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Search Results: 1 - 10 of 1958 matches for " Sabine Didlaukat "
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Sensitive and reliable detection of Kit point mutation Asp 816 to Val in pathological material
Christian K?hler, Sabine Didlaukat, Alfred C Feller, Hartmut Merz
Diagnostic Pathology , 2007, DOI: 10.1186/1746-1596-2-37
Abstract: The Kit point mutation Asp 816 to Val is heterozygous which means a problem in detection by PCR because the wild-type allele is also amplified and the number of cells which bear the point mutation is in most of the cases low. Most PCR protocols use probes to block the wild-type allele during amplification with more or less satisfying result. This is why point-mutated forward primers were designed and tested for efficiency in amplification of the mutated allele.One primer combination (A) fits the most for the introduced PCR assay. It was able just to amplify the mutated allele with high specificity from different patient's materials (FFPE or blood) of varying quality and quantity. Moreover, the sensitivity for this assay was convincing because 10 ng of DNA which bears the point mutation could be detected in a total volume of 200 ng of DNA.The PCR assay is able to deal with different materials (blood and FFPE) this means quality and quantity of DNA and can be used for high-througput screening because of its robustness. Moreover, the method is easy-to-use, not labour-intensive, and easy to realise in a standard laboratory.1,000 to 8,000 incidences of human mastocytosis are reported every year in the US [1]. Human mastocytosis is characterised by accumulation of mast cells in different organs. It is a heterogenous group of disorders which can be divided into the categories cutaneous mastocytosis (CM) and systemic mastocytosis (SM) which is commonly seen in adults by histological lesions in the bone marrow and other non-cutaneous organs [2,3]. SM can be further divided into the categories indolent systemic mastocytosis (ISM), SM with an associated clonal hematologic non-mast cell lineage disease (AHNMD), aggressive sytemic mastocytosis (ASM), and mast cell leukemia (MCL). ISM is the most common form which involves skin, bone marrow, and GI tract with good prognosis for the patient. First relations between mastocytosis and activating mutations in the receptor tyrosine kin
Identifying Where the Values Come from IT-Innovations in Health and Social Care  [PDF]
Vivian Vimarlund, Sabine Koch
Intelligent Information Management (IIM) , 2012, DOI: 10.4236/iim.2012.425042
Abstract: Studies aimed to capture the effects of IT-innovations in health and social care have shown that there is a gap between expected and factual outcomes. Many decision makers feel the need to articulate an ideal end-state for their organiza-tions. Striking the balance between novelty and believability of such an ideal end-state is often tricky and they become neither satisfied with the ideal not the visioning. In this study, we explore the contribution of IT-innovations to health and social care. The results showed that coherence between context and IT-innovation is important to capture effects and outcomes. Being coherent rather than visionary contributes to identify where you are, as an organization, and to capture effects and outcomes that “make sense” in the context in question. The paper makes an exposition from the model building, algorithm design to performance analysis and contributes to the academic prosperity in Intelligent In-formation Management The knowledge generated is expected to provide input when identifying goals that IT-investments are supposed to achieve.
Ego Depletion After Social Interference  [PDF]
Alex Bertrams, Sabine Pahl
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.51001

The present study examines whether social interference (i.e., interference with one’s goal attainment by the bodily presence of others) depletes the limited resource of self-control strength. In an experimental laboratory study (N = 34), half the participants experienced social interference whereas the other half did not experience social interference by two confederates during a dexterity task. Afterwards, we measured participants’ momentary self-control strength applying a Stroop colour-naming task. In line with our prediction, participants’ performance in the Stroop task indicated that social interference reduced self-control strength. We discuss implications for crowding research and crowding in natural settings.

