survival was 92.2%, the distant metastasis reported in 19 patients which represent (7.8%) of all patients, median survival is 75 months ranged from 49 to 102 months and overall survival was 88.6%.
The Effect of Body Mass Index on Survival in Breast Cancer  [PDF]
Aiat Morsy, Samir Shehata
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.1012075
Abstract: Background: Obesity is a well-known risk factor for breast cancer recurrence and poor prognosis. The objective of this study was to evaluate the effect of body mass index (BMI) on survival in breast cancer patients. Methods: We performed a retrospective analysis of 50 breast cancer patients treated in our hospital from January 2012 to December 2013. Patients were divided according to body mass index when diagnosed into: normal weight BMI < 25 Kg/m2, over weight BMI 25 Kg/m2 to < 30 Kg/m2, obesity BMI 30 Kg/m2. In this study the effect of body mass index on progression free survival (PFS) and overall survival (OS) was evaluated.
Virtual Learning System (Miqra’ah) for Quran Recitations for Sighted and Blind Students  [PDF]
Samir A. Elsagheer Mohamed, Allam Shehata Hassanin, Mohamed Taher Ben Othman
Journal of Software Engineering and Applications (JSEA) , 2014, DOI: 10.4236/jsea.2014.74021

Quran has ten famous recitations and twenty different narrations. It is well known that the best way is to learn from qualified and authentic scientists (Sheikh's) in one or more of these narrations. Due to 1) the widespread of the Internet and the ease of use and availability of computers and the smart phones that enables access to the Internet; 2) the business of people hindering them to attend physical learning environments; and 3) the very few number of elder licensed scientists, we have developed a virtual learning system (Electronic Miqra’ah). Scientists can supervise remotely the registered students. Students (from different ages) can register from anywhere in the world given that they have Internet connection. Students can interact with the scientist in real time so that they can help them memorize (Tahfeez), guide them for error correction, and give them lectures or lessons through virtual learning rooms. The targeted groups of users can be nonblind people, blind people, manual-disabled people and illiterate people. We have developed this system such that it takes the commands via voice in addition to the normal inputs like mouse and keyboard. Users can dictate the commands to the system orally and the system recognizes the spoken phrases and executes them. We have developed an efficient speech recognition engine that is speaker independent and accent independent. The system administrators create several virtual learning rooms and register the licensed scientists. Administrators prepare a daily schedule for each room. Students can register to any of these rooms by pronouncing its name. Each student is allocated a portion of time where he/she can interact directly by voice with the scientist. Other students can listen to the current student’s recitation and the error corrections, guidance or lessons from the scientists.

Educational System for the Holy Quran and Its Sciences for Blind and Handicapped People Based on Google Speech API  [PDF]
Samir A. Elsagheer Mohamed, Allam Shehata Hassanin, Mohamed Tahar Ben Othman
Journal of Software Engineering and Applications (JSEA) , 2014, DOI: 10.4236/jsea.2014.73017

There is a great need to provide educational environments for blind and handicapped people. There are many Islamic websites and applications dedicated to the educational services for the Holy Quran and Its Sciences (Quran Recitations, the interpretations, etc.) on the Internet. Unfortunately, blind and handicapped people could not use these services. These people cannot use the keyboard and the mouse. In addition, the ability to read and write is essential to benefit from these services. In this paper, we present an educational environment that allows these people to take full advantage of the scientific materials. This is done through the interaction with the system using voice commands by speaking directly without the need to write or to use the mouse. Google Speech API is used for the universal speech recognition after a preprocessing and post processing phases to improve the accuracy. For blind people, responses of these commands will be played back through the audio device instead of displaying the text to the screen. The text will be displayed on the screen to help other people make use of the system.

