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Search Results: 1 - 10 of 1201 matches for " Sachiko Hara "
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Characteristics of Geriatric Health Service Facilities Designated as Sites of Death  [PDF]
Mitsumi Ono, Hideyuki Kanda, Yuko Takeda, Sachiko Hara
Health (Health) , 2015, DOI: 10.4236/health.2015.710142
Abstract: There are many deaths occurring among the aged population in Japan. Geriatric Health Service Facilities (GHSFs) are highlighted as some of the chosen facilities designated as sites of death. The aim of our study was to clarify the characteristics and related factors, including physical signs first noticed by staff at the end-of-life period, in GHSFs designated as sites of death, using a nationwide survey in Japan. We administered a questionnaire to 3971 GHSFs in Japan. Eligible responses for the study were obtained from 854 GHSFs. We found that GHSFs designated as sites of death were more likely to have basic policies and documented preferences regarding end-of-life care. We also found that staff members in GHSFs designated as sites of death were less likely to first notice physical signs of pain. We found that GHSFs designated as sites of death tended to identify earlier symptoms, such as reduced oral intake and less vigor. Our results would enable elderly persons, their families, and staff in GHSFs to prepare for the elderly’s death more efficiently though earlier identification of the end-of-life period. We hope that GHSFs have an important role to play in end-of-life care provision to elderly persons in Japan, through the strengthening of these intermediate facilities.
Factors Related to Nocturia in Elderly People Living in Local Remote Area in Japan  [PDF]
Yuko Takeda, Mitsumi Ono, Hideyuki Kanda, Sachiko Hara, Keiko Takeda
Health (Health) , 2017, DOI: 10.4236/health.2017.94047
Abstract:
The elderly people are prone to be affected by quality of life (QOL) by nocturia becoming the multiple times. A purpose of this study was to determine it about a factor associated with the night urination. This survey was conducted in 2015 as a cross-sectional study. Anonymous, self-administered questionnaires were used to prevent individuals from being identified. The analysis subjects were 699 elderly people with the nocturia which belonged to club of the aged 65 years or older. Those with nocturia were placed in the Nocturia-1 group if they reported experiencing nocturia once per night or in the Nocturia- ≥ 2 group if they reported experiencing nocturia two or more times per night. We analyzed the relationships between the characteristics, lower urinary tract symptoms, and opportunities to go outdoors in the Nocturia-1 and Nocturia- ≥ 2 groups based on sex using the χ2 test. In addition, to investigate the factors that influence the change from nocturia once per night to two or more times per night, we performed logistic regression analysis using the χ2 test on the characteristics and lower urinary tract symptoms that showed significant differences separately for men and women. Among the men, factors with a significant positive relation-ship were age, diabetes mellitus, lower back pain, daytime frequency, and urinary urgency. Among the women, factors with a significant positive relationship were age, requiring support 1-requiring long-term care 2, urinary urgency, and feeling of incomplete emptying. It was suggested that the life of elderly people improved by nocturia not increasing.
Bacterial ArtA protein specifically binds to the internal region of IS1 in vitro  [PDF]
Sachiko Matsutani
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.37108
Abstract: The internal region of bacterial translocatable IS1 acts as a cis-element to stimulate transcription from the various promoters located upstream. The product of the artA gene is genetically shown to stimulate transcription with the cis-element. Here, a codon-optimized artA gene was synthesized and cloned to express the ArtA protein. ArtA was purified as the Histagged protein. Nitrocellulose filter binding assay showed that ArtA specifically binds to the IS1 internal region. Electrophoretic mobility shift assay also showed specific binding of ArtA to the IS1 internal region. These results imply that ArtA directly binds to the IS1 internal region and stimulates transcription.
