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Search Results: 1 - 10 of 200699 matches for " Salina P Waddy "
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Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome
Thomas M Morgan, John A House, Sharon Cresci, Philip Jones, Hooman Allayee, Stanley L Hazen, Yesha Patel, Riyaz S Patel, Danny J Eapen, Salina P Waddy, Arshed A Quyyumi, Marcus E Kleber, Winfried M?rz, Bernhard R Winkelmann, Bernhard O Boehm, Harlan M Krumholz, John A Spertus
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-127
Abstract: We examined 95 polymorphisms in 69 distinct gene regions identified in a GWAS for premature myocardial infarction for their association with post-ACS mortality among 811 whites recruited from university-affiliated hospitals in Kansas City, Missouri. We then sought replication of a positive genetic association in a large, racially diverse cohort of myocardial infarction patients (N = 2284) using Kaplan-Meier survival analyses and Cox regression to adjust for relevant covariates. Finally, we investigated the apparent association further in 6086 additional coronary artery disease patients.After Cox adjustment for other ACS risk factors, of 95 SNPs tested in 811 whites only the association with the rs6922269 in MTHFD1L was statistically significant, with a 2.6-fold mortality hazard (P = 0.007). The recessive A/A genotype was of borderline significance in an age- and race-adjusted analysis of the entire combined cohort (N = 3095; P = 0.052), but this finding was not confirmed in independent cohorts (N = 6086).We found no support for the hypothesis that the GWAS-identified variants in this study substantially alter the probability of post-ACS survival. Large-scale, collaborative, genome-wide studies may be required in order to detect genetic variants that are robustly associated with survival in patients with coronary artery disease.Genome-wide association studies (GWAS) have identified robust genetic associations in a variety of common diseases [1], including myocardial infarction (MI) [2-6]. The GWAS approach, with its emphasis on large sample sizes and inclusion of hundreds of thousands of genetic markers, has produced a degree of reproducibility that was generally lacking in earlier candidate gene studies of MI [7]. However, nine GWAS-identified genetic susceptibility markers, all meeting criteria for genome-wide statistical significance, collectively account for only 3% of the estimated heritability of early-onset myocardial infarction (MI), raising questions about t
Safety and in vivo Expression of a GNE-Transgene: A Novel Treatment Approach for Hereditary Inclusion Body Myopathy-2
Anagha P. Phadke,Chris Jay,Salina J. Chen,Courtney Haddock
Gene Regulation and Systems Biology , 2009,
Abstract: Hereditary inclusion body myopathy-2 (HIBM2) is an adult-onset, muscular disease caused by mutations in the GNE gene. HIBM2-associated GNE mutations causing hyposialyation have been proposed to contribute to reduced muscle function in patients with HIBM2, though the exact cause of this disease is unknown. In the current studies we examined pre-clinical in vivo toxicity, and expression of the plasmid-based, CMV driven wild-type GNE plasmid vector. The plasmid vector was injected intramuscularly (IM) or systemically (IV) into BALB/c mice, following encapsulation in a cationic liposome (DOTAP:Cholesterol). Single IM injections of the GNE-lipoplex at 40 μg did not produce overt toxicity or deaths, indicating that the no observable adverse effect level (NOAEL) dose for IM injection was ≥40 μg. Single intravenous (IV) infusion of GNE-lipoplex was lethal in 33% of animals at 100 μg dose, with a small proportion of animals in the 40 μg cohort demonstrating transient toxicity. Thus the NOAEL dose by the IV route was greater than 10 μg and less than or equal to 40 μg. Real-time RT-qPCR analysis demonstrated recombinant human GNE mRNA expression in 100% of muscle tissues that received IM injection of 40 μg GNE-lipoplex, at 2 weeks. These results indicate that GNE-lipoplex gene transfer is safe and can produce durable transgene expression in treated muscles. Our findings support future exploration of the clinical efficacy of GNE-lipoplex for experimental gene therapy of HIBM2.
