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Search Results: 1 - 10 of 325269 matches for " S.;Teneud "
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A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function
Gonzalez L.E.,Parada M.A.,Tucci S.,Teneud L.
Brazilian Journal of Medical and Biological Research , 2003,
Abstract: Breeding for high and low hypothermic responses to systemic administration of a serotonin1A (5-HT1A) receptor agonist (8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT) has resulted in high DPAT-sensitive (HDS) and low DPAT-sensitive (LDS) lines of rats, respectively. These lines also differ in several behavioral measures associated with stress. In the present microdialysis study we observed that basal 5-HT concentrations in the prefrontal cortex and dorsal hippocampus did not differ significantly between HDS and LDS rats. Thus, behavioral differences between the HDS and LDS lines might not be attributed to differences in basal 5-HT release. However, both lines had lower basal levels of 5-HT release than their randomly bred control group (random DPAT-sensitive, RDS) in the prefrontal cortex (mean ± SEM, pg/20 μl, was 3.0 ± 0.4 for LDS, 3.8 ± 0.3 for HDS and 6.4 ± 0.6 for RDS; F(2,59) = 5.8, P<0.005). The administration of (±)-fenfluramine (10 mg/kg) induced a greater increase in hippocampal 5-HT levels in HDS rats (500%) as compared with LDS (248%) or RDS (243%) rats (P<0.0001). There were no significant differences in the prefrontal cortex among lines, with a fenfluramine-induced 5-HT increase of about 900% in the three groups. This differential response to fenfluramine may be due to functional alterations of hippocampal 5-HT reuptake sites in the HDS line.
A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function
Gonzalez, L.E.;Parada, M.A.;Tucci, S.;Teneud, L.;Overstreet, D.H.;Hernandez, L.;
Brazilian Journal of Medical and Biological Research , 2003, DOI: 10.1590/S0100-879X2003000200014
Abstract: breeding for high and low hypothermic responses to systemic administration of a serotonin1a (5-ht1a) receptor agonist (8-hydroxy-2-(di-n-propylamino)tetralin, 8-oh-dpat) has resulted in high dpat-sensitive (hds) and low dpat-sensitive (lds) lines of rats, respectively. these lines also differ in several behavioral measures associated with stress. in the present microdialysis study we observed that basal 5-ht concentrations in the prefrontal cortex and dorsal hippocampus did not differ significantly between hds and lds rats. thus, behavioral differences between the hds and lds lines might not be attributed to differences in basal 5-ht release. however, both lines had lower basal levels of 5-ht release than their randomly bred control group (random dpat-sensitive, rds) in the prefrontal cortex (mean ± sem, pg/20 μl, was 3.0 ± 0.4 for lds, 3.8 ± 0.3 for hds and 6.4 ± 0.6 for rds; f(2,59) = 5.8, p<0.005). the administration of (±)-fenfluramine (10 mg/kg) induced a greater increase in hippocampal 5-ht levels in hds rats (500%) as compared with lds (248%) or rds (243%) rats (p<0.0001). there were no significant differences in the prefrontal cortex among lines, with a fenfluramine-induced 5-ht increase of about 900% in the three groups. this differential response to fenfluramine may be due to functional alterations of hippocampal 5-ht reuptake sites in the hds line.
Expresión del receptor del factor de crecimiento epidérmico en biopsias renales de pacientes con nefronoptisis del adolescente
Ramírez,A. E.; Fernández,C.; Narváez,D.; Teneud,L.;
Nefrología (Madrid) , 2010,
Abstract: introduction: in venezuela has been described a new form of nephronophthisis, called adolescent nephronophthisis, with clinical and histological findings very similar to others varieties described. however, pathogenesis in not well known. the aim of this study was to determine the expression of human epidermal growth factor receptor (egfr) in tubular epithelial cells of patients with adolescent nephronophthisis. methods: renal biopsies of 8 patients with adolescent nephronophthisis were studied by immunohistochemistry to determine renal expression of egfr. results: in all patients, there was no expression of epidermal growth factor receptor. conclusion: these findings indicate a deficiency of growth factor receptor in undifferentiated epithelial cells, which could be one factor in the development of cysts in nephronophthisis.
Efecto protector de la melatonina y el tiosulfato de sodio sobre la histopatología y la ultraestructura del ri?ón en ratas con intoxicación aguda por Paraquat
Ramírez-Zambrano,Elizabeth; Zambrano,Eulogia; Rojas,Gloria; Zambrano,Miguel; Teneud,Luis;
Investigación Clínica , 2007,
Abstract: paraquat (pq) toxicity produces severe injures in many major organs systems, including kidney, developing renal failure with fatal evolution in most of the cases. several antidotes have been used in the treatment of paraquat intoxication without satisfactory results. the antioxidative effect of melatonin (mlt) and sodium thiosulphate (sts) on kidney in rats with acute intoxication by pq was studied. forty male wistar rats were used, divided in 4 groups of 10 rats each. group i, control, was injected intraperitoneally (ip) with 1 ml of saline solution; group ii, received dl50 of pq, ip; groups iii and iv, dl50 of pq, and simultaneously the first dose of mlt (15 mg/kg, ip) or sts (1,5 g/kg, ip) respectively. thirty minutes later, groups iii and iv received a second similar dose of mlt and tss. after 24 hours, rats were sacrificed with pentobarbital, and kidneys were extracted for morphological study. light and electronic microscopy observations showed in group ii morphological changes of acute tubular necrosis in proximal tubule in group ii, similar findings, with lesser magnitude, were observed in the animals treated with the antidotes, suggesting a partial protection. in conclusion, individual use of mlt and sts at the doses and time used partially prevent damage caused by paraquat to the cell. in consequence, more experiments with these drugs are necessary to considere them as specific treatments in cases of poisoning by paraquat.
