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Search Results: 1 - 10 of 411011 matches for " S. O. Bakare "
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Influence of a Low Fat Meal on the Pharmacokinetics and Bioavailability of Nifedipine Tablets
S.O. Okeniyi,M.T. Odunola-Bakare
Research Journal of Applied Sciences , 2012,
Abstract: In vivo bioavailaibility studies of nifedipine tablets were carried out in six healthy human subjects in fasting state and after a low-fat meal. A simple, reliable and rapid HPLC method of nifedipine estimation preceded by an extraction technique was employed for the determination of plasma and saliva nifedipine levels. Pharmacokinetic parameters were generated by computer application. The low fat meal taken appeared to reduce the absorption rate constant of nifedipine, in plasma and saliva from 0.96h-1 0.104 to 0.57h-1 0.168 and 0.86h-1 0.38 to 0.41h-1 0.03 respectively and increase the lag time in plasma and saliva from 0.13h 0.37 to 0.36h 0.58 and 0.17h 0.08 to 0.34h 0.18, respectively.
TRADE OPENNESS AND ITS IMPACT ON NIGERIA’S NON-OIL INDUSTRIAL SECTOR: 1979-2009
Bakare A.S Ph.D,Fawehinmi, F. O
Economics and Finance Review , 2011,
Abstract: The growth of the industrial sector and the resultant export witnessed in Nigeria in the 1960s and 1970s was largely the outcome of a policy of import substitution which precipitated the overvaluation of the domestic currency partly through the encouragement of low return investments by preferential credit policies and direct public investment in industrial ventures. The ‘fait accompli’ adoption of the IMF – induced structural economic reforms whose main trust is trade openness among others was targeted at restructuring the economy away from over dependence on the oil sector. This study focused on the impact of trade openness on Nigeria’s industrial performance with a view to determining the spill over effect of the policy on the major contending sectors in the economy. This study therefore examined the relationship between trade openness and industrial performance,armed with secondary time series data and using an ordinary least square multiple regression analytical method. The study found that the unilateral trade openness of 1986 produced the sustainable impact on the nonoil industrial sector of the Nigerian economy. It was observed that Public domestic investment, saving rate, capacity utilization and infrastructure has negative impacts on Nigeria’s industrial performance. Our findings and conclusion support the need for the government to consolidate and maintain the credibility of the trade policies for sustainable growth and development. More progress will be achieved if the conditions needed for a deregulated trade system to work properly are set in place.
Serum Magnesium Levels in Healthy Pregnant and Pre-Eclamptic Patients
—A Cross-Section Study
 [PDF]

D. A. Adekanle, O. T. Adeyemo, A. A. Adeniyi, R. A. Okere, A. K. Jimoh, I. O. Adebara, A. Bakare, A. S. Atiba, A. Adelekan, B. A. Olofinbiyi
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.49080
Abstract:

Background: Pre-eclampsia complicates 2% - 8% of pregnancies. Various efforts have been put forward for its prevention and treatment. Magnesium sulphate is presently the recommended drug for the prevention and treatment of eclampsia and severe pre-eclampsia. Objectives: The study aimed to compare the serum magnesium in a healthy pregnant women and pre-eclamptic women. It determined demographic characteristic of the study population and recommended the prophylactic usage of magnesium sulphate in pregnancy in our environment. Method: This was a prospective case control study comparing the serum magnesium levels in pre-eclampsia and normal pregnancy tertiary hospitals. The women who satisfied the inclusion criteria were recruited in the two groups (seventy five in the healthy pregnant women and seventy five in the pre-eclamptic women). The blood samples were collected and analysed for the serum magnesium and urine sample for urinalysis. Result: Total of 150 patients comprises 75 normal pregnant women and 75 cases of pre-eclampsia. The mean serum magnesium in the normal pregnant women was 0.73 (±0.14) mmol/L while in preeclampsia the level was 0.58 (±0.17) mmol/L. This is statistically significant (t = 6.120, p = 0.000). There was significance difference in the mean age of patients with pre-eclampsia and normal pregnancy. The mean parity in the pre-eclampsia was 0.80 and in the normal pregnancy was 1.4 and was statistically significant (t = 3.40, p value < 0.001). The mean gestational age of the pre-eclamptic was 36.5 weeks while it was 28.7 weeks in the normal pregnant women (t = 10.80, p = 0.000). Conclusion: The findings in this research work revealed that the pre-eclamptic women have lower serum magnesium level compared to the normal pregnant women, and it may therefore be interesting to do a larger multicenter study with possibility of developing a marker for this disease of theories.