Effect of Dehydrated Digested Effluent of Manure on Yield and Quality of Annual Forages and Soil Chemical Properties in Southern Kyushu, Japan  [PDF]
Sachiko Idota, Yasuyuki Ishii
Agricultural Sciences (AS) , 2014, DOI: 10.4236/as.2014.510090
Abstract:

Digested effluent of manure (DEM) produced by biogas-plants contains many macro- and micro-nutrients. In an experiment conducted in southern Kyushu (Japan), forage crops cultivated after receiving DEM and chemical fertilizers exhibited similar dry matter yields. From a logistical standpoint, however, DEM in liquid form is difficult to handle and apply due to the low concentration of nutrients. To overcome this shortcoming, we prepared dehydrated DEM (DDEM) by adding DEM to cattle manure without disturbing the manure fermentation process. The objective of this research was to evaluate the effect of DDEM on dry matter yield and nitrogen recovery rate in annual dual-cropping systems (summer crop of maize or sorghum and winter crop of Italian ryegrass) that are typical of the region and to compare these results to commercial cattle manure alone, in combination with chemical fertilizer (CM or CM + CF), or no fertilizer application (NF). In both cropping systems, the DDEM treatment produced similar dry matter yields (2.6 to 3.02 kg·m-2) and apparent nitrogen recovery rates (43% to 53%) as the CM + CF and CM treatments. This suggests that DDEM can potentially replace chemical fertilizers and commercial cattle manure in the region.

Quest for Potentials in the Quintessence Scenario  [PDF]
Tetsuya Hara
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.42027
Abstract:

The time evolution of the equation of state w for quintessence scenario with a scalar field as dark energy is studied up to the third derivative (d3w/da3) with respect to the scale factor a, in order to predict the future observations and specify the scalar potential parameters with the observables. The third derivative of w for general potential V is derived and applied to several types of potentials. They are the inverse power-law (V = M4 + α/Qα), the exponential ?\"\", the mixed \"\" , the cosine \"\" ?and the Gaussian types \"\" , which are prototypical potentials for the freezing and thawing models. If the parameter number for a potential form is n, it is necessary to find at least for n + 2 independent observations to identify the potential for0m and the evolution of the scalar field (Q and \"\"

Links Between Repeated Sequences
Sachiko Matsutani
Journal of Biomedicine and Biotechnology , 2006, DOI: 10.1155/jbb/2006/13569
Abstract: L1 and Alu elements are long and short interspersed retrotransposable elements (LINEs and SINEs) in humans, respectively. Proteins encoded in the autonomous L1 mediate retrotransposition of the nonautonomous Alu and cellular mRNAs. Alu is the only active SINE in the human genome and is derived from 7SL RNA of signal recognition particle. In the other eukaryotic genomes, various tRNA- and 5S rRNA-derived SINEs are found. Some of the tRNA- and 5S rRNA-derived SINEs have partner LINEs of which 3' sequences are similar to those of the SINEs. One of the tRNA-derived SINEs is shown to be mobilized by its partner LINE. Many copies of tRNA and 5S rRNA pseudogenes are present in the human genome. These pseudogenes may have been generated via the retrotransposition process using L1 proteins. Although there are no sequence similarities between L1 and Alu, L1 functionally links with Alu and even cellular genes, impacting on our genome shaping.
Secondary Leukemia Associated with the Anti-Cancer Agent, Etoposide, a Topoisomerase II Inhibitor
Sachiko Ezoe
International Journal of Environmental Research and Public Health , 2012, DOI: 10.3390/ijerph9072444
Abstract: Etoposide is an anticancer agent, which is successfully and extensively used in treatments for various types of cancers in children and adults. However, due to the increases in survival and overall cure rate of cancer patients, interest has arisen on the potential risk of this agent for therapy-related secondary leukemia. Topoisomerase II inhibitors, including etoposide and teniposide, frequently cause rearrangements involving the mixed lineage leukemia ( MLL) gene on chromosome 11q23, which is associated with secondary leukemia. The prognosis is extremely poor for leukemias associated with rearrangements in the MLL gene, including etoposide-related secondary leukemias. It is of great importance to gain precise knowledge of the clinical aspects of these diseases and the mechanism underlying the leukemogenesis induced by this agent to ensure correct assessments of current and future therapy strategies. Here, I will review current knowledge regarding the clinical aspects of etoposide-related secondary leukemia, some probable mechanisms, and strategies for treating etoposide-induced leukemia.