Effect of Deep Brain Stimulation on Speech Performance in Parkinson's Disease
Sabine Skodda
Parkinson's Disease , 2012, DOI: 10.1155/2012/850596
Abstract: Deep brain stimulation (DBS) has been reported to be successful in relieving the core motor symptoms of Parkinson's disease (PD) and motor fluctuations in the more advanced stages of the disease. However, data on the effects of DBS on speech performance are inconsistent. While there are some series of patients documenting that speech function was relatively unaffected by DBS of the nucleus subthalamicus (STN), other investigators reported on improvements of distinct parameters of oral control and voice. Though, these ameliorations of single speech modalities were not always accompanied by an improvement of overall speech intelligibility. On the other hand, there are also indications for an induction of dysarthria as an adverse effect of STN-DBS occurring at least in some patients with PD. Since a deterioration of speech function has more often been observed under high stimulation amplitudes, this phenomenon has been ascribed to a spread of current-to-adjacent pathways which might also be the reason for the sporadic observation of an onset of dysarthria under DBS of other basal ganglia targets (e.g., globus pallidus internus/GPi or thalamus/Vim). The aim of this paper is to review and evaluate reports in the literature on the effects of DBS on speech function in PD. 1. Introduction 1.1. Dysarthria in Parkinson’s Disease (PD) Nearly 90% of individuals with Parkinson’s disease (PD) develop voice and speech disorders (dysarthria) in the course of their disease [1]. Affected patients may complain about a quiet or weak voice and about difficulties to get speech started. Further, they often report that they are asked to repeat their words because listeners have difficulties to understand although patients themselves may self-estimate their speech as loud and sufficiently articulated [2]. Dysarthria can emerge at any stage of the disease and worsen in the later stages [3] causing a progressive loss of communication and leading to social isolation. Parkinsonian dysarthria has traditionally been interpreted as manifestation of rigor and hypokinesia on the speech effector organs [4] inducing to a multidimensional motor speech impairment including alterations of speech respiration, phonation, articulation, and prosody. Thus, based upon global clinical impression, hypokinetic dysarthria is characterized by a breathy and harsh voice, monotony of pitch and loudness, reduced stress, variable speech rate with short rushes of speech, and imprecise articulation resulting in a reduction of overall speech intelligibility [5–8]. From the therapeutic point of view, the effect
Global Diversity of Aloricate Oligotrichea (Protista, Ciliophora, Spirotricha) in Marine and Brackish Sea Water
Sabine Agatha
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0022466
Abstract: Oligotrichids and choreotrichids are ciliate taxa contributing to the multi-step microbial food web and episodically dominating the marine microzooplankton. The global diversity and distribution of aloricate Oligotrichea are unknown. Here, the geographic ranges of the 141 accepted species and their synonyms in marine and brackish sea water are analyzed, using hundreds of taxonomical and ecological studies; the quality of the records is simultaneously evaluated. The aloricate Oligotrichea match the moderate endemicity model, i.e., the majority (94) of morphospecies has a wide, occasionally cosmopolitan distribution, while 47 morphospecies show biogeographic patterns: they are restricted to single geographic regions and probably include 12 endemic morphospecies. These endemics are found in the Antarctic, North Pacific, and Black Sea, whereas the “flagship” species Strombidinopsis cercionis is confined to the Caribbean Sea. Concerning genera, again several geographic patterns are recognizable. The species richness is distinctly lower in the southern hemisphere than in the northern, ranging from nine morphospecies in the South Pacific to 95 in the North Atlantic; however, this pattern is probably caused by undersampling. Since the loss of species might affect higher trophical levels substantially, the aloricate Oligotrichea should not any longer be ignored in conservation issues. The ecophysiological diversity is considerably larger than the morphological, and even tops the richness of SSrRNA and ITS haplotypes, indicating that probably more than 83–89% of the diversity in aloricate Oligotrichea are unknown. The huge challenge to discover all these species can only be managed by combining the expertises of morphological taxonomists, molecular biologists, ecologists, and physiologists.
"No remoinho da tendência-espiral": quest?es de estética, literatura e ciências naturais na obra de Goethe
Mainberger, Sabine;
Estudos Avan?ados , 2010, DOI: 10.1590/S0103-40142010000200013
Abstract: in his final years goethe was obsessed by the so-called "spiral tendency". the problem, however, was far from new to him as the versions and variations of curved lines and spirals in goethe's work clearly show. these forms can actually be found at the crossroads of poetry, visual aesthetics (namely of ornaments), and scientific studies. a crucial point of reference for aesthetics in the later 18th century was william hogarth's famous concept and model of the "line of beauty" (1753), which also left its traces in goethe's writings, even in his late period. this study examines his elegy "amyntas" (1799), the essay "fossile bull" (1822), and texts on the metamorphoses of plants and the spiral tendency in vegetation. spiral forms seem to be so fascinating for goethe because, with their manifold functions and meanings, they allow us to cross the borders between different genres and disciplines and to connect different kinds of thinking. this transgressive intellectual activity, which we could call 'transdisciplinary', remains a model for important thinkers of the 20th century, such as paul valéry, walter benjamin or aby warburg.
