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Search Results: 1 - 10 of 325556 matches for " S. Sudha "
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High Frequency Charging Techniques—Grid Connected Power Generation Using Switched Reluctance Generator  [PDF]
S. Sridharan, S. Sudha
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.714352
Abstract: Power generation becomes the need of developed, developing and under developed countries to meet their increasing power requirements. When affordability increases their requirement of power increases, this happens when increased per capita consumption. The existing power scenario states that highest power is produced using firing of coals called thermal energy. A high efficiency Switched Reluctance Generator (SRG) based high frequency switching scheme to enhance the output for grid connectivity is designed, fabricated and evaluated. This proposed method generates the output for the low wind speed. It provides output at low speed because of multi-level DC-DC converter and storage system. It is an efficient solution for low wind power generation. The real time readings and results are discussed.
Feature Selection Based on Enhanced Cuckoo Search for Breast Cancer Classification in Mammogram Image  [PDF]
M. N. Sudha, S. Selvarajan
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.74028
Abstract: Proposed system has been developed to extract the optimal features from the breast tumors using Enhanced Cuckoo Search (ECS) and presented in this paper. The texture feature, intensity histogram feature, radial distance feature and shape features have been extracted and the optimal feature set has been obtained using ECS. The overall accuracy of a minimum distance classifier and k-Nearest Neighbor (k-NN) on validation samples is used as a fitness value for ECS. The new approach is carried out on the extracted feature dataset. The proposed system selects only the minimum number of features and performed the accuracy of 98.75% with Minimum Distance Classifier and 99.13% with k-NN Classifier. The performance of the new ECS is compared with the Cuckoo Search and Harmony Search. This result shows that the ECS algorithm is more accurate than the other algorithm. The proposed system can provide valuable information to the physician in medical pathology.
LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN SOUTH INDIAN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Prakash S,Sudha S
International Research Journal of Pharmacy , 2012,
Abstract: An imbalance between reactive oxygen species production and antioxidant scavenging has been implicated in type 2 diabetes. Reports indicate that several complications of diabetes mellitus are associated with increased activity of free radicals and accumulation of lipid peroxidation products. The aim of this study was to test the hypothesis that type 2 diabetes mellitus is associated with increased oxidative stress in south Indian subjects. Fasting blood samples were obtained from 50 diabetic patients (26 male and 24 female) and 50 (26 male and 24 female) healthy control subjects. Plasma malondialdehyde (MDA), Superoxide dismutase (SOD) reduced glutathione (GSH) and Vitamin C levels were measured and the results were compared with those of controls. MDA levels were found to be significantly higher, SOD and GSH activities were found to be significantly lower in type 2 diabetic patients when compared with controls (P<0.05). There was a decrease in vitamin C level was observed in patients (P<0.05). In this study lower lipid peroxidation is inversely proportional to the antioxidant levels in type 2 diabetics. Therefore, the future studies need to focus on gathering large sample sizes to clarify the relationship between antioxidant depletion and type 2 diabetes mellitus.
REDUCED PLASMA ANTIOXIDANT LEVELS IN SMOKING ASTHMATICS
Rajalakshmi G,Sudha S
International Research Journal of Pharmacy , 2012,
Abstract: The imbalance in antioxidants is thought to play an important role in the pathogenesis of bronchial asthma. The present study was undertaken to evaluate the status of lipid peroxidation and antioxidants as biomarkers in human plasma. The extent of lipid peroxidation as evidenced by the formation of thiobarbituric acid reactive substances (TBARS) and the status of the antioxidants by reduced glutathione (GSH) in the smokers with and without asthma. The mean TBARS levels were higher among smokers with asthma (2.97±1.09) when compared with control smokers (0.75 ±0.81). The mean GSH level were higher in control non-smokers (0.172±0.21) compared to asthma smokers (0.032±0.03) and non smokers (0.061±0.06). Measured parameters confirm that cigarette smoke mediated oxidative stress could represent the primary causative factor in the pathogenesis of asthma.