Similarities in transcription factor IIIC subunits that bind to the posterior regions of internal promoters for RNA polymerase III
Sachiko Matsutani
BMC Evolutionary Biology , 2004, DOI: 10.1186/1471-2148-4-26
Abstract: Here, I reported the results of PSI-BLAST searches using the B-block binding subunits of human and Shizosacchromyces pombe as queries, showing that the same Arabidopsis proteins were hit with low E-values in both searches. Comparison of the convergent iterative alignments obtained by these PSI-BLAST searches revealed that the vertebrate, yeast, and Arabidopsis proteins have similarities in their N-terminal one-third regions. In these regions, there were three domains with conserved sequence similarities, one located in the N-terminal end region. The N-terminal end region of the B-block binding subunit of Saccharomyces cerevisiae is tentatively identified as a HMG box, which is the DNA binding motif. Although I compared the alignment of the N-terminal end regions of the B-block binding subunits, and their homologs, with that of the HMG boxes, it is not clear whether they are related.Molecular phylogenetic analyses using the small subunit rRNA and ubiquitous proteins like actin and α-tubulin, show that fungi are more closely related to animals than either is to plants. Interestingly, the results obtained in this study show that, with respect to the B-block binding subunits of TFIIICs, animals appear to be evolutionarily closer to plants than to fungi.Phylogenetic relationships among animals, fungi, and plants have been a controversial issue. Although fungi traditionally had been considered more closely related to plants than to animals, Whittaker and Margulis [1] classified the fungi as a separate kingdom in their five-kingdom classification: the three major multicellular groups of animals, fungi, and green plants were each given the status of kingdoms derived from different protistan lineages of uncertain affinities. With the determination of the primary structures of homologous macromolecules in various organisms, spanning several kingdoms, molecular phylogenetic techniques resulted in new hypotheses about the relationships among eukaryotes. Small subunit rRNA, and
Links Between Repeated Sequences
Sachiko Matsutani
Journal of Biomedicine and Biotechnology , 2006,
Abstract: L1 and Alu elements are long and short interspersed retrotransposable elements (LINEs and SINEs) in humans, respectively. Proteins encoded in the autonomous L1 mediate retrotransposition of the nonautonomous Alu and cellular mRNAs. Alu is the only active SINE in the human genome and is derived from 7SL RNA of signal recognition particle. In the other eukaryotic genomes, various tRNA- and 5S rRNA-derived SINEs are found. Some of the tRNA- and 5S rRNA-derived SINEs have partner LINEs of which 3' sequences are similar to those of the SINEs. One of the tRNA-derived SINEs is shown to be mobilized by its partner LINE. Many copies of tRNA and 5S rRNA pseudogenes are present in the human genome. These pseudogenes may have been generated via the retrotransposition process using L1 proteins. Although there are no sequence similarities between L1 and Alu, L1 functionally links with Alu and even cellular genes, impacting on our genome shaping.
The Role of ATP in Sleep Regulation
Sachiko Chikahisa
Frontiers in Neurology , 2011, DOI: 10.3389/fneur.2011.00087
Abstract: One of the functions of sleep is to maintain energy balance in the brain. There are a variety of hypotheses related to how metabolic pathways interact with sleep/wake regulation. A major finding that demonstrates an interaction between sleep and metabolic homeostasis is the involvement of adenosine in sleep homeostasis. An accumulation of adenosine is supplied from ATP, which can act as an energy currency in the cell. Extracellularly, ATP can act as an activity-dependent signaling molecule, especially in regard to communication between neurons and glia, including astrocytes. Furthermore, the intracellular AMP/ATP ratio controls the activity of AMP-activated protein kinase, which is a potent energy regulator and is recently reported to play a role in the regulation of sleep homeostasis. Brain ATP may support multiple functions in the regulation of the sleep/wake cycle and sleep homeostasis.
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