Training of Food Providers for Improved Environmental Conditions of Food Service Outlets in Urban Area Nigeria  [PDF]
Motunrayo F. Olumakaiye, Kudirat O. Bakare
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.47A012
Abstract: Environmental conditions and hygiene practices under which foods are prepared and served for public consumption are a matter of concern. The study was conducted to investigate the impact of training of food providers on environmental conditions of food service outlets (FSO) in and around a university community in Southwestern Nigeria. Structured questionnaire and “Spot Check Observation” (SCO) were used to assess the hygiene practices and environmental condition of the FSO respectively. Sixteen (16) High Density Food Service Outlets (HDFSO) and twelve (12) Low Density Food Service Outlets (LDFSO) were investigated. From the findings, mean score of SCO for HDFSO was low (2.93 ± 0.09) compared to LDFSO (4.32 ± 0.56) (p = 0.014). There were significant differences in source of cooking water (p = 0.003), solid waste disposal method (p = 0.031), liquid waste disposal method (p = 0.023) and toilet facilities (p = 0.001) between HDFSO and LDFSO. Significant differences existed in the environmental hygiene between HDFSO and LDFSO (p < 0.05). A significant relationship existed between educational level (r = 0.789, p = 0.038), age (r = 0.631, p = 0.045), income (r = 0.623, p = 0.004) of food service providers and environmental condition. Service providers that were >40 years of age were more likely to score high in SCO in HDFSO than the other age groups (OR = 1.80, 95%CI = 1.21, 2.68). Those with tertiary education were twice more likely to score high in SCO compared to those with lower educational qualifications in LDFSO (OR = 2.03, 95%CI = 1.48 2.78). Those who earned above ?40,000.00 were more likely to have higher SCO among both categories. A 3-day food safety workshop was organized among both groups at different times, three months later, SCO was conducted and scores improved greatly. Constant training of food service providers is important to improving the environmental condition of food service outlets in high-density urban areas in order to ensure food safety.
Optimization of protocols for DNA extraction and RAPD analysis in West African fonio (Digitaria exilis and Digitaria iburua ) germplasm characterization
DD Kuta, E Kwon-Ngung, S Dachi, O Bakare, LA Ogunkanmi
African Journal of Biotechnology , 2005,
Abstract: Fonio is an important indigenous grain crop of West Africa, but the extent of genetic diversity in fonio, its origin and phylogeny are not well understood. DNA markers allow precise characterization of plant germplasm accessions, but there is no literature report of their use in fonio. This paper reports the result of protocol optimization research for DNA isolation and RAPD analyses in fonio. High quality DNA was successfully isolated and RAPD was effectively used to study genetic similarity among fonio accessions. This result might stimulate the application of DNA markers to investigate the origin and phylogeny of fonio in Africa.
Effective therapeutic dosage of antipsychotic medications in patients with psychotic symptoms: Is there a racial difference?
Muideen O Bakare
BMC Research Notes , 2008, DOI: 10.1186/1756-0500-1-25
Abstract: The pertinent question is why the apparent differences in dosage prescription practices across races and regions? The possibility of racial differences in psychotic symptoms response to antipsychotic medications rather than clinicians' prescription attitudes was entertained.Future carefully controlled studies might be needed to test the proposed hypothesis of racial differences in psychotic symptoms response to antipsychotic medications.There might be actual racial influence on psychotic symptoms response to antipsychotic medications. If future carefully controlled studies uphold the hypothesis of racial differences in psychotic symptoms response to antipsychotic medications, there might be need to draw up new treatment or prescription guidelines that would put into consideration variations in genetic make up and consequent racial differences in psychotic symptoms response to antipsychotic medications.Genetic make-up had been known to influence metabolism and utilization of psychotropic medications [1-4]. Genetic and environmental factors also determined the phenotypic inter-racial differences worldwide. Earlier studies had documented racial variation in metabolism of antipsychotic medications based on serum level measurement of the medications and other parameters [5,6]. The findings of these studies [5,6] could be due to racial differences in activities of cytochrome P 450 (CYP 450) enzymes, especially CYP2D6 and CYP2C19 which are largely responsible for metabolism of antipsychotic medications and other psychotropic drugs [1-4]. Another possible factor that could be responsible for racial variation in serum level of antipsychotic medications and other parameters of psychotic symptoms response is individual variation in dopamine receptor occupancy of antipsychotic medications which had been documented [7].In the past two decades, review of literature on pharmacokinetics and pharmacodynamics of psychotropic medications and socio-cultural influences on response to ps
Debt Forgiveness and its Impact on the Growth of Nigerian Economy: An Empirical Study
A.S. Bakare
Pakistan Journal of Social Sciences , 2012, DOI: 10.3923/pjssci.2010.34.39
Abstract: Despite the debt forgiveness to the tune of $18 billion received by Nigeria from Paris club since year 2005 including the subsequent payment of $12 billion to upset the remaining debt, there is no evidence of accelerating pace of growth and development of the country. It is therefore, instructive to find out the direction and the extent of the effectiveness of the debt relief granted to Nigeria. This forms the objective of this study. The secondary data used for the investigation were processed using the ordinary least square packages. The result of the OLS model showed that the debt overhang problem of Nigeria has been alleviated by the debt relief package but the debt service relief did not positively influence the growth indicator. The results strongly support the need for tougher conditionality in future debt forgiveness initiative. Donor countries should monitor the allocation pattern of debt relief maintain the conditionalities and reward sound policies and improvements of governance quality in debtor countries.