Safety and in vivo Expression of a GNE-Transgene: A Novel Treatment Approach for Hereditary Inclusion Body Myopathy-2
Anagha P. Phadke,Chris Jay,Salina J. Chen,Courtney Haddock
Gene Regulation and Systems Biology , 2009,
Abstract: Hereditary inclusion body myopathy-2 (HIBM2) is an adult-onset, muscular disease caused by mutations in the GNE gene. HIBM2-associated GNE mutations causing hyposialyation have been proposed to contribute to reduced muscle function in patients with HIBM2, though the exact cause of this disease is unknown. In the current studies we examined pre-clinical in vivo toxicity, and expression of the plasmid-based, CMV driven wild-type GNE plasmid vector. The plasmid vector was injected intramuscularly (IM) or systemically (IV) into BALB/c mice, following encapsulation in a cationic liposome (DOTAP:Cholesterol). Single IM injections of the GNE-lipoplex at 40 μg did not produce overt toxicity or deaths, indicating that the no observable adverse effect level (NOAEL) dose for IM injection was ≥40 μg. Single intravenous (IV) infusion of GNE-lipoplex was lethal in 33% of animals at 100 μg dose, with a small proportion of animals in the 40 μg cohort demonstrating transient toxicity. Thus the NOAEL dose by the IV route was greater than 10 μg and less than or equal to 40 μg. Real-time RT-qPCR analysis demonstrated recombinant human GNE mRNA expression in 100% of muscle tissues that received IM injection of 40 μg GNE-lipoplex, at 2 weeks. These results indicate that GNE-lipoplex gene transfer is safe and can produce durable transgene expression in treated muscles. Our findings support future exploration of the clinical efficacy of GNE-lipoplex for experimental gene therapy of HIBM2.
Edema, Enigma: 11 B-Hydroxysteroid Dehydrogenase Type 2 Inhibition by Sweetener “Stevia”  [PDF]
Udaya M. Kabadi, Salina Esmail
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2012, DOI: 10.4236/ojemd.2012.23007
Abstract: Intrduction: Edema, Hypertension and Hypokalemia occur with inhibition of 11 B-Hydroxysteroid Dehydrogenase Type 2 (11B-HSD2) by chronic Licorice ingestion. However, a similar presentation following a chronic use of another commonly used sweetener “Stevia” is not reported. Objective: To document a first case report of a subject presenting with Edema, Prehypertension and Hypokalemia induced by 11B-HSD2 inhibition induced by chronic ingestion of sweetener stevia. Case Report: 32 year old Caucasian woman presented with generalized edema (feet, hands and face) of over 6 months. She was noted to also manifest Prehypertension (138/88 mmHg) and Hypokalemia (3.4 mM/l). Laboratory tests revealed decline in serum aldosterone and plasma renin activity, an increase in plasma cortisol/cortisone ratio. On persistent interrogation, patient admitted to daily consumption of sweetener stevia for over 9 months. All the presenting manifestations resolved with normalization of the laboratory tests on withdrawal of stevia. Conclusion: This case report indicates that chronic ingestion of sweetener stevia may induce edema, hypertension and hypokalemia via reduced conversion of cortisol into cortisone by inhibition of 11 B-Hydroxysteroid Dehydrogenase Type 2.