Adelbert von Chamisso e o narcisismo primário
Parmentier, Sabine;
ágora: Estudos em Teoria Psicanalítica , 2005, DOI: 10.1590/S1516-14982005000200004
Abstract: chamisso was a german writer and poet born in an aristocratic french family emigrated to germany in 1792. this paper, inquiring into chamisso's tale "l'étrange histoire de peter schlemihl", his first issued writing, points to its autobiographical features that anticipate the life of its author even in its precise details. this paper shows how artistic sublimation allowed the writer to succeed in finding for himself a path towards scientific work and literary creation, and emphasizes that this kind of "intellectual acceptation" of the repressed could be seen as equivalent to the result of a psychoanalysis treatment.
,,etwas über Gleise" oder Versuchsanordnung ?ffentlicher Platz: Zu Lichtenbergs Sudelbuchaufzeichnung J 528
Mainberger, Sabine;
Pandaemonium Germanicum , 2010, DOI: 10.1590/S1982-88372010000100002
Abstract: the essay analyses the aphorism j 528 in lichtenberg's sudelbüchern as a model study of elementary questions and interests of the enlightenment, and as an example of the author's specific way of thinking and writing focusing on three aspects: 1) epistemological: lichtenberg's text deals with the relationship between reason and anthropological as well as social factors, offering a kind of genealogy of rational behavior; 2) methodological and poetological: the text is a paradigm of lichtenberg's transferring scientific method to non-scientific subjects; 3) reception: lichtenberg's poetics find their complement in a specific way of reading: the reader has to be as active as the writer and is invited to do similar scientific experiments as does the observer of the public place he reads about. in other notes in the sudelbücher, lichtenberg attends to problems of physiology and psychology of perception as, in the 20th century, they will be a main issue in the theory of gestalt. as lichtenberg's way of thinking and writing is a criticism of self imposed immaturity as well as of dogmatic rationalism, enlightenment itself is enlightened.
Processo de vulnerabiliza??o e danos ao ofício: a Moderniza??o do Trabalho em quest?o
Fortino, Sabine;
Revista Brasileira de Saúde Ocupacional , 2012, DOI: 10.1590/S0303-76572012000200004
Abstract: the study analyzes intensification and individualization in the core of "work modernization". both are seen as processes that cause workers suffering and pain. in "modern" organizations, work has constantly been assessed by a single aspect: performance and economic profitability. when it happens within service relations, even within public service - it is the meaning of work that is affected. supported by an empiric research involving travel packages and tickets salespersons from a large transport company, "breaking" of professions was investigated as a bullying at work strategy, which deteriorates wage earners' individual and collective defenses. the investigation found these sales professionals have increasingly been feeling they are losing control of their work, at significant cost to their mental health.
Abundance and distribution of small infauna in mangroves of Missionary Bay, North Queensland, Australia
Revista de Biología Tropical , 2001,
Abstract: to assess the occurrence, spatial distribution and species composition of small infauna on a mangrove shore, core samples were taken along a transect in missionary bay at hinchinbrook island, north-east australia. three sites were arranged within the mangrove forest and one site was located in an adjacent mudflat. the sites were surveyed four times between november 1988 and october 1989. based on the records from all samples and sites, 39 taxa were identified. diversity (h') ranged from 1.18 to 2.38. overall, total abundances of small infauna (retained on a 0.25 mm sieve) reached a mean value of 5 477 ind. m-2 with little variation throughout the transect or over time. species numbers and diversity were higher in the mudflat than at the mangrove sites. the taxonomic composition changed between the mangrove forest and the mudflat: oligochaeta were more abundant in mangrove sediments, whereas polychaeta dominated in the mudflat. of the polychaetes, capitellidae were almost restricted to the mangrove sites, sabellidae were recorded frequently at all sites, and sigambra parva and myriochele sp. were confined to the mudflat and the mangrove fringe. these species accounted also for dissimilarities between sites. multivariate analyses showed a distinct assemblage at the mudflat compared to the mangrove sites. this survey showed that small infauna is an abundant component of mangrove sediments, which has been previously underestimated.
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