A randomized, phase 2 study comparing pemetrexed plus best supportive care versus best supportive care as maintenance therapy after first-line treatment with pemetrexed and cisplatin for advanced, non-squamous, non-small cell lung cancer
Mubarak Nabil,Gaafar Rabab,Shehata Samir,Hashem Tarek
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-423
Abstract: Background Maintenance therapy for non-small cell lung cancer (NSCLC) aims to extend disease control after first-line chemotherapy with active and well-tolerated agents. The utility of continuation maintenance therapy requires further research. Methods This multicenter, randomized, phase 2 study compared continuation maintenance therapy with pemetrexed (500 mg/m2 every 21 days) and best supportive care (BSC) versus BSC alone in patients with advanced, non-squamous NSCLC who had not progressed after 4 cycles of induction chemotherapy with pemetrexed (500 mg/m2) and cisplatin (75 mg/m2). The primary endpoint was progression-free survival (PFS) from randomization, was analyzed using a Cox model, stratified for the tumor response at the end of induction therapy, at a one-sided alpha of 0.2. Secondary endpoints: response and disease control rates, overall survival (OS), one year survival rates, and treatment-emergent adverse events (TEAEs). Results A total of 106 patients commenced induction therapy, of whom 55 patients were randomized to maintenance pemetrexed/BSC (n = 28) or BSC (n = 27). Although the median PFS time for maintenance phase for both arms was 3.2 months, the one-sided p-value for the PFS HR comparison was less than the prespecified limit of 0.2 (HR = 0.76, two-sided 95% confidence interval [CI]: 0.42 to 1.37; one-sided p-value = 0.1815), indicating that PFS was sufficiently long in the pemetrexed/BSC arm to warrant further investigation. Similar PFS results were observed for the overall study period (induction plus maintenance) and when the PFS analysis was adjusted for sex, baseline disease stage, and the ECOG PS prior to randomization. The median OS for the maintenance phase was 12.2 months (95%CI: 5.6 to 20.6) for the pemetrexed/BSC arm and 11.8 months (95% CI: 6.3 to 25.6) for BSC arm. The one-year survival probabilities were similar for both arms for the maintenance phase and the overall study period. Both the induction and continuation maintenance therapies were generally well-tolerated, and similar proportion of patients in each arm experienced at least 1 grade 3/4 TEAE (pemetrexed/BSC, 17.9%; BSC, 18.5%). Conclusions Continuation pemetrexed maintenance therapy resulted in promising PFS with an acceptable safety profile in a Middle Eastern population with advanced non-squamous NSCLC and is worthy of further investigation. Trial registration NCT00606021
Toxicity of Hypofractionated Radiotherapy Following Breast Conservative Surgery in Breast Cancer  [PDF]
Aiat Morsy, Sara H. Hammouda, Samir Shehata, Ali Zedan
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.105031
Abstract: Background:Adjuvant radiotherapy has increased disease-free and overall survival rates in breast cancer. Conventionally fractionated radiotherapy delivers 50 Gy over 5 weeks which is the standard approach. A shorter duration of hypofractionated radiotherapy (HFRT) will be more convenient for patients and treatment providers if found safe and equally effective. Material and Methods: Fifty-four breast cancer patients who underwent breast conservative surgery (BCS) were enrolled in this study. The patients received 4005 cGy/15 fractions. A boost to the tumor bed was administered in all patients. In this study, radiotherapy induced toxicity was evaluated. Results: In this study, the median age of our patients was 48 years with age ranged from 28 to 69 years. Acute skin toxicity was assessed, and it was noted that grade 2 skin toxicity was shown in only 6 patients (11.1%) at the end of radiotherapy and disappeared after 6 weeks of treatment. Late skin toxicity (telangectasia
On p and q-Horn’s Matrix Function of Two Complex Variables  [PDF]
Ayman Shehata
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.212203
Abstract: The main aim of this paper is to define and study of a new Horn’s matrix function, say, the p and q-Horn’s matrix function of two complex variables. The radius of regularity on this function is given when the positive integers p and q are greater than one, an integral representation of pHq 2 is obtained, recurrence relations are established. Finally, we obtain a higher order partial differential equation satisfied by the p and q-Horn’s matrix function.
Certain pl(m,n)-Kummer Matrix Function of Two Complex Variables under Differential Operator  [PDF]
Ayman Shehata
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.41016

The main aim of this paper is to define and study of a new matrix functions, say, the pl(m,n)-Kummer matrix function of two complex variables. The radius of regularity, recurrence relation and several new results on this function are established when the positive integers p is greater than one. Finally, we obtain a higher order partial differential equation satisfied by the pl(m,n)-Kummer matrix function and some special properties.

Time-Optimal Control Problem for n× n Co-Operative Parabolic Systems with Control in Initial Conditions  [PDF]
Mohammed A. Shehata
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.39A1006

In this paper, time-optimal control problem for a liner n× n co-operative parabolic system involving Laplace operator is considered. This problem is, steering an initial state y(0)=u , with control u so that an observation y(t) hitting a given target set in minimum time. First, the existence and uniqueness of solutions of such system under conditions on the coefficients are proved. Afterwards necessary and sufficient conditions of optimality are obtained. Finally a scaler case is given.

A Study of Some Nonlinear Partial Differential Equations by Using Adomian Decomposition Method and Variational Iteration Method  [PDF]
Marha M. Shehata
American Journal of Computational Mathematics (AJCM) , 2015, DOI: 10.4236/ajcm.2015.52016
Abstract: In this paper, a numerical solution of nonlinear partial differential equation, Benjamin-Bona-Mahony (BBM) and Cahn-Hilliard equation is presented by using Adomain Decomposition Method (ADM) and Variational Iteration Method (VIM). The results reveal that the two methods are very effective, simple and very close to the exact solution.
Page 1 /1612
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.