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Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway
Hongjie Zhu, Mikhail B. Bogdanov, Stephen H. Boyle, Wayne Matson, Swati Sharma, Samantha Matson, Erik Churchill, Oliver Fiehn, John A. Rush, Ranga R. Krishnan, Eve Pickering, Marielle Delnomdedieu, Rima Kaddurah-Daouk, Pharmacometabolomics Research Network
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068283
Abstract: Therapeutic response to selective serotonin (5-HT) reuptake inhibitors in Major Depressive Disorder (MDD) varies considerably among patients, and the onset of antidepressant therapeutic action is delayed until after 2 to 4 weeks of treatment. The objective of this study was to analyze changes within methoxyindole and kynurenine (KYN) branches of tryptophan pathway to determine whether differential regulation within these branches may contribute to mechanism of variation in response to treatment. Metabolomics approach was used to characterize early biochemical changes in tryptophan pathway and correlated biochemical changes with treatment outcome. Outpatients with MDD were randomly assigned to sertraline (n = 35) or placebo (n = 40) in a double-blind 4-week trial; response to treatment was measured using the 17-item Hamilton Rating Scale for Depression (HAMD17). Targeted electrochemistry based metabolomic platform (LCECA) was used to profile serum samples from MDD patients. The response rate was slightly higher for sertraline than for placebo (21/35 [60%] vs. 20/40 [50%], respectively, χ2(1) = 0.75, p = 0.39). Patients showing a good response to sertraline had higher pretreatment levels of 5-methoxytryptamine (5-MTPM), greater reduction in 5-MTPM levels after treatment, an increase in 5-Methoxytryptophol (5-MTPOL) and Melatonin (MEL) levels, and decreases in the (KYN)/MEL and 3-Hydroxykynurenine (3-OHKY)/MEL ratios post-treatment compared to pretreatment. These changes were not seen in the patients showing poor response to sertraline. In the placebo group, more favorable treatment outcome was associated with increases in 5-MTPOL and MEL levels and significant decreases in the KYN/MEL and 3-OHKY/MEL; changes in 5-MTPM levels were not associated with the 4-week response. These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL.
Exploring Possible Encounters between New Governance, Law and Constitutionalism in the European Union  [PDF]
Samantha Velluti
Beijing Law Review (BLR) , 2013, DOI: 10.4236/blr.2013.41002

The current European Union (EU) is a highly institutionalized template for integration, equipped with a whole spectrum of different modes of regulation ranging from “hard” to “soft” which, particularly in recent years, have been pragmatically combined together to develop a hybrid and multi-tiered EU system. The dramatic expansion of the EU’s governance tool-kit and the variety of objectives and internal structures of these EU governance tools have relied on a non-clearly identifiable mix of legal and policy instruments. These changes in EU governance pose a challenge to the rule of law and its main tenets and do not sit well with the jurisprudence of the Court of Justice of the European Union (CJEU) because they occupy an unsettled constitutional space. This space is characterized by a range of possible encounters between constitutionalism and governance. In this context, New Governance forces European scholars to rethink the way the EU system operates and the way Europeanization is being pursued. The paper explores the relationship between New Governance, law and constitutionalism and the problems concerning their conceptualization and further understanding. Its main argument is that a stronger dialogue between what are known as “soft” and “hard” regulatory mechanisms may lead to a hybridized EU governance regime in which all governance tools are designed to achieve the same set of goals.

S. Go, Marine Insurance in the Netherlands 1600-1870: A Comparative Institutional Approach
C. Matson
BMGN : Low Countries Historical Review , 2011,
Reviewing the trends of nursing doctoral thesis research in Hong Kong  [PDF]
Yingchun Zeng, Samantha Pang
Open Journal of Nursing (OJN) , 2012, DOI: 10.4236/ojn.2012.24051
Abstract: This review aimed to analyze the trends and contributions of nursing doctoral theses produced in Hong Kong. A total of 56 nursing doctoral theses were included in this review. The most often studied topic was cardiovascular rehabilitation care (n = 9, 16%). More recently, the most often studied topics has been health technology advancements in nursing care (n = 6, 10.7%). The common trend of study methods was to be quantitative in nature. Of the total, 35 out of 56 were quantitative studies. Half were experimental/ quasi-experimental research studies (n = 28, 50%). For theoretical foundations or applications, the majority (n = 21, 36%) of doctoral theses had no specific theoretical/conceptual models as study frameworks. This trend indicates that there is space for improving the theoretical and philosophical foundation of nursing research in Hong Kong. For the contributions of doctoral thesis research, Hong Kong nursing scholars place more emphasis on direct enhancement of clinical practice or the improvement of patient outcomes. This review provides concrete evidence of the status of nursing research and knowledge development in Hong Kong nursing.