Marked Improvement in Glycemic Control with Exenatide on Addition to Metformin, Sulfonylurea and Insulin Glargine in Type 2 Diabetes Mellitus, a Real World Experience  [PDF]
Salina Esmail, Sonal Banzal, Udaya M. Kabadi
Journal of Diabetes Mellitus (JDM) , 2018, DOI: 10.4236/jdm.2018.84015
Abstract: Background: The major effect of Exenatide is attributed to lowering of post-prandial glycemia, whereas insulin glargine mainly improves fasting glycemia [FPG]. Objective: Therefore, we assessed effect of Exenatide administration at 6 months and for at 1 year on glycemic control, lipids, body weight [BW], daily insulin dose and hypoglycemic events. Methods: Records of 164 subjects, 126 men and 38 women administered Exenatide between January 2011 and December 2013 are included in this report. Exenatide was initiated at 5 mcg subcutaneously twice daily [BID] in obese subjects, BMI > 30 kg/m2, with C-peptide > 1 ng/d, and HbA1c 7.5% - 9.5%, while receiving daily metformin 2000 mg, Sulfonylurea Glimepiride 8 mg and insulin Glargine [GLAR]. Exclusion criteria were creatinine > 1.5 mg/dL and liver enzymes > 2.5 times upper limit of normal. Indices of glycemic control include fasting plasma glucose levels and HbA1c. Lipids include serum concentrations of total, LDL and HDL cholesterol. Other endpoints are body weight, daily insulin dose and number of hypoglycemic events per patient during 4 weeks prior to initiation of Exenatide, at 6 months and 1 year of therapy. Results: In 37 subjects, Exenatide was discontinued within 1 - 3 weeks; 29 due to onset of nausea and vomiting. Seven of these also complained of abdominal pain and in these, serum amylase and lipase were elevated indicating presence of acute pancreatitis. One subject discontinued because of chest pain. Fasting plasma Glucose remained unchanged following Exenatide administration. However, HbA1c declined significantly denoting improvement in overall glycemic control without significant changes in body weight, daily insulin dose and hypoglycemic events. Lipid panel improved as well. Conclusion: Exenatide may be an appropriate
Organisational Barriers in Working With Child Sexual Abuse (Csa) Cases: The Malaysian Professionals’ Experiences
Salina Nen,Jill Astbury
e-BANGI : Journal of Social Sciences and Humanities , 2012,
Abstract: The purpose of this study is to examine organisational barriers faced by professionals working with child sexual abuse (CSA) cases in Malaysia. This study was conducted from a diverse sample of 18 social workers, medical social workers, counsellors and police officers who worked in CSA cases. These participants came from different organisations namely the royal police of Malaysia, the welfare department, hospitals and non-government agency. A qualitative approach was used for collecting and analysing data; and semi structured interview was used to guide the interview. Two main factors had been identified as barriers in working with CSA cases, namely within and between organisations. In terms of within organisations, participants identified factors such as inadequate support, excessive workload, safety issue and lack of resources as the major barriers. As for between organisations, factors such as conflict of power and disorganised system were mentioned as factors preventing capabilities of professionals in giving help. This paper provides an in depth analysis of major barriers facing by professionals working with CSA in Malaysia.
REARRANGEMENT IN THE B-GENOME FROM DIPLOID PROGENITOR TO WHEAT ALLOPOLYPOLID
Salina E.A.
Journal of Stress Physiology & Biochemistry , 2012,
Abstract: Three key periods that were accompanied by considerable rearrangements in the B genome of wheat and its progenitor can be considered. The first period covers the period from the divergence of diploid Triticum and Aegilops species from their common progenitor (2.5–6 million years ago) to formation of the tetraploid T. diccocoides (about 500 thousand years ago). Significant genomic rearrangements in the diploid progenitor of the B genome, Ae. speltoides (SS genome), involved a considerable amplification of repeated DNA sequences, which led to an increase in the number of heterochromatin blocks on chromosomes relative to other diploid Aegilops and Triticum species. Our analysis has demonstrated that during this period the Spelt1 repeats intensively amplified as well as several mobile elements proliferated, in particular, the genome-specific gypsy LTR-retrotransposon Fatima and CACTA DNA-transposon Caspar. The second period in the B-genome evolution was associated with the emergence of tetraploid (BBAA genome) and its subsequent evolution. The third most important event leading to the next rearrangement of the B genome took place relatively recently, 7000–9500 years ago, being associated with the emergence of hexaploid wheat with the genomic formula BBAADD. The evolution of the B/S genome involved intergenomic and intragenomic translocations and chromosome inversions. So far, five rearrangements in the B-genome