Study of the Structural and Electrical Properties of Cr-Doped BiFeO3 Ceramic  [PDF]
S. S. Arafat, S. Ibrahim
Materials Sciences and Applications (MSA) , 2017, DOI: 10.4236/msa.2017.810051
Abstract: Multiferroic BiFe1-xCrxO3 (x = 0.2 and 0.4) ceramics were synthesized in a single phase. The effects of Cr3+ substitution on the crystal structure, dielectric permittivity and leakage current were investigated. Preliminary X-ray structural studies revealed that the samples had a rhombohedral perovskite crystal structure. The dielectric constant ε' significantly increased while the dielectric loss tanδ was substantially decreased with the increase in Cr3+ substitution. The temperature effect on the dielectric properties exhibited an anomaly corresponding to magneto-electric coupling in the samples and was shifted to lower temperatures with the increase in Cr3+ substitution. The leakage current density also reduced in magnitude with the increase in the Cr3+ substitution.
Degree Splitting of Root Square Mean Graphs  [PDF]
S. S. Sandhya, S. Somasundaram, S. Anusa
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.66086
Abstract: Let \"\" be an injective function. For a vertex labeling f, the induced edge labeling \"\" is defined by, \"\" or \"\"; then, the edge labels are distinct and are from \"\". Then f is called a root square mean labeling of G. In this paper, we prove root square mean labeling of some degree splitting graphs.
A Parameter Estimation Model of G-CSF: Mathematical Model of Cyclical Neutropenia  [PDF]
S. Balamuralitharan, S. Rajasekaran
American Journal of Computational Mathematics (AJCM) , 2012, DOI: 10.4236/ajcm.2012.21002
Abstract: We investigate the FFT (Fast Fourier Transform) model and G-CSF (granulocyte colony-stimulating factor) treatment of CN (Cyclical Neutropenia). We collect grey collies and normal dog’s data from CN and analyze the G-CSF treatment. The model develops the dynamics of circulating blood cells before and after the G-CSF treatment. This is quite natural and useful for the collection of laboratory data for investigation. The proposed interventions are practical. This reduces the quantity of G-CSF required for potential maintenance. This model gives us good result in treatment. The changes would be practical and reduce the risk side as well as the cost of treatment in G-CSF.
Synthesis, Thermal Behaviour, XRD, and Luminescent Properties of Lighter Lanthanidethiodipropionate Hydrates Containing Aminogunidine as Neutral Ligand  [PDF]
S. Packiaraj, S. Govindarajan
Open Journal of Inorganic Chemistry (OJIC) , 2014, DOI: 10.4236/ojic.2014.43006
Abstract:
Aminoguanidine lanthanide thiodipropionate hydrates of composition [Ln(Agun)2(tdp)3·nH2O], Agun = Aminoguanidine, tdp = thiodipropionic acid, where Ln = La, Pr, Nd and Sm if n = 2, have been prepared and characterized by physic-chemical techniques.
Fuzzy Based Intelligent Monitoring of Critical Lines in the Restructured Power Market  [PDF]
S. Rajasekaran, S. Sathiyamoorthy
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.79191
Abstract: Restructured electric market environment allows the power wheeling transactions between the power producers and customers to meet the growing load demand. This will lead to the possible of congestion in the transmission lines. The possible contingencies of power components further worsen the scenario. This paper describes the methodology for the identification of critical transmission line by computing the real power and reactive power performance indices. It also demonstrates the importance of fuzzy logic technique used to rank the transmission lines according to the severity and demonstrated on IEEE-30 bus system.
Error Correction Circuit for Single-Event Hardening of Delay Locked Loops  [PDF]
S. Balaji, S. Ramasamy
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.79210
Abstract: In scaled CMOS processes, the single-event effects generate missing output pulses in Delay-Locked Loop (DLL). Due to its effective sequence detection of the missing pulses in the proposed Error Correction Circuit (ECC) and its portability to be applied to any DLL type, the ECC mitigates the impact of single-event effects and completes its operation with less design complexity without any concern about losing the information. The ECC has been implemented in 180 nm CMOS process and measured the accuracy of mitigation on simulations at LETs up to 100 MeV-cm2/mg. The robustness and portability of the mitigation technique are validated through the results obtained by implementing proposed ECC in XilinxArtix 7 FPGA.
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