Baseline Levels of Siderastrea siderea Bleaching under Normal Environmental Conditions in Little Cayman  [PDF]
Samantha Banks, Kristi Foster
Open Journal of Marine Science (OJMS) , 2017, DOI: 10.4236/ojms.2017.71011
Abstract: This study describes the health status of Siderastrea siderea in Little Cayman before, during, and after the 2015 Caribbean-wide elevated temperature anomaly. Colony color was used as a proxy for health during snorkel and scuba surveys of shallow (<2 m depth) and deep (6 - 16 m depth) reefs. Baseline demographics indicated that 6% of this species were pale or blue pre-disturbance. When seawater temperatures exceeded 30.5°C, S. siderea were early indicators of reef stress and among the first corals to bleach. Depth and site resilience did not significantly impact temperature susceptibility; however, smaller colonies (<200 cm2 surface area) were more likely to change color than the larger size classes. Little Cayman’s S. siderea were capable of surviving large-scale (>80%) bleaching: mortality was observed for only one colony. Resilience rates varied considerably: one-third of the impacted population returned to the normal brown color within two months, one-third required 3 - 9 months to recover, and the fates of the remaining one-third remain to be determined. If the return to normal color is indicative of resistance to reef disturbances, S. siderea may be among the “winning” coral species following elevated temperature anomalies which are predicted to occur with increasing frequency and severity as a result of climate change.
Osteoporosis: A Disease of Men  [PDF]
Anu Garg, Samantha Kay
Health (Health) , 2018, DOI: 10.4236/health.2018.101005
Abstract: Objective: The goal of this study was to evaluate osteoporosis screening practices in male patients aged 70 and older. Methods: A survey-based study was carried out over six months at an academic primary care institution in the Midwest. Results: Seventy-nine male patients and fifteen primary care physicians were surveyed. Less than 10% of males recalled being screened for osteoporosis. Two-thirds of physicians reported regularly screening males for osteoporosis. Conclusion: Elderly male patients are overwhelmingly under-screened and undertreated for osteoporosis.
The Effect of the 12-micrometer Band: Comparing GOES-11 and GOES-12 Data Using the 3-Channel Volcanic Ash Algorithm
Emily M. Matson
Physics , 2006,
Abstract: The 12-micrometer channel on GOES-11 has been replaced by the 13.3-micrometer channel on the latest geosynchronous satellite, GOES-12. There has been concern that this 13.3-micrometer channel will not be as accurate in detecting volcanic ash. Volcanic ash is highlighted using a special volcanic ash algorithm, an arithmetic combination of the brightness temperatures as measured by three channels, yielding a unitless brightness count whose values comprise an IR image. Degradation in cloud detection, especially low clouds, was also expected. IR data from GOES-11 and GOES-12 for two Mexican volcanoes, Colima and Popocatepetl, was analyzed. The data indicates that, in general, the GOES-11 volcanic ash algorithm with the 12-micrometer band provides much better data for various types of clouds. It emphasizes the importance of the 12-micrometer band and provides scope for future research in this area.
Contribui??o ao estudo da microinfiltra??o in vitro de les?es cervicais n?o cariosas restauradas com diferentes materiais adesivos e técnicas
MATOS, Adriana Bona;MATSON, Edmir;
Revista de Odontologia da Universidade de S?o Paulo , 1997, DOI: 10.1590/S0103-06631997000500007
Abstract: restoration of noncarious cervical lesions is a usual clinical procedure, and there is a high incidence of restoration loss, marginal discoloration, and recurrent caries. all the factors that play an important role in this process have to be considered when studying this kind of lesion of complex multifactorial etiology. microleakage was evaluated related to the type of material used (two fourth generation bonding systems used with two types of composite resins: hybrid and microfill), two polymerization methods for bonding systems (photo and dual cure) and two restorative techniques (incremental and bulk). this study used thermal and mechanical cycling procedures, infiltration tests with silver nitrate solution, longitudinal multiple sections, and the results were measured by a scale of scores. less microleakage was found with hybrid composite resin when compared to the microfill composite. microleakage was lower with dual polymerization of the adhesive system than with photopolymerization only. restorative techniques used did not influence the microleakage pattern of restorations of noncarious cervical lesions
Contribui o ao estudo da microinfiltra o in vitro de les es cervicais n o cariosas restauradas com diferentes materiais adesivos e técnicas
MATOS Adriana Bona,MATSON Edmir
Revista de Odontologia da Universidade de S?o Paulo , 1997,
Accurate Measurement of Magnetic Resonance Imaging Gradient Characteristics
Hui Liu,Gerald B. Matson
Materials , 2014, DOI: 10.3390/ma7010001
Abstract: Recently, gradient performance and fidelity has become of increasing interest, as the fidelity of the magnetic resonance (MR) image is somewhat dependent on the fidelity of the gradient system. In particular, for high fidelity non-Cartesian imaging, due to non-fidelity of the gradient system, it becomes necessary to know the actual k-space trajectory as opposed to the requested trajectory. In this work we show that, by considering the gradient system as a linear time-invariant system, the gradient impulse response function (GIRF) can be reliably measured to a relatively high degree of accuracy with a simple setup, using a small phantom and a series of simple experiments. It is shown experimentally that the resulting GIRF is able to predict actual gradient performance with a high degree of accuracy. The method captures not only the frequency response but also gradient timing errors and artifacts due to mechanical vibrations of the gradient system. Some discussion is provided comparing the method presented here with other analogous methods, along with limitations of these methods.
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