Albumin microspheres as an ocular delivery system for pilocarpine nitrate
Rathod Sudha,Deshpande S
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: Pilocarpine nitrate loaded egg albumin microspheres were prepared by thermal denaturation process in the size range of 1-12 μm. A series of batches were prepared to study factors, which may affect the size and entrapment efficiency of drug in microspheres and optimized the process. Drug loaded microspheres so obtained were evaluated for their size, entrapment efficiency, release rate and biological response. Electron photomicrographs were taken (8000X) to study the morphological characteristics of microspheres. The entrapment and encapsulation of pilocarpine after process optimization was found to be 82.63% and 62.5% respectively. In vitro dissolution rate studies revealed that the release of drug from the microspheres followed spherical matrix mechanism. Biological response of microspheric suspension was measured by reduction in intraocular pressure in albino rabbit eyes and compared with marketed eye drops. Various pharmacokinetic parameters viz. onset of action, duration of action, Tmax and AUC were studied. A measurable difference was found in the mean miotic response, duration and AUC of pilocarpine nitrate microspheric suspension.
CHUNNAM: A COMMENDED DOSAGE FORM IN SIDDHA MEDICINE
Ayyasamy S,Sudha R
International Journal of Research in Ayurveda and Pharmacy , 2013,
Abstract: Siddha system of medicine is one of the ancient living systems of healing in southern India. A vast cornucopia of different dosage forms of inorganic formulations are indicated in classical texts of this system. Chunnam is one such, highly acclaimed dosage form of alkaline group of drugs indicated for chronic degenerative diseases. Highly commended medicine in Siddha classics, muppu chunnam also falls under this category which is used in kayakalpam treatment. A detailed review is made in this article regarding the special features of chunnam preparations, its comprehensive uses in drug making and therapeutic effects which makes this dosage form as an indispensible one in Siddha medicine. This paper aims to highlight an important thrust area of Siddha medicine which enables to unearth many possible medicines for life style disease of this millennium.
Perioperative Adjunct Magnesium Decreases Postoperative Opioid Requirements—A Meta-Analysis  [PDF]
Sudha Arumugam, Christine S. M. Lau, Ronald S. Chamberlain
International Journal of Clinical Medicine (IJCM) , 2016, DOI: 10.4236/ijcm.2016.75032
Abstract: Objectives: Magnesium (Mg) is the fourth most common cation in the body and has numerous physiological activities and anti-nociceptive effects. The anti-nociceptive effects are primarily mediated by regulation of calcium influx into the cell and antagonism of the N-Methyl-D-aspartate glutamate receptors. Opioids are widely used as analgesics to minimize postoperative pain, but their use is associated with various side effects as well as the potential for addiction and tolerance. Systemic Mg has been proposed as an adjunct to minimize postoperative pain in numerous clinical studies. This meta-analysis aims to critically examine the ability of perioperative intravenous (IV) Mg to reduce opioid use and its’ side effects. Methods: A comprehensive literature search of Pub Med, Cochrane Central Registry of Controlled Trials, and Google Scholar (1966-2016) was performed to identify all randomized control trials (RCTs) assessing the use of perioperative IV Mg in the reduction of postoperative opioid consumption. Keywords searched included combinations of “magnesium”, “pain”, “postoperative”, “preoperative”, “analgesia” and “opioid”. Inclusion criteria included RCTs comparing the use of perioperative IV Mg with a control group in adult patients (>18 yrs) undergoing elective surgery. Cumulative opioid consumption within the first 24 hours (hrs) postoperative period and the incidence of nausea and vomiting were analyzed. Results: 14 RCTs involving 910 patients were identified (455 patients received Mg and 455 patients received placebo or no therapy). Opioid consumption was significantly decreased in the systemic Mg group (standard mean difference [SMD]: 1.39, 95% CI 1.83 to -0.96; p < 0.001) at 24 hrs postoperatively. Subgroup analysis revealed a significant reduction in the morphine consumption (SMD: -1.37, 95% CI: -1.79 to -0.95; p < 0.001) with the use of IV Mg. There was a decrease in tramadol consumption; however, this did not reach statistical significance (SMD: -1.74, 95% CI: -4.62 to 1.13; p = 0.234). Systemic Mg adjunct had no significant effect on postoperative nausea and vomiting (RR = 0.63; 95% CI 0.38 to 1.04; p = 0.07). Conclusion: Perioperative IV Mg administration reduces opioid use in the first 24 hours postoperatively without any serious adverse events. The decreased need for postoperative opioids in the Mg group was not associated with a decrease in opioid-related side effects such as nausea and vomiting. Mg is an efficacious adjunct for postoperative analgesia and should be considered in multimodal analgesic
Effect of different concentrations of metal ions on alpha amylase production by Bacillus amyloliquefaciens
Sudha
Research in Biotechnology , 2012,
Abstract: Bacillus amyloliquefaciens is obtained from soil which produces extracellular alphaamylase enzyme. The present study is concerned with effect of metal ions on alpha amylaseproduction. Metal ions are Ca2+, Cu2+, Mg2+, Fe2+ and Mn2+ at different concentrations 2g/l,5g/l and 7g/l. Supplementations of salts of certain ions provide good growth ofmicroorganism and production of alpha amylase. Ca2+and Mg2+exhibit positive influence onalpha-amylase production. Our results show that the amylase production is higher in thepresence of Ca2+ (0.439) IU/ml/min at 7g/l concentration in comparison of other metal ions.The enzyme activity of Mg2+(0.321) IU/ml/min at 2g/l concentration. The study focuses onsupplementation of metal ions increase the production of amylase.
Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander?
Zaldy S Tan, Sudha Seshadri
Alzheimer's Research & Therapy , 2010, DOI: 10.1186/alzrt29
Abstract: While the blood-brain barrier restricts the flow of blood-borne ions, molecules, and cells into the neural tissue, protecting the central nervous system from insult and injury, it also diminishes the utility of measuring circulating biomarkers to study changes that may be happening within the brain. However, peripheral blood monocytes and macrophages actively cross the blood-brain barrier and hence may better reflect inflammation within the neuropil. Thus, whereas three large population studies failed to relate circulating levels of inflammatory markers, such as C-reactive protein (CRP), to risk of cognitive decline and clinical Alzheimer disease (AD) [1-3], one of these, the Framingham Study, reported an association between the increased production of cytokines (inter leukin-1 [IL-1] and tumor necrosis factor-alpha) by peripheral blood monocytes and an approximately twofold increase in risk of incident AD [3]. Although late-onset AD (LOAD) in patients older than 65 years of age appears to be strongly heritable, a substantial proportion of this heritability remains unexplained by known genetic and environmental factors [4]. The strongest known risk factors for LOAD remain a positive family history and the APOE ε4 allele. van Exel and colleagues [5] use these known risk factors to identify high- and low-risk samples of middle-aged persons in whom they compare levels of inflammatory and vascular risk factors. In this Dutch study, they observed that middle-aged persons with a parental history of LOAD had adverse levels of certain vascular risk factors (higher systolic and diastolic blood pressures and a lower ankle-brachial index) and greater production of proinflammatory cytokines in lipopolysaccharide-stimulated whole blood samples when compared with middle-aged persons whose parents were known to be free of dementia. While the APOE ε4 allele genotype was more frequent among offspring with parental AD compared with controls, these findings were independent of APOE ge
PSOWNN Based Relaying for Power Transformer Protection
S. Sudha,A. Ebenezer Jeyakumar
International Journal of Electrical and Power Engineering , 2012,
Abstract: This study presents a new, efficient, fast and reliable technique to discriminate internal faults from no fault conditions (inrush condition, normal, over excitation and external faults with CT saturation) in 3 phase transformers. A typical 100 MVA, 110/220 KV, Δ/Y 3 phase transformer connected between a 110 KV source at the sending end and a 220 KV transmission line connected to an infinite bus power system at the receiving end are simulated using PSCAD/EMTDC software. Various types of fault and no fault conditions are simulated and the differential currents are obtained. Wavelet transformation is done on the differential current and the d1 coefficients are obtained. The d1 coefficients are given as inputs to the wavelet based neural network trained by Particle Swarm Optimization (PSO-WNN). The simulation results show that PSO-WNN has very simple architecture, negligible error and provides more accurate results when compared to wavelet combined neural network trained by back propagation algorithm (WNN) and neural network trained by giving 3 phase differential currents as input (ANN). The performance of PSO-WNN based relay is also compared with the conventional harmonic blocking relay. PSO-WNN based relaying provides a high operating sensitivity for internal faults and remains stable for no fault conditions of the power transformers.
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