Multinational Direct Investment and Economic Growth in Nigeria: An Empirical Study
A.S. Bakare
International Business Management , 2012, DOI: 10.3923/ibm.2010.171.176
Abstract: One of the major macroeconomic variables that stimulate growth is investment. Economic theories have shown that there is a causal relationship between economic growth and the increase in investment. This study, however examined the growth implications of multinational direct investment in Nigeria. The results of the data analysis and estimation were obtained using the parsimonious error correction mechanism. The result demonstrated that there is a positive relationship between multinational direct investment and growth in Nigeria. It shows that 1% rise in multinational direct investments will cause as much as 80% growth in the gross domestic output. This result indicated that multinational direct investment has the greatest influence on the growth of Nigerian economy compare to other variable in the model and strongly support the need for the government to encourage multinational corporation to establish more direct foreign investment in Nigeria. This is possible by simplifying the screening process and by creating more conducive political, social and economic environment for effective operation of multinational corporations.
THE ECONOMIC IMPLICATION OF OIL BOOM ON AGRICULTURAL EXPORTS TRADE INSTABILITY IN NIGERIA: AN EMPIRICAL STUDY
Bakare A.S
Contemporary Marketing Review , 2011,
Abstract: The central issues with which this study is concerned revolve around the major determinants of agricultural export instability in Nigeria. Specifically, the study examined the relationship between oil export and the agricultural export performance in Nigeria. In trying to achieve this objective, an ordinary least square multiple regression approach was adopted for the data analysis. Some statistical tools were employed to determine the statistical significant relationship between these variables. The analysis started with the test of stationarity and co-integration of Nigeria’s time series data. The empirical study found that the data were stationary and co integrated. The multiple regression results showed a significant but negative relationship between oil export and the agricultural export performance in Nigeria. These results were robust to a number of econometric specifications. Our findings and conclusion support the need for the government to diversify the oil sector and encourage agriculture through incentives to farmers, mechanization and positive policy measures. In complement of the above, it is important for the government to consolidate and maintain export incentives comprising a duty draw-back scheme, explicit export bonuses, currency retention scheme and other direct fiscal incentives (such as the exemption of export transactions from stamp duties).
THE CONSEQUENCES OF TRADE LIBERALIZATION FOR ECONOMIC GROWTH IN NIGERIA: A STOCHASTIC INVESTIGATION
Bakare A.S
Contemporary Marketing Review , 2011,
Abstract: This paper investigated the growth implications of trade liberalization arising from tariff reductions on final goods and on intermediate inputs, using Nigeria data. The ordinary least square multiple regression analytical method was used to examine the relationship between trade liberalization and economic growth. Some statistical tools were employed to explore the relationship between these variables. The analysis started with the test of stationarity and co-integration of Nigeria’s time series data. Thereafter an error correction mechanism was used to determine the long-run relationship among the variables examined. The empirical study found that the data were stationary and co integrated and showed that there is a long run significant relationship between trade liberalization and economic growth in Nigeria. The multiple regression results showed a significant and positive relationship between trade liberalization and economic growth in Nigeria. These results were robust to a number of econometric specifications. The econometric results and conclusion support the need for the government to develop the trade sector towards greater effectiveness and efficiency. In complement of the above, it is important for the government to consolidate and maintain the credibility of the trade policies for sustainable growth and development.
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