chromosomes of polyploid wheats has been observed and described; the majority of them took place during the formation and evolution of tetraploid species. The mapping of the S-genome chromosomes and comparison with the B-genome chromosome maps have demonstrated that individual rearrangements pre-existed in Ae. speltoides; moreover, Ae. speltoides is polymorphic for these rearrangements.Chromosome 5B is nearly 870 Mbp (5BL = 580 Mbp and 5BS = 290 Mbp) and is known to carry important genes controlling the key aspects of wheat biology, in particular, Ph1, critical for correct mitosis and meiosis in the allopolyploid nucleus; Kr1, controlling interspecific incompatibility; the genes controlling hybrid necrosis and response to vernalization, Ne1 and Vrn-B1; and genes controlling resistance to various pathogens and bread-making quality. The translocations and inversions of chromosome 5B/5S, which could have taken place in the evolution of Ae. speltoides and allopolyploid wheats, yet has not been detected so far. On the other hand, the changes in chromosome 5B that had brought forth the locus Ph1 took place due to certain yet unknown mechanisms. Constructio
Personality Traits: Business versus Technical Graduates
Nurazariah Abidin,Salina Daud
Communications of the IBIMA , 2012,
Abstract: Effective interactions depend largely on personality traits, which is a consistent and long-lasting tendency in behavior. In psychology, five major trait factors (Big Five personality traits) have been generally used to assess personality of people. The study highlights the practicality of importance-performance analysis as a means to assessing the importance of personality traits dimension that should be possessed by Malaysian graduates. The importance-performance analysis is used to evaluate the gap in personality traits possessed by Business and Technical Graduates. The study is carried out in two phases: Phase 1 which involves a focus group session and Phase 2 which focus on establishing a questionnaire appropriate to the study across a diverse range of industries. The questionnaires were distributed to managers selected from a sampling frame. Graduates’ personality attributes are analysed in terms of big five personality traits which include openness, conscientiousness, extroversion, agreeableness and emotional stability traits. The findings of this study suggest that Higher Education Institutions in Malaysia should target improvements on a specific personality development component pertaining to openness and extroversion personality for business management graduates, and conscientiousness personality for technical graduates as part of the curriculum development strategies of these Higher Education Institutions.
Conjugate Effects of Heat and Mass Transfer on Natural Convection Flow along an Isothermal Sphere with Radiation Heat Loss  [PDF]
Salina Aktar, Mahmuda Binte Mostafa Ruma, Md. Abdul Alim
Open Journal of Fluid Dynamics (OJFD) , 2013, DOI: 10.4236/ojfd.2013.32012
Abstract: Conjugate effects heat and mass transfer on free convection flow across an isothermal sphere immersed in a viscous incompressible fluid in the presence of species concentration with radiation heat loss has been investigated in this paper. The governing boundary layer equations are first transformed into a non-dimensional form and the resulting nonlinear systems of partial differential equations are then solved numerically using Finite—difference method with Keller-box Scheme. We have focused our attention on the evaluation velocity profiles, temperature profiles and species concentration profiles of the fluid as well as the local skin friction coefficient, local heat transfer rate and local species concentration transfer rate for a wide range of radiation parameter Rd, Schmidt number Sc and Prandlt number Pr.
Which Model Performs Better While Forecasting Stock Market Volatility? Answer for Dhaka Stock Exchange (DSE)  [PDF]
S. M. Abdullah, Mohammod Akbar Kabir, Kawsar Jahan, Salina Siddiqua
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.814199
Abstract: An efficient and well behaved capital market can be regarded as a prerequisite for the sustainable financial development for an economy. For making the stock market efficient and reducing uncertainty, volatility measure is necessary for the policy makers. The main objective of this paper is to examine relative ability of various models to forecast future volatility and to devise appropriate volatility model for capturing variability in stock returns of Dhaka Stock Exchange (DSE). By exploiting daily data spanning from 27th November, 2001 to 31st July, 2013, it was found that, from volatility persistency perspective MA(2)-GARCH(2, 1) is better due to both in sample and out of sample accuracy. In contrast, from capturing asymmetric effect perspective MA(2)-EGARCH(1, 3) is better. Thus, there was no clear winner and hence the decision should depend on the purpose of the concerned people.
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