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Search Results: 1 - 10 of 1651 matches for " Said Saab "
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Physical activity reduces risk for colon polyps in a multiethnic colorectal cancer screening population
Nelson F Sanchez, Bryan Stierman, Said Saab, Divya Mahajan, Howa Yeung, Fritz Francois
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-312
Abstract: We enrolled 982 patients: 558 Hispanic, 202 Asian,149 Black, and 69 White. Patients who reported exercising one or more hours weekly had a lower prevalence of any polyps (25.3% vs 33.2%, P?=?0.008) as well as adenomas (13.8 vs. 18.9%, P?=?0.03) compared to those who did not exercise. Black and Hispanic patients and those who were overweight or obese also had lower prevalence of polyps if they led an active lifestyle. Multivariate analysis revealed that age >55, male sex, and Black race/ethnicity were positively associated with the presence of adenomas, while a history of exercising one hour or more weekly was an independent negative predictor for the presence of adenomas anywhere in the colon (OR 0.67; 95% CI 0.4 - 0.9, P?=?0.03).Exercising one hour per week was associated with a lower prevalence of polyps and adenomas when compared to those who exercised less or not at all. An active lifestyle provides benefits to groups who are at risk for colorectal cancer, such as Blacks. It also provides significant protection to overweight and obese individuals. Public health initiatives should promote physical activity as a cancer prevention tool in multiethnic populations.noneAs the second leading cause of overall cancer death in the United States, colorectal cancer (CRC) remains an important preventable public health concern. In 2010 an estimated 142,570 new cases of CRC were diagnosed and there were 51,370 associated deaths [1]. There are notable racial/ethnic differences in the epidemiology of the disease. The National Cancer Institute’s 2007 Surveillance Epidemiology and End Results (SEER) Report determined a colorectal cancer incidence rate of 54.71/100,000 for Blacks versus 43.16 for Whites, 39.78 for Asians, and 35.84 for Hispanics [2]. Identifying modifiable factors that influence the epidemiology of colorectal cancer incidence among multiethnic groups might be informative for the development of public health strategies targeting the disease.Physical activity has bee
Genetic Polymorphisms of CYP2C9: Comparison of Prevalence in the Lebanese Population with Other Populations  [PDF]
Yolande B. Saab, Taimour Langaee
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.22011
Abstract: Background: There is little knowledge about genotyping of cytochrome P450s in the Middle East, and there has not been any report on the genotype of CYP 2C9 allelic variants in Lebanese population. Aims and objectives: The purpose of the study was to determine and compare the frequencies of the cytochrome P450 CYP2C9 variants in the Lebanese population with the frequencies in other ethnic populations. Methods: CYP2C9 genotypes were determined in a total of 146 samples of unrelated, healthy Lebanese individuals residing in different areas in Lebanon. Following DNA extraction from buccal cells and polymerase chain reaction, genotyping was performed by Pyrosequencing method. CYP2C9 genotypes results were compared to other populations; i.e., Middle Easterns, Europeans, Asians, and African Americans. Results and discussion: The frequencies of the CYP2C29*2, CYP2C9*3, and CYP2C9*4 alleles were 11.305%, 11.645%, and 1.025% respectively. No CYP2C9*5 allele variants were found among the Lebanese study sample. Vol- unteers could be divided into three CYP2C9 genotype groups: subjects (76.71%) with no mutated alleles (CYP 2C9*1*1; homozygous extensive metabolizers, EM), 21.23% with one mutated allele (CYP 2C9*1*2, *1*3, *1*4, and *1*5; heterozygous intermediate metabolizers IM), and 2.06% with two mutated alleles, homozygous variants as poor metabolizers, PM). The comparative analysis using genotype groups of different populations showed differences among Leba- nese and other Caucasians. Conclusion: This is the first report from Lebanon on CYP2C9 variants; it highlights a higher frequency of CYP2C9 extensive metabolizers compared to other populations including Caucasians. The results serve as a database on CYP 2C9 polymorphisms and baseline clinical data for dosing and avoiding adverse drug reac- tions of drugs metabolised by CYP2C9 in Lebanese patients.
A New 2-way Multi-level Partitioning Algorithm
Youssef Saab
VLSI Design , 2000, DOI: 10.1155/2000/65821
Abstract: Partitioning is a fundamental problem in the design of VLSI circuits. In recent years, the multi-level partitioning approach has been used with success by a number of researchers. This paper describes a new multi-level partitioning algorithm (PART) that combines a blend of iterative improvement and clustering, biasing of node gains, and local uphill climbs. PART is competitive with recent state-of-the-art partitioning algorithms. PART was able to find new lower cuts for many benchmark circuits. Under suitably mild assumptions, PART also runs in linear time.
A Contraction-based Ratio-cut Partitioning Algorithm
Youssef Saab
VLSI Design , 2002, DOI: 10.1080/1065514021000012093
Abstract: Partitioning is a fundamental problem in the design of VLSI circuits. In recent years, ratio-cut partitioning has received attention due to its tendency to partition circuits into their natural clusters. Node contraction has also been shown to enhance the performance of iterative partitioning algorithms. This paper describes a new simple ratio-cut partitioning algorithm using node contraction. This new algorithm combines iterative improvement with progressive cluster formation. Under suitably mild assumptions, the new algorithm runs in linear time. It is also shown that the new algorithm compares favorably with previous approaches.
New Methods for the Construction of TestCases for Partitioning Heuristics
Youssef Saab
VLSI Design , 1995, DOI: 10.1155/1995/81535
A Fast Clustering-Based Min-Cut Placement AlgorithmWith Simulated-Annealing Performance
Youssef Saab
VLSI Design , 1996, DOI: 10.1155/1996/58084
Cellular Senescence: Many Roads, One Final Destination
Raya Saab
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.68
Una aproximación naturalista al problema de la conciencia
Salma Saab
Signos filosóficos , 2000,
Abstract: "Una aproximación al problema de la conciencia" En Wittgenstein nuestras capacidades racionales y conceptuales forman parte de nuestra historia natural como especie y se ponen en juego en una gran cantidad de prácticas sociales. Este ensayo profundiza en este hecho y lo pone en relación con el problema de la conciencia y el de la formación de nuestros juicios. "An approach to the problem of consciousness" For Wittgenstein, our rational and conceptual abilities are part of our natural history as a specie and are displayed in most social practices. This essay takes a look into this idea and relates it to the problem of conscience and opinion.
An Introduction to Dark Matter Direct Detection Searches & Techniques
Tarek Saab
Physics , 2012,
Abstract: Weakly Interacting Massive Particles (WIMPs), are a leading candidate for the dark matter that is observed to constitute ~25% of the total mass-energy density of the Universe. The direct detection of relic WIMPs (those produced during the early moments of the Universe's expansion) is at the forefront of active research areas in particle astrophysics with a numerous international experimental collaborations pursuing this goal. This paper presents an overview of the theoretical and practical considerations common to the design and operation of direct detection experiments, as well as their unique features and capabilities.
Integral Operators on Spaces of Continuous Vector-valued Functions
Paulette Saab
Mathematics , 1990,
Abstract: Let $X$ be a compact Hausdorff space, let $E$ be a Banach space, and let $C(X,E)$ stand for the Banach space of $E$-valued continuous functions on $X$ under the uniform norm. In this paper we characterize Integral operators (in the sense of Grothendieck) on $C(X,E)$ spaces in term of their representing vector measures. This is then used to give some applications to Nuclear operators on $C(X,E)$ spaces.
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